This year's prize from "Dr. Ragnar Mørk legacy" is awarded Anne Simonsen from the Department of Biochemistry at the Norwegian Radium Hospital.
The "Dr. Ragnar Mørk legacy" prize is distributed annually to a scientist who has achieved excellent results throughout years of outstanding research.
The ceremony took place in the seminar room at the Institute for Cancer Research on Friday 22nd of November. Simonsen gave a lecture summarizing her work.
The purpose of the prize is to promote and encourage cancer research at the Norwegian Radium Hospital. The award is personal, and amounts to NOK 200.000. This is the sixth time this mark of honor is distributed. Last years's prize went to Bjørn Naume.
Anne Simonsen has for several years been trying to understand how the enzyme PI 3-kinase regulates intracellular transport. She is currently project leader for "Autophagy in health and disease". This project is aiming to clarify how autophagy is regulated, and how faulty regulation of autophagy can lead to diseases such as cancer and neurodegenerative illness. In a work presented on the cover of the last issue of the prestigious Journal of Cell Biology Simonsen presents evidence pointing to that certain inborn forms mental disability result from reduced autophagy in the central nervous system.
JCB cover story: Cancer researchers shed light on inherited brain damage (news article from radium.no)
Autophagy in health and disease - Project group led by Anne Simonsen
From major journals, first or last author from the Institute for Cancer Research
Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen
Mol Oncol (in press)
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Mol Syst Biol, 17 (3), e9526
Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Eur J Cancer, 148, 124-133 (in press)