Stephen Hewitt

  • MD
 

Publications 2020

Gonzalez-Ericsson PI, Stovgaard ES, Sua LF, Reisenbichler E, Kos Z, Carter JM, Michiels S, Le Quesne J, Nielsen TO, Laenkholm AV, Fox SB, Adam J, Bartlett JM, Rimm DL, Quinn C, Peeters D, Dieci MV, Vincent-Salomon A, Cree I, Hida AI, Balko JM, Haynes HR, Frahm I, Acosta-Haab G, Balancin M et al. (2020)
The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice
J Pathol, 250 (5), 667-684
DOI 10.1002/path.5406, PubMed 32129476

Hewitt S, Kristinsson J, Aasheim ET, Blom-Høgestøl IK, Aaseth E, Jahnsen J, Eriksen EF, Mala T (2020)
Relationships Between Vitamin D Status and PTH over 5 Years After Roux-en-Y Gastric Bypass: a Longitudinal Cohort Study
Obes Surg, 30 (9), 3426-3434
DOI 10.1007/s11695-020-04582-5, PubMed 32306297

Kherad O, Peiffer-Smadja N, Karlafti L, Lember M, Aerde NV, Gunnarsson O, Baicus C, Vieira MB, Vaz-Carneiro A, Brucato A, Lazurova I, Leśniak W, Hanslik T, Hewitt S, Papanicolaou E, Boeva O, Dicker D, Ivanovska B, Yldiz P, Lacor P, Cranston M, Weidanz F, Costantino G, Montano N (2020)
The challenge of implementing Less is More medicine: A European perspective
Eur J Intern Med, 76, 1-7
DOI 10.1016/j.ejim.2020.04.014, PubMed 32303454

Kos Z, Roblin E, Kim RS, Michiels S, Gallas BD, Chen W, van de Vijver KK, Goel S, Adams S, Demaria S, Viale G, Nielsen TO, Badve SS, Symmans WF, Sotiriou C, Rimm DL, Hewitt S, Denkert C, Loibl S, Luen SJ, Bartlett JMS, Savas P, Pruneri G, Dillon DA, Cheang MCU et al. (2020)
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
NPJ Breast Cancer, 6, 17
DOI 10.1038/s41523-020-0156-0, PubMed 32411819

Roper N, Brown AL, Wei JS, Pack S, Trindade C, Kim C, Restifo O, Gao S, Sindiri S, Mehrabadi F, El Meskini R, Ohler ZW, Maity TK, Venugopalan A, Cultraro CM, Akoth E, Padiernos E, Chen H, Kesarwala A, Smart DK, Nilubol N, Rajan A, Piotrowska Z, Xi L, Raffeld M et al. (2020)
Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer
Cell Rep Med, 1 (1)
DOI 10.1016/j.xcrm.2020.100007, PubMed 32483558

Royal V, Zee J, Liu Q, Avila-Casado C, Smith AR, Liu G, Mariani LH, Hewitt S, Holzman LB, Gillespie BW, Hodgin JB, Barisoni L (2020)
Ultrastructural Characterization of Proteinuric Patients Predicts Clinical Outcomes
J Am Soc Nephrol, 31 (4), 841-854
DOI 10.1681/ASN.2019080825, PubMed 32086276

Zeligs KP, Morelli MP, David JM, Neuman M, Hernandez L, Hewitt S, Ozaki M, Osei-Tutu A, Anderson D, Andresson T, Das S, Lack J, Abdelmaksoud A, Fantini M, Arlen PM, Tsang KY, Annunziata CM (2020)
Evaluation of the Anti-Tumor Activity of the Humanized Monoclonal Antibody NEO-201 in Preclinical Models of Ovarian Cancer
Front Oncol, 10, 805
DOI 10.3389/fonc.2020.00805, PubMed 32637350

Publications 2019

Blom-Høgestøl IK, Hewitt S, Chahal-Kummen M, Brunborg C, Gulseth HL, Kristinsson JA, Eriksen EF, Mala T (2019)
Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass
Bone, 127, 436-445
DOI 10.1016/j.bone.2019.07.014, PubMed 31323430

