Publications from OUS - Dept. of Microbiology, Lab for genome repair and regulation (Klungland)

88 publications found

Publications 2020

  1. Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M (2020)
    Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
    Sci Rep, 10 (1), 5656
    DOI 10.1038/s41598-020-62548-0, PubMed 32221390
  2. Grøsvik K, Tesfahun AN, Muruzábal-Lecumberri I, Haugland GT, Leiros I, Ruoff P, Kvaløy JT, Knævelsrud I, Ånensen H, Alexeeva M, Sato K, Matsuda A, Alseth I, Klungland A, Bjelland S (2020)
    The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
    Front Microbiol, 11, 263
    DOI 10.3389/fmicb.2020.00263, PubMed 32158436
  3. Iversen R, Amundsen SF, Kleppa L, du Pré MF, Stamnaes J, Sollid LM (2020)
    Evidence That Pathogenic Transglutaminase 2 in Celiac Disease Derives From Enterocytes
    Gastroenterology, 159 (2), 788-790
    DOI 10.1053/j.gastro.2020.04.018, PubMed 32302613
  4. Khelik K, Sandve GK, Nederbragt AJ, Rognes T (2020)
    NucBreak: location of structural errors in a genome assembly by using paired-end Illumina reads
    BMC Bioinformatics, 21 (1), 66
    DOI 10.1186/s12859-020-3414-0, PubMed 32085722
  5. Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vågbø C, Suganthan R, Segers F, Holm S, Quiles-Jiménez A, Gregersen I, Fladeby C, Aukrust P, Bjørås M, Klungland A, Halvorsen B, Alseth I (2020)
    Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
    Nucleic Acids Res, 48 (8), 4463-4479
    DOI 10.1093/nar/gkaa115, PubMed 32083667
  6. Li M, Klungland A (2020)
    Modifications and interactions at the R-loop
    DNA Repair (Amst), 96, 102958 (in press)
    DOI 10.1016/j.dnarep.2020.102958, PubMed 32961406
  7. Sankar A, Lerdrup M, Manaf A, Johansen JV, Gonzalez JM, Borup R, Blanshard R, Klungland A, Hansen K, Andersen CY, Dahl JA, Helin K, Hoffmann ER (2020)
    KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
    Nat Cell Biol, 22 (4), 380-388
    DOI 10.1038/s41556-020-0494-z, PubMed 32231309
  8. Saue T, Bast R, Gomes ASP, Jensen HJA, Visscher L, Aucar IA, Di Remigio R, Dyall KG, Eliav E, Fasshauer E, Fleig T, Halbert L, Hedegård ED, Helmich-Paris B, Iliaš M, Jacob CR, Knecht S, Laerdahl JK, Vidal ML, Nayak MK, Olejniczak M, Olsen JMH, Pernpointner M, Senjean B, Shee A et al. (2020)
    The DIRAC code for relativistic molecular calculations
    J Chem Phys, 152 (20), 204104
    DOI 10.1063/5.0004844, PubMed 32486677
  9. Vander Zanden CM, Czarny RS, Ho EN, Robertson AB, Ho PS (2020)
    Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function
    Nucleic Acids Res, 48 (7), 3962-3974
    DOI 10.1093/nar/gkaa117, PubMed 32095813
  10. Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
    OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
    Cell Rep, 30 (12), 4165-4178.e7
    DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476
  11. Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ (2020)
    LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
    Sci Adv, 6 (37)
    DOI 10.1126/sciadv.abc0367, PubMed 32917713

