Publications from OUS - Experimental Immunotherapy (Olweus)
79 publications found
Publications 2025
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 Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
 Immunity, 58 (1), 247-262.e9
 DOI 10.1016/j.immuni.2024.12.004, PubMed 39755122
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 TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors
 Nat Immunol, 26 (10), 1726-1736
 DOI 10.1038/s41590-025-02252-1, PubMed 40866620
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 Targeting the roots of myeloid malignancies with T cell receptors
 Nat Rev Cancer (in press)
 DOI 10.1038/s41568-025-00857-0, PubMed 40841587
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 Precision T cell correction platform for inborn errors of immunity
 Mol Ther (in press)
 DOI 10.1016/j.ymthe.2025.08.018, PubMed 40808259
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 Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire
 J Immunother Cancer, 13 (5)
 DOI 10.1136/jitc-2024-011351, PubMed 40316304
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 Translation dysregulation in cancer as a source for targetable antigens
 Cancer Cell, 43 (5), 823-840.e18
 DOI 10.1016/j.ccell.2025.03.003, PubMed 40154482
Publications 2024
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 Impact of Rare Structural Variant Events in Newly Diagnosed Multiple Myeloma
 Clin Cancer Res, 30 (3), 575-585
 DOI 10.1158/1078-0432.CCR-23-1045, PubMed 37939148
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 The function of the complement system remains fully intact throughout the course of allogeneic stem cell transplantation
 Front Immunol, 15, 1422370
 DOI 10.3389/fimmu.2024.1422370, PubMed 38938578
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 CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity
 Mol Ther Oncol, 32 (3), 200841
 DOI 10.1016/j.omton.2024.200841, PubMed 39474602
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 An adjusted droplet digital PCR assay for quantification of vector copy number in CAR-T cell and TCR-T cell products
 Immunooncol Technol, 25, 101031
 DOI 10.1016/j.iotech.2024.101031, PubMed 40236328
Publications 2023
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 Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
 Clin Cancer Res, 29 (19), 3901-3913
 DOI 10.1158/1078-0432.CCR-22-3209, PubMed 37449980
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 A systematic safety pipeline for selection of T-cell receptors to enter clinical use
 NPJ Vaccines, 8 (1), 126
 DOI 10.1038/s41541-023-00713-y, PubMed 37607971
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 A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
 Nat Cancer, 4 (10), 1474-1490
 DOI 10.1038/s43018-023-00642-8, PubMed 37783807
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 Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
 Cell Rep, 42 (1), 111995
 DOI 10.1016/j.celrep.2023.111995, PubMed 36656713
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 Extreme body mass index and survival in newly diagnosed multiple myeloma patients
 Blood Cancer J, 13 (1), 13
 DOI 10.1038/s41408-022-00782-7, PubMed 36631444
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 Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
 Blood Adv, 7 (23), 7216-7230
 DOI 10.1182/bloodadvances.2023010158, PubMed 37695745
Publications 2022
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 Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy
 Neoplasia, 26, 100779
 DOI 10.1016/j.neo.2022.100779, PubMed 35247801
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 Chasing neoantigens; invite naïve T cells to the party
 Curr Opin Immunol, 75, 102172
 DOI 10.1016/j.coi.2022.102172, PubMed 35279483
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 Capture Rate of V(D)J Sequencing for Minimal Residual Disease Detection in Multiple Myeloma
 Clin Cancer Res, 28 (10), 2160-2166
 DOI 10.1158/1078-0432.CCR-20-2995, PubMed 35553646
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 T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation
 Br J Haematol, 198 (3), 556-573
 DOI 10.1111/bjh.18285, PubMed 35655388
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 Immunogenicity and Safety of a Third SARS-CoV-2 Vaccine Dose in Patients With Multiple Sclerosis and Weak Immune Response After COVID-19 Vaccination
 JAMA Neurol, 79 (3), 307-309
 DOI 10.1001/jamaneurol.2021.5109, PubMed 35072702
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 Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
 Leukemia, 36 (7), 1887-1897
 DOI 10.1038/s41375-022-01597-y, PubMed 35643867
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 Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
 Nature, 603 (7902), 721-727
 DOI 10.1038/s41586-022-04499-2, PubMed 35264796
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 Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
 Nature, 608 (7922), E20
 DOI 10.1038/s41586-022-05097-y, PubMed 35840685
