Selected publications Major journals, first or last author from the Institute for Cancer Research

Kidd SG, Bogaard M, Carm KT, Bakken AC, Maltau AMV, Løvf M, Lothe RA, Axcrona K, Axcrona U, Skotheim RI (2022)
In situ expression of ERG protein in the context of tumor heterogeneity identifies prostate cancer patients with inferior prognosis
Mol Oncol (in press)
DOI 10.1002/1878-0261.13225, PubMed 35574900

Khadse A, Haakensen VD, Silwal-Pandit L, Hamfjord J, Micke P, Botling J, Brustugun OT, Lingjærde OC, Helland Å, Kure EH (2022)
Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma
Front Oncol, 12, 873532
DOI 10.3389/fonc.2022.873532, PubMed 35574381

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909

Emaldi M, Nunes-Xavier CE (2022)
B7-H4 Immune Checkpoint Protein Affects Viability and Targeted Therapy of Renal Cancer Cells
Cells, 11 (9)
DOI 10.3390/cells11091448, PubMed 35563753

Khezri R, Rusten TE (2022)
Autophagy power expands: fuse those cells!
EMBO J, e111424 (in press)
DOI 10.15252/embj.2022111424, PubMed 35561082

Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES, CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R, InPreD-Norway and National Molecular Tumor Board Consortium, IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å (2022)
A national precision cancer medicine implementation initiative for Norway
Nat Med (in press)
DOI 10.1038/s41591-022-01777-4, PubMed 35513529

Bergsland CH, Jeanmougin M, Moosavi SH, Svindland A, Bruun J, Nesbakken A, Sveen A, Lothe RA (2022)
Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer
Mod Pathol (in press)
DOI 10.1038/s41379-022-01086-8, PubMed 35484226

Zhang Q, Olberg A, Sioud M (2022)
Structural Requirements for the Binding of a Peptide to Prohibitins on the Cell Surface of Monocytes/Macrophages
Int J Mol Sci, 23 (8)
DOI 10.3390/ijms23084282, PubMed 35457098

Palacios D, Momayyezi P, Huhn O, Ask EH, Dunst J, Malmberg KJ, Hammer Q (2022)
An optimized platform for efficient siRNA delivery into human NK cells
Eur J Immunol (in press)
DOI 10.1002/eji.202149710, PubMed 35416292

Engedal N, Proikas-Cezanne T, Albertini MC, Žerovnik E, Lane JD (2022)
Transautophagy: Research and Translation of Autophagy Knowledge 2020
Oxid Med Cell Longev, 2022, 9792132
DOI 10.1155/2022/9792132, PubMed 35340207

Salberg UB, Skingen VE, Fjeldbo CS, Hompland T, Ragnum HB, Vlatkovic L, Hole KH, Seierstad T, Lyng H (2022)
A prognostic hypoxia gene signature with low heterogeneity within the dominant tumour lesion in prostate cancer patients
Br J Cancer (in press)
DOI 10.1038/s41416-022-01782-x, PubMed 35332267

Skotland T, Sandvig K (2022)
Need for more focus on lipid species in studies of biological and model membranes
Prog Lipid Res, 86, 101160
DOI 10.1016/j.plipres.2022.101160, PubMed 35288150

Bollineni RC, Tran TT, Lund-Johansen F, Olweus J (2022)
Chasing neoantigens; invite naïve T cells to the party
Curr Opin Immunol, 75, 102172
DOI 10.1016/j.coi.2022.102172, PubMed 35279483

Ianevski A, Giri AK, Aittokallio T (2022)
Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data
Nat Commun, 13 (1), 1246
DOI 10.1038/s41467-022-28803-w, PubMed 35273156

Mo T, Brandal SHB, Köhn-Luque A, Engebraaten O, Kristensen VN, Fleischer T, Hompland T, Seierstad T (2022)
Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer
Cancers (Basel), 14 (5)
DOI 10.3390/cancers14051326, PubMed 35267636

Aittokallio T (2022)
What are the current challenges for machine learning in drug discovery and repurposing?
Expert Opin Drug Discov, 17 (5), 423-425
DOI 10.1080/17460441.2022.2050694, PubMed 35255749

Migliano SM, Wenzel EM, Stenmark H (2022)
Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
Curr Opin Cell Biol, 75, 102062
DOI 10.1016/j.ceb.2022.01.007, PubMed 35248976

Ali M, Fulci G, Grigalavicius M, Pulli B, Li A, Wojtkiewicz GR, Wang C, Hsieh KL, Linnoila JJ, Theodossiou TA, Chen JW (2022)
Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy
Neoplasia, 26, 100779
DOI 10.1016/j.neo.2022.100779, PubMed 35247801

Simonsen A, Wollert T (2022)
Don't forget to be picky - selective autophagy of protein aggregates in neurodegenerative diseases
Curr Opin Cell Biol, 75, 102064
DOI 10.1016/j.ceb.2022.01.009, PubMed 35240373

Skånland SS, Inngjerdingen M, Bendiksen H, York J, Spetalen S, Munthe LA, Tjønnfjord GE (2022)
Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case
Haematologica (in press)
DOI 10.3324/haematol.2021.280393, PubMed 35236056

Hammer Q, Dunst J, Christ W, Picarazzi F, Wendorff M, Momayyezi P, Huhn O, Netskar HK, Maleki KT, García M, Sekine T, Sohlberg E, Azzimato V, Aouadi M, Karolinska COVID-19 Study Group, Severe COVID-19 GWAS Group, Degenhardt F, Franke A, Spallotta F, Mori M, Michaëlsson J, Björkström NK, Rückert T, Romagnani C, Horowitz A et al. (2022)
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Cell Rep, 38 (10), 110503
DOI 10.1016/j.celrep.2022.110503, PubMed 35235832

Dominguez-Valentin M, Sampson JR, Seppälä TT, Møller P (2022)
Response to Chambuso et al
Genet Med, 24 (5), 1151
DOI 10.1016/j.gim.2022.01.005, PubMed 35216900

Strømme JM, Johannessen B, Kidd SG, Bogaard M, Carm KT, Zhang X, Sveen A, Mathelier A, Lothe RA, Axcrona U, Axcrona K, Skotheim RI (2022)
Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity
Cancer Gene Ther (in press)
DOI 10.1038/s41417-022-00444-7, PubMed 35194199

Enserink JM, Chymkowitch P (2022)
Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries
Int J Mol Sci, 23 (3)
DOI 10.3390/ijms23031293, PubMed 35163213

Kyte JA (2022)
Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers
Cancers (Basel), 14 (3)
DOI 10.3390/cancers14030571, PubMed 35158839

Nissen-Meyer J, Skotland T, Boye E (2022)
Are doping tests in sports trustworthy?: Athletes suffer from insufficiently defined criteria for doping tests: Athletes suffer from insufficiently defined criteria for doping tests
EMBO Rep, 23 (3), e54431
DOI 10.15252/embr.202154431, PubMed 35156749

Giliberto M, Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Tjønnfjord GE, Schjesvold F, Munthe LA, Taskén K (2022)
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically
Mol Oncol, 16 (6), 1241-1258
DOI 10.1002/1878-0261.13191, PubMed 35148457

Mateus D, Wiedlocha A (2022)
FGF-FGFR signaling promotes the development of invasive cervical cancer
FEBS J (in press)
DOI 10.1111/febs.16384, PubMed 35146913

Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A (2022)
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
J Cell Sci, 135 (4)
DOI 10.1242/jcs.259138, PubMed 35099014

Sivanesan S, Taskén KA, Grytli HH (2022)
Association of β-Blocker Use at Time of Radical Prostatectomy With Rate of Treatment for Prostate Cancer Recurrence
JAMA Netw Open, 5 (1), e2145230
DOI 10.1001/jamanetworkopen.2021.45230, PubMed 35080602

Kryeziu K, Bergsland CH, Guren TK, Sveen A, Lothe RA (2022)
Multiplex immunohistochemistry of metastatic colorectal cancer and ex vivo tumor avatars
Biochim Biophys Acta Rev Cancer, 1877 (1), 188682
DOI 10.1016/j.bbcan.2022.188682, PubMed 35065193

Nilsen A, Hillestad T, Skingen VE, Aarnes EK, Fjeldbo CS, Hompland T, Evensen TS, Stokke T, Kristensen GB, Grallert B, Lyng H (2022)
miR-200a/b/-429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer
Mol Oncol, 16 (6), 1402-1419
DOI 10.1002/1878-0261.13184, PubMed 35064630

Skotheim RI, Axcrona U, Axcrona K (2022)
Re: Fibroblast Growth Factor Receptor 1 Drives the Metastatic Progression of Prostate Cancer
Eur Urol, 81 (4), 431
DOI 10.1016/j.eururo.2021.12.031, PubMed 35031159

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Simonsen A (2022)
GAK and PRKCD kinases regulate basal mitophagy
Autophagy, 18 (2), 467-469
DOI 10.1080/15548627.2021.2015154, PubMed 35001811

Garcia I, Orellana-Muñoz S, Ramos-Alonso L, Andersen AN, Zimmermann C, Eriksson J, Bøe SO, Kaferle P, Papamichos-Chronakis M, Chymkowitch P, Enserink JM (2021)
Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
Cell Rep, 37 (13), 110186
DOI 10.1016/j.celrep.2021.110186, PubMed 34965431

Nunes-Xavier CE, Zaldumbide L, Mosteiro L, López-Almaraz R, García de Andoin N, Aguirre P, Emaldi M, Torices L, López JI, Pulido R (2021)
Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets
Front Cell Dev Biol, 9, 811297
DOI 10.3389/fcell.2021.811297, PubMed 34957126

Sønstevold T, Engedal N, Torgersen ML (2021)
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
Cells, 10 (12)
DOI 10.3390/cells10123432, PubMed 34943939

Sharma K, Asp NT, Harrison SP, Siller R, Baumgarten SF, Gupta S, Chollet ME, Andersen E, Sullivan GJ, Simonsen A (2021)
Autophagy modulates cell fate decisions during lineage commitment
Autophagy
DOI 10.1080/15548627.2021.2008691, PubMed 34923909

Bruun J, Eide PW, Bergsland CH, Bruck O, Svindland A, Arjama M, Välimäki K, Bjørnslett M, Guren MG, Kallioniemi O, Nesbakken A, Lothe RA, Pellinen T (2021)
E-cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models
Mol Oncol
DOI 10.1002/1878-0261.13159, PubMed 34890102

Lien TG, Ohnstad HO, Lingjærde OC, Vallon-Christersson J, Aaserud M, Sveli MAT, Borg Å, Osbreac OBO, Garred Ø, Borgen E, Naume B, Russnes H, Sørlie T (2021)
Sample Preparation Approach Influences PAM50 Risk of Recurrence Score in Early Breast Cancer
Cancers (Basel), 13 (23)
DOI 10.3390/cancers13236118, PubMed 34885228

Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT et al. (2021)
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Nat Biotechnol, 40 (4), 488-498
DOI 10.1038/s41587-021-01089-x, PubMed 34873326

Melvold K, Giliberto M, Karlsen L, Ayuda-Durán P, Hanes R, Holien T, Enserink J, Brown JR, Tjønnfjord GE, Taskén K, Skånland SS (2021)
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol Oncol, 16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2021)
Publisher Correction: Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 12 (1), 7073
DOI 10.1038/s41467-021-27175-x, PubMed 34848706

Ramirez-Garrastacho M, Berge V, Linē A, Llorente A (2021)
Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients
Br J Cancer, 126 (3), 492-501
DOI 10.1038/s41416-021-01598-1, PubMed 34811506

Ramirez-Garrastacho M, Bajo-Santos C, Line A, Martens-Uzunova ES, de la Fuente JM, Moros M, Soekmadji C, Tasken KA, Llorente A (2021)
Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research
Br J Cancer, 126 (3), 331-350
DOI 10.1038/s41416-021-01610-8, PubMed 34811504

Weisheit S, Wegner CS, Ailte I, Radulovic M, Weyergang A, Selbo PK, Brech A (2021)
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy
Biochem Pharmacol, 194, 114837
DOI 10.1016/j.bcp.2021.114837, PubMed 34780750

Schink KO, Tan KW, Spangenberg H, Martorana D, Sneeggen M, Stévenin V, Enninga J, Campsteijn C, Raiborg C, Stenmark H (2021)
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
Nat Commun, 12 (1), 6577
DOI 10.1038/s41467-021-26775-x, PubMed 34772942

Sioud M, Juzenas P, Zhang Q, Kleinauskas A, Peng Q (2021)
Correction: Sioud et al. Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Monolayer and Multicellular Tumor Spheroid Models. Cancers 2021, 13, 3356
Cancers (Basel), 13 (21)
DOI 10.3390/cancers13215513, PubMed 34771754

Wong JJW, Selbo PK (2021)
Light-controlled elimination of PD-L1+ cells
J Photochem Photobiol B, 225, 112355
DOI 10.1016/j.jphotobiol.2021.112355, PubMed 34768077

Engebraaten O, Yau C, Berg K, Borgen E, Garred Ø, Berstad MEB, Fremstedal ASV, DeMichele A, Veer LV', Esserman L, Weyergang A (2021)
RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
Nat Commun, 12 (1), 6427
DOI 10.1038/s41467-021-26018-z, PubMed 34741021

Flatmark K, Torgunrud A, Fleten KG, Davidson B, Juul HV, Mensali N, Lund-Andersen C, Inderberg EM (2021)
Peptide vaccine targeting mutated GNAS: a potential novel treatment for pseudomyxoma peritonei
J Immunother Cancer, 9 (10)
DOI 10.1136/jitc-2021-003109, PubMed 34711663

Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH (2021)
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4⁺ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A (2021)
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015

Ballester PJ, Stevens R, Haibe-Kains B, Huang RS, Aittokallio T (2022)
Artificial intelligence for drug response prediction in disease models
Brief Bioinform, 23 (1)
DOI 10.1093/bib/bbab450, PubMed 34655289

Martens-Uzunova ES, Blijdorp CJ, Burger D, Erdbrügger U, Llorente A (2021)
Urinary Extracellular Vesicles in Urology: Current Successes and Challenges Ahead
Eur Urol, 81 (1), 127-128
DOI 10.1016/j.eururo.2021.09.025, PubMed 34625312

