Publications: Cellular Cholesterol Metabolism
Publications 2025
LDL-cholesterol in newborns and children with genetically verified familial hypercholesterolaemia: implications for cholesterol-based screening
Eur Heart J, 46 (48), 5261-5269
DOI 10.1093/eurheartj/ehaf815, PubMed 41127896
Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways
PLoS One, 20 (12), e0338076
DOI 10.1371/journal.pone.0338076, PubMed 41343507
Functional characterization of genetic variants affecting the intracellular domains of ATP-binding cassette transporter A1 (ABCA1)
J Lipid Res, 66 (8), 100854
DOI 10.1016/j.jlr.2025.100854, PubMed 40617357
Corrigendum to: Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay [Journal of Lipid Research 65/1 (2024) 100482]
J Lipid Res, 66 (9), 100891
DOI 10.1016/j.jlr.2025.100891, PubMed 40885025
Correction: Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP
PLoS One, 20 (9), e0332400
DOI 10.1371/journal.pone.0332400, PubMed 40938802
Publications 2024
The singular French PCSK9-p.Ser127Arg gain-of-function variant: A significant player in cholesterol levels from a 775-year-old common ancestor
Atherosclerosis, 399, 118596
DOI 10.1016/j.atherosclerosis.2024.118596, PubMed 39500114
Flavonoids regulate LDLR through different mechanisms tied to their specific structures
J Lipid Res, 65 (5), 100539
DOI 10.1016/j.jlr.2024.100539, PubMed 38556050
The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms
Atherosclerosis, 401, 119082
DOI 10.1016/j.atherosclerosis.2024.119082, PubMed 39700747
Molecular genetics in 1991 arrhythmia probands and 2782 relatives in Norway: Results from 17 years of genetic testing in a national laboratory
Clin Genet, 106 (5), 585-602
DOI 10.1111/cge.14593, PubMed 39073097
Publications 2023
Relationship between physical and psychological functioning and health-related quality of life in congenital Aniridia
Acta Ophthalmol, 102 (5), 590-599
DOI 10.1111/aos.16615, PubMed 38131258
Missense mutation Q384K in the APOB gene affecting the large lipid transfer module of apoB reduces the secretion of apoB-100 in the liver without reducing the secretion of apoB-48 in the intestine
J Clin Lipidol, 17 (6), 800-807
DOI 10.1016/j.jacl.2023.08.009, PubMed 37718180
Molecular genetic testing and measurement of levels of GPIHBP1 autoantibodies in patients with severe hypertriglyceridemia: The importance of identifying the underlying cause of hypertriglyceridemia
J Clin Lipidol, 18 (1), e80-e89
DOI 10.1016/j.jacl.2023.11.002, PubMed 37981531
Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay
J Lipid Res, 65 (1), 100482
DOI 10.1016/j.jlr.2023.100482, PubMed 38052254
Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP
PLoS One, 18 (12), e0294764
DOI 10.1371/journal.pone.0294764, PubMed 38039300
Publications 2020
Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional
Hum Mol Genet, 29 (8), 1229-1238
DOI 10.1093/hmg/ddz238, PubMed 31600776
Triciribine Engages ZFP36L1 and HuR to Stabilize LDLR mRNA
Molecules, 25 (19)
DOI 10.3390/molecules25194505, PubMed 33019656
Publications 2019
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms
PLoS One, 14 (6), e0218537
DOI 10.1371/journal.pone.0218537, PubMed 31216345
Strategies to prevent cleavage of the linker region between ligand-binding repeats 4 and 5 of the LDL receptor
Hum Mol Genet, 28 (22), 3734-3741
DOI 10.1093/hmg/ddz164, PubMed 31332430
Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein
Proteins, 88 (3), 440-448
DOI 10.1002/prot.25821, PubMed 31587363
Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
Hum Mol Genet, 28 (18), 3043-3052
DOI 10.1093/hmg/ddz114, PubMed 31131398
Publications 2018
Effect of epilepsy on autism symptoms in Angelman syndrome
Mol Autism, 9, 2
DOI 10.1186/s13229-017-0185-1, PubMed 29340132
MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent
Atherosclerosis, 276, 28-38
DOI 10.1016/j.atherosclerosis.2018.07.009, PubMed 30025252
Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA
Sci Rep, 8 (1), 16174
DOI 10.1038/s41598-018-34237-6, PubMed 30385871
Vigorous exercise in patients with hypertrophic cardiomyopathy
Int J Cardiol, 250, 157-163
DOI 10.1016/j.ijcard.2017.07.015, PubMed 29169752
Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals
Nutr Metab Cardiovasc Dis, 28 (7), 735-742
DOI 10.1016/j.numecd.2018.03.004, PubMed 29699815
[Cardiomyopathy in hereditary muscular dystrophies]
Tidsskr Nor Laegeforen, 138 (1)
DOI 10.4045/tidsskr.16.0683, PubMed 29313627
Lamin A/C cardiomyopathy: young onset, high penetrance, and frequent need for heart transplantation
Eur Heart J, 39 (10), 853-860
DOI 10.1093/eurheartj/ehx596, PubMed 29095976
Whole-exome sequencing for diagnosis of hereditary ichthyosis
J Eur Acad Dermatol Venereol, 32 (6), 1022-1027
DOI 10.1111/jdv.14870, PubMed 29444371
Publications 2017
Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy
Data Brief, 15, 30-39
DOI 10.1016/j.dib.2017.08.018, PubMed 28971120
The systolic paradox in hypertrophic cardiomyopathy
Open Heart, 4 (1), e000571
DOI 10.1136/openhrt-2016-000571, PubMed 28674623
Temple syndrome as a differential diagnosis to Prader-Willi syndrome: Identifying three new patients
Am J Med Genet A, 176 (1), 175-180
DOI 10.1002/ajmg.a.38533, PubMed 29159982
Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics
Lipids Health Dis, 16 (1), 115
DOI 10.1186/s12944-017-0511-9, PubMed 28606150
Mutations affecting the transmembrane domain of the LDL receptor: impact of charged residues on the membrane insertion
Hum Mol Genet, 26 (9), 1634-1642
DOI 10.1093/hmg/ddx068, PubMed 28334946
Novel mutation in the SLC12A3 gene in a Sri Lankan family with Gitelman syndrome & coexistent diabetes: a case report
BMC Nephrol, 18 (1), 140
DOI 10.1186/s12882-017-0563-0, PubMed 28446151
Prevalence of cholesteryl ester storage disease among hypercholesterolemic subjects and functional characterization of mutations in the lysosomal acid lipase gene
Mol Genet Metab, 123 (2), 169-176
DOI 10.1016/j.ymgme.2017.11.008, PubMed 29196158
Publications 2016
Variable phenotypic expression of nonsense mutation p.Thr5* in the APOE gene
Mol Genet Metab Rep, 9, 67-70
DOI 10.1016/j.ymgmr.2016.10.007, PubMed 27830118
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
PLoS Curr, 8
DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492
Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia
J Clin Lipidol, 10 (4), 816-823
DOI 10.1016/j.jacl.2016.02.015, PubMed 27578112
Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow
Cell Cycle, 15 (5), 628-43
DOI 10.1080/15384101.2016.1146834, PubMed 27104745
Studies of the autoinhibitory segment comprising residues 31-60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations
Mol Genet Metab Rep, 9, 86-93
DOI 10.1016/j.ymgmr.2016.11.003, PubMed 27896130
Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing
J Allergy Clin Immunol, 138 (4), 1142-1151.e2
DOI 10.1016/j.jaci.2016.05.035, PubMed 27484032
Publications 2015
Mild phenotype in an adult male with X-linked adrenoleukodystrophy - case report
Clin Case Rep, 4 (2), 177-81
DOI 10.1002/ccr3.434, PubMed 26862418
Mutation p.L799R in the LDLR, which affects the transmembrane domain of the LDLR, prevents membrane insertion and causes secretion of the mutant LDLR
Hum Mol Genet, 24 (20), 5836-44
DOI 10.1093/hmg/ddv304, PubMed 26220972
Publications 2014
Type 1 hyperlipoproteinemia due to a novel deletion of exons 3 and 4 in the GPIHBP1 gene
Atherosclerosis, 234 (1), 30-3
DOI 10.1016/j.atherosclerosis.2014.02.005, PubMed 24589565
The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon
Gene, 543 (2), 268-74
DOI 10.1016/j.gene.2014.02.042, PubMed 24583166
Age-dependent penetrance among females with X-linked adrenoleukodystrophy
Brain, 138 (Pt 2), e325
DOI 10.1093/brain/awu232, PubMed 25149409
Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum
FEBS Open Bio, 4, 321-7