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 Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination
 Br J Haematol, 197 (6), 697-708
 DOI 10.1111/bjh.18149, PubMed 35254660
Publications 2021
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 T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
 Nat Biotechnol, 40 (4), 488-498
 DOI 10.1038/s41587-021-01089-x, PubMed 34873326
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 Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
 J Neurol Neurosurg Psychiatry, 94 (1), 19-22
 DOI 10.1136/jnnp-2021-327612, PubMed 34670844
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 Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
 Nat Commun, 12 (1), 5172
 DOI 10.1038/s41467-021-25469-8, PubMed 34453055
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 Chromothripsis as a pathogenic driver of multiple myeloma
 Semin Cell Dev Biol, 123, 115-123
 DOI 10.1016/j.semcdb.2021.04.014, PubMed 33958284
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 Advances in immune therapies in hematological malignancies
 J Intern Med, 292 (2), 205-220
 DOI 10.1111/joim.13395, PubMed 34624160
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 Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
 MAbs, 13 (1), 1893888
 DOI 10.1080/19420862.2021.1893888, PubMed 33691596
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 mmsig: a fitting approach to accurately identify somatic mutational signatures in hematological malignancies
 Commun Biol, 4 (1), 424
 DOI 10.1038/s42003-021-01938-0, PubMed 33782531
Publications 2020
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 A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
 Med, 2 (2), 180-195.e5
 DOI 10.1016/j.medj.2020.10.006, PubMed 35590201
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 Anti-tumour immunity induces aberrant peptide presentation in melanoma
 Nature, 590 (7845), 332-337
 DOI 10.1038/s41586-020-03054-1, PubMed 33328638
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 Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies
 MAbs, 12 (1), 1795505
 DOI 10.1080/19420862.2020.1795505, PubMed 32744145
Publications 2019
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 Induction of neoantigen-reactive T cells from healthy donors
 Nat Protoc, 14 (6), 1926-1943
 DOI 10.1038/s41596-019-0170-6, PubMed 31101906
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 Finding Neo (antigens, that is)
 Blood, 134 (2), 108-109
 DOI 10.1182/blood.2019001334, PubMed 31296544
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 Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
 NPJ Breast Cancer, 5, 13
 DOI 10.1038/s41523-019-0108-8, PubMed 30993194
Publications 2018
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 Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
 Cancer Immunol Res, 6 (4), 467-480
 DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477
Publications 2017
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 Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
 Sci Rep, 7 (1), 4916
 DOI 10.1038/s41598-017-04982-1, PubMed 28687807
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 The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
 Front Immunol, 8, 1718
 DOI 10.3389/fimmu.2017.01718, PubMed 29321773
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 Manufacture of CAR-T cells in the body
 Nat Biotechnol, 35 (6), 520-521
 DOI 10.1038/nbt.3898, PubMed 28591119
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 Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
 Arthritis Res Ther, 19 (1), 284
 DOI 10.1186/s13075-017-1494-7, PubMed 29268795
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 Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
 Sci Rep, 7, 39710
 DOI 10.1038/srep39710, PubMed 28054583
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 Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
 J Autoimmun, 81, 110-119
 DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239
Publications 2016
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 Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
 J Hepatol, 66 (1), 116-122
 DOI 10.1016/j.jhep.2016.09.002, PubMed 27647428
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 Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
 Oncoimmunology, 5 (5), e1138199
 DOI 10.1080/2162402X.2016.1138199, PubMed 27467957
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 Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
 Science, 352 (6291), 1337-41
 DOI 10.1126/science.aaf2288, PubMed 27198675
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 Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
 Clin Immunol, 175, 69-74
 DOI 10.1016/j.clim.2016.11.014, PubMed 27919819
Publications 2015
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 Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model
 Gene Ther, 22 (5), 391-403
 DOI 10.1038/gt.2015.4, PubMed 25652098
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 T-cell receptor gene therapy--ready to go viral?