Publications 2019

  1. Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A (2019)
    N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
    Nat Genet, 52 (1), 48-55
    DOI 10.1038/s41588-019-0549-x, PubMed 31844323
  2. Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S (2019)
    Excision of uracil from DNA by hSMUG1 includes strand incision and processing
    Nucleic Acids Res, 47 (2), 779-793
    DOI 10.1093/nar/gky1184, PubMed 30496516
  3. Berges N, Nawaz MS, Børresdatter Dahl T, Hagen L, Bjørås M, Laerdahl JK, Alseth I (2019)
    Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
    PLoS One, 14 (11), e0225081
    DOI 10.1371/journal.pone.0225081, PubMed 31703097
  4. Fosslie M, Manaf A, Lerdrup M, Hansen K, Gilfillan GD, Dahl JA (2019)
    Going low to reach high: Small-scale ChIP-seq maps new terrain
    Wiley Interdiscip Rev Syst Biol Med, 12 (1), e1465
    DOI 10.1002/wsbm.1465, PubMed 31478357
  5. Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, Ougland R (2019)
    "Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
    Clin Epigenetics, 11 (1), 135
    DOI 10.1186/s13148-019-0718-x, PubMed 31519213
  6. Lie-Jensen A, Ivanauskiene K, Malerød L, Jain A, Tan KW, Laerdahl JK, Liestøl K, Stenmark H, Haglund K (2019)
    Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
    Curr Biol, 29 (20), 3538-3548.e7
    DOI 10.1016/j.cub.2019.09.025, PubMed 31607533
  7. Pilžys T, Marcinkowski M, Kukwa W, Garbicz D, Dylewska M, Ferenc K, Mieczkowski A, Kukwa A, Migacz E, Wołosz D, Mielecki D, Klungland A, Piwowarski J, Poznański J, Grzesiuk E (2019)
    ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
    Sci Rep, 9 (1), 13249
    DOI 10.1038/s41598-019-49550-x, PubMed 31519943
  8. Prikrylova T, Robertson J, Ferrucci F, Konorska D, Aanes H, Manaf A, Zhang B, Vågbø CB, Kuśnierczyk A, Gilljam KM, Løvkvam-Køster C, Otterlei M, Dahl JA, Enserink J, Klungland A, Robertson AB (2019)
    5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
    Sci Rep, 9 (1), 11065
    DOI 10.1038/s41598-019-47528-3, PubMed 31363131
  9. Strøm TB, Vinje T, Bjune K, da Costa LT, Laerdahl JK, Leren TP (2019)
    Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein
    Proteins, 88 (3), 440-448
    DOI 10.1002/prot.25821, PubMed 31587363
  10. Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S (2019)
    Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
    Aging Cell, 18 (2), e12897
    DOI 10.1111/acel.12897, PubMed 30712319
  11. Vinje T, Laerdahl JK, Bjune K, Leren TP, Strøm TB (2019)
    Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
    Hum Mol Genet, 28 (18), 3043-3052
    DOI 10.1093/hmg/ddz114, PubMed 31131398
  12. Zhang Z, Manaf A, Li Y, Perez SP, Suganthan R, Dahl JA, Bjørås M, Klungland A (2019)
    Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
    Mol Neurobiol, 57 (2), 997-1008
    DOI 10.1007/s12035-019-01777-5, PubMed 31654318

Publications 2018

  1. Alexeeva M, Guragain P, Tesfahun AN, Tomkuvienė M, Arshad A, Gerasimaitė R, Rukšėnaitė A, Urbanavičiūtė G, Bjørås M, Laerdahl JK, Klungland A, Klimašauskas S, Bjelland S (2018)
    Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
    Philos Trans R Soc Lond B Biol Sci, 373 (1748)
    DOI 10.1098/rstb.2017.0337, PubMed 29685966
  2. Askeland G, Dosoudilova Z, Rodinova M, Klempir J, Liskova I, Kuśnierczyk A, Bjørås M, Nesse G, Klungland A, Hansikova H, Eide L (2018)
    Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
    Sci Rep, 8 (1), 9817
    DOI 10.1038/s41598-018-27985-y, PubMed 29959348
  3. Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L (2018)
    A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
    Dis Model Mech, 11 (10)
    DOI 10.1242/dmm.035949, PubMed 30254085
  4. Bagger SO, Hopkinson BM, Pandey DP, Bak M, Brydholm AV, Villadsen R, Helin K, Rønnov-Jessen L, Petersen OW, Kim J (2018)
    Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity
    Mol Cancer, 17 (1), 171
    DOI 10.1186/s12943-018-0918-6, PubMed 30526604
  5. Dahl JA, Gilfillan GD (2018)
    How low can you go? Pushing the limits of low-input ChIP-seq
    Brief Funct Genomics, 17 (2), 89-95
    DOI 10.1093/bfgp/elx037, PubMed 29087438
  6. Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
    STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
    Cell Calcium, 76, 87-100
    DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422
  7. Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I et al. (2018)
    Positioning Europe for the EPITRANSCRIPTOMICS challenge
    RNA Biol, 15 (6), 829-831
    DOI 10.1080/15476286.2018.1460996, PubMed 29671387
  8. Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A (2018)
    Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
    Genome Biol, 19 (1), 69
    DOI 10.1186/s13059-018-1436-y, PubMed 29855337
  9. Ma C, Chang M, Lv H, Zhang ZW, Zhang W, He X, Wu G, Zhao S, Zhang Y, Wang D, Teng X, Liu C, Li Q, Klungland A, Niu Y, Song S, Tong WM (2018)
    RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum
    Genome Biol, 19 (1), 68
    DOI 10.1186/s13059-018-1435-z, PubMed 29855379
  10. Skjærven KH, Jakt LM, Fernandes JMO, Dahl JA, Adam AC, Klughammer J, Bock C, Espe M (2018)
    Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring
    Sci Rep, 8 (1), 3055
    DOI 10.1038/s41598-018-21211-5, PubMed 29445184
  11. Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A, Jia G, Chen J, He C (2018)
    Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
    Mol Cell, 71 (6), 973-985.e5
    DOI 10.1016/j.molcel.2018.08.011, PubMed 30197295