DOI 10.1016/j.fob.2014.03.007, PubMed 24918045
PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum
Biochem J, 457 (1), 99-105
DOI 10.1042/BJ20130930, PubMed 24144304
Publications 2013
Genetics of hypertrophic cardiomyopathy in Norway
Clin Genet, 86 (4), 355-60
DOI 10.1111/cge.12286, PubMed 24111713
Risk prediction of ventricular arrhythmias and myocardial function in Lamin A/C mutation positive subjects
Europace, 16 (4), 563-71
DOI 10.1093/europace/eut291, PubMed 24058181
Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype
PLoS One, 8 (11), e78241
DOI 10.1371/journal.pone.0078241, PubMed 24244297
Adrenoleukodystrophy in Norway: high rate of de novo mutations and age-dependent penetrance
Pediatr Neurol, 48 (3), 212-9
DOI 10.1016/j.pediatrneurol.2012.12.007, PubMed 23419472
PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment
J Lipid Res, 54 (6), 1560-1566
DOI 10.1194/jlr.M034371, PubMed 23509406
De novo 19p13.2 microdeletion encompassing the insulin receptor and resistin genes in a patient with obesity and learning disability
Am J Med Genet A, 161A (6), 1480-6
DOI 10.1002/ajmg.a.35927, PubMed 23637016
Publications 2012
Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor-independent pathways
Transl Res, 160 (2), 125-30
DOI 10.1016/j.trsl.2012.01.010, PubMed 22683370
Postmortem genetic testing of the ryanodine receptor 2 (RYR2) gene in a cohort of sudden unexplained death cases
Int J Legal Med, 127 (1), 139-44
DOI 10.1007/s00414-011-0658-2, PubMed 22222782
Mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia
Atherosclerosis, 225 (2), 370-5
DOI 10.1016/j.atherosclerosis.2012.10.026, PubMed 23102784
The prevalence of mutations in KCNQ1, KCNH2, and SCN5A in an unselected national cohort of young sudden unexplained death cases
J Cardiovasc Electrophysiol, 23 (10), 1092-8
DOI 10.1111/j.1540-8167.2012.02371.x, PubMed 22882672
Publications 2011
Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors
J Lipid Res, 52 (10), 1787-94
DOI 10.1194/jlr.M018093, PubMed 21771976
Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor
Biochem Biophys Res Commun, 406 (2), 234-8
DOI 10.1016/j.bbrc.2011.02.023, PubMed 21324305
Molecular autopsy in young sudden cardiac death victims with suspected cardiomyopathy
Forensic Sci Int, 219 (1-3), 33-8
DOI 10.1016/j.forsciint.2011.11.020, PubMed 22177269
Subjects with molecularly defined familial hypercholesterolemia or familial defective apoB-100 are not being adequately treated
PLoS One, 6 (2), e16721
DOI 10.1371/journal.pone.0016721, PubMed 21364743
Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells
FEBS J, 278 (16), 2938-50
DOI 10.1111/j.1742-4658.2011.08219.x, PubMed 21692990
The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation
Biochem Biophys Res Commun, 408 (4), 642-6
DOI 10.1016/j.bbrc.2011.04.077, PubMed 21531209
Characterization of residues in the cytoplasmic domain of the LDL receptor required for exit from the endoplasmic reticulum
Biochem Biophys Res Commun, 415 (4), 642-5
DOI 10.1016/j.bbrc.2011.10.127, PubMed 22079632
Characterisation of a novel paralog of scavenger receptor class B member I (SCARB1) in Atlantic salmon (Salmo salar)
BMC Genet, 12, 52
DOI 10.1186/1471-2156-12-52, PubMed 21619714
Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification
Hum Mol Genet, 21 (6), 1402-9
DOI 10.1093/hmg/ddr578, PubMed 22156580
Characterization of a naturally occurring degradation product of the LDL receptor
Mol Genet Metab, 105 (1), 149-54
DOI 10.1016/j.ymgme.2011.10.008, PubMed 22078455
Publications 2010
Mutations in APOA-I and ABCA1 in Norwegians with low levels of HDL cholesterol
Clin Chim Acta, 411 (23-24), 2019-23
DOI 10.1016/j.cca.2010.08.027, PubMed 20800056
Transmural differences in myocardial contraction in long-QT syndrome: mechanical consequences of ion channel dysfunction
Circulation, 122 (14), 1355-63
DOI 10.1161/CIRCULATIONAHA.110.960377, PubMed 20855658
