Publications by Trine Folseraas
63 publications found
Publications 2025
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Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis
J Hepatol (in press)
DOI 10.1016/j.jhep.2025.08.005, PubMed 40846184 - 
T and B cell responses against Epstein-Barr virus in primary sclerosing cholangitis
Nat Med, 31 (7), 2306-2316
DOI 10.1038/s41591-025-03692-w, PubMed 40500415 - 
Mitochondrial dysfunction and lipid alterations in primary sclerosing cholangitis
Scand J Gastroenterol, 60 (2), 165-173
DOI 10.1080/00365521.2024.2447521, PubMed 39764583 - 
Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study
Hepatology (in press)
DOI 10.1097/HEP.0000000000001351, PubMed 40238209 - 
Deep learning analysis of MRI accurately detects early-stage perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis
Hepatology (in press)
DOI 10.1097/HEP.0000000000001314, PubMed 40112296 - 
Liver transplantation for locally advanced non-resectable intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: early results from the TESLA trial
Br J Surg, 112 (3)
DOI 10.1093/bjs/znaf054, PubMed 40099404 
Publications 2024
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Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis
Hepatol Commun, 8 (7)
DOI 10.1097/HC9.0000000000000461, PubMed 38967597 - 
Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
Cell Rep Med, 5 (7), 101620
DOI 10.1016/j.xcrm.2024.101620, PubMed 38901430 - 
Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease
Ann Surg Oncol, 31 (10), 6495-6503
DOI 10.1245/s10434-024-15582-5, PubMed 38896226 
Publications 2023
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Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation
J Hepatol, 79 (4), 955-966
DOI 10.1016/j.jhep.2023.05.038, PubMed 37328069 - 
Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis
Hepatology, 79 (2), 269-288
DOI 10.1097/HEP.0000000000000557, PubMed 37535809 - 
Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis
Exposome, 3 (1), osac011
DOI 10.1093/exposome/osac011, PubMed 36687160 - 
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis
Nat Commun, 14 (1), 1069
DOI 10.1038/s41467-023-36678-8, PubMed 36828809 - 
[Primary sclerosing cholangitis]
Tidsskr Nor Laegeforen, 143 (17)
DOI 10.4045/tidsskr.23.0156, PubMed 37987062 - 
Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma
J Hepatol, 79 (1), 93-108
DOI 10.1016/j.jhep.2023.02.027, PubMed 36868481 - 
ERCP for the initial management of malignant biliary obstruction - real world data on 596 procedures
Scand J Gastroenterol, 59 (3), 369-377
DOI 10.1080/00365521.2023.2282375, PubMed 37994406 - 
A critical spotlight on the paradigms of FFPE-DNA sequencing
Nucleic Acids Res, 51 (14), 7143-7162
DOI 10.1093/nar/gkad519, PubMed 37351572 - 
Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis
JHEP Rep, 6 (2), 100988
DOI 10.1016/j.jhepr.2023.100988, PubMed 38304234 - 
Biopsy helpful in diagnosing a liver mass in pregnancy: focal nodular hyperplasia
Lancet, 402 (10403), e10
DOI 10.1016/S0140-6736(23)01606-9, PubMed 37633669 
Publications 2022
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Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Hum Mol Genet, 31 (23), 3945-3966
DOI 10.1093/hmg/ddac158, PubMed 35848942 - 
Survey uncovering variations in the management of primary sclerosing cholangitis across Europe
JHEP Rep, 4 (11), 100553
DOI 10.1016/j.jhepr.2022.100553, PubMed 36164416 - 
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
J Hepatol, 76 (5), 1109-1121
DOI 10.1016/j.jhep.2021.12.010, PubMed 35167909 - 
Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis
Hepatology, 76 (5), 1360-1375
DOI 10.1002/hep.32456, PubMed 35278227 - 
Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry
Cancers (Basel), 14 (10)
DOI 10.3390/cancers14102389, PubMed 35625993 - 
Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis
Eur Radiol Exp, 6 (1), 58
DOI 10.1186/s41747-022-00312-x, PubMed 36396865 - 
Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease
Commun Biol, 5 (1), 80
DOI 10.1038/s42003-022-03031-6, PubMed 35058554 - 
Risk of hepato-pancreato-biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population-based cohort study
United European Gastroenterol J, 10 (2), 212-224
DOI 10.1002/ueg2.12204, PubMed 35107865 
Publications 2021
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Primary sclerosing cholangitis and the risk of cancer, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of cohort studies
Sci Rep, 11 (1), 10646
DOI 10.1038/s41598-021-90175-w, PubMed 34017024 - 
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand J Gastroenterol, 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627, PubMed 33583308 - 
Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF
JHEP Rep, 3 (5), 100328
DOI 10.1016/j.jhepr.2021.100328, PubMed 34485881 - 
