Helge Rootwelt
Position: Senior Consultant , MD, PhD
Phone: +47 23 07 09 22

Author network for Helge Rootwelt by COREMINE medical

Publications 2014

Vethe NT, Ali AM, Reine PA, Andersen AM, Bremer S, Line PD, Rootwelt H, Bergan S (2014)
Simultaneous quantification of IMPDH activity and purine bases in lymphocytes using LC-MS/MS: assessment of biomarker responses to mycophenolic acid
Ther Drug Monit, 36 (1), 108-18
PubMed 24061448

Publications 2013

Backe PH, Ytre-Arne M, Røhr AK, Brodtkorb E, Fowler B, Rootwelt H, Bjørås M, Mørkrid L (2013)
Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type
JIMD Rep, 11, 79-85
PubMed 23580368

Publications 2012

Bliksrud YT, Brodtkorb E, Backe PH, Woldseth B, Rootwelt H (2012)
Hereditary tyrosinaemia type I in Norway: incidence and three novel small deletions in the fumarylacetoacetase gene
Scand J Clin Lab Invest, 72 (5), 369-73
PubMed 22554029

Helsing P, Nymoen DA, Rootwelt H, Vårdal M, Akslen LA, Molven A, Andresen PA (2012)
MC1R, ASIP, TYR, and TYRP1 gene variants in a population-based series of multiple primary melanomas
Genes Chromosomes Cancer, 51 (7), 654-61
PubMed 22447455

Westlye LT, Reinvang I, Rootwelt H, Espeseth T (2012)
Effects of APOE on brain white matter microstructure in healthy adults
Neurology, 79 (19), 1961-9
PubMed 23100402

Publications 2011

Bremer S, Ohlsson A, Brodtkorb E, Rootwelt H, Rootwelt T, Woldseth B, Mørkrid L (2011)
A novel mucopolysaccharidosis type I associated splice site mutation and IDUA splice variants
Mol Genet Metab, 104 (3), 289-94
PubMed 21831683

Lillenes MS, Espeseth T, Støen M, Lundervold AJ, Frye SA, Rootwelt H, Reinvang I, Tønjum T (2011)
DNA base excision repair gene polymorphisms modulate human cognitive performance and decline during normal life span
Mech Ageing Dev, 132 (8-9), 449-58
PubMed 21884718

Westlye ET, Lundervold A, Rootwelt H, Lundervold AJ, Westlye LT (2011)
Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE ε4 carriers: relationships with memory performance
J Neurosci, 31 (21), 7775-83
PubMed 21613490

Publications 2010

Brodtkorb E, Strand J, Backe PH, Lund AM, Bjørås M, Rootwelt T, Rootwelt H, Woldseth B, Eide L (2010)
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
Mol Genet Metab, 100 (4), 324-32
PubMed 20570198

Espeseth T, Sneve MH, Rootwelt H, Laeng B (2010)
Nicotinic receptor gene CHRNA4 interacts with processing load in attention
PLoS One, 5 (12), e14407
PubMed 21203548

Espeseth T, Westlye LT, Walhovd KB, Fjell AM, Endestad T, Rootwelt H, Reinvang I (2010)
Apolipoprotein E ε4-related thickening of the cerebral cortex modulates selective attention
Neurobiol Aging, 33 (2), 304-322.e1
PubMed 20382449

Reinvang I, Lundervold AJ, Wehling E, Rootwelt H, Espeseth T (2010)
Epistasis between APOE and nicotinic receptor gene CHRNA4 in age related cognitive function and decline
J Int Neuropsychol Soc, 16 (3), 424-32
PubMed 20331911

Solaas K, Legry V, Retterstol K, Berg PR, Holven KB, Ferrières J, Amouyel P, Lien S, Romeo J, Valtueña J, Widhalm K, Ruiz JR, Dallongeville J, Tonstad S, Rootwelt H, Halvorsen B, Nenseter MS, Birkeland KI, Thorsby PM, Meirhaeghe A, Nebb HI (2010)
Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)
BMC Med Genet, 11, 144
PubMed 20939869