High prevalence of exercise-induced arrhythmias in catecholaminergic polymorphic ventricular tachycardia mutation-positive family members diagnosed by cascade genetic screening
Europace, 12 (3), 417-23
DOI 10.1093/europace/eup448, PubMed 20106799
Analysis of LDLR mRNA in patients with familial hypercholesterolemia revealed a novel mutation in intron 14, which activates a cryptic splice site
J Hum Genet, 55 (10), 676-80
DOI 10.1038/jhg.2010.87, PubMed 20703241
[Catecholaminergic polymorphic ventricular tachycardia]
Tidsskr Nor Laegeforen, 130 (2), 139-42
DOI 10.4045/tidsskr.09.0529, PubMed 20125202
Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain
Mol Genet Metab, 101 (1), 76-80
DOI 10.1016/j.ymgme.2010.05.003, PubMed 20659812
A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study)
Obesity (Silver Spring), 19 (3), 612-7
DOI 10.1038/oby.2010.219, PubMed 20885390
FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study)
Exp Clin Endocrinol Diabetes, 118 (9), 649-52
DOI 10.1055/s-0030-1249636, PubMed 20373279
Publications 2009
Splice-site mutation c.313+1, G>A in intron 3 of the LDL receptor gene results in transcripts with skipping of exon 3 and inclusion of intron 3
Clin Chim Acta, 403 (1-2), 131-5
DOI 10.1016/j.cca.2009.02.001, PubMed 19361455
Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C
Atherosclerosis, 209 (1), 163-6
DOI 10.1016/j.atherosclerosis.2009.08.039, PubMed 19765707
Nonsense-mediated decay of human LDL receptor mRNA
Scand J Clin Lab Invest, 69 (3), 409-17
DOI 10.1080/00365510802707163, PubMed 19148831
Effects of intronic mutations in the LDLR gene on pre-mRNA splicing: Comparison of wet-lab and bioinformatics analyses
Mol Genet Metab, 96 (4), 245-52
DOI 10.1016/j.ymgme.2008.12.014, PubMed 19208450
A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9
Mol Genet Metab, 99 (2), 149-56
DOI 10.1016/j.ymgme.2009.09.012, PubMed 19828345
Comparison of clinical and molecular genetic criteria for diagnosing familial hypercholesterolemia
Clin. Lipidol., 4 (3), 303-310
DOI 10.2217/CLP.09.24
The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis
J Intern Med, 266 (6), 507-19
DOI 10.1111/j.1365-2796.2009.02167.x, PubMed 19930098
Gene expression profiles reflect sclerosing cholangitis activity in abcb4 (-/-) mice
Scand J Gastroenterol, 44 (2), 211-8
DOI 10.1080/00365520802400867, PubMed 18785065
Changes in lipid metabolism associated gene transcripts during porcine adipogenesis
Comp Biochem Physiol B Biochem Mol Biol, 153 (1), 8-17
DOI 10.1016/j.cbpb.2008.12.019, PubMed 19416703
Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial hypercholesterolemia heterozygotes
Clin Chim Acta, 411 (3-4), 229-33
DOI 10.1016/j.cca.2009.11.008, PubMed 19917273
Identification of a novel allele of peroxisome proliferator-activated receptor gamma (PPARG) and its association with resistance to Aeromonas salmonicida in Atlantic salmon (Salmo salar)
Fish Shellfish Immunol, 28 (2), 394-400
DOI 10.1016/j.fsi.2009.11.023, PubMed 20004720
Gene expression of fatty acid-binding proteins, fatty acid transport proteins (cd36 and FATP) and beta-oxidation-related genes in Atlantic salmon (Salmo salar L.) fed fish oil or vegetable oil
Aquac. Nutr., 15 (4), 440-451
DOI 10.1111/j.1365-2095.2008.00609.x
Functional analysis of the synonymous R385R mutation in the low-density lipoprotein receptor gene
Genet Test Mol Biomarkers, 13 (2), 243-8
DOI 10.1089/gtmb.2008.0125, PubMed 19371225
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR
Acta Biochim Biophys Sin (Shanghai), 41 (3), 246-55
DOI 10.1093/abbs/gmp008, PubMed 19280064
A double blind evaluation of cognitive decline in a Norwegian cohort of asymptomatic carriers of Huntington's disease
J Clin Exp Neuropsychol, 32 (6), 590-8
DOI 10.1080/13803390903337878, PubMed 19916101
Mutations in the melanocortin 4 receptor (MC4R) gene in obese patients in Norway
Exp Clin Endocrinol Diabetes, 117 (6), 266-73
