Translational Neurodegeneration Research & Neuropathology
Jens Pahnke Group leaderThis combined research and diagnostic lab is located at Rikshospitalet. We provide daily diagnostic service for brain biopsy diagnostics, muscle disease diagnostics, routine autopsy diagnostics for adults, kids and fetuses, and forensic neuropathology consultations. Our research focuses on basic and molecular neurodegeneration research, translational projects, patient-related treatment and diagnostic research. We have several unique mouse lines located at the Radium Hospital mouse facility.
Currently Externally Funded Projects
PROP-AD: Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier (JPND / EU / NFR)
PhytoAD: St. John’s wort as Alzheimer’s treatment – New ways of identification, exploitation and use of natural resources (SAW Leibniz Society Grant / EFRE)
Blood-brain barrier ABCG2 function in Alzheimer´s disease – LSC14-008 funded
ABC-HC: The importance of ABC transporters for the pathogenesis and treatment of Huntington’s disease (HSØ)
ABC-S1P: S1P and ABC transporters – synergistic treatment targets for Alzheimer´s disease (HSØ)
REPURPOSE-DMF: Dimethyl fumarate – Repurposing a MS drug to treat AD (Nationalforeningen)
ShortAbeta: Short Aβ-related peptides in the pathogenesis of Alzheimer’s disease – new avenues for treatment (LZPP Latvia)
Establishment of comprehensive molecular diagnostics for kids’ brain tumours in Norway (Barnekreftforeningen)
Villa M, Wu J, Hansen S, Pahnke J(2024) Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System Cells, 13(9) DOI 10.3390/cells13090740, PubMed 38727275
Mairinger S, Jackwerth M, Soukup O, Blaickner M, Decristoforo C, Nics L, Pahnke J, Hacker M, Zeitlinger M, Langer O(2024) Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates EJNMMI Radiopharm Chem, 9(1), 34 DOI 10.1186/s41181-024-00265-z, PubMed 38683266
Lauritzen T, Munkhaugen J, Bergan S, Peersen K, Svarstad AC, Andersen AM, Pahnke J, Husebye E, Vethe NT(2024) The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study Atheroscler Plus, 55, 31-38 DOI 10.1016/j.athplu.2024.01.001, PubMed 38293288