Graff-Iversen S, Hewitt S, Forsén L, Grøtvedt L, Ariansen I (2019)
Associations of tobacco smoking with body mass distribution; a population-based study of 65,875 men and women in midlife
BMC Public Health, 19 (1), 1439
DOI 10.1186/s12889-019-7807-9, PubMed 31675936

Mullooly M, Ehteshami Bejnordi B, Pfeiffer RM, Fan S, Palakal M, Hada M, Vacek PM, Weaver DL, Shepherd JA, Fan B, Mahmoudzadeh AP, Wang J, Malkov S, Johnson JM, Herschorn SD, Sprague BL, Hewitt S, Brinton LA, Karssemeijer N, van der Laak J, Beck A, Sherman ME, Gierach GL (2019)
Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density
NPJ Breast Cancer, 5, 43
DOI 10.1038/s41523-019-0134-6, PubMed 31754628

Thomas A, Vilimas R, Trindade C, Erwin-Cohen R, Roper N, Xi L, Krishnasamy V, Levy E, Mammen A, Nichols S, Chen Y, Velcheti V, Yin F, Szabo E, Pommier Y, Steinberg SM, Trepel JB, Raffeld M, Young HA, Khan J, Hewitt S, Lee JM (2019)
Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study
J Thorac Oncol, 14 (8), 1447-1457
DOI 10.1016/j.jtho.2019.04.026, PubMed 31063862

Publications 2018

Abubakar M, Chang-Claude J, Ali HR, Chatterjee N, Coulson P, Daley F, Blows F, Benitez J, Milne RL, Brenner H, Stegmaier C, Mannermaa A, Rudolph A, Sinn P, Couch FJ, Devilee P, Tollenaar RAEM, Seynaeve C, Figueroa J, Lissowska J, Hewitt S, Hooning MJ, Hollestelle A, Foekens R, Koppert LB et al. (2018)
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation
Int J Cancer, 143 (4), 746-757
DOI 10.1002/ijc.31352, PubMed 29492969

Hewitt S, Aasheim ET, Søvik TT, Jahnsen J, Kristinsson J, Eriksen EF, Mala T (2018)
Relationships of serum 25-hydroxyvitamin D, ionized calcium and parathyroid hormone after obesity surgery
Clin Endocrinol (Oxf), 88 (3), 372-379
DOI 10.1111/cen.13531, PubMed 29235126

Sahores A, Figueroa V, May M, Liguori M, Rubstein A, Fuentes C, Jacobsen BM, Elía A, Rojas P, Sequeira GR, Álvarez MM, González P, Gass H, Hewitt S, Molinolo A, Lanari C, Lamb CA (2018)
Increased High Molecular Weight FGF2 in Endocrine-Resistant Breast Cancer
Horm Cancer, 9 (5), 338-348
DOI 10.1007/s12672-018-0339-4, PubMed 29956066

Publications 2017

Clarke MA, Luhn P, Gage JC, Bodelon C, Dunn ST, Walker J, Zuna R, Hewitt S, Killian JK, Yan L, Miller A, Schiffman M, Wentzensen N (2017)
Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer
Int J Cancer, 141 (4), 701-710
DOI 10.1002/ijc.30781, PubMed 28500655

Dieci MV, Radosevic-Robin N, Fineberg S, van den Eynden G, Ternes N, Penault-Llorca F, Pruneri G, D'Alfonso TM, Demaria S, Castaneda C, Sanchez J, Badve S, Michiels S, Bossuyt V, Rojo F, Singh B, Nielsen T, Viale G, Kim SR, Hewitt S, Wienert S, Loibl S, Rimm D, Symmans F, Denkert C et al. (2017)
Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer
Semin Cancer Biol, 52 (Pt 2), 16-25
DOI 10.1016/j.semcancer.2017.10.003, PubMed 29024776

Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S et al. (2017)
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research
Adv Anat Pathol, 24 (5), 235-251
DOI 10.1097/PAP.0000000000000162, PubMed 28777142

Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S et al. (2017)
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Adv Anat Pathol, 24 (6), 311-335
DOI 10.1097/PAP.0000000000000161, PubMed 28777143

Høgestøl IK, Chahal-Kummen M, Eribe I, Brunborg C, Stubhaug A, Hewitt S, Kristinsson J, Mala T (2017)
Chronic Abdominal Pain and Symptoms 5 Years After Gastric Bypass for Morbid Obesity
Obes Surg, 27 (6), 1438-1445
DOI 10.1007/s11695-016-2499-z, PubMed 28028658