DOI 10.1055/s-0028-1102942, PubMed 19301229
Publications 2008
Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers
Scand J Clin Lab Invest, 68 (5), 362-8
DOI 10.1080/00365510701765643, PubMed 18752142
Characterization of novel mutations in the catalytic domain of the PCSK9 gene
J Intern Med, 263 (4), 420-31
DOI 10.1111/j.1365-2796.2007.01915.x, PubMed 18266662
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
FEBS J, 275 (16), 4121-33
DOI 10.1111/j.1742-4658.2008.06553.x, PubMed 18631360
Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage
Atherosclerosis, 203 (1), 161-5
DOI 10.1016/j.atherosclerosis.2008.10.007, PubMed 19022446
Berberine decreases PCSK9 expression in HepG2 cells
Atherosclerosis, 201 (2), 266-73
DOI 10.1016/j.atherosclerosis.2008.02.004, PubMed 18355829
Identification of mutations in the apolipoprotein B-100 gene and in the PCSK9 gene as the cause of hypocholesterolemia
Clin Chim Acta, 397 (1-2), 92-5
DOI 10.1016/j.cca.2008.07.025, PubMed 18710658
Diagnosis of familial hypercholesterolemia in general practice using clinical diagnostic criteria or genetic testing as part of cascade genetic screening
Community Genet, 11 (1), 26-35
DOI 10.1159/000111637, PubMed 18196915
ABCB4 sequence variations in young adults with cholesterol gallstone disease
Liver Int, 29 (5), 743-7
DOI 10.1111/j.1478-3231.2008.01914.x, PubMed 19018976
Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
J Cell Physiol, 217 (2), 459-67
DOI 10.1002/jcp.21519, PubMed 18570182
Expression of DLK1 splice variants during porcine adipocyte development in vitro and in vivo
Anim Genet, 40 (2), 239-41
DOI 10.1111/j.1365-2052.2008.01812.x, PubMed 19032696
Differential gene expression of fatty acid binding proteins during porcine adipogenesis
Comp Biochem Physiol B Biochem Mol Biol, 151 (2), 147-52
DOI 10.1016/j.cbpb.2008.06.010, PubMed 18621139
Depot specific differences during adipogenesis of porcine stromal-vascular cells
Cell Biol Int, 32 (5), 525-31
DOI 10.1016/j.cellbi.2008.01.001, PubMed 18299211
Changes in fatty acids metabolism during differentiation of Atlantic salmon preadipocytes; effects of n-3 and n-9 fatty acids
Biochim Biophys Acta, 1781 (6-7), 326-35
DOI 10.1016/j.bbalip.2008.04.014, PubMed 18503782
Publications 2007
The effect of red wine on plasma leptin levels and vasoactive factors from adipose tissue: a randomized crossover trial
Alcohol Alcohol, 42 (6), 525-8
DOI 10.1093/alcalc/agm056, PubMed 17670801
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
N Engl J Med, 356 (3), 237-47
DOI 10.1056/NEJMoa063988, PubMed 17229951
Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
BMC Cell Biol, 8, 9
DOI 10.1186/1471-2121-8-9, PubMed 17328821
Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults
J Nutr, 137 (8), 1951-4
DOI 10.1093/jn/137.8.1951, PubMed 17634269
[Lipid profile in children and adolescents with familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 127 (18), 2363-6
PubMed 17895939
Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis
Scand J Gastroenterol, 42 (10), 1245-55
DOI 10.1080/00365520701320521, PubMed 17852852
4-Phenylbutyrate restores the functionality of a misfolded mutant low-density lipoprotein receptor
FEBS J, 274 (8), 1881-93
DOI 10.1111/j.1742-4658.2007.05735.x, PubMed 17408384
Publications 2006
Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
Arterioscler Thromb Vasc Biol, 26 (5), 1094-100
DOI 10.1161/01.ATV.0000204337.81286.1c, PubMed 16424354
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
Hum Mol Genet, 15 (9), 1551-8
DOI 10.1093/hmg/ddl077, PubMed 16571601
Low-density lipoprotein receptor activity in Epstein-Barr virus-transformed lymphocytes from heterozygotes for the D374Y mutation in the PCSK9 gene
Scand J Clin Lab Invest, 66 (4), 317-28
DOI 10.1080/00365510600672775, PubMed 16777760
Effects of 3-thia fatty acids on expression of some lipid related genes in Atlantic salmon (Salmo salar L.)