 Mol Oncol, 9 (10), 2019-42
 DOI 10.1016/j.molonc.2015.10.006, PubMed 26548533
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 "In situ" vaccination for systemic effects in follicular lymphoma
 Oncoimmunology, 4 (7), e1014773
 DOI 10.1080/2162402X.2015.1014773, PubMed 26140239
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 High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
 Hepatology, 63 (5), 1608-19
 DOI 10.1002/hep.28116, PubMed 26257205
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 Cancer immunotherapy--Converting immune failure to clinical response
 Mol Oncol, 9 (10), 1891-3
 DOI 10.1016/j.molonc.2015.10.017, PubMed 26563645
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 Unpredicted phenotypes of two mutants of the TcR DMF5
 J Immunol Methods, 425, 37-44
 DOI 10.1016/j.jim.2015.06.006, PubMed 26079729
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 Soluble T-cell receptors produced in human cells for targeted delivery
 PLoS One, 10 (4), e0119559
 DOI 10.1371/journal.pone.0119559, PubMed 25875651
Publications 2014
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 Low incidence of hyperfibrinolysis and thromboembolism in 195 primary liver transplantations transfused with solvent/detergent-treated plasma
 Clin Med Res, 12 (1-2), 27-32
 DOI 10.3121/cmr.2013.1168, PubMed 24415744
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 High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells
 Eur J Immunol, 44 (11), 3439-52
 DOI 10.1002/eji.201444662, PubMed 25103993
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 Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
 Clin Exp Immunol, 175 (3), 439-48
 DOI 10.1111/cei.12239, PubMed 24237110
Publications 2013
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 Non-allergic, mastocytosis-associated rhinitis
 Clin Exp Allergy, 43 (4), 406-12
 DOI 10.1111/cea.12053, PubMed 23517036
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 Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
 Proc Natl Acad Sci U S A, 111 (1), 403-8
 DOI 10.1073/pnas.1306549111, PubMed 24344295
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 Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation
 Eur J Immunol, 44 (3), 774-84
 DOI 10.1002/eji.201343671, PubMed 24293164
Publications 2012
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 Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity
 PLoS One, 7 (9), e45422
 DOI 10.1371/journal.pone.0045422, PubMed 23028998
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 Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
 PLoS One, 7 (10), e46117
 DOI 10.1371/journal.pone.0046117, PubMed 23049692
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 [Can the immune system target cancer?]
 Tidsskr Nor Laegeforen, 132 (7), 784-5
 DOI 10.4045/tidsskr.12.0156, PubMed 22511078
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 Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1
 Traffic, 13 (5), 650-64
 DOI 10.1111/j.1600-0854.2012.01341.x, PubMed 22321063
Publications 2011
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 T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
 Int J Cancer, 130 (8), 1821-32
 DOI 10.1002/ijc.26209, PubMed 21630262
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 Socio-demographic determinants of infant neurodevelopment at 18 months of age: Mother-Child Cohort (Rhea Study) in Crete, Greece
 Infant Behav Dev, 35 (1), 48-59
 DOI 10.1016/j.infbeh.2011.09.005, PubMed 22018719
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 A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation
 Biochem J, 436 (2), 371-85
 DOI 10.1042/BJ20101493, PubMed 21388347
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 A practical approach to T-cell receptor cloning and expression
 PLoS One, 6 (11), e27930
 DOI 10.1371/journal.pone.0027930, PubMed 22132171
Publications 2010
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 Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
 Leukemia, 24 (11), 1901-9
 DOI 10.1038/leu.2010.186, PubMed 20844564
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 Transiently redirected T cells for adoptive transfer
 Cytotherapy, 13 (5), 629-40
 DOI 10.3109/14653249.2010.542461, PubMed 21174490
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 Long-term muscular outcome and predisposing and prognostic factors in juvenile dermatomyositis: A case-control study
 Arthritis Care Res (Hoboken), 62 (8), 1103-11
 DOI 10.1002/acr.20203, PubMed 20506141
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 Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy
 Cardiovasc Res, 86 (3), 374-82
 DOI 10.1093/cvr/cvq023, PubMed 20097676
Publications 2009
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 [Myositis-specific autoantibodies]
 Tidsskr Nor Laegeforen, 129 (16), 1631-4
 DOI 10.4045/tidsskr.09.35501, PubMed 19721478
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 Dendritic cells in cytomegalovirus infection: viral evasion and host countermeasures
 APMIS, 117 (5-6), 413-26
 DOI 10.1111/j.1600-0463.2009.02449.x, PubMed 19400865
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 Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells
 Scand J Immunol, 69 (4), 319-28
 DOI 10.1111/j.1365-3083.2008.02223.x, PubMed 19284496
Publications 2007
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 [A three-year-old boy with bullous skin eruptions and paresis]
 Tidsskr Nor Laegeforen, 127 (15), 1950-2
 PubMed 17708060
Publications 2006
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 Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
 N Engl J Med, 355 (12), 1199-209
 DOI 10.1056/NEJMoa055706, PubMed 16990383
