Publications

Publications published since 2003 from OUS - Unit for Cell Signalling (Krauss)

65 publications found

Publications 2021

1. Busek M, Novik S, Aizenshtadt A, Amirola-Martinez M, Combriat T, Grunzner S, Krauss S (2021)
   Thermoplastic Elastomer (TPE)-Poly(Methyl Methacrylate) (PMMA) Hybrid Devices for Active Pumping PDMS-Free Organ-on-a-Chip Systems
   Biosensors-Basel, 11 (5), 162
   DOI 10.3390/bios11050162
2. Leenders RGG, Brinch SA, Sowa ST, Amundsen-Isaksen E, Galera-Prat A, Murthy S, Aertssen S, Smits JN, Nieczypor P, Damen E, Wegert A, Nazare M, Lehtio L, Waaler J, Krauss S (2021)
   Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
   J. Med. Chem.
   DOI 10.1021/acs.jmedchem.1c01264
3. Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygard S, Chi NW, Lin E, Tan J, Yu YH, Costa M, Krauss S, Waaler J (2021)
   Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
   iScience, 24 (7), 102807
   DOI 10.1016/j.isci.2021.102807
4. Olsen PA, Krauss S (2021)
   The Adenoviral E1B-55k Protein Present in HEK293 Cells Mediates Abnormal Accumulation of Key WNT Signaling Proteins in Large Cytoplasmic Aggregates
   Genes, 12 (12), 1920
   DOI 10.3390/genes12121920
5. Skottvoll FS, Hansen FA, Harrison S, Boger IS, Mrsa A, Restan MS, Stein M, Lundanes E, Pedersen-Bjergaard S, Aizenshtadt A, Krauss S, Sullivan G, Bogen IL, Wilson SR (2021)
   Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies
   Anal. Chem., 93 (7), 3576-3585
   DOI 10.1021/acs.analchem.0c05082

Publications 2020

1. Abadpour S, Aizenshtadt A, Olsen PA, Shoji K, Wilson SR, Krauss S, Scholz H (2020)
   Pancreas-on-a-Chip Technology for Transplantation Applications
   Curr. Diabetes Rep., 20 (12), 72
   DOI 10.1007/s11892-020-01357-1
2. Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO (2020)
   A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
   Cancers, 12 (6), 1630
   DOI 10.3390/cancers12061630
3. Lien VT, Kristiansen MK, Pettersen S, Haugen MH, Krauss S, Olberg DE, Waaler J, Klaveness J (2020)
   Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation (vol 9, pg 37092, 2019)
   RSC Adv., 10 (9), 4927
   DOI 10.1039/d0ra90007a
4. Lin A, Skottvoll FS, Rayner S, Pedersen-Bjergaard S, Sullivan G, Krauss S, Wilson SR, Harrison S (2020)
   3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry
   Electrophoresis, 41 (1-2), 56-64
   DOI 10.1002/elps.201900170
5. Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP (2020)
   Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells
   Commun. Biol., 3 (1), 123
   DOI 10.1038/s42003-020-0851-2
6. Wang H, Kuusela S, Rinnankoski-Tuikka R, Dumont V, Bouslama R, Ramadan UA, Waaler J, Linden AM, Chi NW, Krauss S, Pirinen E, Lehtone S (2020)
   Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice
   Int. J. Obes., 44 (8), 1691-1702
   DOI 10.1038/s41366-020-0573-z
7. Waaler J, Leenders RGG, Sowa ST, Brinch SA, Lycke M, Nieczypor P, Aertssen S, Murthy S, Galera-Prat A, Damen E, Wegert A, Nazare M, Lehtio L, Krauss S (2020)
   Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
   J. Med. Chem., 63 (13), 6834-6846
   DOI 10.1021/acs.jmedchem.0c00208
8. Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Boe SL, Heintz KM, Hovig E, Hammarstrom C, Corthay A, Krauss S (2020)
   Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
   Commun. Biol., 3 (1)
   DOI 10.1038/s42003-020-0916-2

Publications 2019

1. Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P et al. (2019)
   EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
   SLAS Discov., 24 (3), 398-413
   DOI 10.1177/2472555218816276
2. Skottvoll FS, Berg HE, Bjorseth K, Lund K, Roos N, Bekhradnia S, Thiede B, Sandberg C, Vik-Mo EO, Roberg-Larsen H, Nystrom B, Lundanes E, Wilson SR (2019)
   Ultracentrifugation versus kit exosome isolation: nanoLC-MS and other tools reveal similar performance biomarkers, but also contaminations
   Futur. Sci. OA, 5 (1), FSO359
   DOI 10.4155/fsoa-2018-0088
3. Solberg NT, Melheim M, Strand MF, Olsen PA, Krauss S (2019)
   MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition
   Cancers, 11 (2), 164
   DOI 10.3390/cancers11020164

