Publications 2025

Follin LF, Zahid AN, Viste R, Vevelstad J, Kaufmann T, Ramm-Pettersen A, Juvodden HT, Hansen BH, Christensen JAE, Knudsen-Heier S (2025)
An inter-rater variability study between human and automatic scorers in 5-s mini-epochs of sleep
Sleep Med, 128, 139-150
DOI 10.1016/j.sleep.2025.02.005, PubMed 39938170

Maanaki HA, Knudsen-Heier S, Kornum BR (2025)
[Narcolepsy type 1 and hypocretin neurons]
Ugeskr Laeger, 187 (8)
DOI 10.61409/V09240580, PubMed 40025890

Publications 2024

Juvodden HT, Alnæs D, Agartz I, Andreassen OA, Server A, Thorsby PM, Westlye LT, Knudsen-Heier S (2024)
Cortical thickness and sub-cortical volumes in post-H1N1 narcolepsy type 1: A brain-wide MRI case-control study
Sleep Med, 116, 81-89
DOI 10.1016/j.sleep.2024.02.031, PubMed 38432031

Publications 2023

Cesari M, Heidbreder A, St Louis EK, Sixel-Döring F, Bliwise DL, Baldelli L, Bes F, Fantini ML, Iranzo A, Knudsen-Heier S, Mayer G, McCarter S, Nepozitek J, Pavlova M, Provini F, Santamaria J, Sunwoo JS, Videnovic A, Högl B, Jennum P, Christensen JAE, Stefani A (2023)
Polysomnographic diagnosis of REM sleep behavior disorder: a change is needed
Sleep, 46 (1)
DOI 10.1093/sleep/zsac276, PubMed 36519899

Hansen BH, Andresen HN, Gjesvik J, Thorsby PM, Naerland T, Knudsen-Heier S (2023)
Associations between psychiatric comorbid disorders and executive dysfunctions in hypocretin-1 deficient pediatric narcolepsy type1
Sleep Med, 109, 149-157
DOI 10.1016/j.sleep.2023.06.021, PubMed 37442017

Juvodden HT, Alnæs D, Lund MJ, Agartz I, Andreassen OA, Server A, Thorsby PM, Westlye LT, Knudsen Heier S (2023)
Larger hypothalamic volume in narcolepsy type 1
Sleep, 46 (11)
DOI 10.1093/sleep/zsad173, PubMed 37463428

Ollila HM, Sharon E, Lin L, Sinnott-Armstrong N, Ambati A, Yogeshwar SM, Hillary RP, Jolanki O, Faraco J, Einen M, Luo G, Zhang J, Han F, Yan H, Dong XS, Li J, Zhang J, Hong SC, Kim TW, Dauvilliers Y, Barateau L, Lammers GJ, Fronczek R, Mayer G, Santamaria J et al. (2023)
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Nat Commun, 14 (1), 2709
DOI 10.1038/s41467-023-36120-z, PubMed 37188663

Plazzi G, Pizza F, Lecendreux M, Gringras P, Barateau L, Bruni O, Franco P, Iranzo A, Jennum P, Khatami R, Knudsen-Heier S, Miano S, Nobili L, Partinen M, Reading P, Sonka K, Szakacs A, Zenti M, Kallweit U, Lammers GJ, Dauvilliers Y, Bassetti CLA (2023)
Pharmacological management of narcolepsy in children and adolescents
J Sleep Res, 33 (4), e14055
DOI 10.1111/jsr.14055, PubMed 38050449

Viste R, Follin LF, Kornum BR, Lie BA, Viken MK, Thorsby PM, Rootwelt T, Christensen JAE, Knudsen-Heier S (2023)
Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings
Sleep, 46 (3)
DOI 10.1093/sleep/zsac316, PubMed 36562330

Publications 2022

Cesari M, Heidbreder A, St Louis EK, Sixel-Döring F, Bliwise DL, Baldelli L, Bes F, Fantini ML, Iranzo A, Knudsen-Heier S, Mayer G, McCarter S, Nepozitek J, Pavlova M, Provini F, Santamaria J, Sunwoo JS, Videnovic A, Högl B, Jennum P, Christensen JAE, Stefani A (2022)
Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the International RBD Study Group
Sleep, 45 (3)
DOI 10.1093/sleep/zsab257, PubMed 34694408