Gaustad JV, Rofstad EK (2021)
Assessment of Intratumor Heterogeneity in Parametric Dynamic Contrast-Enhanced MR Images: A Comparative Study of Novel and Established Methods
Front Oncol, 11, 722773
DOI 10.3389/fonc.2021.722773, PubMed 34621674

Lone AM, Giansanti P, Jørgensen MJ, Gjerga E, Dugourd A, Scholten A, Saez-Rodriguez J, Heck AJR, Taskén K (2021)
Systems approach reveals distinct and shared signaling networks of the four PGE₂ receptors in T cells
Sci Signal, 14 (703), eabc8579
DOI 10.1126/scisignal.abc8579, PubMed 34609894

Chellappa S, Kushekhar K, Hagness M, Horneland R, Taskén K, Aandahl EM (2021)
The Presence of Activated T Cell Subsets prior to Transplantation Is Associated with Increased Rejection Risk in Pancreas Transplant Recipients
J Immunol, 207 (10), 2501-2511
DOI 10.4049/jimmunol.2001103, PubMed 34607938

Wiedlocha A, Haugsten EM, Zakrzewska M (2021)
Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation
Cells, 10 (9)
DOI 10.3390/cells10092231, PubMed 34571880

Isaksen KT, Mastroianni MA, Rinde M, Rusten LS, Barzenje DA, Ramslien LF, Slaaen M, Jerm MB, Smeland EB, Rostoft S, Liestøl K, Brodtkorb M, Holte H (2021)
A simplified frailty score predicts survival and can aid treatment-intensity decisions in older patients with DLBCL
Blood Adv, 5 (22), 4771-4782
DOI 10.1182/bloodadvances.2021004777, PubMed 34543384

Bergholtz H, Carter JM, Cesano A, Cheang MCU, Church SE, Divakar P, Fuhrman CA, Goel S, Gong J, Guerriero JL, Hoang ML, Hwang ES, Kuasne H, Lee J, Liang Y, Mittendorf EA, Perez J, Prat A, Pusztai L, Reeves JW, Riazalhosseini Y, Richer JK, Sahin Ö, Sato H, Schlam I et al. (2021)
Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx^® Digital Spatial Profiler
Cancers (Basel), 13 (17)
DOI 10.3390/cancers13174456, PubMed 34503266

Kryeziu K, Moosavi SH, Bergsland CH, Guren MG, Eide PW, Totland MZ, Lassen K, Abildgaard A, Nesbakken A, Sveen A, Lothe RA (2021)
Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases
J Transl Med, 19 (1), 384
DOI 10.1186/s12967-021-03062-3, PubMed 34496878

Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A, Nätkin R, Häkkinen T, Devlies W, Henttinen S, Kaarijärvi R, Lahnalampi M, Kaljunen H, Nowakowska K, Syvälä H, Bläuer M, Cremaschi P, Claessens F, Visakorpi T, Tammela TLJ, Murtola T et al. (2021)
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Nat Commun, 12 (1), 5307
DOI 10.1038/s41467-021-25624-1, PubMed 34489465

Møller P, Sampson JR, Dominguez-Valentin M, Seppälä TT (2021)
Towards evidence-based personalised precision medicine for Lynch syndrome
Lancet Oncol, 22 (9), e383
DOI 10.1016/S1470-2045(21)00400-9, PubMed 34478667

Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA (2021)
The expressed mutational landscape of microsatellite stable colorectal cancers
Genome Med, 13 (1), 142
DOI 10.1186/s13073-021-00955-2, PubMed 34470667

Moosavi SH, Eide PW, Eilertsen IA, Brunsell TH, Berg KCG, Røsok BI, Brudvik KW, Bjørnbeth BA, Guren MG, Nesbakken A, Lothe RA, Sveen A (2021)
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
Genome Med, 13 (1), 143
DOI 10.1186/s13073-021-00956-1, PubMed 34470666

Dillard C, Reis JGT, Rusten TE (2021)
Ras^V12; scrib^-/- Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
Int J Mol Sci, 22 (16)
DOI 10.3390/ijms22168873, PubMed 34445578

Vedeld HM, Grimsrud MM, Andresen K, Pharo HD, von Seth E, Karlsen TH, Honne H, Paulsen V, Färkkilä MA, Bergquist A, Jeanmougin M, Aabakken L, Boberg KM, Folseraas T, Lind GE (2021)
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
Hepatology, 75 (1), 59-73
DOI 10.1002/hep.32125, PubMed 34435693

Öjlert ÅK, Nebdal D, Snapkov I, Olsen V, Kidman J, Greiff V, Chee J, Helland Å (2021)
Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor
Mol Oncol, 15 (11), 2958-2968
DOI 10.1002/1878-0261.13082, PubMed 34402187

Rødland GE, Hauge S, Hasvold G, Bay LTE, Raabe TTH, Joel M, Syljuåsen RG (2021)
Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells
Cancers (Basel), 13 (15)
DOI 10.3390/cancers13153790, PubMed 34359691

Christopoulos PF, Grigalavicius M, Corthay A, Berg K, Theodossiou TA (2021)
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements
Antioxidants (Basel), 10 (7)
DOI 10.3390/antiox10071149, PubMed 34356382

Anda S, Boye E, Schink KO, Grallert B (2021)
Cosegregation of asymmetric features during cell division
Open Biol, 11 (8), 210116
DOI 10.1098/rsob.210116, PubMed 34343465

Nakken S, Saveliev V, Hofmann O, Møller P, Myklebost O, Hovig E (2021)
Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer
Int J Cancer, 149 (11), 1955-1960
DOI 10.1002/ijc.33749, PubMed 34310709

Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder NS, Rahman MM, Teles Reis JG, Brech A, Jasper H, Rusan NM, Jahren AH, Gottlieb E, Rusten TE (2021)
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
EMBO J, 40 (18), e107336
DOI 10.15252/embj.2020107336, PubMed 34309071

Ellingsen EB, Mangsbo SM, Hovig E, Gaudernack G (2021)
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
Front Immunol, 12, 682492
DOI 10.3389/fimmu.2021.682492, PubMed 34290704

Sioud M, Juzenas P, Zhang Q, Kleinauskas A, Peng Q (2021)
Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133356, PubMed 34283089

Kukkonen K, Taavitsainen S, Huhtala L, Uusi-Makela J, Granberg KJ, Nykter M, Urbanucci A (2021)
Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133325, PubMed 34283056

Eide PW, Moosavi SH, Eilertsen IA, Brunsell TH, Langerud J, Berg KCG, Røsok BI, Bjørnbeth BA, Nesbakken A, Lothe RA, Sveen A (2021)
Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer
NPJ Genom Med, 6 (1), 59
DOI 10.1038/s41525-021-00223-7, PubMed 34262039

Spasevska I, Myklebust JH (2021)
What It Takes to Transform a T Cell
Cancer Res, 81 (12), 3160-3161
DOI 10.1158/0008-5472.CAN-21-0784, PubMed 34224376

Nowosielska EM, Cheda A, Pociegiel M, Cheda L, Szymański P, Wiedlocha A (2021)
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice
Int J Mol Sci, 22 (12)
DOI 10.3390/ijms22126309, PubMed 34208396

Vikan AK, Kostas M, Haugsten EM, Selbo PK, Wesche J (2021)
Efficacy and Selectivity of FGF2-Saporin Cytosolically Delivered by PCI in Cells Overexpressing FGFR1
Cells, 10 (6)
DOI 10.3390/cells10061476, PubMed 34204611

Andersson Y, Fleten KG, Abrahamsen TW, Reed W, Davidson B, Flatmark K (2021)
Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale
Cancers (Basel), 13 (11)
DOI 10.3390/cancers13112819, PubMed 34198773

Dagenborg VJ, Marshall SE, Grzyb K, Fretland ÅA, Lund-Iversen M, Mælandsmo GM, Ree AH, Edwin B, Yaqub S, Flatmark K (2021)
Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer
Front Oncol, 11, 671629
DOI 10.3389/fonc.2021.671629, PubMed 34178659

Rye IH, Huse K, Josefsson SE, Kildal W, Danielsen HE, Schlichting E, Garred Ø, Riis ML, Osbreac, Lingjaerde OC, Myklebust JH, Russnes HG (2021)
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression
Mol Oncol, 16 (1), 88-103
DOI 10.1002/1878-0261.13047, PubMed 34165864

Tan KW, Nähse V, Campsteijn C, Brech A, Schink KO, Stenmark H (2021)
JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes
J Cell Sci, 134 (14)
DOI 10.1242/jcs.258495, PubMed 34109410

Berg J, Ramberg C, Haugstvedt JOS, Bengtson MB, Gabrielsen AM, Brustugun OT, Halvorsen AR, Helland Å (2021)
Lung Function After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer, Changes and Predictive Markers
Front Oncol, 11, 674731
DOI 10.3389/fonc.2021.674731, PubMed 34109123

Fløisand Y, Schroeder MA, Chevallier P, Selleslag D, Devine S, Renteria AS, Mohty M, Yakoub-Agha I, Chen C, Parfionovas A, Quadri S, Jansson J, Akbari M, Chen YB (2021)
A phase 2a randomized clinical trial of intravenous vedolizumab for the treatment of steroid-refractory intestinal acute graft-versus-host disease
Bone Marrow Transplant, 56 (10), 2477-2488
DOI 10.1038/s41409-021-01356-0, PubMed 34108672

Kidd SG, Carm KT, Bogaard M, Olsen LG, Bakken AC, Løvf M, Lothe RA, Axcrona K, Axcrona U, Skotheim RI (2021)
High expression of SCHLAP1 in primary prostate cancer is an independent predictor of biochemical recurrence, despite substantial heterogeneity
Neoplasia, 23 (6), 634-641
DOI 10.1016/j.neo.2021.05.012, PubMed 34107378

Gaustad JV, Rofstad EK (2021)
Assessment of Hypoxic Tissue Fraction and Prediction of Survival in Cervical Carcinoma by Dynamic Contrast-Enhanced MRI
Front Oncol, 11, 668916
DOI 10.3389/fonc.2021.668916, PubMed 34094964

Cichońska A, Ravikumar B, Allaway RJ, Wan F, Park S, Isayev O, Li S, Mason M, Lamb A, Tanoli Z, Jeon M, Kim S, Popova M, Capuzzi S, Zeng J, Dang K, Koytiger G, Kang J, Wells CI, Willson TM, IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, Oprea TI, Schlessinger A, Drewry DH, Stolovitzky G et al. (2021)
Crowdsourced mapping of unexplored target space of kinase inhibitors
Nat Commun, 12 (1), 3307
DOI 10.1038/s41467-021-23165-1, PubMed 34083538

Szybowska P, Kostas M, Wesche J, Haugsten EM, Wiedlocha A (2021)
Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling
Cells, 10 (6)
DOI 10.3390/cells10061342, PubMed 34071546

Stenberg VY, Larsen RH, Ma LW, Peng Q, Juzenas P, Bruland ØS, Juzeniene A (2021)
Evaluation of the PSMA-Binding Ligand ²¹²Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094815, PubMed 34062920

Haakensen VD, Nowak AK, Ellingsen EB, Farooqi SJ, Bjaanæs MM, Horndalsveen H, Mcculloch T, Grundberg O, Cedres SM, Helland Å (2021)
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma
J Transl Med, 19 (1), 232
DOI 10.1186/s12967-021-02905-3, PubMed 34059094

Øverbye A, Torgersen ML, Sønstevold T, Iversen TG, Mørch Ý, Skotland T, Sandvig K (2021)
Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: toxicity and changes in the proteome of breast, colon and prostate cancer cells
Nanotoxicology, 15 (7), 865-884
DOI 10.1080/17435390.2021.1924888, PubMed 34047629

Thorgersen EB, Asvall J, Frøysnes IS, Schjalm C, Larsen SG, Dueland S, Andersson Y, Fodstad Ø, Mollnes TE, Flatmark K (2021)
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann Surg Oncol, 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0, PubMed 34019185

Holland P, Hagopian WM, Jahren AH, Rusten TE (2021)
Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo
BMC Biol, 19 (1), 85
DOI 10.1186/s12915-021-01012-5, PubMed 33966633

Sioud M (2021)
Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy
EBioMedicine, 67, 103351
DOI 10.1016/j.ebiom.2021.103351, PubMed 33965875

Hamfjord J, Guren TK, Glimelius B, Sorbye H, Pfeiffer P, Dajani O, Lingjaerde OC, Tveit KM, Pallisgaard N, Spindler KG, Kure EH (2021)
Clinicopathological factors associated with tumour-specific mutation detection in plasma of patients with RAS-mutated or BRAF-mutated metastatic colorectal cancer
Int J Cancer, 149 (6), 1385-1397
DOI 10.1002/ijc.33672, PubMed 33961700

Li RG, Lindland K, Tonstad SK, Bønsdorff TB, Juzeniene A, Westrøm S, Larsen RH (2021)
Improved Formulation of ²²⁴Ra-Labeled Calcium Carbonate Microparticles by Surface Layer Encapsulation and Addition of EDTMP
Pharmaceutics, 13 (5)
DOI 10.3390/pharmaceutics13050634, PubMed 33946852

Thorgersen EB, Flatmark K (2021)
ASO Author Reflections: The Peritoneum is an Active Immunological Compartment
Ann Surg Oncol, 28 (9), 5263-5264
DOI 10.1245/s10434-021-10036-8, PubMed 33939046

Aure MR, Fleischer T, Bjørklund S, Ankill J, Castro-Mondragon JA, OSBREAC, Børresen-Dale AL, Tost J, Sahlberg KK, Mathelier A, Tekpli X, Kristensen VN (2021)
Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer
Genome Med, 13 (1), 72
DOI 10.1186/s13073-021-00880-4, PubMed 33926515

Pandya AD, Iversen TG, Moestue S, Grinde MT, Mørch Ý, Snipstad S, Åslund AKO, Øy GF, Kildal W, Engebråten O, Sandvig K, Skotland T, Mælandsmo GM (2021)
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Nanomaterials (Basel), 11 (5)
DOI 10.3390/nano11051140, PubMed 33924869

Caulier B, Enserink JM, Wälchli S (2021)
Pharmacologic Control of CAR T Cells
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094320, PubMed 33919245

