The Experimental Cardiology research group studies disease mechanisms, particularly those underlying chronic heart failure and arrhythmias, with the aim of identifying new therapeutic targets. The group has focused specifically on ion transporters in cardiac myocytes, the signaling molecules that regulate them, and how pharmacological modulation of these transporters alters cardiac function and potentially counteracts heart disease. The main focus is on Ca2+ homeostasis and its interaction with Na+ fluxes, and regulation of the main ion transporters with compartmentalized phosphodiesterase signalling.

Research projects

• Molecular regulation of the sodium-potassium ATPase (NKA) in cardiac myocytes
• Molecular regulation of the SR Ca2+-ATPase (SERCA2) in cardiac myocytes
• Regulation of cardiac function by phosphodiesterase 8
• Regulation of cardiac calcium handling by phosphodiesterase 1
• Development of a systems biology model for myocardial remodeling (spatio-temporal pheno-omics)
• The role of phosphodiesterases in the initiation of atrial fibrillation”

Visit our homepage at UiO for more information:
Experimental cardiology (med.uio.no)