REPLY
Hepatology, 74 (4), 2319-2321
DOI 10.1002/hep.31904, PubMed 33998692 - 
REPLY
Hepatology, 74 (2), 1129-1131
DOI 10.1002/hep.31740, PubMed 33550618 - 
Letter to the Editor: Does Multiple Intrahepatic Cholangiocarcinoma Worsen Prognosis as "M1" Stage? REPLY
Hepatology, 74 (2), 1129-1131
DOI 10.1002/hep.31740 - 
Liver Metastases of Intrahepatic Cholangiocarcinoma: Implications for an Updated Staging System
Hepatology, 73 (6), 2311-2325
DOI 10.1002/hep.31598, PubMed 33073396 - 
Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation
Hepatology, 74 (1), 281-295
DOI 10.1002/hep.31652, PubMed 33226645 - 
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
Hepatology, 75 (1), 59-73
DOI 10.1002/hep.32125, PubMed 34435693 - 
[Diagnosis and treatment of autoimmune hepatitis]
Tidsskr Nor Laegeforen, 141 (10)
DOI 10.4045/tidsskr.20.1045, PubMed 34182737 
Publications 2020
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Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Hepatology, 72 (4), 1253-1266
DOI 10.1002/hep.31110, PubMed 31925805 - 
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N Engl J Med, 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283, PubMed 32558485 - 
Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis - The promise of DNA methylation and molecular biomarkers
JHEP Rep, 2 (5), 100143
DOI 10.1016/j.jhepr.2020.100143, PubMed 32939446 
Publications 2019
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Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Hepatology, 69 (2), 622-638
DOI 10.1002/hep.30210, PubMed 30102768 - 
Pathogenesis, diagnosis and treatment of premalignant and malignant stages of cholangiocarcinoma in primary sclerosing cholangitis
Liver Int, 39 (12), 2230-2237
DOI 10.1111/liv.14180, PubMed 31216595 
Publications 2018
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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report
World J Surg Oncol, 16 (1), 180
DOI 10.1186/s12957-018-1482-7, PubMed 30185175 
Publications 2017
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Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025 - 
Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
Am J Pathol, 188 (3), 627-639
DOI 10.1016/j.ajpath.2017.11.010, PubMed 29248458 - 
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma
Biochim Biophys Acta Mol Basis Dis, 1864 (4 Pt B), 1390-1400
DOI 10.1016/j.bbadis.2017.08.020, PubMed 28844951 - 
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657 - 
Primary sclerosing cholangitis - a comprehensive review
J Hepatol, 67 (6), 1298-1323
DOI 10.1016/j.jhep.2017.07.022, PubMed 28802875 
Publications 2016
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Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Nat Rev Gastroenterol Hepatol, 13 (5), 261-80
DOI 10.1038/nrgastro.2016.51, PubMed 27095655 - 
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Nat Genet, 48 (5), 510-8
DOI 10.1038/ng.3528, PubMed 26974007 - 
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Nat Genet, 49 (2), 269-273
DOI 10.1038/ng.3745, PubMed 27992413 
Publications 2015
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Cancer Risk and Surveillance in Primary Sclerosing Cholangitis
Clin Liver Dis, 20 (1), 79-98
DOI 10.1016/j.cld.2015.08.014, PubMed 26593292 - 
Genetics in PSC: what do the "risk genes" teach us?
Clin Rev Allergy Immunol, 48 (2-3), 154-64
DOI 10.1007/s12016-014-8417-z, PubMed 24736995 - 
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat Commun, 6, 6804
DOI 10.1038/ncomms7804, PubMed 25891430 - 
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol J, 4 (1), 84-91
DOI 10.1177/2050640615581577, PubMed 26966527 
Publications 2014
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Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis
Aliment Pharmacol Ther, 39 (8), 873-82
DOI 10.1111/apt.12663, PubMed 24612312 
Publications 2013
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Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
DOI 10.1002/hep.25977, PubMed 22821403 - 
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet, 45 (6), 670-5
DOI 10.1038/ng.2616, PubMed 23603763 - 
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J Hepatol, 59 (6), 1278-84
DOI 10.1016/j.jhep.2013.08.005, PubMed 23958938 
Publications 2012
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Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342 
Publications 2011
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To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?
Liver Int, 31 (6), 751-4
DOI 10.1111/j.1478-3231.2011.02471.x, PubMed 21645205 - 
Genetics in primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 25 (6), 713-26
DOI 10.1016/j.bpg.2011.09.010, PubMed 22117637 - 
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-85
DOI 10.1002/hep.24307, PubMed 21425313