Kosanović M, Llorente A, Glamočlija S, Valdivielso JM, Bozic M (2021)
Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
Int J Mol Sci, 22 (8)
DOI 10.3390/ijms22083887, PubMed 33918699

Wirth M, Mouilleron S, Zhang W, Sjøttem E, Princely Abudu Y, Jain A, Lauritz Olsvik H, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA (2021)
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
J Mol Biol, 433 (13), 166987
DOI 10.1016/j.jmb.2021.166987, PubMed 33845085

Johannesen TB, Smeland S, Aaserud S, Buanes EA, Skog A, Ursin G, Helland Å (2021)
COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway
Front Oncol, 11, 652535
DOI 10.3389/fonc.2021.652535, PubMed 33842366

Hølmebakk T, Boye K (2021)
Correction to: ASO Author Reflections: How to Identify Patients at Genuinely High Risk of Recurrence from Localized Gastrointestinal Stromal Tumor of the Stomach?
Ann Surg Oncol, 28 (Suppl 3), 873
DOI 10.1245/s10434-021-09939-3, PubMed 33829360

Rustad EH, Nadeu F, Angelopoulos N, Ziccheddu B, Bolli N, Puente XS, Campo E, Landgren O, Maura F (2021)
mmsig: a fitting approach to accurately identify somatic mutational signatures in hematological malignancies
Commun Biol, 4 (1), 424
DOI 10.1038/s42003-021-01938-0, PubMed 33782531

Barkovskaya A, Goodwin CM, Seip K, Hilmarsdottir B, Pettersen S, Stalnecker C, Engebraaten O, Briem E, Der CJ, Moestue SA, Gudjonsson T, Maelandsmo GM, Prasmickaite L (2021)
Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen
Mol Oncol, 15 (8), 2026-2045
DOI 10.1002/1878-0261.12951, PubMed 33759347

Jaiswal A, Gautam P, Pietilä EA, Timonen S, Nordström N, Akimov Y, Sipari N, Tanoli Z, Fleischer T, Lehti K, Wennerberg K, Aittokallio T (2021)
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Mol Syst Biol, 17 (3), e9526
DOI 10.15252/msb.20209526, PubMed 33750001

Georgiesh T, Namløs HM, Sharma N, Lorenz S, Myklebost O, Bjerkehagen B, Meza-Zepeda LA, Boye K (2021)
Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour
Pathology, 53 (6), 713-719
DOI 10.1016/j.pathol.2020.11.010, PubMed 33745702

Seppälä TT, Dominguez-Valentin M, Crosbie EJ, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W et al. (2021)
Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Eur J Cancer, 148, 124-133
DOI 10.1016/j.ejca.2021.02.022, PubMed 33743481

Hølmebakk T, Boye K (2021)
ASO Author Reflections: How to Identify Patients at Genuinely High Risk of Recurrence from Localized Gastrointestinal Stromal Tumor of the Stomach?
Ann Surg Oncol, 28 (11), 6846-6847
DOI 10.1245/s10434-021-09608-5, PubMed 33687615

Juzeniene A, Stenberg VY, Bruland ØS, Larsen RH (2021)
Preclinical and Clinical Status of PSMA-Targeted Alpha Therapy for Metastatic Castration-Resistant Prostate Cancer
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040779, PubMed 33668474

Hølmebakk T, Wiedswang AM, Meza-Zepeda LA, Hompland I, Lobmaier IVK, Berner JM, Stoldt S, Boye K (2021)
Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach
Ann Surg Oncol, 28 (11), 6837-6845
DOI 10.1245/s10434-021-09605-8, PubMed 33651216

Sørensen O, Andersen AM, Larsen SG, Giercksky KE, Flatmark K (2021)
Correction to: Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of highgrade pseudomyxoma peritonei
Clin Exp Metastasis, 38 (2), 253
DOI 10.1007/s10585-021-10084-0, PubMed 33649933

Zhen Y, Radulovic M, Vietri M, Stenmark H (2021)
Sealing holes in cellular membranes
EMBO J, 40 (7), e106922
DOI 10.15252/embj.2020106922, PubMed 33644904

Akimov Y, Aittokallio T (2021)
Re-defining synthetic lethality by phenotypic profiling for precision oncology
Cell Chem Biol, 28 (3), 246-256
DOI 10.1016/j.chembiol.2021.01.026, PubMed 33631125

Schultz SW, Agudo-Canalejo J, Chino H, Migliano SM, Saito C, Koyama-Honda I, Stenmark H, Brech A, Mizushima N, Knorr RL, May AI (2021)
Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation
Autophagy, 17 (4), 1046-1048
DOI 10.1080/15548627.2021.1887548, PubMed 33629888

Ianevski A, Lahtela J, Javarappa KK, Sergeev P, Ghimire BR, Gautam P, Vähä-Koskela M, Turunen L, Linnavirta N, Kuusanmäki H, Kontro M, Porkka K, Heckman CA, Mattila P, Wennerberg K, Giri AK, Aittokallio T (2021)
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations
Sci Adv, 7 (8)
DOI 10.1126/sciadv.abe4038, PubMed 33608276

Gaustad JV, Simonsen TG, Hansem LMK, Rofstad EK (2021)
Intravital microscopy of tumor vessel morphology and function using a standard fluorescence microscope
Eur J Nucl Med Mol Imaging, 48 (10), 3089-3100
DOI 10.1007/s00259-021-05243-0, PubMed 33606081

Boye K, Longhi A, Guren T, Lorenz S, Næss S, Pierini M, Taksdal I, Lobmaier I, Cesari M, Paioli A, Løndalen AM, Setola E, Hompland I, Meza-Zepeda LA, Sundby Hall K, Palmerini E (2021)
Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial
Cancer Immunol Immunother, 70 (9), 2617-2624
DOI 10.1007/s00262-021-02876-w, PubMed 33580363

Skånland SS, Mato AR (2021)
Overcoming resistance to targeted therapies in chronic lymphocytic leukemia
Blood Adv, 5 (1), 334-343
DOI 10.1182/bloodadvances.2020003423, PubMed 33570649

Tanoli Z, Vähä-Koskela M, Aittokallio T (2021)
Artificial intelligence, machine learning, and drug repurposing in cancer
Expert Opin Drug Discov, 16 (9), 977-989
DOI 10.1080/17460441.2021.1883585, PubMed 33543671

Hompland T, Fjeldbo CS, Lyng H (2021)
Tumor Hypoxia as a Barrier in Cancer Therapy: Why Levels Matter
Cancers (Basel), 13 (3)
DOI 10.3390/cancers13030499, PubMed 33525508

Ravussin A, Brech A, Tooze SA, Stenmark H (2021)
The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy
J Cell Sci, 134 (3)
DOI 10.1242/jcs.250670, PubMed 33468622

Refinetti P, Morgenthaler S, Thilly WG, Arstad C, Ekstrøm PO (2020)
Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Front Oncol, 10, 523860
DOI 10.3389/fonc.2020.523860, PubMed 33344219

Wang T, Gautam P, Rousu J, Aittokallio T (2020)
Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer
Comput Struct Biotechnol J, 18, 3819-3832
DOI 10.1016/j.csbj.2020.11.001, PubMed 33335681

Berg KCG, Brunsell TH, Sveen A, Alagaratnam S, Bjørnslett M, Hektoen M, Brudvik KW, Røsok BI, Bjørnbeth BA, Nesbakken A, Lothe RA (2021)
Genomic and prognostic heterogeneity among RAS/BRAF^V600E /TP53 co-mutated resectable colorectal liver metastases
Mol Oncol, 15 (4), 830-845
DOI 10.1002/1878-0261.12885, PubMed 33325154

Halvorsen AR, Haugen MH, Öjlert ÅK, Lund-Iversen M, Jørgensen L, Solberg S, Mælandsmo GM, Brustugun OT, Helland Å (2020)
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients
Front Oncol, 10, 590755
DOI 10.3389/fonc.2020.590755, PubMed 33324562

Lachota M, Vincenti M, Winiarska M, Boye K, Zagożdżon R, Malmberg KJ (2020)
Prospects for NK Cell Therapy of Sarcoma
Cancers (Basel), 12 (12)
DOI 10.3390/cancers12123719, PubMed 33322371

Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Fløisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM (2020)
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632

Flatin BTB, Vedeld HM, Pinto R, Langerud J, Lind GE, Lothe RA, Sveen A, Jeanmougin M (2020)
Multiregional assessment of CIMP in primary colorectal cancers: Phenotype concordance but marker variability
Int J Cancer, 148 (7), 1652-1657
DOI 10.1002/ijc.33425, PubMed 33284993

Landsverk HB, Sandquist LE, Bay LTE, Steurer B, Campsteijn C, Landsverk OJB, Marteijn JA, Petermann E, Trinkle-Mulcahy L, Syljuåsen RG (2020)
WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
Cell Rep, 33 (9), 108469
DOI 10.1016/j.celrep.2020.108469, PubMed 33264625

Dominguez-Valentin M, Crosbie EJ, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Nakken S, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W et al. (2020)
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Genet Med, 23 (4), 705-712
DOI 10.1038/s41436-020-01029-1, PubMed 33257847

Bergsland CH, Bruun J, Guren MG, Svindland A, Bjørnslett M, Smeby J, Hektoen M, Kolberg M, Domingo E, Pellinen T, Tomlinson I, Kerr D, Church DN, Nesbakken A, Sveen A, Lothe RA (2020)
Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer
ESMO Open, 5 (6), e001040
DOI 10.1136/esmoopen-2020-001040, PubMed 33219056

Patel S, Malmberg KJ (2020)
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Cell Calcium, 92, 102289
DOI 10.1016/j.ceca.2020.102289, PubMed 33027744

Radulovic M, Stenmark H (2020)
LRRK2 to the rescue of damaged endomembranes
EMBO J, 39 (18), e106162
DOI 10.15252/embj.2020106162, PubMed 32803793

Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A (2020)
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
EBioMedicine, 59, 102923
DOI 10.1016/j.ebiom.2020.102923, PubMed 32799124

Dominguez-Valentin M, Sampson JR, Møller P, Seppälä TT, PLSD Collaborators (2020)
Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum
Int J Cancer, 148 (2), 512-513
DOI 10.1002/ijc.33214, PubMed 32783184

Gaustad JV, Hauge A, Wegner CS, Simonsen TG, Lund KV, Hansem LMK, Rofstad EK (2020)
DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071979, PubMed 32698525

Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP, Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A et al. (2020)
Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Genet Med, 22 (9), 1569
DOI 10.1038/s41436-020-0892-4, PubMed 32690931

Cieslar-Pobuda A, Ahrens TD, Caglayan S, Behringer S, Hannibal L, Staerk J (2020)
DNMT3B deficiency alters mitochondrial biogenesis and α-ketoglutarate levels in human embryonic stem cells
Stem Cells, 38 (11), 1409-1422
DOI 10.1002/stem.3256, PubMed 32652733

Kyte JA, Andresen NK, Russnes HG, Fretland SØ, Falk RS, Lingjærde OC, Naume B (2020)
ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer
J Transl Med, 18 (1), 269
DOI 10.1186/s12967-020-02421-w, PubMed 32620163

Hillestad T, Hompland T, Fjeldbo CS, Skingen VE, Salberg UB, Aarnes EK, Nilsen A, Lund KV, Evensen TS, Kristensen GB, Stokke T, Lyng H (2020)
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Cancer Res, 80 (18), 3993-4003
DOI 10.1158/0008-5472.CAN-20-0950, PubMed 32606004

Lavelle TJ, Alver TN, Heintz KM, Wernhoff P, Nygaard V, Nakken S, Øy GF, Bøe SL, Urbanucci A, Hovig E (2020)
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071719, PubMed 32605315

Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C (2020)
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867
DOI 10.1038/s41556-020-0537-5, PubMed 32601372

Hoff AM, Kraggerud SM, Alagaratnam S, Berg KCG, Johannessen B, Høland M, Nilsen G, Lingjærde OC, Andrews PW, Lothe RA, Skotheim RI (2020)
Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas
Endocr Relat Cancer, 27 (9), 457-468
DOI 10.1530/ERC-20-0064, PubMed 32580154

Fjeldbo CS, Hompland T, Hillestad T, Aarnes EK, Günther CC, Kristensen GB, Malinen E, Lyng H (2020)
Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity
EBioMedicine, 57, 102841
DOI 10.1016/j.ebiom.2020.102841, PubMed 32580139

Bergholtz H, Lien TG, Swanson DM, Frigessi A, Oslo Breast Cancer Research Consortium (OSBREAC), Daidone MG, Tost J, Wärnberg F, Sørlie T (2020)
Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions
NPJ Breast Cancer, 6, 26
DOI 10.1038/s41523-020-0167-x, PubMed 32577501

Kyte JA, Røssevold A, Falk RS, Naume B (2020)
ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer
J Transl Med, 18 (1), 252
DOI 10.1186/s12967-020-02424-7, PubMed 32576225

Munthe E, Raiborg C, Stenmark H, Wenzel EM (2020)
Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
J Cell Sci, 133 (13)
DOI 10.1242/jcs.244467, PubMed 32546530

Flatmark K, Mohamed F (2020)
ASO Author Reflections: Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method
Ann Surg Oncol, 27 (Suppl 3), 771-772
DOI 10.1245/s10434-020-08691-4, PubMed 32495284

von der Lippe Gythfeldt H, Lien T, Tekpli X, Silwal-Pandit L, Borgen E, Garred Ø, Skjerven H, Schlichting E, Lundgren S, Wist E, Naume B, Kristensen V, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2020)
Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer
Int J Cancer, 147 (9), 2515-2525
DOI 10.1002/ijc.33108, PubMed 32488909

Patrick-Brown TDJH, Carr NJ, Swanson DM, Larsen S, Mohamed F, Flatmark K (2020)
Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method
Ann Surg Oncol, 28 (1), 252-257
DOI 10.1245/s10434-020-08655-8, PubMed 32488520

Pedersen NM, Wenzel EM, Wang L, Antoine S, Chavrier P, Stenmark H, Raiborg C (2020)
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion
J Cell Biol, 219 (8)
DOI 10.1083/jcb.202003063, PubMed 32479595