Publications 2009

Bremer S, Vethe NT, Rootwelt H, Jørgensen PF, Stenstrøm J, Holdaas H, Midtvedt K, Bergan S (2009)
Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients - a pilot study
J Transl Med, 7, 64
PubMed 19635156

Espeseth T, Rootwelt H, Reinvang I (2009)
Apolipoprotein E modulates auditory event-related potentials in healthy aging
Neurosci Lett, 459 (2), 91-5
PubMed 19409447

Reinvang I, Lundervold AJ, Rootwelt H, Wehling E, Espeseth T (2009)
Individual variation in a cholinergic receptor gene modulates attention
Neurosci Lett, 453 (3), 131-4
PubMed 19429020

Reinvang I, Winjevoll IL, Rootwelt H, Espeseth T (2009)
Working memory deficits in healthy APOE epsilon 4 carriers
Neuropsychologia, 48 (2), 566-73
PubMed 19879282

Ystad MA, Lundervold AJ, Wehling E, Espeseth T, Rootwelt H, Westlye LT, Andersson M, Adolfsdottir S, Geitung JT, Fjell AM, Reinvang I, Lundervold A (2009)
Hippocampal volumes are important predictors for memory function in elderly women
BMC Med Imaging, 9, 17
PubMed 19698138

Publications 2008

Bremer S, Mandla R, Vethe NT, Rasmussen I, Rootwelt H, Line PD, Midtvedt K, Bergan S (2008)
Expression of IMPDH1 and IMPDH2 after transplantation and initiation of immunosuppression
Transplantation, 85 (1), 55-61
PubMed 18192912

Bremer S, Vethe NT, Rootwelt H, Bergan S (2008)
Expression of IMPDH1 is regulated in response to mycophenolate concentration
Int Immunopharmacol, 9 (2), 173-80
PubMed 19010451

Utheim ØA, Ritland JS, Utheim TP, Espeseth T, Lydersen S, Rootwelt H, Semb SO, Elsås T (2008)
Apolipoprotein E genotype and risk for development of cataract and age-related macular degeneration
Acta Ophthalmol, 86 (4), 401-3
PubMed 18498549

Vethe NT, Bremer S, Rootwelt H, Bergan S (2008)
Pharmacodynamics of mycophenolic acid in CD4+ cells: a single-dose study of IMPDH and purine nucleotide responses in healthy individuals
Ther Drug Monit, 30 (6), 647-55
PubMed 18806697

Publications 2007

Bremer S, Rootwelt H, Bergan S (2007)
Real-time PCR determination of IMPDH1 and IMPDH2 expression in blood cells
Clin Chem, 53 (6), 1023-9
PubMed 17463174

Espeseth T, Endestad T, Rootwelt H, Reinvang I (2007)
Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks
Neuroscience, 147 (4), 974-85
PubMed 17590520

Ritland JS, Utheim TP, Utheim OA, Espeseth T, Lydersen S, Semb SO, Rootwelt H, Elsås T (2007)
Effects of APOE and CHRNA4 genotypes on retinal nerve fibre layer thickness at the optic disc and on risk for developing exfoliation syndrome
Acta Ophthalmol Scand, 85 (3), 257-61
PubMed 17488453

Saether T, Tran TN, Rootwelt H, Grav HJ, Christophersen BO, Haugen TB (2007)
Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis
Reproduction, 133 (2), 467-77
PubMed 17307914

Publications 2006

Bergan S, Rootwelt H (2006)
[Customized drugs?]
Tidsskr Nor Laegeforen, 126 (18), 2364
PubMed 16998544

Espeseth T, Greenwood PM, Reinvang I, Fjell AM, Walhovd KB, Westlye LT, Wehling E, Lundervold A, Rootwelt H, Parasuraman R (2006)
Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults
Cogn Affect Behav Neurosci, 6 (1), 31-43
PubMed 16869227

Espeseth T, Westlye LT, Fjell AM, Walhovd KB, Rootwelt H, Reinvang I (2006)
Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4
Neurobiol Aging, 29 (3), 329-40
PubMed 17161508

Hauge Opdal S, Melien Ø, Rootwelt H, Vege A, Arnestad M, Ole Rognum T (2006)
The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection
Acta Paediatr, 95 (9), 1129-32
PubMed 16938762