Publications 2017

  1. Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
    TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
    Proc Natl Acad Sci U S A, 114 (5), 1039-1044
    DOI 10.1073/pnas.1615093114, PubMed 28096404
  2. Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D (2017)
    ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage
    Cell Death Dis, 8 (7), e2947
    DOI 10.1038/cddis.2017.343, PubMed 28726787
  3. Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A (2017)
    Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia
    Mol Med Rep, 15 (4), 1513-1526
    DOI 10.3892/mmr.2017.6185, PubMed 28259955
  4. Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
    Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
    Cell Discov, 3, 17013
    DOI 10.1038/celldisc.2017.13, PubMed 28529766
  5. Malachin G, Reiten MR, Salvesen Ø, Aanes H, Kamstra JH, Skovgaard K, Heegaard PMH, Ersdal C, Espenes A, Tranulis MA, Bakkebø MK (2017)
    Loss of prion protein induces a primed state of type I interferon-responsive genes
    PLoS One, 12 (6), e0179881
    DOI 10.1371/journal.pone.0179881, PubMed 28651013
  6. Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
    NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
    Cell Rep, 18 (1), 82-92
    DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
  7. Pawar T, Bjørås M, Klungland A, Eide L (2017)
    Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
    Mitochondrion, 40, 16-28
    DOI 10.1016/j.mito.2017.09.002, PubMed 28893634
  8. Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
    No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
    Sci Rep, 7 (1), 4384
    DOI 10.1038/s41598-017-04472-4, PubMed 28663564
  9. Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B (2017)
    Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
    DNA Repair (Amst), 58, 13-20
    DOI 10.1016/j.dnarep.2017.08.005, PubMed 28843610
  10. Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W (2017)
    ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells
    Proc Natl Acad Sci U S A, 115 (2), E325-E333
    DOI 10.1073/pnas.1717794115, PubMed 29279410
  11. Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A (2017)
    Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
    PLoS One, 12 (3), e0168182
    DOI 10.1371/journal.pone.0168182, PubMed 28288181