Publications 2021

Viste R, Lie BA, Viken MK, Rootwelt T, Knudsen-Heier S, Kornum BR (2021)
Narcolepsy type 1 patients have lower levels of effector memory CD4⁺ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status
Sleep Med, 85, 271-279
DOI 10.1016/j.sleep.2021.07.024, PubMed 34388506

Viste R, Viken MK, Lie BA, Juvodden HT, Nordstrand SEH, Thorsby PM, Rootwelt T, Kornum BR, Knudsen-Heier S (2021)
High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1
Sleep, 44 (8)
DOI 10.1093/sleep/zsab062, PubMed 33710305

Publications 2020

Hansen BH, Juvodden HT, Nordstrand SH, Viste R, Thorsby PM, Swanson D, Nilsen KB, Nærland T, Knudsen-Heier S (2020)
High prevalence of ADHD symptoms in unmedicated youths with post-H1N1 narcolepsy type 1
Sleep Med, 75, 171-180
DOI 10.1016/j.sleep.2020.06.014, PubMed 32858357

Juvodden HT, Viken MK, Nordstrand SEH, Viste R, Westlye LT, Thorsby PM, Lie BA, Knudsen-Heier S (2020)
HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives
Sleep, 43 (3)
DOI 10.1093/sleep/zsz239, PubMed 31606740

Nordstrand SEH, Juvodden HT, Viste R, Rootwelt T, Karlsen TI, Thorsby PM, Swanson D, Nilsen KB, Hansen BH, Knudsen-Heier S (2020)
Obesity and other medical comorbidities among NT1 patients after the Norwegian H1N1 influenza epidemic and vaccination campaign
Sleep, 43 (5)
DOI 10.1093/sleep/zsz277, PubMed 31724727

Publications 2019

Juvodden HT, Alnæs D, Lund MJ, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2019)
Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing
Sleep, 42 (7)
DOI 10.1093/sleep/zsz082, PubMed 30923809

Nordstrand SEH, Hansen BH, Rootwelt T, Karlsen TI, Swanson D, Nilsen KB, Knudsen S (2019)
Psychiatric symptoms in patients with post-H1N1 narcolepsy type 1 in Norway
Sleep, 42 (4)
DOI 10.1093/sleep/zsz008, PubMed 30649483

Pedersen NW, Holm A, Kristensen NP, Bjerregaard AM, Bentzen AK, Marquard AM, Tamhane T, Burgdorf KS, Ullum H, Jennum P, Knudsen S, Hadrup SR, Kornum BR (2019)
CD8⁺ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
Nat Commun, 10 (1), 837
DOI 10.1038/s41467-019-08774-1, PubMed 30783092

Publications 2018

Engstrom M, Aarrestad S, Eldoen G, Alme A, Bjorge T, Miljeteig H, Bjorvatn B, Knudsen S, Indrekvam S, Nilsen KB (2018)
New recommendations for objective examination of sleep and sleep disorders
Tidsskr. Nor. Laegeforen., 138 (19), 1805-1806

Engstrøm M, Aarrestad S, Eldøen G, Alme A, Bjørge T, Miljeteig H, Bjorvatn B, Knudsen S, Indrekvam S, Nilsen KB (2018)
[New recommendations for objective investigation of sleep and sleep disorders]
Tidsskr Nor Laegeforen, 138 (19)
DOI 10.4045/tidsskr.18.0741, PubMed 30497241

Juvodden HT, Alnæs D, Lund MJ, Agartz I, Andreassen OA, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2018)
Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives
Sleep, 41 (10)
DOI 10.1093/sleep/zsy145, PubMed 30016530

Nordstrand SH, Hansen BH, Kamaleri Y, Nilsen KB, Rootwelt T, Karlsen TI, Knudsen S (2018)
Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year prospective cohort study
Sleep Med, 50, 175-180
DOI 10.1016/j.sleep.2018.05.037, PubMed 30075393

Publications 2017

Kornum BR, Burgdorf KS, Holm A, Ullum H, Jennum P, Knudsen S (2017)
Absence of autoreactive CD4⁺ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot
J Neuroimmunol, 309, 7-11
DOI 10.1016/j.jneuroim.2017.05.001, PubMed 28601291