Pfefferle A, Jacobs B, Haroun-Izquierdo A, Kveberg L, Sohlberg E, Malmberg KJ (2020)
Deciphering Natural Killer Cell Homeostasis
Front Immunol, 11, 812
DOI 10.3389/fimmu.2020.00812, PubMed 32477340

Haakensen VD, Khadse A, Sandhu V, Halvorsen AR, Solberg SK, Jørgensen LH, Brustugun OT, Kure EH, Helland Å (2020)
Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy
Int J Cancer, 147 (10), 2957-2966
DOI 10.1002/ijc.33121, PubMed 32468587

Lingelem ABD, Kavaliauskiene S, Halsne R, Klokk TI, Surma MA, Klose C, Skotland T, Sandvig K (2020)
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus
Cell Mol Life Sci, 78 (3), 985-1009
DOI 10.1007/s00018-020-03551-6, PubMed 32447426

Hauge A, Rofstad EK (2020)
Antifibrotic therapy to normalize the tumor microenvironment
J Transl Med, 18 (1), 207
DOI 10.1186/s12967-020-02376-y, PubMed 32434573

Clement D, Goodridge JP, Grimm C, Patel S, Malmberg KJ (2020)
TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
Front Immunol, 11, 753
DOI 10.3389/fimmu.2020.00753, PubMed 32411146

Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878

Skotland T, Kavaliauskiene S, Sandvig K (2020)
The role of lipid species in membranes and cancer-related changes
Cancer Metastasis Rev, 39 (2), 343-360
DOI 10.1007/s10555-020-09872-z, PubMed 32314087

Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA (2020)
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity
Clin Cancer Res, 26 (15), 4107-4119
DOI 10.1158/1078-0432.CCR-19-3637, PubMed 32299813

Fougner C, Bergholtz H, Norum JH, Sørlie T (2020)
Re-definition of claudin-low as a breast cancer phenotype
Nat Commun, 11 (1), 1787
DOI 10.1038/s41467-020-15574-5, PubMed 32286297

Ianevski A, Giri AK, Aittokallio T (2020)
SynergyFinder 2.0: visual analytics of multi-drug combination synergies
Nucleic Acids Res, 48 (W1), W488-W493
DOI 10.1093/nar/gkaa216, PubMed 32246720

Malenge MM, Patzke S, Ree AH, Stokke T, Ceuppens P, Middleton B, Dahle J, Repetto-Llamazares AHV (2020)
¹⁷⁷Lu-Lilotomab Satetraxetan Has the Potential to Counteract Resistance to Rituximab in Non-Hodgkin Lymphoma
J Nucl Med, 61 (10), 1468-1475
DOI 10.2967/jnumed.119.237230, PubMed 32245896

Pladsen AV, Nilsen G, Rueda OM, Aure MR, Borgan Ø, Liestøl K, Vitelli V, Frigessi A, Langerød A, Mathelier A, OSBREAC, Engebråten O, Kristensen V, Wedge DC, Van Loo P, Caldas C, Børresen-Dale AL, Russnes HG, Lingjærde OC (2020)
DNA copy number motifs are strong and independent predictors of survival in breast cancer
Commun Biol, 3 (1), 153
DOI 10.1038/s42003-020-0884-6, PubMed 32242091

Lopes N, Bergsland C, Bruun J, Bjørnslett M, Vieira AF, Mesquita P, Pinto R, Gomes R, Cavadas B, Bennett E, Pereira L, Lothe RA, Almeida R, David L (2020)
A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis
Gastric Cancer, 23 (5), 811-823
DOI 10.1007/s10120-020-01064-6, PubMed 32215766

Eide IJZ, Helland Å, Ekman S, Mellemgaard A, Hansen KH, Cicenas S, Koivunen J, Grønberg BH, Brustugun OT (2020)
Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study)
Lung Cancer, 143, 27-35
DOI 10.1016/j.lungcan.2020.03.009, PubMed 32200138

Akimov Y, Bulanova D, Timonen S, Wennerberg K, Aittokallio T (2020)
Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics
Mol Syst Biol, 16 (3), e9195
DOI 10.15252/msb.20199195, PubMed 32187448

Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Mol Oncol, 14 (5), 1016-1027
DOI 10.1002/1878-0261.12668, PubMed 32171051

Skotland T, Sagini K, Sandvig K, Llorente A (2020)
An emerging focus on lipids in extracellular vesicles
Adv Drug Deliv Rev, 159, 308-321
DOI 10.1016/j.addr.2020.03.002, PubMed 32151658

Pandya AD, Øverbye A, Sahariah P, Gaware VS, Høgset H, Masson M, Høgset A, Mælandsmo GM, Skotland T, Sandvig K, Iversen TG (2020)
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer
Biomacromolecules, 21 (4), 1489-1498
DOI 10.1021/acs.biomac.0c00061, PubMed 32092254

Wong JJW, Berstad MB, Fremstedal ASV, Berg K, Patzke S, Sørensen V, Peng Q, Selbo PK, Weyergang A (2020)
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965

Møller P, Dominguez-Valentin M, Rødland EA, Hovig E (2020)
Correction: Møller, P.; et al. Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift. Cancers 2019, 11, 132
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020410, PubMed 32050665

Georgiesh T, Boye K, Bjerkehagen B (2020)
A novel risk score to predict early and late recurrence in solitary fibrous tumour
Histopathology, 77 (1), 123-132
DOI 10.1111/his.14078, PubMed 31991494

Chu DT, Phuong TNT, Tien NLB, Tran DK, Thanh VV, Quang TL, Truong DT, Pham VH, Ngoc VTN, Chu-Dinh T, Kushekhar K (2020)
An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells
Int J Mol Sci, 21 (3)
DOI 10.3390/ijms21030708, PubMed 31973182

Saeednejad Zanjani L, Madjd Z, Rasti A, Asgari M, Abolhasani M, Tam KJ, Roudi R, Mælandsmo GM, Fodstad Ø, Andersson Y (2019)
Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics
Front Oncol, 9, 1302
DOI 10.3389/fonc.2019.01302, PubMed 31921617

Simonsen TG, Gaustad JV, Rofstad EK (2020)
Bevacizumab treatment of meningeal melanoma metastases
J Transl Med, 18 (1), 13
DOI 10.1186/s12967-020-02212-3, PubMed 31915016

Szwed M, Torgersen ML, Kumari RV, Yadava SK, Pust S, Iversen TG, Skotland T, Giri J, Sandvig K (2020)
Biological response and cytotoxicity induced by lipid nanocapsules
J Nanobiotechnology, 18 (1), 5
DOI 10.1186/s12951-019-0567-y, PubMed 31907052

Sveen A, Cremolini C, Dienstmann R (2019)
Predictive modeling in colorectal cancer: time to move beyond consensus molecular subtypes
Ann Oncol, 30 (11), 1682-1685
DOI 10.1093/annonc/mdz412, PubMed 31868904

Rødland GE, Melhus K, Generalov R, Gilani S, Bertoni F, Dahle J, Syljuåsen RG, Patzke S (2019)
The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37-Targeted Radioimmunotherapy in Activated B Cell Like Diffuse Large B Cell Lymphoma Cell Lines
Front Oncol, 9, 1301
DOI 10.3389/fonc.2019.01301, PubMed 31850205

Pashov A, Shivarov V, Hadzhieva M, Kostov V, Ferdinandov D, Heintz KM, Pashova S, Todorova M, Vassilev T, Kieber-Emmons T, Meza-Zepeda LA, Hovig E (2019)
Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries
Front Immunol, 10, 2796
DOI 10.3389/fimmu.2019.02796, PubMed 31849974

Sampson JR, Dominguez-Valentin M, Seppälä TT, Møller P (2019)
Response to Tolva et al
Genet Med, 22 (4), 813-814
DOI 10.1038/s41436-019-0717-5, PubMed 31801985

Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø, OSBREAC, Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN (2019)
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat Commun, 10 (1), 5499
DOI 10.1038/s41467-019-13329-5, PubMed 31796750

Pfefferle A, Jacobs B, Netskar H, Ask EH, Lorenz S, Clancy T, Goodridge JP, Sohlberg E, Malmberg KJ (2019)
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Cell Rep, 29 (8), 2284-2294.e4
DOI 10.1016/j.celrep.2019.10.058, PubMed 31747601

Vietri M, Radulovic M, Stenmark H (2019)
The many functions of ESCRTs
Nat Rev Mol Cell Biol, 21 (1), 25-42
DOI 10.1038/s41580-019-0177-4, PubMed 31705132

Namløs HM, Boye K, Meza-Zepeda LA (2019)
Cell-free DNA in blood as a noninvasive insight into the sarcoma genome
Mol Aspects Med, 72, 100827
DOI 10.1016/j.mam.2019.10.004, PubMed 31703948

Fornes O, Castro-Mondragon JA, Khan A, van der Lee R, Zhang X, Richmond PA, Modi BP, Correard S, Gheorghe M, Baranašić D, Santana-Garcia W, Tan G, Chèneby J, Ballester B, Parcy F, Sandelin A, Lenhard B, Wasserman WW, Mathelier A (2020)
JASPAR 2020: update of the open-access database of transcription factor binding profiles
Nucleic Acids Res, 48 (D1), D87-D92
DOI 10.1093/nar/gkz1001, PubMed 31701148

Wise JF, Lawrence MS (2019)
Huge whole-genome study of human metastatic cancers
Nature, 575 (7781), 60-61
DOI 10.1038/d41586-019-03123-0, PubMed 31690848

Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A (2019)
Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer
Cancer Lett, 469, 246-255
DOI 10.1016/j.canlet.2019.10.040, PubMed 31678167

Nguéa P A, Robertson J, Herrera MC, Chymkowitch P, Enserink JM (2019)
Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast
J Biol Chem, 294 (49), 18784-18795
DOI 10.1074/jbc.RA119.009721, PubMed 31676685

Fromm B, Domanska D, Høye E, Ovchinnikov V, Kang W, Aparicio-Puerta E, Johansen M, Flatmark K, Mathelier A, Hovig E, Hackenberg M, Friedländer MR, Peterson KJ (2020)
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D1172
DOI 10.1093/nar/gkz1016, PubMed 31642479

Lopes N, Bergsland CH, Bjørnslett M, Pellinen T, Svindland A, Nesbakken A, Almeida R, Lothe RA, David L, Bruun J (2019)
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
Lab Invest, 100 (1), 120-134
DOI 10.1038/s41374-019-0336-4, PubMed 31641225

Lie-Jensen A, Ivanauskiene K, Malerød L, Jain A, Tan KW, Laerdahl JK, Liestøl K, Stenmark H, Haglund K (2019)
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533

Fromm B, Domanska D, Høye E, Ovchinnikov V, Kang W, Aparicio-Puerta E, Johansen M, Flatmark K, Mathelier A, Hovig E, Hackenberg M, Friedländer MR, Peterson KJ (2020)
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D132-D141
DOI 10.1093/nar/gkz885, PubMed 31598695

Dillard C, Rusten TE (2019)
Cell Competition Triggers Suicide by Autophagy
Dev Cell, 51 (1), 4-5
DOI 10.1016/j.devcel.2019.09.014, PubMed 31593651

Enqvist M, Jacobs B, Junlén HR, Schaffer M, Melén CM, Friberg D, Wahlin BE, Malmberg KJ (2019)
Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma
Front Immunol, 10, 2085
DOI 10.3389/fimmu.2019.02085, PubMed 31572357

Gaustad JV, Simonsen TG, Wegner CS, Rofstad EK (2019)
Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts
Front Oncol, 9, 845
DOI 10.3389/fonc.2019.00845, PubMed 31555596

Sørensen O, Andersen AM, Larsen SG, Giercksky KE, Flatmark K (2019)
Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of high-grade pseudomyxoma peritonei
Clin Exp Metastasis, 36 (6), 511-518
DOI 10.1007/s10585-019-09991-0, PubMed 31541325

Zhu Q, Tekpli X, Troyanskaya OG, Kristensen VN (2020)
Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations
Bioinformatics, 36 (4), 994-999
DOI 10.1093/bioinformatics/btz709, PubMed 31529022

Halvorsen AR, Ragle Aure M, Õjlert ÅK, Brustugun OT, Solberg S, Nebdal D, Helland Å (2019)
Identification of microRNAs involved in pathways which characterize the expression subtypes of NSCLC
Mol Oncol, 13 (12), 2604-2615
DOI 10.1002/1878-0261.12571, PubMed 31505091

Totland MZ, Rasmussen NL, Knudsen LM, Leithe E (2019)
Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
Cell Mol Life Sci, 77 (4), 573-591
DOI 10.1007/s00018-019-03285-0, PubMed 31501970

Pandya AD, Jäger E, Bagheri Fam S, Höcherl A, Jäger A, Sincari V, Nyström B, Štěpánek P, Skotland T, Sandvig K, Hrubý M, Mælandsmo GM (2019)
Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
Int J Nanomedicine, 14, 6269-6285
DOI 10.2147/IJN.S208938, PubMed 31496685

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2019)
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929

Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K (2019)
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia, 34 (2), 478-487
DOI 10.1038/s41375-019-0569-7, PubMed 31471562

Nome ME, Euceda LR, Jabeen S, Debik J, Bathen TF, Giskeødegård GF, Taskén KA, Maelandsmo GM, Halvorsen B, Yndestad A, Borgen E, Garred Ø, Aukrust P, Ueland T, Engebraaten O, Kristensen VN, Tekpli X (2019)
Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
Int J Cancer, 146 (1), 223-235
DOI 10.1002/ijc.32638, PubMed 31444972

Della Valle A, Rossi BM, Palmero EI, Antelo M, Vaccaro CA, López-Kostner F, Alvarez K, Cruz-Correa M, Bruno LI, Forones NM, Mindiola JAR, Buleje J, Spirandelli F, Bohorquez M, Cock-Rada AM, Sullcahuaman Y, Nascimento I, Abe-Sandes K, Lino-Silva LS, Petracchi F, Mampel A, Rodriguez Y, Rossi NT, Yañez CB, Rubio C et al. (2019)
A snapshot of current genetic testing practice in Lynch syndrome: The results of a representative survey of 33 Latin American existing centres/registries
Eur J Cancer, 119, 112-121
DOI 10.1016/j.ejca.2019.07.017, PubMed 31442815

Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S (2019)
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
Cell Rep, 28 (7), 1907-1922.e6
DOI 10.1016/j.celrep.2019.07.025, PubMed 31412255

Lindholm EM, Ragle Aure M, Haugen MH, Kleivi Sahlberg K, Kristensen VN, Nebdal D, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2019)
miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer
Mol Oncol, 13 (10), 2278-2296
DOI 10.1002/1878-0261.12561, PubMed 31402562

Braadland PR, Ramberg H, Grytli HH, Urbanucci A, Nielsen HK, Guldvik IJ, Engedal A, Ketola K, Wang W, Svindland A, Mills IG, Bjartell A, Taskén KA (2019)
The β₂-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells
Mol Cancer Res, 17 (11), 2154-2168
DOI 10.1158/1541-7786.MCR-18-0605, PubMed 31395667

Sioud M, Pettersen S, Ailte I, Fløisand Y (2019)
Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
Cancers (Basel), 11 (8)
DOI 10.3390/cancers11081088, PubMed 31370273

Fougner C, Bergholtz H, Kuiper R, Norum JH, Sørlie T (2019)
Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers
Breast Cancer Res, 21 (1), 85
DOI 10.1186/s13058-019-1170-8, PubMed 31366361

Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP, Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A et al. (2019)
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Genet Med, 22 (1), 15-25
DOI 10.1038/s41436-019-0596-9, PubMed 31337882

Smeby J, Sveen A, Bergsland CH, Eilertsen IA, Danielsen SA, Eide PW, Hektoen M, Guren MG, Nesbakken A, Bruun J, Lothe RA (2019)
Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
ESMO Open, 4 (3), e000523
DOI 10.1136/esmoopen-2019-000523, PubMed 31321083

Berg KCG, Sveen A, Høland M, Alagaratnam S, Berg M, Danielsen SA, Nesbakken A, Søreide K, Lothe RA (2019)
Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
Oncogene, 38 (33), 6109-6122
DOI 10.1038/s41388-019-0868-5, PubMed 31308487

Olweus J, Lund-Johansen F (2019)
Finding Neo (antigens, that is)
Blood, 134 (2), 108-109
DOI 10.1182/blood.2019001334, PubMed 31296544

Skånland SS, Taskén K (2019)
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
J Immunol, 203 (4), 1055-1063
DOI 10.4049/jimmunol.1801660, PubMed 31292214

Sveen A, Kopetz S, Lothe RA (2019)
Biomarker-guided therapy for colorectal cancer: strength in complexity
Nat Rev Clin Oncol, 17 (1), 11-32
DOI 10.1038/s41571-019-0241-1, PubMed 31289352

Visnovska T, Biggs PJ, Schmeier S, Frizelle FA, Purcell RV (2019)
Metagenomics and transcriptomics data from human colorectal cancer
Sci Data, 6 (1), 116
DOI 10.1038/s41597-019-0117-3, PubMed 31278253

Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO (2019)
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
Nat Commun, 10 (1), 2850
DOI 10.1038/s41467-019-10794-w, PubMed 31253801

Gheorghe M, Sandve GK, Khan A, Chèneby J, Ballester B, Mathelier A (2019)
A map of direct TF-DNA interactions in the human genome
Nucleic Acids Res, 47 (14), 7715
DOI 10.1093/nar/gkz582, PubMed 31251803

Skotland T, Sandvig K (2019)
The role of PS 18:0/18:1 in membrane function
Nat Commun, 10 (1), 2752
DOI 10.1038/s41467-019-10711-1, PubMed 31227693

Norum JH, Frings O, Kasper M, Bergholtz H, Zell Thime H, Bergström Å, Andersson A, Kuiper R, Fredlund E, Sørlie T, Toftgård R (2019)
GLI1-induced mammary gland tumours are transplantable and maintain major molecular features
Int J Cancer, 146 (4), 1125-1138
DOI 10.1002/ijc.32522, PubMed 31219615

Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM (2019)
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 8 (6)
DOI 10.3390/cells8060518, PubMed 31146385

Ali M, Foldvari Z, Giannakopoulou E, Böschen ML, Strønen E, Yang W, Toebes M, Schubert B, Kohlbacher O, Schumacher TN, Olweus J (2019)
Induction of neoantigen-reactive T cells from healthy donors
Nat Protoc, 14 (6), 1926-1943
DOI 10.1038/s41596-019-0170-6, PubMed 31101906

Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
Oncogenesis, 8 (6), 35
DOI 10.1038/s41389-019-0141-3, PubMed 31092812

Hamfjord J, Guren TK, Dajani O, Johansen JS, Glimelius B, Sorbye H, Pfeiffer P, Lingjærde OC, Tveit KM, Kure EH, Pallisgaard N, Spindler KG (2019)
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy
Ann Oncol, 30 (7), 1088-1095
DOI 10.1093/annonc/mdz139, PubMed 31046124

Zhang B, Ayuda-Durán P, Piechaczyk L, Fløisand Y, Safont MM, Karlsen IT, Fandalyuk Z, Tadele D, van Mierlo P, Rowe AD, Robertson JM, Gjertsen BT, McCormack E, Enserink JM (2019)
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, 104 (5), e229
DOI 10.3324/haematol.2019.220533, PubMed 31040234

Zakrzewska M, Opalinski L, Haugsten EM, Otlewski J, Wiedlocha A (2019)
Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling
Int J Mol Sci, 20 (8)
DOI 10.3390/ijms20081826, PubMed 31013829

Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Schink KO, Olsen CE, Wälchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019)
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194

Kyte JA, Fåne A, Pule M, Gaudernack G (2019)
Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination
Oncoimmunology, 8 (4), e1565236
DOI 10.1080/2162402X.2019.1565236, PubMed 30906659

Nunes-Xavier CE, Zaldumbide L, Aurtenetxe O, López-Almaraz R, López JI, Pulido R (2019)
Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
Int J Mol Sci, 20 (5)
DOI 10.3390/ijms20051170, PubMed 30866462

Hauge A, Gaustad JV, Huang R, Simonsen TG, Wegner CS, Andersen LMK, Rofstad EK (2019)
DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 104 (3), 666-676
DOI 10.1016/j.ijrobp.2019.03.002, PubMed 30858145

Jonsson M, Fjeldbo CS, Holm R, Stokke T, Kristensen GB, Lyng H (2019)
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer
Neoplasia, 21 (4), 353-362
DOI 10.1016/j.neo.2019.01.002, PubMed 30856376

Öjlert ÅK, Halvorsen AR, Nebdal D, Lund-Iversen M, Solberg S, Brustugun OT, Lingjaerde OC, Helland Å (2019)
The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery
Mol Oncol, 13 (5), 1166-1179
DOI 10.1002/1878-0261.12475, PubMed 30854794

Steen CB, Leich E, Myklebust JH, Lockmer S, Wise JF, Wahlin BE, Østenstad B, Liestøl K, Kimby E, Rosenwald A, Smeland EB, Holte H, Lingjærde OC, Brodtkorb M (2019)
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy
Haematologica, 104 (10), e460-e464
DOI 10.3324/haematol.2018.209080, PubMed 30846496

Braadland PR, Urbanucci A (2019)
Chromatin reprogramming as an adaptation mechanism in advanced prostate cancer
Endocr Relat Cancer, 26 (4), R211-R235
DOI 10.1530/ERC-18-0579, PubMed 30844748

Ree AH, Nygaard V, Russnes HG, Heinrich D, Nygaard V, Johansen C, Bergheim IR, Hovig E, Beiske K, Negård A, Børresen-Dale AL, Flatmark K, Mælandsmo GM (2019)
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006

Hanes R, Munthe E, Grad I, Han J, Karlsen I, McCormack E, Meza-Zepeda LA, Stratford EW, Myklebost O (2019)
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma
Cells, 8 (2)
DOI 10.3390/cells8020189, PubMed 30795553

Szwed M, Sønstevold T, Øverbye A, Engedal N, Grallert B, Mørch Ý, Sulheim E, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2019)
Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death
Nanotoxicology, 13 (6), 761-782
DOI 10.1080/17435390.2019.1576238, PubMed 30760074

Sioud M (2019)
Releasing the Immune System Brakes Using siRNAs Enhances Cancer Immunotherapy
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020176, PubMed 30717461

Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Lüders T, Engebraaten O, Børresen-Dale AL, Kyte JA, Gromov P, Naume B, Kristensen V, Gromova I, Tekpli X (2018)
Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
Oncoimmunology, 8 (2), e1537691
DOI 10.1080/2162402X.2018.1537691, PubMed 30713794

Kryeziu K, Bruun J, Guren TK, Sveen A, Lothe RA (2019)
Combination therapies with HSP90 inhibitors against colorectal cancer
Biochim Biophys Acta Rev Cancer, 1871 (2), 240-247
DOI 10.1016/j.bbcan.2019.01.002, PubMed 30708039

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P (2019)
Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 10 (1), 525
DOI 10.1038/s41467-019-08512-7, PubMed 30692535

Chellappa S, Kushekhar K, Munthe LA, Tjønnfjord GE, Aandahl EM, Okkenhaug K, Taskén K (2019)
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
J Immunol, 202 (5), 1397-1405
DOI 10.4049/jimmunol.1701703, PubMed 30692213

Møller P, Dominguez-Valentin M, Rødland EA, Hovig E (2019)
Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020132, PubMed 30678073

Camilio KA, Wang MY, Mauseth B, Waagene S, Kvalheim G, Rekdal Ø, Sveinbjørnsson B, Mælandsmo GM (2019)
Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model
Breast Cancer Res, 21 (1), 9
DOI 10.1186/s13058-018-1092-x, PubMed 30670061

Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH (2019)
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053

Jacobs B, Pfefferle A, Clement D, Berg-Larsen A, Saetersmoen ML, Lorenz S, Wiiger MT, Goodridge JP, Malmberg KJ (2018)
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J Immunol, 202 (3), 736-746
DOI 10.4049/jimmunol.1801146, PubMed 30578306

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P (2018)
Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 9 (1), 5397
DOI 10.1038/s41467-018-07842-2, PubMed 30559362

Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG (2019)
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
Nucleic Acids Res, 47 (4), 1797-1813
DOI 10.1093/nar/gky1233, PubMed 30541148

Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM (2018)
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
J Control Release, 293, 183-192
DOI 10.1016/j.jconrel.2018.11.029, PubMed 30529259

Gheorghe M, Sandve GK, Khan A, Chèneby J, Ballester B, Mathelier A (2019)
A map of direct TF-DNA interactions in the human genome
Nucleic Acids Res, 47 (4), e21
DOI 10.1093/nar/gky1210, PubMed 30517703

Vietri M, Stenmark H (2018)
Orchestrating Nuclear Envelope Sealing during Mitosis
Dev Cell, 47 (5), 541-542
DOI 10.1016/j.devcel.2018.11.020, PubMed 30513298

Höglander EK, Nord S, Wedge DC, Lingjærde OC, Silwal-Pandit L, Gythfeldt HV, Vollan HKM, Fleischer T, Krohn M, Schlitchting E, Borgen E, Garred Ø, Holmen MM, Wist E, Naume B, Van Loo P, Børresen-Dale AL, Engebraaten O, Kristensen V (2018)
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
Genome Med, 10 (1), 92
DOI 10.1186/s13073-018-0601-y, PubMed 30497530

Eide PW, Eilertsen IA, Sveen A, Lothe RA (2019)
Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties
Int J Cancer, 144 (11), 2843-2853
DOI 10.1002/ijc.31998, PubMed 30447009

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271

Jabeen S, Zucknick M, Nome M, Dannenfelser R, Fleischer T, Kumar S, Lüders T, von der Lippe Gythfeldt H, Troyanskaya O, Kyte JA, Børresen-Dale AL, Naume B, Tekpli X, Engebraaten O, Kristensen V (2018)
Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab
Oncoimmunology, 7 (11), e1457598
DOI 10.1080/2162402X.2018.1457598, PubMed 30377556

Saetersmoen ML, Hammer Q, Valamehr B, Kaufman DS, Malmberg KJ (2018)
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
Semin Immunopathol, 41 (1), 59-68
DOI 10.1007/s00281-018-0721-x, PubMed 30361801

Radulovic M, Schink KO, Wenzel EM, Nähse V, Bongiovanni A, Lafont F, Stenmark H (2018)
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
EMBO J, 37 (21)
DOI 10.15252/embj.201899753, PubMed 30314966

Vaccaro CA, López-Kostner F, Adriana DV, Palmero EI, Rossi BM, Antelo M, Solano A, Carraro DM, Forones NM, Bohorquez M, Lino-Silva LS, Buleje J, Spirandelli F, Abe-Sandes K, Nascimento I, Sullcahuaman Y, Sarroca C, Gonzalez ML, Herrando AI, Alvarez K, Neffa F, Galvão HC, Esperon P, Golubicki M, Cisterna D et al. (2018)
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America
Int J Cancer, 145 (2), 318-326
DOI 10.1002/ijc.31920, PubMed 30303536

Fromm B, Kang W, Rovira C, Cayota A, Witwer K, Friedländer MR, Tosar JP (2018)
Plant microRNAs in human sera are likely contaminants
J Nutr Biochem, 65, 139-140
DOI 10.1016/j.jnutbio.2018.07.019, PubMed 30266285

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619

Seip K, Jørgensen K, Haselager MV, Albrecht M, Haugen MH, Egeland EV, Lucarelli P, Engebraaten O, Sauter T, Mælandsmo GM, Prasmickaite L (2018)
Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment
Cancer Lett, 439, 1-13
DOI 10.1016/j.canlet.2018.09.023, PubMed 30240588

Weyergang A, Fremstedal AS, Skarpen E, Peng Q, Mohamedali KA, Eng MS, Cheung LH, Rosenblum MG, Waltenberger J, Berg K (2018)
Light-enhanced VEGF₁₂₁/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J Control Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005, PubMed 30217739

Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
Eur Urol, 75 (3), 498-505
DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068

Risberg B, Tsui DWY, Biggs H, Ruiz-Valdepenas Martin de Almagro A, Dawson SJ, Hodgkin C, Jones L, Parkinson C, Piskorz A, Marass F, Chandrananda D, Moore E, Morris J, Plagnol V, Rosenfeld N, Caldas C, Brenton JD, Gale D (2018)
Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients
J Mol Diagn, 20 (6), 883-892
DOI 10.1016/j.jmoldx.2018.07.005, PubMed 30165204