Publications 2018

1. Norum JH, Skarpen E, Brech A, Kuiper R, Waaler J, Krauss S, Sorlie T (2018)
   The tankyrase inhibitor G007-LK inhibits small intestine LGR5(+) stem cell proliferation without altering tissue morphology
   Biol. Res., 51, 3
   DOI 10.1186/s40659-017-0151-6
2. Solberg NT, Waaler J, Lund K, Mygland L, Olsen PA, Krauss S (2018)
   TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer
   Mol. Cancer Res., 16 (3), 543-553
   DOI 10.1158/1541-7786.MCR-17-0362

Publications 2017

1. Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaii E, Majouga AG, Leonov S, von Kries JP, Lehtio L, Krauss S, Nazare M (2017)
   Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
   J. Med. Chem., 60 (24), 10013-10025
   DOI 10.1021/acs.jmedchem.7b00883
2. Lund K, Olsen CE, Wong JJW, Olsen PA, Solberg NT, Hogset A, Krauss S, Selbo PK (2017)
   5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
   J. Exp. Clin. Cancer Res., 36, 187
   DOI 10.1186/s13046-017-0662-6
3. Roberg-Larsen H, Lund K, Seterdal KE, Solheim S, Vehus T, Solberg N, Krauss S, Lundanes E, Wilson SR (2017)
   Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes
   J. Steroid Biochem. Mol. Biol., 169, 22-28
   DOI 10.1016/j.jsbmb.2016.02.006
4. Vehus T, Waaler J, Krauss S, Lundanes E, Wilson SR (2017)
   Combining HIC, SEC, and IEX with Fluorescence Polarization for Drug Target Discovery
   LC GC Eur., 30 (5), 232-239

Publications 2016

1. Haikarainen T, Waaler J, Ignatev A, Nkizinkiko Y, Venkannagari H, Obaji E, Krauss S, Lehtio L (2016)
   Development and structural analysis of adenosine site binding tankyrase inhibitors
   Bioorg. Med. Chem. Lett., 26 (2), 328-333
   DOI 10.1016/j.bmcl.2015.12.018
2. Vehus T, Roberg-Larsen H, Waaler J, Aslaksen S, Krauss S, Wilson SR, Lundanes E (2016)
   Versatile, sensitive liquid chromatography mass spectrometry - Implementation of 10 mu m OT columns suitable for small molecules, peptides and proteins
   Sci Rep, 6, 37507
   DOI 10.1038/srep37507
3. Vehus T, Seterdal KE, Krauss S, Lundanes E, Wilson SR (2016)
   Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics
   Futur. Sci. OA, 2 (2), FSO119
   DOI 10.4155/fsoa-2016-0014
4. Zhong LL, Ding Y, Bandyopadhyay G, Waaler J, Borgeson E, Smith S, Zhang MC, Phillips SA, Mahooti S, Mahata SK, Shao JH, Krauss S, Chi NW (2016)
   The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice
   Diabetologia, 59 (3), 582-591
   DOI 10.1007/s00125-015-3815-1

Publications 2015

1. Machon O, Masek J, Machonova O, Krauss S, Kozmik Z (2015)
   Meis2 is essential for cranial and cardiac neural crest development
   BMC Dev. Biol., 15, 40
   DOI 10.1186/s12861-015-0093-6
2. Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestol K, Waaler J, Krauss S, Stenmark H (2015)
   Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
   Mol. Cancer Res., 13 (11), 1487-1501
   DOI 10.1158/1541-7786.MCR-15-0125

