Aminoacridines with dual SARS-CoV2 antiviral and immunostimulating activity

At present there is no effective treatment of Covid-19. The most affected patients get serious respiratory distress resulting from a combination of a strong SARS-CoV2 viral infection of the lower airways and a partly lacking, partly dysfunctional immune response. We have identified a series of compounds that regulate and potentially can improve anti-viral immune responses and that in addition have a direct inhibitory effect on the virus. The present project will the effect of one such drug development candidate with combined immunostimulating and SARS-CoV2 anti-viral effect in a Covid-19 animal model, which will determine whether this series of drug candidates should be developed further for use in humans.

Project leader:

Kjetil Taskén

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