Publications 2016

  1. A Alemu E, He C, Klungland A (2016)
    ALKBHs-facilitated RNA modifications and de-modifications
    DNA Repair (Amst), 44, 87-91
    DOI 10.1016/j.dnarep.2016.05.026, PubMed 27237585
  2. Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A (2016)
    Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
    Nature, 537 (7621), 548-552
    DOI 10.1038/nature19360, PubMed 27626377
  3. Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A (2016)
    Reversible RNA modifications in meiosis and pluripotency
    Nat Methods, 14 (1), 18-22
    DOI 10.1038/nmeth.4111, PubMed 28032624
  4. Klungland A, Robertson AB (2016)
    Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
    Free Radic Biol Med, 107, 62-68
    DOI 10.1016/j.freeradbiomed.2016.11.038, PubMed 27890639
  5. Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P (2016)
    Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
    Fertil Steril, 105 (5), 1170-1179.e5
    DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768
  6. Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH (2016)
    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
    Neurobiol Aging, 48, 34-47
    DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119
  7. Lillenes MS, Rabano A, Støen M, Riaz T, Misaghian D, Møllersen L, Esbensen Y, Günther CC, Selnes P, Stenset VT, Fladby T, Tønjum T (2016)
    Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease
    Mol Brain, 9 (1), 61
    DOI 10.1186/s13041-016-0237-z, PubMed 27234294
  8. Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
    ALKBH1-Mediated tRNA Demethylation Regulates Translation
    Cell, 167 (7), 1897
    DOI 10.1016/j.cell.2016.11.045, PubMed 27984735
  9. Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
    ALKBH1-Mediated tRNA Demethylation Regulates Translation
    Cell, 167 (3), 816-828.e16
    DOI 10.1016/j.cell.2016.09.038, PubMed 27745969
  10. Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L (2016)
    Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
    PLoS Curr, 8
    DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492
  11. Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E (2016)
    Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells
    Cell Physiol Biochem, 38 (1), 173-84
    DOI 10.1159/000438619, PubMed 26765775
  12. Rasmussen EMK, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA (2016)
    DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
    Biochem Biophys Rep, 6, 9-15
    DOI 10.1016/j.bbrep.2016.02.011, PubMed 28955859
  13. Skjærven KH, Jakt LM, Dahl JA, Espe M, Aanes H, Hamre K, Fernandes JM (2016)
    Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
    Sci Rep, 6, 34535
    DOI 10.1038/srep34535, PubMed 27731423
  14. Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
    Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
    Epigenetics Chromatin, 9, 21
    DOI 10.1186/s13072-016-0070-8, PubMed 27252783
  15. Vander Zanden CM, Rowe RK, Broad AJ, Robertson AB, Ho PS (2016)
    Effect of Hydroxymethylcytosine on the Structure and Stability of Holliday Junctions
    Biochemistry, 55 (41), 5781-5789
    DOI 10.1021/acs.biochem.6b00801, PubMed 27653243
  16. Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA (2016)
    Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation
    Mol Cell Neurosci, 77, 47-52
    DOI 10.1016/j.mcn.2016.10.004, PubMed 27751903
  17. Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P (2016)
    Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
    Nat Commun, 7, 10806
    DOI 10.1038/ncomms10806, PubMed 26932196

Publications 2015

  1. Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M (2015)
    Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
    Cell Rep, 13 (12), 2671-8
    DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335
  2. Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
    Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
    Genome Res, 25 (6), 897-906
    DOI 10.1101/gr.185793.114, PubMed 25800674
  3. Fusser M, Kernstock S, Aileni VK, Egge-Jacobsen W, Falnes PØ, Klungland A (2015)
    Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
    PLoS One, 10 (11), e0141472
    DOI 10.1371/journal.pone.0141472, PubMed 26544960
  4. Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE, Darnell RB (2015)
    A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation
    Genes Dev, 29 (19), 2037-53
    DOI 10.1101/gad.269415.115, PubMed 26404942
  5. Klungland A, Yang YG (2015)
    Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015
    Genomics Proteomics Bioinformatics, 14 (3), 122-125
    DOI 10.1016/j.gpb.2015.11.001, PubMed 26689322
  6. Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
    Am J Physiol Heart Circ Physiol, 309 (3), H434-49
    DOI 10.1152/ajpheart.00253.2014, PubMed 26055793
  7. Mi S, Klungland A, Yang YG (2015)
    Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015
    Sci China Life Sci, 59 (1), 89-92
    DOI 10.1007/s11427-015-4983-4, PubMed 26676642
  8. Ougland R, Rognes T, Klungland A, Larsen E (2015)
    Non-homologous functions of the AlkB homologs
    J Mol Cell Biol, 7 (6), 494-504
    DOI 10.1093/jmcb/mjv029, PubMed 26003568