Rye IH, Trinh A, Saetersdal AB, Nebdal D, Lingjaerde OC, Almendro V, Polyak K, Børresen-Dale AL, Helland Å, Markowetz F, Russnes HG (2018)
Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors
Mol Oncol, 12 (11), 1838-1855
DOI 10.1002/1878-0261.12375, PubMed 30133130

Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA (2018)
Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
Int J Cancer, 144 (4), 841-847
DOI 10.1002/ijc.31809, PubMed 30121958

Kostas M, Lampart A, Bober J, Wiedlocha A, Tomala J, Krowarsch D, Otlewski J, Zakrzewska M (2018)
Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation
J Mol Biol, 430 (21), 4087-4101
DOI 10.1016/j.jmb.2018.08.004, PubMed 30099027

Namløs HM, Boye K, Mishkin SJ, Barøy T, Lorenz S, Bjerkehagen B, Stratford EW, Munthe E, Kudlow BA, Myklebost O, Meza-Zepeda LA (2018)
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor
Mol Cancer Ther, 17 (11), 2473-2480
DOI 10.1158/1535-7163.MCT-18-0174, PubMed 30097488

Skotland T, Hessvik NP, Sandvig K, Llorente A (2018)
Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology
J Lipid Res, 60 (1), 9-18
DOI 10.1194/jlr.R084343, PubMed 30076207

Stonyte V, Boye E, Grallert B (2018)
Regulation of global translation during the cell cycle
J Cell Sci, 131 (17)
DOI 10.1242/jcs.220327, PubMed 30072440

Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nähse V, Carlson A, Brech A, Stenmark H, Raiborg C (2018)
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Nat Commun, 9 (1), 2932
DOI 10.1038/s41467-018-05345-8, PubMed 30050131

Fornes O, Gheorghe M, Richmond PA, Arenillas DJ, Wasserman WW, Mathelier A (2018)
MANTA2, update of the Mongo database for the analysis of transcription factor binding site alterations
Sci Data, 5, 180141
DOI 10.1038/sdata.2018.141, PubMed 30040077

Høland M, Kolberg M, Danielsen SA, Bjerkehagen B, Eilertsen IA, Hektoen M, Mandahl N, van den Berg E, Smeland S, Mertens F, Sundby Hall K, Picci P, Sveen A, Lothe RA (2018)
Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53
Mod Pathol, 31 (11), 1694-1707
DOI 10.1038/s41379-018-0074-y, PubMed 29946184

Hompland T, Hole KH, Ragnum HB, Aarnes EK, Vlatkovic L, Lie AK, Patzke S, Brennhovd B, Seierstad T, Lyng H (2018)
Combined MR Imaging of Oxygen Consumption and Supply Reveals Tumor Hypoxia and Aggressiveness in Prostate Cancer Patients
Cancer Res, 78 (16), 4774-4785
DOI 10.1158/0008-5472.CAN-17-3806, PubMed 29945958

Sioud M, Westby P, Vasovic V, Fløisand Y, Peng Q (2018)
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies
FASEB J, 32 (9), 5063-5077
DOI 10.1096/fj.201701544R, PubMed 29913558

Radulovic M, Stenmark H (2018)
ESCRTs in membrane sealing
Biochem Soc Trans, 46 (4), 773-778
DOI 10.1042/BST20170435, PubMed 29903934

Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA (2018)
Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
Mol Oncol, 12 (9), 1639-1655
DOI 10.1002/1878-0261.12347, PubMed 29900672

Wegner CS, Hauge A, Simonsen TG, Gaustad JV, Andersen LMK, Rofstad EK (2018)
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts
Neoplasia, 20 (7), 734-744
DOI 10.1016/j.neo.2018.05.006, PubMed 29886124

Flem-Karlsen K, Fodstad Ø, Tan M, Nunes-Xavier CE (2018)
B7-H3 in Cancer - Beyond Immune Regulation
Trends Cancer, 4 (6), 401-404
DOI 10.1016/j.trecan.2018.03.010, PubMed 29860983

Simonsen TG, Lund KV, Hompland T, Kristensen GB, Rofstad EK (2018)
DCE-MRI-Derived Measures of Tumor Hypoxia and Interstitial Fluid Pressure Predict Outcomes in Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 102 (4), 1193-1201
DOI 10.1016/j.ijrobp.2018.04.035, PubMed 29859790

Malerød L, Le Borgne R, Lie-Jensen A, Eikenes ÅH, Brech A, Liestøl K, Stenmark H, Haglund K (2018)
Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
EMBO J, 37 (13)
DOI 10.15252/embj.201797741, PubMed 29858227

Vedeld HM, Nesbakken A, Lothe RA, Lind GE (2018)
Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
Clin Epigenetics, 10, 70
DOI 10.1186/s13148-018-0503-2, PubMed 29854011

Zhang B, Durán PA, Piechaczyk L, Fløisand Y, Safont MMS, Karlsen IT, Fandalyuk Z, Tadele D, Mierlo PV, Rowe AD, Robertson JM, Gjertsen BT, McCormack E, Enserink JM, Bjørn Tore Gjertsen Group, Emmet McCormack Group (2018)
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445

Prasmickaite L, Tenstad EM, Pettersen S, Jabeen S, Egeland EV, Nord S, Pandya A, Haugen MH, Kristensen VN, Børresen-Dale AL, Oslo Breast Cancer Research Consortium (OSBREAC), Engebråten O, Maelandsmo GM (2018)
Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4
Mol Oncol, 12 (9), 1540-1558
DOI 10.1002/1878-0261.12319, PubMed 29741811

Huang R, Rofstad EK (2018)
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
J Exp Clin Cancer Res, 37 (1), 92
DOI 10.1186/s13046-018-0763-x, PubMed 29703238

Khan A, Montenegro-Montero A, Mathelier A (2018)
Put science first and formatting later
EMBO Rep, 19 (5)
DOI 10.15252/embr.201845731, PubMed 29650529

Gouravan S, Meza-Zepeda LA, Myklebost O, Stratford EW, Munthe E (2018)
Preclinical Evaluation of Vemurafenib as Therapy for BRAF^V600E Mutated Sarcomas
Int J Mol Sci, 19 (4)
DOI 10.3390/ijms19040969, PubMed 29570692

Rajpert-De Meyts E, Skotheim RI (2018)
Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology
Eur Urol, 73 (6), 832-833
DOI 10.1016/j.eururo.2018.02.023, PubMed 29530636

Smeby J, Sveen A, Merok MA, Danielsen SA, Eilertsen IA, Guren MG, Dienstmann R, Nesbakken A, Lothe RA (2018)
CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer
Ann Oncol, 29 (5), 1227-1234
DOI 10.1093/annonc/mdy085, PubMed 29518181

Pharo HD, Andresen K, Berg KCG, Lothe RA, Jeanmougin M, Lind GE (2018)
A robust internal control for high-precision DNA methylation analyses by droplet digital PCR
Clin Epigenetics, 10, 24
DOI 10.1186/s13148-018-0456-5, PubMed 29484034

Braadland PR, Giskeødegård G, Sandsmark E, Bertilsson H, Euceda LR, Hansen AF, Guldvik IJ, Selnæs KM, Grytli HH, Katz B, Svindland A, Bathen TF, Eri LM, Nygård S, Berge V, Taskén KA, Tessem MB (2018)
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 118 (6), e11
DOI 10.1038/bjc.2017.470, PubMed 29462127

Oei VYS, Siernicka M, Graczyk-Jarzynka A, Hoel HJ, Yang W, Palacios D, Almåsbak H, Bajor M, Clement D, Brandt L, Önfelt B, Goodridge J, Winiarska M, Zagozdzon R, Olweus J, Kyte JA, Malmberg KJ (2018)
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Cancer Immunol Res, 6 (4), 467-480
DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477

Våtsveen TK, Myhre MR, Steen CB, Wälchli S, Lingjærde OC, Bai B, Dillard P, Theodossiou TA, Holien T, Sundan A, Inderberg EM, Smeland EB, Myklebust JH, Oksvold MP (2018)
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389

Björklund AT, Carlsten M, Sohlberg E, Liu LL, Clancy T, Karimi M, Cooley S, Miller JS, Klimkowska M, Schaffer M, Watz E, Wikström K, Blomberg P, Wahlin BE, Palma M, Hansson L, Ljungman P, Hellström-Lindberg E, Ljunggren HG, Malmberg KJ (2018)
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Clin Cancer Res, 24 (8), 1834-1844
DOI 10.1158/1078-0432.CCR-17-3196, PubMed 29444931

Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J (2018)
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors
Mol Cell Proteomics, 17 (5), 850-870
DOI 10.1074/mcp.RA117.000538, PubMed 29371290

Boye K, Berner JM, Hompland I, Bruland ØS, Stoldt S, Sundby Hall K, Bjerkehagen B, Hølmebakk T (2018)
Genotype and risk of tumour rupture in gastrointestinal stromal tumour
Br J Surg, 105 (2), e169-e175
DOI 10.1002/bjs.10743, PubMed 29341147

Karpanen T, Olweus J (2017)
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
Front Immunol, 8, 1718
DOI 10.3389/fimmu.2017.01718, PubMed 29321773

Norum JH, Skarpen E, Brech A, Kuiper R, Waaler J, Krauss S, Sørlie T (2018)
The tankyrase inhibitor G007-LK inhibits small intestine LGR5⁺ stem cell proliferation without altering tissue morphology
Biol Res, 51 (1), 3
DOI 10.1186/s40659-017-0151-6, PubMed 29316982

Lund K, Olsen CE, Wong JJW, Olsen PA, Solberg NT, Høgset A, Krauss S, Selbo PK (2017)
5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
J Exp Clin Cancer Res, 36 (1), 187
DOI 10.1186/s13046-017-0662-6, PubMed 29258566

Vedeld HM, Goel A, Lind GE (2017)
Epigenetic biomarkers in gastrointestinal cancers: The current state and clinical perspectives
Semin Cancer Biol, 51, 36-49
DOI 10.1016/j.semcancer.2017.12.004, PubMed 29253542

Inderberg EM, Mensali N, Oksvold MP, Fallang LE, Fåne A, Skorstad G, Stenvik GE, Progida C, Bakke O, Kvalheim G, Myklebust JH, Wälchli S (2017)
Human c-SRC kinase (CSK) overexpression makes T cells dummy
Cancer Immunol Immunother, 67 (4), 525-536
DOI 10.1007/s00262-017-2105-9, PubMed 29248956

Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2017)
Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
Clin Cancer Res, 24 (4), 794-806
DOI 10.1158/1078-0432.CCR-17-1234, PubMed 29242316

Josefsson SE, Huse K, Kolstad A, Beiske K, Pende D, Steen CB, Inderberg EM, Lingjærde OC, Østenstad B, Smeland EB, Levy R, Irish JM, Myklebust JH (2017)
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Clin Cancer Res, 24 (4), 870-881
DOI 10.1158/1078-0432.CCR-17-2337, PubMed 29217528

Skotland T (2017)
Injection of nanoparticles into cloven-hoof animals: Asking for trouble
Theranostics, 7 (19), 4877-4878
DOI 10.7150/thno.22420, PubMed 29187910

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts
J Transl Med, 15 (1), 241
DOI 10.1186/s12967-017-1347-9, PubMed 29183378

Khan A, Fornes O, Stigliani A, Gheorghe M, Castro-Mondragon JA, van der Lee R, Bessy A, Chèneby J, Kulkarni SR, Tan G, Baranasic D, Arenillas DJ, Sandelin A, Vandepoele K, Lenhard B, Ballester B, Wasserman WW, Parcy F, Mathelier A (2018)
JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework
Nucleic Acids Res, 46 (D1), D1284
DOI 10.1093/nar/gkx1188, PubMed 29161433

Quigley DA, Tahiri A, Lüders T, Riis MH, Balmain A, Børresen-Dale AL, Bukholm I, Kristensen V (2017)
Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue
Oncoimmunology, 6 (11), e1356142
DOI 10.1080/2162402X.2017.1356142, PubMed 29147603

Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E, Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN (2017)
DNA methylation at enhancers identifies distinct breast cancer lineages
Nat Commun, 8 (1), 1379
DOI 10.1038/s41467-017-00510-x, PubMed 29123100

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment
J Transl Med, 15 (1), 225
DOI 10.1186/s12967-017-1331-4, PubMed 29100521

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P (2017)
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 8 (1), 1221
DOI 10.1038/s41467-017-01355-0, PubMed 29089486

O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE (2017)
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199

Rothe C, Rødland GE, Anda S, Stonyte V, Boye E, Lopez-Aviles S, Grallert B (2017)
A checkpoint-independent mechanism delays entry into mitosis after UV irradiation
J Cell Sci, 130 (23), 4028-4037
DOI 10.1242/jcs.204693, PubMed 29046339

Norum OJ, Fremstedal ASV, Weyergang A, Golab J, Berg K (2017)
Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity
J Control Release, 268, 120-127
DOI 10.1016/j.jconrel.2017.10.015, PubMed 29042319

Hong Z, Pedersen NM, Wang L, Torgersen ML, Stenmark H, Raiborg C (2017)
PtdIns3P controls mTORC1 signaling through lysosomal positioning
J Cell Biol, 216 (12), 4217-4233
DOI 10.1083/jcb.201611073, PubMed 29030394

Huang R, Andersen LMK, Rofstad EK (2017)
Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts
J Transl Med, 15 (1), 203
DOI 10.1186/s12967-017-1307-4, PubMed 29017512

Braadland PR, Giskeødegård G, Sandsmark E, Bertilsson H, Euceda LR, Hansen AF, Guldvik IJ, Selnæs KM, Grytli HH, Katz B, Svindland A, Bathen TF, Eri LM, Nygård S, Berge V, Taskén KA, Tessem MB (2017)
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 117 (11), 1656-1664
DOI 10.1038/bjc.2017.346, PubMed 28972967

Malmberg KJ, Carlsten M, Björklund A, Sohlberg E, Bryceson YT, Ljunggren HG (2017)
Natural killer cell-mediated immunosurveillance of human cancer
Semin Immunol, 31, 20-29
DOI 10.1016/j.smim.2017.08.002, PubMed 28888619