Publications 2014

1. Haikarainen T, Krauss S, Lehtio L (2014)
   Tankyrases: Structure, Function and Therapeutic Implications in Cancer
   Curr. Pharm. Design, 20 (41), 6472-6488
   DOI 10.2174/1381612820666140630101525
2. Hustoft HK, Vehus T, Brandtzaeg OK, Krauss S, Greibrokk T, Wilson SR, Lundanes E (2014)
   Open Tubular Lab-On-Column/Mass Spectrometry for Targeted Proteomics of Nanogram Sample Amounts
   PLoS One, 9 (9), e106881
   DOI 10.1371/journal.pone.0106881
3. Lund K, Bostad M, Skarpen E, Braunagel M, Kiprijanov S, Krauss S, Duncan A, Hogset A, Selbo PK (2014)
   The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
   mAbs, 6 (4), 1038-1050
   DOI 10.4161/mabs.28207
4. Olsen PA, Solberg NT, Lund K, Vehus T, Gelazauskaite M, Wilson SR, Krauss S (2014)
   Implications of Targeted Genomic Disruption of beta-Catenin in BxPC-3 Pancreatic Adenocarcinoma Cells
   PLoS One, 9 (12), e115496
   DOI 10.1371/journal.pone.0115496
5. Roberg-Larsen H, Lund K, Vehus T, Solberg N, Vesterdal C, Misaghian D, Olsen PA, Krauss S, Wilson SR, Lundanes E (2014)
   Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols
   J. Lipid Res., 55 (7), 1531-1536
   DOI 10.1194/jlr.D048801
6. Roberg-Larsen H, Strand MF, Krauss S, Wilson SR (2014)
   Metabolites in vertebrate Hedgehog signaling
   Biochem. Biophys. Res. Commun., 446 (3), 669-674
   DOI 10.1016/j.bbrc.2014.01.087
7. Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O (2014)
   The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
   Cancer Med., 3 (1), 36-46
   DOI 10.1002/cam4.170

Publications 2013

1. Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M (2013)
   A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth
   Cancer Res., 73 (10), 3132-3144
   DOI 10.1158/0008-5472.CAN-12-4562
2. Lehtio L, Chi NW, Krauss S (2013)
   Tankyrases as drug targets
   FEBS J., 280 (15), 3576-3593
   DOI 10.1111/febs.12320
3. Voronkov A, Holsworth DD, Waaler J, Wilson SR, Ekblad B, Perdreau-Dahl H, Dinh H, Drewes G, Hopf C, Morth JP, Krauss S (2013)
   Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor
   J. Med. Chem., 56 (7), 3012-3023
   DOI 10.1021/jm4000566
4. Voronkov A, Krauss S (2013)
   Wnt/beta-Catenin Signaling and Small Molecule Inhibitors
   Curr. Pharm. Design, 19 (4), 634-664
   DOI 10.2174/138161213804581837

Publications 2012

1. Holsworth DD, Krauss S (2012)
   Recent Advances in Wnt/beta-Catenin Pathway Small-Molecule Inhibitors
   Annu. Rep. Med. Chem., 47, 393-409
   DOI 10.1016/B978-0-12-396492-2.00026-6
2. Roberg-Larsen H, Strand MF, Grimsmo A, Olsen PA, Dembinski JL, Rise F, Lundanes E, Greibrokk T, Krauss S, Wilson SR (2012)
   High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry
   J. Chromatogr. A, 1255, 291-297
   DOI 10.1016/j.chroma.2012.02.002
3. Solberg N, Machon O, Krauss S (2012)
   Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene
   Mol. Cell. Biochem., 360 (1-2), 289-299
   DOI 10.1007/s11010-011-1068-y
4. Solberg N, Machon O, Machonova O, Krauss S (2012)
   Mouse Tcf3 represses canonical Wnt signaling by either competing for beta-catenin binding or through occupation of DNA-binding sites
   Mol. Cell. Biochem., 365 (1-2), 53-63
   DOI 10.1007/s11010-012-1243-9
5. Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S (2012)
   A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
   Cancer Res., 72 (11), 2822-2832
   DOI 10.1158/0008-5472.CAN-11-3336

Publications 2011

1. Jing Y, Machon O, Hampl A, Dvorak P, Xing Y, Krauss S (2011)
   In Vitro Differentiation of Mouse Embryonic Stem Cells into Neurons of the Dorsal Forebrain
   Cell. Mol. Neurobiol., 31 (5), 715-727
   DOI 10.1007/s10571-011-9669-2
2. Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, Gradl D, Paulsen JE, Machonova O, Dembinski JL, Dinh H, Krauss S (2011)
   Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth
   Cancer Res., 71 (1), 197-205
   DOI 10.1158/0008-5472.CAN-10-1282