Publications 2014

  1. Klungland A, Dahl JA (2014)
    Dynamic RNA modifications in disease
    Curr Opin Genet Dev, 26, 47-52
    DOI 10.1016/j.gde.2014.05.006, PubMed 25005745
  2. Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A (2014)
    ALKBH4 depletion in mice leads to spermatogenic defects
    PLoS One, 9 (8), e105113
    DOI 10.1371/journal.pone.0105113, PubMed 25153837
  3. Robertson AB, Dahl JA, Klungland A (2014)
    DNA metabolism: bases of DNA repair and regulation
    Nat Chem Biol, 10 (7), 487-8
    DOI 10.1038/nchembio.1553, PubMed 24937064
  4. Robertson AB, Robertson J, Fusser M, Klungland A (2014)
    Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
    Nucleic Acids Res., 42 (21), 13280-13293
  5. Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ (2014)
    Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
    PLoS One, 9 (6), e98729
    DOI 10.1371/journal.pone.0098729, PubMed 24914785

Publications 2013

  1. Jonson I, Ougland R, Klungland A, Larsen E (2013)
    Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells
    Stem Cell Res, 11 (3), 1264-71
    DOI 10.1016/j.scr.2013.08.010, PubMed 24041806
  2. Jonson I, Ougland R, Larsen E (2013)
    DNA repair mechanisms in Huntington's disease
    Mol Neurobiol, 47 (3), 1093-102
    DOI 10.1007/s12035-013-8409-7, PubMed 23361256
  3. Solberg A, Robertson AB, Aronsen JM, Rognmo Ø, Sjaastad I, Wisløff U, Klungland A (2013)
    Deletion of mouse Alkbh7 leads to obesity
    J Mol Cell Biol, 5 (3), 194-203
    DOI 10.1093/jmcb/mjt012, PubMed 23572141

Publications 2012

  1. Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM, Bjørås M, Klungland A (2012)
    Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
    Hum Mol Genet, 21 (22), 4939-47
    DOI 10.1093/hmg/dds337, PubMed 22914735

Publications 2011

  1. Robertson AB, Dahl JA, Vågbø CB, Tripathi P, Krokan HE, Klungland A (2011)
    A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
    Nucleic Acids Res, 39 (8), e55
    DOI 10.1093/nar/gkr051, PubMed 21300643

Publications 2007

  1. Klungland A, Andersson KB (2007)
    [Nobel Prize for genetic modification]
    Tidsskr Nor Laegeforen, 127 (23), 3054
    PubMed 18049491
  2. Larsen E, Meza TJ, Kleppa L, Klungland A (2007)
    Organ and cell specificity of base excision repair mutants in mice
    Mutat Res, 614 (1-2), 56-68
    DOI 10.1016/j.mrfmmm.2006.01.023, PubMed 16765995
  3. Nordstrand LM, Ringvoll J, Larsen E, Klungland A (2007)
    Genome instability and DNA damage accumulation in gene-targeted mice
    Neuroscience, 145 (4), 1309-17
    DOI 10.1016/j.neuroscience.2006.10.059, PubMed 17218062

Publications 2006

  1. Larsen E, Reite K, Nesse G, Gran C, Seeberg E, Klungland A (2006)
    Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
    Oncogene, 25 (17), 2425-32
    DOI 10.1038/sj.onc.1209284, PubMed 16369492

Publications 2002

  1. Birkeland NK, Anensen H, Knaevelsrud I, Kristoffersen W, Bjørås M, Robb FT, Klungland A, Bjelland S (2002)
    Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus
    Biochemistry, 41 (42), 12697-705
    DOI 10.1021/bi020334w, PubMed 12379112
  2. Osterod M, Larsen E, Le Page F, Hengstler JG, Van Der Horst GT, Boiteux S, Klungland A, Epe B (2002)
    A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
    Oncogene, 21 (54), 8232-9
    DOI 10.1038/sj.onc.1206027, PubMed 12447686

Publications 2001

  1. Klungland A (2001)
    [Life without DNA repair]
    Tidsskr Nor Laegeforen, 121 (1), 41-9
    PubMed 12013614
  2. Klungland A, Paulsen R, Rolseth V, Yamada Y, Ueno Y, Wiik P, Matsuda A, Seeberg E, Bjelland S (2001)
    5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism
    Toxicol Lett, 119 (1), 71-8
    DOI 10.1016/s0378-4274(00)00308-8, PubMed 11275423

 
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