Rojas PA, May M, Sequeira GR, Elia A, Alvarez M, Martínez P, Gonzalez P, Hewitt S, He X, Perou CM, Molinolo A, Gibbons L, Abba MC, Gass H, Lanari C (2017)
Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness
J Natl Cancer Inst, 109 (7)
DOI 10.1093/jnci/djw317, PubMed 28376177

Publications 2016

Abubakar M, Howat WJ, Daley F, Zabaglo L, McDuffus LA, Blows F, Coulson P, Raza Ali H, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Chang-Claude J, Rudolph A, Sinn P, Couch FJ, Tollenaar RA, Devilee P, Figueroa J, Sherman ME, Lissowska J, Hewitt S, Eccles D, Hooning MJ et al. (2016)
High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium
J Pathol Clin Res, 2 (3), 138-53
DOI 10.1002/cjp2.42, PubMed 27499923

Abubakar M, Orr N, Daley F, Coulson P, Ali HR, Blows F, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Chang-Claude J, Rudolph A, Sinn P, Couch FJ, Devilee P, Tollenaar RA, Seynaeve C, Figueroa J, Sherman ME, Lissowska J, Hewitt S, Eccles D, Hooning MJ, Hollestelle A et al. (2016)
Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups
Breast Cancer Res, 18 (1), 104
DOI 10.1186/s13058-016-0765-6, PubMed 27756439

Publications 2015

Mala T, Hewitt S, Høgestøl IK, Kjellevold K, Kristinsson JA, Risstad H (2015)
[Dumping syndrome following gastric surgery]
Tidsskr Nor Laegeforen, 135 (2), 137-41
DOI 10.4045/tidsskr.14.0550, PubMed 25625992

Mala T, Hewitt S, Høgestøl IK, Kjellevold K, Kristinsson JA, Risstad H (2015)
[Dumping syndrome following gastric surgery]
Tidsskr Nor Laegeforen, 135 (4), 310
DOI 10.4045/tidsskr.15.0163, PubMed 25707648

Risstad H, Søvik TT, Hewitt S, Kristinsson JA, Fagerland MW, Bernklev T, Mala T (2015)
Changes in Health-Related Quality of Life After Gastric Bypass in Patients With and Without Obesity-Related Disease
Obes Surg, 25 (12), 2408-16
DOI 10.1007/s11695-015-1717-4, PubMed 26003550

Publications 2014

Hewitt S, Humerfelt S, Søvik TT, Aasheim ET, Risstad H, Kristinsson J, Mala T (2014)
Long-term improvements in pulmonary function 5 years after bariatric surgery
Obes Surg, 24 (5), 705-11
DOI 10.1007/s11695-013-1159-9, PubMed 24435516

Publications 2013

Aftab H, Risstad H, Søvik TT, Bernklev T, Hewitt S, Kristinsson JA, Mala T (2013)
Five-year outcome after gastric bypass for morbid obesity in a Norwegian cohort
Surg Obes Relat Dis, 10 (1), 71-8
DOI 10.1016/j.soard.2013.05.003, PubMed 24182445

Hewitt S, Søvik TT, Aasheim ET, Kristinsson J, Jahnsen J, Birketvedt GS, Bøhmer T, Eriksen EF, Mala T (2013)
Secondary hyperparathyroidism, vitamin D sufficiency, and serum calcium 5 years after gastric bypass and duodenal switch
Obes Surg, 23 (3), 384-90
DOI 10.1007/s11695-012-0772-3, PubMed 23015268

Publications 2011

Hewitt S, Weidanz F, Westgeest H, Ruza I, Ciferska H, Pasquet F, Salomäki S, Olsen E (2011)
European School of Internal Medicine (ESIM) in Brighton: experiences and reflections
Eur J Intern Med, 22 (3), 238-40
DOI 10.1016/j.ejim.2011.01.006, PubMed 21570640

Publications 2009

Hewitt S, Graff-Iversen S (2009)
Risk factors for cardiovascular diseases and diabetes in disability pensioners aged 40--42 years: a cross-sectional study in Norway
Scand J Public Health, 37 (3), 280-6
DOI 10.1177/1403494808101177, PubMed 19181824

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