Kornum BR, Knudsen S, Ollila HM, Pizza F, Jennum PJ, Dauvilliers Y, Overeem S (2017)
Narcolepsy
Nat Rev Dis Primers, 3, 16100
DOI 10.1038/nrdp.2016.100, PubMed 28179647

Schrölkamp M, Jennum PJ, Gammeltoft S, Holm A, Kornum BR, Knudsen S (2017)
Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2
J Clin Sleep Med, 13 (2), 235-243
DOI 10.5664/jcsm.6454, PubMed 27855741

Viste R, Soosai J, Vikin T, Thorsby PM, Nilsen KB, Knudsen S (2017)
Long-term improvement after combined immunomodulation in early post-H1N1 vaccination narcolepsy
Neurol Neuroimmunol Neuroinflamm, 4 (5), e389
DOI 10.1212/NXI.0000000000000389, PubMed 28840177

Publications 2016

Jennum PJ, Kornum BR, Issa NM, Gammeltoft S, Tommerup N, Morling N, Tümer Z, Knudsen S (2016)
Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis
Neurol Neuroimmunol Neuroinflamm, 3 (4), e249
DOI 10.1212/NXI.0000000000000249, PubMed 27354986

Publications 2015

Kornum BR, Pizza F, Knudsen S, Plazzi G, Jennum P, Mignot E (2015)
Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
Brain Behav Immun, 49, 54-8
DOI 10.1016/j.bbi.2015.03.004, PubMed 25771509

Ollila HM, Ravel JM, Han F, Faraco J, Lin L, Zheng X, Plazzi G, Dauvilliers Y, Pizza F, Hong SC, Jennum P, Knudsen S, Kornum BR, Dong XS, Yan H, Hong H, Coquillard C, Mahlios J, Jolanki O, Einen M, Arnulf I, Högl B, Frauscher B, Crowe C, Partinen M et al. (2015)
HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy
Am J Hum Genet, 96 (1), 136-46
DOI 10.1016/j.ajhg.2014.12.010, PubMed 25574827

Publications 2014

Barloese M, Jennum P, Lund N, Knudsen S, Gammeltoft S, Jensen R (2014)
Reduced CSF hypocretin-1 levels are associated with cluster headache
Cephalalgia, 35 (10), 869-76
DOI 10.1177/0333102414562971, PubMed 25492975

Han F, Lin L, Schormair B, Pizza F, Plazzi G, Ollila HM, Nevsimalova S, Jennum P, Knudsen S, Winkelmann J, Coquillard C, Babrzadeh F, Strom TM, Wang C, Mindrinos M, Fernandez Vina M, Mignot E (2014)
HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency
Sleep, 37 (10), 1601-8
DOI 10.5665/sleep.4066, PubMed 25197808

Holm A, Bang-Berthelsen CH, Knudsen S, Kornum BR, Modvig S, Jennum P, Gammeltoft S (2014)
miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias
Sleep, 37 (9), 1525-33
DOI 10.5665/sleep.4004, PubMed 25142559

Holm A, Bang-Berthelsen CH, Knudsen S, Modvig S, Kornum BR, Gammeltoft S, Jennum PJ (2014)
MiRNA profiles in cerebrospinal fluid from patients with central hypersomnias
J Neurol Sci, 347 (1-2), 199-204
DOI 10.1016/j.jns.2014.09.047, PubMed 25451005

Jensen JB, Sorensen HB, Kempfner J, Sørensen GL, Knudsen S, Jennum P (2014)
Sleep-wake transition in narcolepsy and healthy controls using a support vector machine
J Clin Neurophysiol, 31 (5), 397-401
DOI 10.1097/WNP.0000000000000074, PubMed 25271675

Publications 2013

Heier MS, Gjerstad MD, Knudsen S (2013)
[New knowledge about narcolepsy in children]
Tidsskr Nor Laegeforen, 133 (12-13), 1326-8
DOI 10.4045/tidsskr.13.0414, PubMed 23817265

Jennum P, Ibsen R, Knudsen S, Kjellberg J (2013)
Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study
Sleep, 36 (6), 835-40
DOI 10.5665/sleep.2706, PubMed 23729926

Klein AB, Jennum P, Knudsen S, Gammeltoft S, Mikkelsen JD (2013)
Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy
Neurosci Lett, 544, 31-5
DOI 10.1016/j.neulet.2013.03.031, PubMed 23570723

