A retrospective pooled biomarker study to predict overall survival beyond the TNM system

Researchers Stine Aske Danielsen and Anita Sveen.
Researchers Stine Aske Danielsen and Anita Sveen.

K.G.Jebsen Colorectal Cancer Research Centre scientists participated with data from patients admitted to OUH in a multicenter study of >7000 stage II and III CRC recently reported in Annals of Oncology (Dienstmann et al).
Incorporation of MSI, BRAFV600E and KRAS mutation status to overall survival models with TNM staging improves the ability to precisely prognosticate in stage II and III CC patients, but only modestly increases prediction accuracy in multivariable models that include clinicopathological features, particularly in chemotherapy-treated patients.

Links:

The article:
Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study.
Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J.
Ann Oncol. 2017 Feb 9. doi: 10.1093/annonc/mdx052. 
PMID: 28184430

Home page of Ragnhild A. Lothe's Genetics group

Department of Molecular Oncology 

K. G. Jebsen Colorectal Cancer Research Centre