Comp Biochem Physiol B Biochem Mol Biol, 145 (2), 239-48
DOI 10.1016/j.cbpb.2006.07.012, PubMed 16971150
Model system for phenotypic characterization of sequence variations in the LDL receptor gene
Clin Chem, 52 (8), 1469-79
DOI 10.1373/clinchem.2006.068627, PubMed 16740646
A twin study of nitric oxide levels measured by serum nitrite/nitrate
Twin Res Hum Genet, 9 (2), 210-4
DOI 10.1375/183242706776382464, PubMed 16611490
Analysis of alternatively spliced isoforms of human LDL receptor mRNA
Clin Chim Acta, 373 (1-2), 151-7
DOI 10.1016/j.cca.2006.05.031, PubMed 16828075
Publications 2005
[DNA-based diagnostics of long QT syndrome]
Tidsskr Nor Laegeforen, 125 (20), 2783-6
PubMed 16244680
[Cardiac ion channel disorders--diagnosis and treatment]
Tidsskr Nor Laegeforen, 125 (20), 2778-81
PubMed 16244679
Identification of deletions and duplications in the low density lipoprotein receptor gene by MLPA
Clin Chim Acta, 356 (1-2), 164-71
DOI 10.1016/j.cccn.2005.01.028, PubMed 15936313
A daily glass of red wine: does it affect markers of inflammation?
Alcohol Alcohol, 40 (2), 102-5
DOI 10.1093/alcalc/agh132, PubMed 15642722
Differential regulation of vacuolar H+ -ATPase and Na+/H+ exchanger 3 in rat cholangiocytes after bile duct ligation
Histochem Cell Biol, 125 (4), 419-28
DOI 10.1007/s00418-005-0082-0, PubMed 16267653
[Genetic causes of obesity]
Tidsskr Nor Laegeforen, 125 (22), 3090-3
PubMed 16299561
Publications 2004
Investigation of a peroxisome proliferator-activated receptor gamma haplotype effect on meat quality and carcass traits in pigs
Anim Genet, 35 (3), 238-41
DOI 10.1111/j.1365-2052.2004.01126.x, PubMed 15147398
Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels
Physiol Res, 53 (4), 395-401
PubMed 15311998
Publications 2003
Sitosterolemia: a gateway to new knowledge about cholesterol metabolism
Ann Med, 35 (7), 502-11
DOI 10.1080/07853890310014588, PubMed 14649332
A twin study of C-Reactive Protein compared to other risk factors for coronary heart disease
Atherosclerosis, 169 (2), 279-82
DOI 10.1016/s0021-9150(03)00192-8, PubMed 12921979
Plasma total homocysteine levels and prognosis in patients with previous premature myocardial infarction: a 10-year follow-up study
J Intern Med, 253 (3), 284-92
DOI 10.1046/j.1365-2796.2003.01096.x, PubMed 12603495
An in vitro method for studying the proliferation and differentiation of Atlantic salmon preadipocytes
Lipids, 38 (3), 289-96
DOI 10.1007/s11745-003-1063-3, PubMed 12784870
Publications 2002
Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8
J Lipid Res, 43 (3), 486-94
PubMed 11893785
Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro
Inflammation, 26 (3), 103-10
DOI 10.1023/a:1015585530204, PubMed 12083416
Induced changes in the consumption of coffee alter ad libitum dietary intake and physical activity level
Br J Nutr, 87 (3), 261-6
DOI 10.1079/BJNBJN2001506, PubMed 12064335
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
J Biol Chem, 277 (21), 18793-800
DOI 10.1074/jbc.M109927200, PubMed 11901146
C-reactive protein predicts death in patients with previous premature myocardial infarction--a 10 year follow-up study
Atherosclerosis, 160 (2), 433-40
DOI 10.1016/s0021-9150(01)00595-0, PubMed 11849668
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
J Clin Invest, 110 (5), 671-80
DOI 10.1172/JCI16001, PubMed 12208868
Publications 2001
Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol--a randomized controlled trial
Am J Clin Nutr, 74 (3), 302-7
DOI 10.1093/ajcn/74.3.302, PubMed 11522552
Polymorphisms in candidate genes for blood pressure regulation in young men with normal or elevated screening blood pressure
Blood Press, 10 (2), 92-100
DOI 10.1080/08037050152112078, PubMed 11467765
Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia
Hum Mutat, 18 (4), 359-60
DOI 10.1002/humu.1206, PubMed 11668628
Detection of mRNA for the terminal complement components C5, C6, C8 and C9 in human umbilical vein endothelial cells in vitro
APMIS, 109 (1), 73-8
DOI 10.1111/j.1600-0463.2001.tb00016.x, PubMed 11297196
Plasma N-terminal pro-atrial natriuretic peptide predicts death after premature myocardial infarction, but not as well as radionuclide ejection fraction. A ten-year follow-up study
Scand Cardiovasc J, 35 (6), 373-8
DOI 10.1080/14017430152754853, PubMed 11837516
Plasma fibrinogen level and long-term prognosis in Norwegian middle-aged patients with previous myocardial infarction. A 10 year follow-up study
J Intern Med, 249 (6), 511-8
DOI 10.1046/j.1365-2796.2001.00837.x, PubMed 11422657
Tissue distribution of porcine peroxisome proliferator-activated receptor alpha: detection of an alternatively spliced mRNA
Gene, 273 (1), 105-13
DOI 10.1016/s0378-1119(01)00562-5, PubMed 11483366
Identification of a novel peroxisome proliferator-activated receptor (PPAR) gamma promoter in man and transactivation by the nuclear receptor RORalpha1
Biochem Biophys Res Commun, 287 (2), 383-90
DOI 10.1006/bbrc.2001.5602, PubMed 11554739
Publications 2000
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
Science, 290 (5497), 1771-5
DOI 10.1126/science.290.5497.1771, PubMed 11099417
Evolutionary conservation of the apolipoprotein E-C1-C2 gene cluster on bovine chromosome 18q24
Gene, 241 (2), 241-5
DOI 10.1016/s0378-1119(99)00492-8, PubMed 10675035
Rapid communication: physical and genetic mapping of the Peroxisome Proliferator Activated Receptor gamma (PPAR-gamma) gene to porcine chromosome 13
J Anim Sci, 78 (5), 1391-2
DOI 10.2527/2000.7851391x, PubMed 10834598
Publications 1999
Whole blood folate, homocysteine in serum, and risk of first acute myocardial infarction
Atherosclerosis, 147 (2), 317-26
DOI 10.1016/s0021-9150(99)00202-6, PubMed 10559518
Publications 1998
Polymorphisms at the angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) loci and normal blood pressure
Clin Genet, 53 (3), 214-9
DOI 10.1111/j.1399-0004.1998.tb02680.x, PubMed 9630078
Characterisation of porcine peroxisome proliferator-activated receptors gamma 1 and gamma 2: detection of breed and age differences in gene expression
Biochem Biophys Res Commun, 249 (3), 713-8
DOI 10.1006/bbrc.1998.9212, PubMed 9731203
Publications 1997
A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction
Clin Genet, 52 (2), 71-6
DOI 10.1111/j.1399-0004.1997.tb02521.x, PubMed 9298740
Analyses of mutations in the human renal kallikrein (hKLK1) gene and their possible relevance to blood pressure regulation and risk of myocardial infarction
Clin Genet, 52 (2), 86-95
DOI 10.1111/j.1399-0004.1997.tb02524.x, PubMed 9298743
Cardiovascular risk factors in people with different genotypes in the insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme (ACE)
Clin Genet, 52 (6), 422-6
DOI 10.1111/j.1399-0004.1997.tb02562.x, PubMed 9520252
Studies on effects of Lp(a) lipoprotein on gene expression in endothelial cells in vitro
Clin Genet, 52 (5), 314-25
DOI 10.1111/j.1399-0004.1997.tb04349.x, PubMed 9520122
[Application of gene technology in the diagnosis of familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 117 (5), 678-81
PubMed 9102960
Molecular genetics of familial hypercholesterolaemia in Norway
J Intern Med, 241 (3), 185-94
DOI 10.1046/j.1365-2796.1997.78119000.x, PubMed 9104431
Two novel polymorphisms in the bovine obesity gene (OBS)
Anim. Genet., 28 (3), 245
Characterisation of bovine peroxisome proliferator-activated receptors gamma 1 and gamma 2: genetic mapping and differential expression of the two isoforms
Biochem Biophys Res Commun, 239 (3), 857-61
DOI 10.1006/bbrc.1997.7564, PubMed 9367859