Lind GE, Guriby M, Ahlquist T, Hussain I, Jeanmougin M, Søreide K, Kørner H, Lothe RA, Nordgård O (2017)
Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
Clin Epigenetics, 9, 97
DOI 10.1186/s13148-017-0397-4, PubMed 28878843

Olsen CE, Weyergang A, Edwards VT, Berg K, Brech A, Weisheit S, Høgset A, Selbo PK (2017)
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem Pharmacol, 144, 63-77
DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290

Ree AH, Russnes HG, Heinrich D, Dueland S, Boye K, Nygaard V, Silwal-Pandit L, Østrup O, Hovig E, Nygaard V, Rødland EA, Nakken S, Øien JT, Johansen C, Bergheim IR, Skarpeteig V, Sathermugathevan M, Sauer T, Lund-Iversen M, Beiske K, Nasser S, Julsrud L, Reisse CH, Ruud EA, Flørenes VA et al. (2017)
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
ESMO Open, 2 (2), e000158
DOI 10.1136/esmoopen-2017-000158, PubMed 28761742

Møller P, Seppälä TT, Bernstein I, Holinski-Feder E, Sala P, Gareth Evans D, Lindblom A, Macrae F, Blanco I, Sijmons RH, Jeffries J, Vasen HFA, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen JT, Jenkins MA, Green K, Lalloo F, Sunde L, Mints M et al. (2017)
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
Gut, 67 (7), 1306-1316
DOI 10.1136/gutjnl-2017-314057, PubMed 28754778

Hessvik NP, Llorente A (2017)
Current knowledge on exosome biogenesis and release
Cell Mol Life Sci, 75 (2), 193-208
DOI 10.1007/s00018-017-2595-9, PubMed 28733901

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
J Cell Sci, 130 (17), 2867-2882
DOI 10.1242/jcs.202408, PubMed 28733455

Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Mol Cancer, 16 (1), 116
DOI 10.1186/s12943-017-0691-y, PubMed 28683746

Liu LL, Béziat V, Oei VYS, Pfefferle A, Schaffer M, Lehmann S, Hellström-Lindberg E, Söderhäll S, Heyman M, Grandér D, Malmberg KJ (2017)
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Cancer Immunol Res, 5 (8), 654-665
DOI 10.1158/2326-6066.CIR-16-0296, PubMed 28637877

Katheder NS, Rusten TE (2017)
Microenvironment and tumors-a nurturing relationship
Autophagy, 13 (7), 1241-1243
DOI 10.1080/15548627.2017.1310361, PubMed 28632995

Raiborg C, Schink KO, Stenmark H (2017)
Suppressing mTORC1 on the lysosome
EMBO J, 36 (13), 1809-1810
DOI 10.15252/embj.201797469, PubMed 28623241

Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E, Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E et al. (2017)
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
Cell Rep, 19 (10), 2045-2059
DOI 10.1016/j.celrep.2017.05.049, PubMed 28591577

Olweus J (2017)
Manufacture of CAR-T cells in the body
Nat Biotechnol, 35 (6), 520-521
DOI 10.1038/nbt.3898, PubMed 28591119

Kolberg M, Bruun J, Murumägi A, Mpindi JP, Bergsland CH, Høland M, Eilertsen IA, Danielsen SA, Kallioniemi O, Lothe RA (2017)
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
Mol Oncol, 11 (9), 1156-1171
DOI 10.1002/1878-0261.12086, PubMed 28556483

Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, Svindland A, Sjo OH, Hektoen M, Eknaes M, Nesbakken A, Lothe RA, Lind GE (2017)
CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
Int J Cancer, 141 (5), 967-976
DOI 10.1002/ijc.30796, PubMed 28542846

Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
DOI 10.1186/s13073-017-0434-0, PubMed 28539123

Lågstad S, Zhao S, Hoff AM, Johannessen B, Lingjærde OC, Skotheim RI (2017)
chimeraviz: a tool for visualizing chimeric RNA
Bioinformatics, 33 (18), 2954-2956
DOI 10.1093/bioinformatics/btx329, PubMed 28525538

Inderberg EM, Wälchli S, Myhre MR, Trachsel S, Almåsbak H, Kvalheim G, Gaudernack G (2017)
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth
Oncoimmunology, 6 (4), e1302631
DOI 10.1080/2162402X.2017.1302631, PubMed 28507809

Hilmarsdottir B, Briem E, Halldorsson S, Kricker J, Ingthorsson S, Gustafsdottir S, Mælandsmo GM, Magnusson MK, Gudjonsson T (2017)
Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells
Cell Death Dis, 8 (5), e2769
DOI 10.1038/cddis.2017.177, PubMed 28492548

Silwal-Pandit L, Nord S, von der Lippe Gythfeldt H, Møller EK, Fleischer T, Rødland E, Krohn M, Borgen E, Garred Ø, Olsen T, Vu P, Skjerven H, Fangberget A, Holmen MM, Schlitchting E, Wille E, Nordberg Stokke M, Moen Vollan HK, Kristensen V, Langerød A, Lundgren S, Wist E, Naume B, Lingjærde OC, Børresen-Dale AL et al. (2017)
The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer
Clin Cancer Res, 23 (16), 4662-4670
DOI 10.1158/1078-0432.CCR-17-0160, PubMed 28487444

Taraldsrud E, Fevang B, Jørgensen SF, Moltu K, Hilden V, Taskén K, Aukrust P, Myklebust JH, Olweus J (2017)
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239

Pedersen IB, Helgesen E, Flåtten I, Fossum-Raunehaug S, Skarstad K (2017)
SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms
Nucleic Acids Res, 45 (11), 6471-6485
DOI 10.1093/nar/gkx263, PubMed 28407100

Helland Å, Brustugun OT, Nakken S, Halvorsen AR, Dønnem T, Bremnes R, Busund LT, Sun J, Lorenz S, Solberg SK, Jørgensen LH, Vodak D, Myklebost O, Hovig E, Meza-Zepeda LA (2017)
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924

Aure MR, Vitelli V, Jernström S, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Lüders T, Rødland E, Vaske CJ, Zhao W, Møller EK, Nord S, Giskeødegård GF, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Geisler J, Bukholm IR, Naume B, Schlichting E et al. (2017)
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Breast Cancer Res, 19 (1), 44
DOI 10.1186/s13058-017-0812-y, PubMed 28356166

Skotland T, Sandvig K, Llorente A (2017)
Lipids in exosomes: Current knowledge and the way forward
Prog Lipid Res, 66, 30-41
DOI 10.1016/j.plipres.2017.03.001, PubMed 28342835

Nygaard V, Rødland EA, Hovig E (2017)
Reply to Towfic and others' letter to the editor
Biostatistics, 18 (3), 586-587
DOI 10.1093/biostatistics/kxx001, PubMed 28334081

Theodossiou TA, Olsen CE, Jonsson M, Kubin A, Hothersall JS, Berg K (2017)
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol, 12, 191-197
DOI 10.1016/j.redox.2017.02.018, PubMed 28254657

Balasiddaiah A, Davanian H, Aleman S, Pasetto A, Frelin L, Sällberg M, Lohmann V, Koh S, Bertoletti A, Chen M (2017)
Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties
J Virol, 91 (9)
DOI 10.1128/JVI.00010-17, PubMed 28228595

Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Olsen KH, Giercksky KE, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2017)
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Ann Surg Oncol, 24 (7), 1916-1922
DOI 10.1245/s10434-017-5814-6, PubMed 28224367

Karpanen T, Padberg Y, van de Pavert SA, Dierkes C, Morooka N, Peterson-Maduro J, van de Hoek G, Adrian M, Mochizuki N, Sekiguchi K, Kiefer F, Schulte D, Schulte-Merker S (2017)
An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation
Circ Res, 120 (8), 1263-1275
DOI 10.1161/CIRCRESAHA.116.308813, PubMed 28179432

Boye E, Skotland T, Østerud B, Nissen-Meyer J (2017)
Doping and drug testing: Anti-doping work must be transparent and adhere to good scientific practices to ensure public trust
EMBO Rep, 18 (3), 351-354
DOI 10.15252/embr.201643540, PubMed 28167676

Kristensen VN (2017)
The Antigenicity of the Tumor Cell - Context Matters
N Engl J Med, 376 (5), 491-493
DOI 10.1056/NEJMcibr1613793, PubMed 28146670

Halvorsen AR, Helland Å, Gromov P, Wielenga VT, Talman MM, Brunner N, Sandhu V, Børresen-Dale AL, Gromova I, Haakensen VD (2016)
Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer
Mol Oncol, 11 (2), 220-234
DOI 10.1002/1878-0261.12025, PubMed 28145100

Kanaya M, Hayashi Y, Hashimoto D, Endo T, Sugita J, Ohigashi H, Hashiguchi J, Matsukawa T, Matsuoka S, Kosugi-Kanaya M, Goto H, Onozawa M, Kahata K, Fujimoto K, Kondo T, Akizawa K, Shibuya H, Shimizu C, Teshima T (2017)
MALDI-TOF MS in post-transplant bloodstream infections: reliable identification of causative bacteria in the neutropenic phase
Bone Marrow Transplant, 52 (5), 778-780
DOI 10.1038/bmt.2016.365, PubMed 28134922

Kyte JA, Gaudernack G, Faane A, Lislerud K, Inderberg EM, Brunsvig P, Aamdal S, Kvalheim G, Wälchli S, Pule M (2016)
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy
Oncoimmunology, 5 (12), e1249090
DOI 10.1080/2162402X.2016.1249090, PubMed 28123886

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404

Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE (2017)
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876

Ailte I, Lingelem AB, Kvalvaag AS, Kavaliauskiene S, Brech A, Koster G, Dommersnes PG, Bergan J, Skotland T, Sandvig K (2017)
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Traffic, 18 (3), 176-191
DOI 10.1111/tra.12468, PubMed 28067430

Fleten KG, Flørenes VA, Prasmickaite L, Hill O, Sykora J, Mælandsmo GM, Engesæter B (2016)
hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma
Cell Death Discov, 2, 16081
DOI 10.1038/cddiscovery.2016.81, PubMed 28028438

McGowan M, Hoven AS, Lund-Iversen M, Solberg S, Helland Å, Hirsch FR, Brustugun OT (2016)
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma
Lung Cancer, 103, 52-57
DOI 10.1016/j.lungcan.2016.11.018, PubMed 28024696

Kyte JA, Aamdal S, Dueland S, Sæbøe-Larsen S, Inderberg EM, Madsbu UE, Skovlund E, Gaudernack G, Kvalheim G (2016)
Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells
Oncoimmunology, 5 (11), e1232237
DOI 10.1080/2162402X.2016.1232237, PubMed 27999747

Eide HA, Halvorsen AR, Sandhu V, Fåne A, Berg J, Haakensen VD, Kure EH, Brustugun OT, Kiserud CE, Kyte JA, Helland Å (2016)
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Clin Transl Immunology, 5 (11), e109
DOI 10.1038/cti.2016.65, PubMed 27990285

Skotland T, Ekroos K, Kauhanen D, Simolin H, Seierstad T, Berge V, Sandvig K, Llorente A (2016)
Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers
Eur J Cancer, 70, 122-132
DOI 10.1016/j.ejca.2016.10.011, PubMed 27914242

Silwal-Pandit L, Langerød A, Børresen-Dale AL (2017)
TP53 Mutations in Breast and Ovarian Cancer
Cold Spring Harb Perspect Med, 7 (1)
DOI 10.1101/cshperspect.a026252, PubMed 27815305

Fleten KG, Bakke KM, Mælandsmo GM, Abildgaard A, Redalen KR, Flatmark K (2016)
Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases
Clin Exp Metastasis, 34 (1), 51-62
DOI 10.1007/s10585-016-9829-3, PubMed 27812769

Nähse V, Christ L, Stenmark H, Campsteijn C (2016)
The Abscission Checkpoint: Making It to the Final Cut
Trends Cell Biol, 27 (1), 1-11
DOI 10.1016/j.tcb.2016.10.001, PubMed 27810282

Thorgersen EB, Goscinski MA, Spasojevic M, Solbakken AM, Mariathasan AB, Boye K, Larsen SG, Flatmark K (2016)
Deep Pelvic Surgical Site Infection After Radiotherapy and Surgery for Locally Advanced Rectal Cancer
Ann Surg Oncol, 24 (3), 721-728
DOI 10.1245/s10434-016-5621-5, PubMed 27766561

Christ L, Raiborg C, Wenzel EM, Campsteijn C, Stenmark H (2016)
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery
Trends Biochem Sci, 42 (1), 42-56
DOI 10.1016/j.tibs.2016.08.016, PubMed 27669649

Fiorito E, Sharma Y, Gilfillan S, Wang S, Singh SK, Satheesh SV, Katika MR, Urbanucci A, Thiede B, Mills IG, Hurtado A (2016)
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Nucleic Acids Res, 44 (22), 10588-10602
DOI 10.1093/nar/gkw785, PubMed 27638884

Dominguez-Valentin M, Wernhoff P, Cajal AR, Kalfayan PG, Piñero TA, Gonzalez ML, Ferro A, Sammartino I, Causada Calo NS, Vaccaro CA (2016)
MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
Front Oncol, 6, 189
DOI 10.3389/fonc.2016.00189, PubMed 27606285

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H (2016)
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
DOI 10.1038/bjc.2016.278, PubMed 27599042

Schink KO, Tan KW, Stenmark H (2016)
Phosphoinositides in Control of Membrane Dynamics
Annu Rev Cell Dev Biol, 32, 143-171
DOI 10.1146/annurev-cellbio-111315-125349, PubMed 27576122

Tekpli X, Skaug V, Bæra R, Phillips DH, Haugen A, Mollerup S (2016)
Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
Cell Oncol (Dordr), 39 (6), 583-589
DOI 10.1007/s13402-016-0295-3, PubMed 27572263

Mathelier A, Xin B, Chiu TP, Yang L, Rohs R, Wasserman WW (2016)
DNA Shape Features Improve Transcription Factor Binding Site Predictions In Vivo
Cell Syst, 3 (3), 278-286.e4
DOI 10.1016/j.cels.2016.07.001, PubMed 27546793