Publications 2003

Saether T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB (2003)
Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis
Biol Reprod, 69 (1), 117-24
PubMed 12606372

Publications 2002

Johansen PW, Bergan S, Rootwelt H, Kvittingen EA, Rugstad HE (2002)
[Individualized pharmacotherapy based on cytochrome P-450 (CYP) genotyping]
Tidsskr Nor Laegeforen, 122 (29), 2781-3
PubMed 12523145

Molden E, Johansen PW, Bøe GH, Bergan S, Christensen H, Rugstad HE, Rootwelt H, Reubsaet L, Lehne G (2002)
Pharmacokinetics of diltiazem and its metabolites in relation to CYP2D6 genotype
Clin Pharmacol Ther, 72 (3), 333-42
PubMed 12235455

Publications 2000

Liestøl K, Kvittingen EA, Rootwelt H, Dunlop O, Goplen AK, Pedersen JC, Brorson SH, Børresen-Dale AL, Myrvang B, Maehlen J (2000)
Association between apolipoprotein E genotypes and cancer risk in patients with acquired immunodeficiency syndrome
Cancer Detect Prev, 24 (5), 496-9
PubMed 11129992

Publications 1997

Dunlop O, Goplen AK, Liestøl K, Myrvang B, Rootwelt H, Christophersen B, Kvittingen EA, Maehlen J (1997)
HIV dementia and apolipoprotein E
Acta Neurol Scand, 95 (5), 315-8
PubMed 9188909

Publications 1996

Rootwelt H, Høie K, Berger R, Kvittingen EA (1996)
Fumarylacetoacetase mutations in tyrosinaemia type I
Hum Mutat, 7 (3), 239-43
PubMed 8829657

Publications 1994

Kvittingen EA, Rootwelt H, Berger R, Brandtzaeg P (1994)
Self-induced correction of the genetic defect in tyrosinemia type I
J Clin Invest, 94 (4), 1657-61
PubMed 7929843

Rootwelt H, Berger R, Gray G, Kelly DA, Coşkun T, Kvittingen EA (1994)
Novel splice, missense, and nonsense mutations in the fumarylacetoacetase gene causing tyrosinemia type 1
Am J Hum Genet, 55 (4), 653-8
PubMed 7942842

Rootwelt H, Brodtkorb E, Kvittingen EA (1994)
Identification of a frequent pseudodeficiency mutation in the fumarylacetoacetase gene, with implications for diagnosis of tyrosinemia type I
Am J Hum Genet, 55 (6), 1122-7
PubMed 7977370

Rootwelt H, Chou J, Gahl WA, Berger R, Coşkun T, Brodtkorb E, Kvittingen EA (1994)
Two missense mutations causing tyrosinemia type 1 with presence and absence of immunoreactive fumarylacetoacetase
Hum Genet, 93 (6), 615-9
PubMed 8005583

Hum. Genet., 93 (6), 615-619

Rootwelt H, Kristensen T, Berger R, Høie K, Kvittingen EA (1994)
Tyrosinemia type 1--complex splicing defects and a missense mutation in the fumarylacetoacetase gene
Hum Genet, 94 (3), 235-9
PubMed 8076937

Publications 1993

Kvittingen EA, Rootwelt H, Brandtzaeg P, Bergan A, Berger R (1993)
Hereditary tyrosinemia type I. Self-induced correction of the fumarylacetoacetase defect
J Clin Invest, 91 (4), 1816-21
PubMed 8473520

Publications 1992

Kvittingen EA, Rootwelt H, van Dam T, van Faassen H, Berger R (1992)
Hereditary tyrosinemia type I: lack of correlation between clinical findings and amount of immunoreactive fumarylacetoacetase protein
Pediatr Res, 31 (1), 43-6
PubMed 1594329

Rootwelt H, Kvittingen EA, Høie K, Agsteribbe E, Hartog M, van Faassen H, Berger R (1992)
The human fumarylacetoacetase gene: characterisation of restriction fragment length polymorphisms and identification of haplotypes in tyrosinemia type 1 and pseudodeficiency
Hum Genet, 89 (2), 229-33
PubMed 1350265