The gene encoding the peroxisome proliferator-activated receptor (PPARA) maps to chromosome 5 in cattle
Anim Genet, 28 (5), 374
DOI 10.1111/j.1365-2052.1997.tb03275.x, PubMed 9363607
Publications 1996
Vitronectin modulates the expression of complement components of the terminal pathway synthesized by human umbilical vein endothelial cells in vitro
APMIS, 104 (7-8), 523-30
DOI 10.1111/j.1699-0463.1996.tb04907.x, PubMed 8920805
Interleukin-1 alpha, interleukin 6 and tumor necrosis factor alpha increase the synthesis and expression of the functional alternative and terminal complement pathways by human umbilical vein endothelial cells in vitro
APMIS, 104 (3), 213-9
DOI 10.1111/j.1699-0463.1996.tb00710.x, PubMed 8611196
Additive analgesic effect of codeine and paracetamol can be detected in strong, but not moderate, pain after Caesarean section. Baseline pain-intensity is a determinant of assay-sensitivity in a postoperative analgesic trial
Acta Anaesthesiol Scand, 40 (4), 399-407
DOI 10.1111/j.1399-6576.1996.tb04460.x, PubMed 8738682
Screening for known mutations in the LDL receptor gene causing familial hypercholesterolemia (vol 95, pg 671, 1995)
Hum. Genet., 97 (2), 268
DOI 10.1007/BF02265281
Linkage mapping of the apolipoprotein A-I gene to bovine chromosome 15
Mamm Genome, 7 (7), 561
DOI 10.1007/s003359900170, PubMed 8672146
A common missense mutation (C210G) in the LDL receptor gene among Norwegian familial hypercholesterolemia subjects
Hum Mutat, 7 (1), 70-1
DOI 10.1002/(SICI)1098-1004(1996)7:1<70::AID-HUMU12>3.0.CO;2-P, PubMed 8664907
Publications 1995
Screening for known mutations in the LDL receptor gene causing familial hypercholesterolemia
Hum Genet, 95 (6), 671-6
DOI 10.1007/BF00209485, PubMed 7789953
[Acute psychosis--an unusual clinical manifestation of primary hyperparathyroidism]
Tidsskr Nor Laegeforen, 115 (29), 3623-4
PubMed 8539717
Publications 1994
No effect on blood pressure level or variability of polymorphisms in DNA at the locus for atrial natriuretic factor (ANF)
Clin Genet, 46 (6), 433-5
DOI 10.1111/j.1399-0004.1994.tb04412.x, PubMed 7889661
No effect of a BglI polymorphism at the renin (REN) locus on blood pressure level or variability
Clin Genet, 46 (6), 436-8
DOI 10.1111/j.1399-0004.1994.tb04413.x, PubMed 7889662
No effect of insertion/deletion polymorphism at the ACE locus on normal blood pressure level or variability
Clin Genet, 45 (4), 169-74
DOI 10.1111/j.1399-0004.1994.tb04017.x, PubMed 8062433
DNA polymorphism at the locus for angiotensinogen I-converting enzyme in Norwegian patients with myocardial infarction and controls
Clin Genet, 46 (1 Spec No), 102-4
DOI 10.1111/j.1399-0004.1994.tb04211.x, PubMed 7988066
Publications 1993
No effect of TaqI polymorphism at the human renal kallikrein (KLK1) locus on normal blood pressure level or variability
Clin Genet, 44 (4), 196-202
DOI 10.1111/j.1399-0004.1993.tb03879.x, PubMed 7903227
Insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme and myocardial infarction
Clin Genet, 44 (6), 292-7
DOI 10.1111/j.1399-0004.1993.tb03903.x, PubMed 8131299
Insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme and parental history of myocardial infarction
Clin Genet, 44 (6), 298-301
DOI 10.1111/j.1399-0004.1993.tb03904.x, PubMed 8131300
Publications 1992
No effect of a Taq1 polymorphism in DNA at the endothelin I (EDN1) locus on normal blood pressure level or variability
Clin Genet, 41 (2), 90-5
DOI 10.1111/j.1399-0004.1992.tb03640.x, PubMed 1347490
Publications 1991
A TaqI RFLP at the human renal kallikrein (KLK1) locus
Clin Genet, 40 (3), 256
DOI 10.1111/j.1399-0004.1991.tb03092.x, PubMed 1685360
Publications 1990
A TaqI RFLP at the EDN1 gene locus
Nucleic Acids Res, 18 (20), 6176
DOI 10.1093/nar/18.20.6176-a, PubMed 1978292