Coordinated inflammation and coagulation are involved in a vast number of human diseases. The research aims to disclose the mechanism regulating inflammation and coagulation and roles of blood cells and extracellular vesicles in these prosesses. Human monocytes and lymphocytes, whole blood models, cell lines and patient samples are used as model systems together with  upfront methodology to disclose new biomarkers.  

The Flow Cytometry Core Facility, Ullevål and the MicroarrayCoreFacility,Ullevål are parts of the group. 

• Extracellular vesicles
• Characterization of extracellular vesicles from human plasma, human skeletal muscle cells, saliva and tear fluid from healthy and diseased donors.  
• Implementation and validation of methods for isolation of EV from plasma
• Functional roles of plasma extracellular vesicles in cardiovascular disease
• Laboratory-oriented coagulation research in patients with increased thrombotic or bleeding tendency
• Hemostatic changes during pregnancy and postpartum – in women with and without increased  thrombotic  tendency
• Traumatic cascadopathy: A study of inflammation and coagulation after severe trauma using high-resolution data capture 
• Molecular and functional characterization of defects in patients with increased bleeding and thrombotic tendency 
• Thrombin generation and complement activation over time in patients with antiphospholipid syndrome 
• Evaluation of the ability of recombinant coagulation factor VIIa to generate factor Xa, thrombin, fibrin and the binding to platelets                                                                                                                                                                                             
• Identification and characterization of hemoglobinopathies in Norway
• Influence on erythrocyte variables
• Inflammation and coagulation in human meningococcal disease.
• mRNA and non-coding RNA in FFPE tissue

Contact information
Group leader Reidun Øvstebø PhD Department of Medical Biochemistry Oslo University Hospital, Ullevål Tel: +47 22119491 Fax: +47 22118189 reidun.ovstebo@ous-hf.no