Publications 2010

1. Dembinski JL, Krauss S (2010)
   A Distinct Slow-Cycling Cancer Stem-like Subpopulation of Pancreatic Adenocarcinoma Cells is maintained in Vivo
   Cancers, 2 (4), 2011-2025
   DOI 10.3390/cancers2042011, PublikaID 116
2. Olsen PA, Gelazauskaite M, Randol M, Krauss S (2010)
   Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction
   BMC Mol. Biol., 11, 35
   DOI 10.1186/1471-2199-11-35
3. Wilson SR, Strand MF, Krapp A, Rise F, Herstad G, Malterud KE, Krauss S (2010)
   Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album
   J. Pharm. Biomed. Anal., 53 (3), 497-502
   DOI 10.1016/j.jpba.2010.05.024
4. Wilson SR, Strand MF, Krapp A, Rise F, Petersen D, Krauss S (2010)
   Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified
   J. Pharm. Biomed. Anal., 52 (5), 707-713
   DOI 10.1016/j.jpba.2010.02.017

Publications 2009

1. Dembinski JL, Krauss S (2009)
   Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma
   Clin. Exp. Metastasis, 26 (7), 611-623
   DOI 10.1007/s10585-009-9260-0
2. Kunke D, Bryja V, Mygland L, Arenas E, Krauss S (2009)
   Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs
   Biochem. Biophys. Res. Commun., 386 (4), 628-633
   DOI 10.1016/j.bbrc.2009.06.084
3. Olsen PA, Solhaug A, Booth JA, Gelazauskaite M, Krauss S (2009)
   Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases
   DNA Repair, 8 (3), 298-308
   DOI 10.1016/j.dnarep.2008.11.011

Publications 2008

1. Solberg N, Machon O, Krauss S (2008)
   Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
   Dev. Dyn., 237 (7), 1799-1811
   DOI 10.1002/dvdy.21586

Publications 2007

1. Fujimura N, Vacik T, Machon O, Vlcek C, Scalabrin S, Speth M, Diep DB, Krauss S, Kozmik Z (2007)
   Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5
   J. Biol. Chem., 282 (2), 1225-1237
   DOI 10.1074/jbc.M605851200
2. Hildrestrand GA, Diep DB, Kunke D, Bolstad N, Bjoras M, Krauss S, Luna L (2007)
   The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
   DNA Repair, 6 (6), 723-732
   DOI 10.1016/j.dnarep.2006.12.008
3. Kadowaki M, Nakamura S, Machon O, Krauss S, Radice GL, Takeichi M (2007)
   N-cadherin mediates cortical organization in the mouse brain
   Dev. Biol., 304 (1), 22-33
   DOI 10.1016/j.ydbio.2006.12.014
4. Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z (2007)
   Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function
   Genesis, 45 (4), 157-168
   DOI 10.1002/dvg.20277
5. Machon O, Backman M, Machonova O, Kozmik Z, Vacik T, Andersen L, Krauss S (2007)
   A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus
   Dev. Biol., 311 (1), 223-237
   DOI 10.1016/j.ydbio.2007.08.038

Publications 2005

1. Backman M, Machon O, Mygland L, van den Bout CJ, Zhong WM, Taketo MM, Krauss S (2005)
   Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
   Dev. Biol., 279 (1), 155-168
   DOI 10.1016/j.ydbio.2004.12.010
2. Machon O, Backman M, Krauss S, Kozmik Z (2005)
   The cellular fate of cortical progenitors is not maintained in neurosphere cultures
   Mol. Cell. Neurosci., 30 (3), 388-397
   DOI 10.1016/j.mcn.2005.08.003
3. Olsen PA, Randol M, Luna L, Brown T, Krauss S (2005)
   Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
   J. Gene. Med., 7 (12), 1534-1544
   DOI 10.1002/jgm.804

Publications 2004

1. Diep DB, Hoen N, Backman M, Machon O, Krauss S (2004)
   Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain
   Dev. Brain Res., 153 (2), 261-270
   DOI 10.1016/j.devbrainres.2004.09.008

Publications 2003

1. Backman M, Machon O, Van Den Bout CJ, Krauss S (2003)
   Targeted disruption of mouse Dach1 results in postnatal lethality
   Dev. Dyn., 226 (1), 139-144
   DOI 10.1002/dvdy.10210
2. Machon O, Van den Bout CJ, Backman M, Kemler R, Krauss S (2003)
   Role of beta-catenin in the developing cortical and hippocampal neuroepithelium
   Neuroscience, 122 (1), 129-143
   DOI 10.1016/S0306-4522(03)00519-0