Jorrit M. Enserink

  • Group leader
  • +47 22 78 19 82
 

Publications 2021

Caulier B, Enserink JM, Wälchli S (2021)
Pharmacologic Control of CAR T Cells
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094320, PubMed 33919245

Grad I, Hanes R, Ayuda-Durán P, Kuijjer ML, Enserink JM, Meza-Zepeda LA, Myklebost O (2021)
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
PLoS One, 16 (3), e0248140
DOI 10.1371/journal.pone.0248140, PubMed 33690666

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751

Melvold K, Giliberto M, Karlsen L, Ayuda-Durán P, Hanes R, Holien T, Enserink J, Brown JR, Tjønnfjord GE, Taskén K, Skånland SS (2021)
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B cell malignancies
Mol Oncol (in press)
DOI 10.1002/1878-0261.13153, PubMed 34861096

Rønneberg L, Cremaschi A, Hanes R, Enserink JM, Zucknick M (2021)
bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments
Brief Bioinform, 22 (6)
DOI 10.1093/bib/bbab251, PubMed 34308471

Publications 2020

Omsland M, Andresen V, Gullaksen SE, Ayuda-Durán P, Popa M, Hovland R, Brendehaug A, Enserink J, McCormack E, Gjertsen BT (2020)
Tyrosine kinase inhibitors and interferon-α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines
FASEB J, 34 (3), 3773-3791
DOI 10.1096/fj.201802061RR, PubMed 31945226

Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Fløisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM (2020)
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632

Publications 2019

Nguéa P A, Robertson J, Herrera MC, Chymkowitch P, Enserink JM (2019)
Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast
J Biol Chem, 294 (49), 18784-18795
DOI 10.1074/jbc.RA119.009721, PubMed 31676685

Prikrylova T, Robertson J, Ferrucci F, Konorska D, Aanes H, Manaf A, Zhang B, Vågbø CB, Kuśnierczyk A, Gilljam KM, Løvkvam-Køster C, Otterlei M, Dahl JA, Enserink J, Klungland A, Robertson AB (2019)
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131

Zhang B, Ayuda-Durán P, Piechaczyk L, Fløisand Y, Safont MM, Karlsen IT, Fandalyuk Z, Tadele D, van Mierlo P, Rowe AD, Robertson JM, Gjertsen BT, McCormack E, Enserink JM (2019)
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, 104 (5), e229
DOI 10.3324/haematol.2019.220533, PubMed 31040234

Publications 2018

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619

Kruitwagen T, Chymkowitch P, Denoth-Lippuner A, Enserink J, Barral Y (2018)
Centromeres License the Mitotic Condensation of Yeast Chromosome Arms
Cell, 175 (3), 780-795.e15
DOI 10.1016/j.cell.2018.09.012, PubMed 30318142

Zhang B, Durán PA, Piechaczyk L, Fløisand Y, Safont MMS, Karlsen IT, Fandalyuk Z, Tadele D, Mierlo PV, Rowe AD, Robertson JM, Gjertsen BT, McCormack E, Enserink JM, Bjørn Tore Gjertsen Group, Emmet McCormack Group (2018)
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445

Publications 2017

Chymkowitch P, Enserink JM (2017)
Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits
Biochim Biophys Acta Gene Regul Mech, 1861 (4), 310-319
DOI 10.1016/j.bbagrm.2017.11.001, PubMed 29127063

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404

Chymkowitch P, P AN, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2017)
Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 27 (2), 334
DOI 10.1101/gr.218370.116, PubMed 28148563

Enserink J, Nguéa P A, Chymkowitch P (2017)
Anabolic transcription: Secrets of the sumo diet
Cell Cycle, 16 (7), 593-594
DOI 10.1080/15384101.2017.1294945, PubMed 28278057

Enserink JM (2017)
Sumo during stress: When transcription takes a pause (comment on DOI.10.1002/bies.201600263)
Bioessays, 39 (6)
DOI 10.1002/bies.201700065, PubMed 28464310

Enserink JM (2017)
Regulation of Cellular Processes by SUMO: Understudied Topics
Adv Exp Med Biol, 963, 89-97
DOI 10.1007/978-3-319-50044-7_5, PubMed 28197907

Pietarinen PO, Eide CA, Ayuda-Durán P, Potdar S, Kuusanmäki H, Andersson EI, Mpindi JP, Pemovska T, Kontro M, Heckman CA, Kallioniemi O, Wennerberg K, Hjorth-Hansen H, Druker BJ, Enserink JM, Tyner JW, Mustjoki S, Porkka K (2017)
Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
Oncotarget, 8 (14), 22606-22615
DOI 10.18632/oncotarget.15146, PubMed 28186983

Zimmermann C, Garcia I, Omerzu M, Chymkowitch P, Zhang B, Enserink JM (2017)
Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28
G3 (Bethesda), 7 (6), 1753-1766
DOI 10.1534/g3.117.042317, PubMed 28428242

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2017)
TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy
Cell Rep, 18 (8), 2073-2074
DOI 10.1016/j.celrep.2017.02.020, PubMed 28228270

Publications 2016

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652

Publications 2015

Chymkowitch P, Nguéa P A, Enserink JM (2015)
SUMO-regulated transcription: challenging the dogma
Bioessays, 37 (10), 1095-105
DOI 10.1002/bies.201500065, PubMed 26354225

Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
DOI 10.1101/gr.185793.114, PubMed 25800674

Enserink JM (2015)
Sumo and the cellular stress response
Cell Div, 10, 4
DOI 10.1186/s13008-015-0010-1, PubMed 26101541

Publications 2014

Davydova E, Ho AYY, Malecki J, Moen A, Enserink JM, Jakobsson ME, Loenarz C, Falnes PØ (2014)
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)
J Biol Chem, 289 (44), 30499-30510
DOI 10.1074/jbc.M114.601658, PubMed 25231979

Enserink JM (2014)
Metabolic pathways further increase the complexity of cell size control in budding yeast
Microb Cell, 1 (9), 276-278
DOI 10.15698/mic2014.09.167, PubMed 28362005

Publications 2013

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2013)
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
Cell Rep, 5 (4), 1036-46
DOI 10.1016/j.celrep.2013.10.024, PubMed 24239358

Publications 2012

Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984

Chymkowitch P, Enserink JM (2012)
The cell cycle rallies the transcription cycle: Cdc28/Cdk1 is a cell cycle-regulated transcriptional CDK
Transcription, 4 (1), 3-6
DOI 10.4161/trns.22456, PubMed 23131667

Enserink JM (2012)
Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways
Molecules, 17 (8), 9258-73
DOI 10.3390/molecules17089258, PubMed 22858845

Enserink JM, Kolodner RD (2012)
What makes the engine hum: Rad6, a cell cycle supercharger
Cell Cycle, 11 (2), 249-52
DOI 10.4161/cc.11.2.19023, PubMed 22214660

Pultz D, Bennetzen MV, Rødkær SV, Zimmermann C, Enserink JM, Andersen JS, Færgeman NJ (2012)
Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae
Mol Biosyst, 8 (3), 796-803
DOI 10.1039/c2mb05356j, PubMed 22218487

Publications 2011

Zimmermann C, Chymkowitch P, Eldholm V, Putnam CD, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM (2011)
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
Proc Natl Acad Sci U S A, 108 (46), 18748-53
DOI 10.1073/pnas.1115885108, PubMed 22042866

Publications 2010

Enserink JM, Kolodner RD (2010)
An overview of Cdk1-controlled targets and processes
Cell Div, 5, 11
DOI 10.1186/1747-1028-5-11, PubMed 20465793

Publications 2009

Enserink JM, Hombauer H, Huang ME, Kolodner RD (2009)
Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae
J Cell Biol, 185 (3), 423-37
DOI 10.1083/jcb.200811083, PubMed 19398760

Kats ES, Enserink JM, Martinez S, Kolodner RD (2009)
The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants
Mol Cell Biol, 29 (19), 5226-37
DOI 10.1128/MCB.00894-09, PubMed 19635810

Publications 2006

Bryn T, Mahic M, Enserink JM, Schwede F, Aandahl EM, Taskén K (2006)
The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages
J Immunol, 176 (12), 7361-70
DOI 10.4049/jimmunol.176.12.7361, PubMed 16751380

Enserink JM, Smolka MB, Zhou H, Kolodner RD (2006)
Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae
J Cell Biol, 175 (5), 729-41
DOI 10.1083/jcb.200605080, PubMed 17130284

Smolka MB, Chen SH, Maddox PS, Enserink JM, Albuquerque CP, Wei XX, Desai A, Kolodner RD, Zhou H (2006)
An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth
J Cell Biol, 175 (5), 743-53
DOI 10.1083/jcb.200605081, PubMed 17130285

Publications 2004

Enserink JM, Price LS, Methi T, Mahic M, Sonnenberg A, Bos JL, Taskén K (2004)
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
J Biol Chem, 279 (43), 44889-96
DOI 10.1074/jbc.M404599200, PubMed 15302884

Johansson CC, Yndestad A, Enserink JM, Ree AH, Aukrust P, Taskén K (2004)
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types
Endocrinology, 145 (11), 5177-84
DOI 10.1210/en.2004-0232, PubMed 15284208

Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K (2004)
Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells
Eur J Immunol, 34 (8), 2191-9
DOI 10.1002/eji.200425036, PubMed 15259016

Publications 2003

Bos JL, de Bruyn K, Enserink J, Kuiperij B, Rangarajan S, Rehmann H, Riedl J, de Rooij J, van Mansfeld F, Zwartkruis F (2003)
The role of Rap1 in integrin-mediated cell adhesion
Biochem Soc Trans, 31 (Pt 1), 83-6
DOI 10.1042/bst0310083, PubMed 12546659

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL (2003)
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor
J Cell Biol, 160 (4), 487-93
DOI 10.1083/jcb.200209105, PubMed 12578910

Publications 2002

Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL (2002)
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
Nat Cell Biol, 4 (11), 901-6
DOI 10.1038/ncb874, PubMed 12402047

Verschure PJ, Van Der Kraan I, Enserink JM, Moné MJ, Manders EM, Van Driel R (2002)
Large-scale chromatin organization and the localization of proteins involved in gene expression in human cells
J Histochem Cytochem, 50 (10), 1303-12
DOI 10.1177/002215540205001003, PubMed 12364563

Publications 2000

Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (2000)
Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2
J Cell Physiol, 185 (2), 269-79
DOI 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L, PubMed 11025449

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