GenSUD
Project leader: Astrid Kristine Bjørnebekk
The GenSUD project will contribute critical insights into the etiology of SUDs, by discerning patterns of disease trajectories using large Norwegian samples with registry data. Furthermore, the project aims to unravel shared genetic risks with mental and somatic diseases to understand underlying molecular pathways. Using data from the Norwegian Patient Registry, we will characterize the SUD patient group and identify clusters of multi-morbidity as well as temporal disease trajectories, taking into account the sequence of diagnoses preceding and following SUD diagnosis. Finally, blood samples from a subpopulation of SUD patients will be used to compute polygenic risk scores to identify genetic overlap psychiatric and somatic diseases and SUD-related phenotypes.