Kornum BR, Knudsen S, Gammeltoft S, Jennum P (2013)
[The association between narcolepsy and H1N1 influenza]
Ugeskr Laeger, 175 (12), 815
PubMed 23582821

Luca G, Haba-Rubio J, Dauvilliers Y, Lammers GJ, Overeem S, Donjacour CE, Mayer G, Javidi S, Iranzo A, Santamaria J, Peraita-Adrados R, Hor H, Kutalik Z, Plazzi G, Poli F, Pizza F, Arnulf I, Lecendreux M, Bassetti C, Mathis J, Heinzer R, Jennum P, Knudsen S, Geisler P, Wierzbicka A et al. (2013)
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study
J Sleep Res, 22 (5), 482-95
DOI 10.1111/jsr.12044, PubMed 23496005

Savvidou A, Knudsen S, Olsson-Engman M, Gammeltoft S, Jennum P, Palm L (2013)
Hypocretin deficiency develops during onset of human narcolepsy with cataplexy
Sleep, 36 (1), 147-8
DOI 10.5665/sleep.2320, PubMed 23288981

Sorensen GL, Knudsen S, Jennum P (2013)
Sleep transitions in hypocretin-deficient narcolepsy
Sleep, 36 (8), 1173-7
DOI 10.5665/sleep.2880, PubMed 23904677

Sorensen GL, Knudsen S, Petersen ER, Kempfner J, Gammeltoft S, Sorensen HB, Jennum P (2013)
Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy
Sleep, 36 (1), 91-8
DOI 10.5665/sleep.2308, PubMed 23288975

Publications 2012

Andlauer O, Moore H, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E (2012)
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy
Sleep, 35 (9), 1247-55F
DOI 10.5665/sleep.2080, PubMed 22942503

Jennum P, Ibsen R, Petersen ER, Knudsen S, Kjellberg J (2012)
Health, social, and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners
Sleep Med, 13 (8), 1086-93
DOI 10.1016/j.sleep.2012.06.006, PubMed 22841027

Knudsen S, Biering-Sørensen B, Kornum BR, Petersen ER, Ibsen JD, Gammeltoft S, Mignot E, Jennum PJ (2012)
Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency
Neurology, 79 (1), 102-3
DOI 10.1212/WNL.0b013e31825dce03, PubMed 22722630

Publications 2010

Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G et al. (2010)
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
Nat Genet, 42 (9), 786-9
DOI 10.1038/ng.647, PubMed 20711174

Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E (2010)
Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy
Sleep, 33 (7), 869-74
DOI 10.1093/sleep/33.7.869, PubMed 20614846

Knudsen S, Gammeltoft S, Jennum PJ (2010)
Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
Brain, 133 (Pt 2), 568-79
DOI 10.1093/brain/awp320, PubMed 20129934

Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S (2010)
Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population
Sleep, 33 (2), 169-76
DOI 10.1093/sleep/33.2.169, PubMed 20175400

Knudsen S, Zoetmulder M, Jennum P (2010)
[Disturbed rapid eye movement-sleep predicts neurodegenerative disease]
Ugeskr Laeger, 172 (12), 963
PubMed 20334797

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P et al. (2010)
Common variants in P2RY11 are associated with narcolepsy
Nat Genet, 43 (1), 66-71
DOI 10.1038/ng.734, PubMed 21170044

Publications 2009

Jennum P, Knudsen S, Kjellberg J (2009)
The economic consequences of narcolepsy
J Clin Sleep Med, 5 (3), 240-5
PubMed 19960645

Publications 2007

Knudsen S, Mikkelsen JD, Jennum P (2007)
Antibodies in narcolepsy-cataplexy patient serum bind to rat hypocretin neurons
Neuroreport, 18 (1), 77-9
DOI 10.1097/WNR.0b013e328010baad, PubMed 17259865

Publications 2006

Knudsen S, Jennum PJ (2006)
[Narcolepsy--new implications of molecular biology]
Ugeskr Laeger, 168 (43), 3699-704
PubMed 17069732

Nielsen K, Rostrup E, Frederiksen JL, Knudsen S, Mathiesen HK, Hanson LG, Paulson OB (2006)
Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla
Invest Radiol, 41 (2), 76-82
DOI 10.1097/01.rli.0000188364.76251.28, PubMed 16428976