Sandhu V, Wedge DC, Bowitz Lothe IM, Labori KJ, Dentro SC, Buanes T, Skrede ML, Dalsgaard AM, Munthe E, Myklebost O, Lingjærde OC, Børresen-Dale AL, Ikdahl T, Van Loo P, Nord S, Kure EH (2016)
The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Cancer Res, 76 (17), 5092-102
DOI 10.1158/0008-5472.CAN-16-0658, PubMed 27488532

Sveen A, Løes IM, Alagaratnam S, Nilsen G, Høland M, Lingjærde OC, Sorbye H, Berg KC, Horn A, Angelsen JH, Knappskog S, Lønning PE, Lothe RA (2016)
Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection
PLoS Genet, 12 (7), e1006225
DOI 10.1371/journal.pgen.1006225, PubMed 27472274

Mensali N, Ying F, Sheng VO, Yang W, Walseng E, Kumari S, Fallang LE, Kolstad A, Uckert W, Malmberg KJ, Wälchli S, Olweus J (2016)
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Oncoimmunology, 5 (5), e1138199
DOI 10.1080/2162402X.2016.1138199, PubMed 27467957

Hessvik NP, Øverbye A, Brech A, Torgersen ML, Jakobsen IS, Sandvig K, Llorente A (2016)
PIKfyve inhibition increases exosome release and induces secretory autophagy
Cell Mol Life Sci, 73 (24), 4717-4737
DOI 10.1007/s00018-016-2309-8, PubMed 27438886

Quigley DA, Kandyba E, Huang P, Halliwill KD, Sjölund J, Pelorosso F, Wong CE, Hirst GL, Wu D, Delrosario R, Kumar A, Balmain A (2016)
Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer
Cell Rep, 16 (4), 1153-1165
DOI 10.1016/j.celrep.2016.06.061, PubMed 27425619

Lesurf R, Aure MR, Mørk HH, Vitelli V, Oslo Breast Cancer Research Consortium (OSBREAC), Lundgren S, Børresen-Dale AL, Kristensen V, Wärnberg F, Hallett M, Sørlie T (2016)
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
Cell Rep, 16 (4), 1166-1179
DOI 10.1016/j.celrep.2016.06.051, PubMed 27396337

Skotland T, Ekroos K, Kavaliauskiene S, Bergan J, Kauhanen D, Lintonen T, Sandvig K (2016)
Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics
J Mol Biol, 428 (24 Pt A), 4856-4866
DOI 10.1016/j.jmb.2016.06.013, PubMed 27363608

Blaker YN, Spetalen S, Brodtkorb M, Lingjaerde OC, Beiske K, Østenstad B, Sander B, Wahlin BE, Melen CM, Myklebust JH, Holte H, Delabie J, Smeland EB (2016)
The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era
Br J Haematol, 175 (1), 102-14
DOI 10.1111/bjh.14201, PubMed 27341313

Raiborg C, Stenmark H (2016)
Plasma membrane repairs by small GTPase Rab3a
J Cell Biol, 213 (6), 613-5
DOI 10.1083/jcb.201606006, PubMed 27325788

Våtsveen TK, Børset M, Dikic A, Tian E, Micci F, Lid AH, Meza-Zepeda LA, Coward E, Waage A, Sundan A, Kuehl WM, Holien T (2016)
VOLIN and KJON-Two novel hyperdiploid myeloma cell lines
Genes Chromosomes Cancer, 55 (11), 890-901
DOI 10.1002/gcc.22388, PubMed 27311012

Ramberg H, Grytli HH, Nygård S, Wang W, Ögren O, Zhao S, Løvf M, Katz B, Skotheim RI, Bjartell A, Eri LM, Berge V, Svindland A, Taskén KA (2016)
PBX3 is a putative biomarker of aggressive prostate cancer
Int J Cancer, 139 (8), 1810-20
DOI 10.1002/ijc.30220, PubMed 27273830

Wegner CS, Gaustad JV, Andersen LM, Simonsen TG, Rofstad EK (2016)
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content
J Transl Med, 14 (1), 161
DOI 10.1186/s12967-016-0920-y, PubMed 27268062

Møller P, Seppälä T, Bernstein I, Holinski-Feder E, Sala P, Evans DG, Lindblom A, Macrae F, Blanco I, Sijmons R, Jeffries J, Vasen H, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen J, Jenkins M, Green K, Lalloo F, Sunde L, Mints M et al. (2016)
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
Gut, 66 (9), 1657-1664
DOI 10.1136/gutjnl-2016-311403, PubMed 27261338

Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN (2016)
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-41
DOI 10.1126/science.aaf2288, PubMed 27198675

Haakensen VD, Nygaard V, Greger L, Aure MR, Fromm B, Bukholm IR, Lüders T, Chin SF, Git A, Caldas C, Kristensen VN, Brazma A, Børresen-Dale AL, Hovig E, Helland Å (2016)
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer, 139 (5), 1117-28
DOI 10.1002/ijc.30142, PubMed 27082076

Raiborg C, Wenzel EM, Pedersen NM, Stenmark H (2016)
ER-endosome contact sites in endosome positioning and protrusion outgrowth
Biochem Soc Trans, 44 (2), 441-6
DOI 10.1042/BST20150246, PubMed 27068952

Raiborg C, Wenzel EM, Pedersen NM, Stenmark H (2016)
Phosphoinositides in membrane contact sites
Biochem Soc Trans, 44 (2), 425-30
DOI 10.1042/BST20150190, PubMed 27068950

Campsteijn C, Vietri M, Stenmark H (2016)
Novel ESCRT functions in cell biology: spiraling out of control?
Curr Opin Cell Biol, 41, 1-8
DOI 10.1016/j.ceb.2016.03.008, PubMed 27031044

Sørlie T (2016)
The Impact of Gene Expression Patterns in Breast Cancer
Clin Chem, 62 (8), 1150-1
DOI 10.1373/clinchem.2015.253229, PubMed 27022070

Vietri M, Stenmark H, Campsteijn C (2016)
Closing a gap in the nuclear envelope
Curr Opin Cell Biol, 40, 90-97
DOI 10.1016/j.ceb.2016.03.001, PubMed 27016712

Fjeldbo CS, Julin CH, Lando M, Forsberg MF, Aarnes EK, Alsner J, Kristensen GB, Malinen E, Lyng H (2016)
Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer
Clin Cancer Res, 22 (16), 4067-76
DOI 10.1158/1078-0432.CCR-15-2322, PubMed 27012812

Flatmark K, Saelen MG, Hole KH, Abrahamsen TW, Fleten KG, Hektoen HH, Redalen KR, Seierstad T, Dueland S, Ree AH (2016)
Individual tumor volume responses to short-course oxaliplatin-containing induction chemotherapy in locally advanced rectal cancer - Targeting the tumor for radiation sensitivity?
Radiother Oncol, 119 (3), 505-11
DOI 10.1016/j.radonc.2016.02.020, PubMed 26968754

Christ L, Wenzel EM, Liestøl K, Raiborg C, Campsteijn C, Stenmark H (2016)
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
J Cell Biol, 212 (5), 499-513
DOI 10.1083/jcb.201507009, PubMed 26929449

Rofstad EK, Simonsen TG, Huang R, Andersen LM, Galappathi K, Ellingsen C, Wegner CS, Hauge A, Gaustad JV (2016)
Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
Cancer Lett, 373 (2), 147-55
DOI 10.1016/j.canlet.2016.01.047, PubMed 26828134

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG (2016)
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779

Juzeniene A, Grigalavicius M, Ma LW, Juraleviciute M (2016)
Folic acid and its photoproducts, 6-formylpterin and pterin-6-carboxylic acid, as generators of reactive oxygen species in skin cells during UVA exposure
J Photochem Photobiol B, 155, 116-21
DOI 10.1016/j.jphotobiol.2016.01.001, PubMed 26780587

Björklund AT, Clancy T, Goodridge JP, Béziat V, Schaffer M, Hovig E, Ljunggren HG, Ljungman PT, Malmberg KJ (2016)
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
J Immunol, 196 (3), 1400-11
DOI 10.4049/jimmunol.1501434, PubMed 26746188

Simonsen TG, Gaustad JV, Rofstad EK (2015)
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
J Exp Clin Cancer Res, 34, 150
DOI 10.1186/s13046-015-0264-0, PubMed 26667022

Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
Cancer Res, 76 (1), 108-16
DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575

Jacobs B, Tognarelli S, Poller K, Bader P, Mackensen A, Ullrich E (2015)
NK Cell Subgroups, Phenotype, and Functions After Autologous Stem Cell Transplantation
Front Immunol, 6, 583
DOI 10.3389/fimmu.2015.00583, PubMed 26635797

Eikenes ÅH, Malerød L, Lie-Jensen A, Sem Wegner C, Brech A, Liestøl K, Stenmark H, Haglund K (2015)
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
Development, 142 (23), 4107-18
DOI 10.1242/dev.124370, PubMed 26628094

Quigley DA, Kristensen V (2015)
Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells
Mol Oncol, 9 (10), 2054-62
DOI 10.1016/j.molonc.2015.10.003, PubMed 26607741

Sioud M, Westby P, Olsen JK, Mobergslien A (2015)
Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells
Mol Ther Methods Clin Dev, 2, 15043
DOI 10.1038/mtm.2015.43, PubMed 26605373

Liu LL, Pfefferle A, Yi Sheng VO, Björklund AT, Béziat V, Goodridge JP, Malmberg KJ (2015)
Harnessing adaptive natural killer cells in cancer immunotherapy
Mol Oncol, 9 (10), 1904-17
DOI 10.1016/j.molonc.2015.10.001, PubMed 26604011

Bjaanæs MM, Fleischer T, Halvorsen AR, Daunay A, Busato F, Solberg S, Jørgensen L, Kure E, Edvardsen H, Børresen-Dale AL, Brustugun OT, Tost J, Kristensen V, Helland Å (2015)
Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
Mol Oncol, 10 (2), 330-43
DOI 10.1016/j.molonc.2015.10.021, PubMed 26601720

Sandhu V, Bowitz Lothe IM, Labori KJ, Skrede ML, Hamfjord J, Dalsgaard AM, Buanes T, Dube G, Kale MM, Sawant S, Kulkarni-Kale U, Børresen-Dale AL, Lingjærde OC, Kure EH (2015)
Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma
Mol Oncol, 10 (2), 303-16
DOI 10.1016/j.molonc.2015.10.011, PubMed 26590090

Gorad SS, Ellingsen C, Bathen TF, Mathiesen BS, Moestue SA, Rofstad EK (2015)
Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS
Neoplasia, 17 (10), 767-75
DOI 10.1016/j.neo.2015.10.001, PubMed 26585232

Theodossiou TA, Wälchli S, Olsen CE, Skarpen E, Berg K (2015)
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462

Olweus J (2015)
Cancer immunotherapy--Converting immune failure to clinical response
Mol Oncol, 9 (10), 1891-3
DOI 10.1016/j.molonc.2015.10.017, PubMed 26563645

Andersson Y, Engebraaten O, Juell S, Aamdal S, Brunsvig P, Fodstad Ø, Dueland S (2015)
Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
Br J Cancer, 113 (11), 1548-55
DOI 10.1038/bjc.2015.380, PubMed 26554649

Karpanen T, Olweus J (2015)
T-cell receptor gene therapy--ready to go viral?
Mol Oncol, 9 (10), 2019-42
DOI 10.1016/j.molonc.2015.10.006, PubMed 26548533

Pickard A, Mills IG (2015)
Maintaining a Healthy Balance: Targeting TERT to Stem Benign Prostatic Hyperplasia
Eur Urol, 69 (4), 555-556
DOI 10.1016/j.eururo.2015.10.028, PubMed 26520704

Skrbo N, Tenstad E, Mælandsmo GM, Sørlie T, Andersen K (2015)
From autonomy to community; new perspectives on tumorigenicity and therapy resistance
Cancer Treat Rev, 41 (10), 809-13
DOI 10.1016/j.ctrv.2015.10.004, PubMed 26519005

Béziat V, Sleiman M, Goodridge JP, Kaarbø M, Liu LL, Rollag H, Ljunggren HG, Zimmer J, Malmberg KJ (2015)
Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients
Front Immunol, 6, 507
DOI 10.3389/fimmu.2015.00507, PubMed 26500647

Hansen GL, Gaudernack G, Brunsvig PF, Cvancarova M, Kyte JA (2015)
Immunological factors influencing clinical outcome in lung cancer patients after telomerase peptide vaccination
Cancer Immunol Immunother, 64 (12), 1609-21
DOI 10.1007/s00262-015-1766-5, PubMed 26498005

Knutsen JH, Rødland GE, Bøe CA, Håland TW, Sunnerhagen P, Grallert B, Boye E (2015)
Stress-induced inhibition of translation independently of eIF2α phosphorylation
J Cell Sci, 128 (23), 4420-7
DOI 10.1242/jcs.176545, PubMed 26493332

Fromm B, Billipp T, Peck LE, Johansen M, Tarver JE, King BL, Newcomb JM, Sempere LF, Flatmark K, Hovig E, Peterson KJ (2015)
A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome
Annu Rev Genet, 49, 213-42
DOI 10.1146/annurev-genet-120213-092023, PubMed 26473382

Klokk TI, Kavaliauskiene S, Sandvig K (2015)
Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic
Cell Mol Life Sci, 73 (6), 1301-16
DOI 10.1007/s00018-015-2049-1, PubMed 26407609

Sanner T, Grimsrud TK (2015)
Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review
Front Oncol, 5, 196
DOI 10.3389/fonc.2015.00196, PubMed 26380225

Egeland EV, Boye K, Pettersen SJ, Haugen MH, Øyjord T, Malerød L, Flatmark K, Mælandsmo GM (2015)
Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes
Clin Exp Metastasis, 32 (8), 755-67
DOI 10.1007/s10585-015-9742-1, PubMed 26349943

Haakensen VD, Steinfeld I, Saldova R, Shehni AA, Kifer I, Naume B, Rudd PM, Børresen-Dale AL, Yakhini Z (2015)
Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome
Mol Oncol, 10 (1), 59-72
DOI 10.1016/j.molonc.2015.08.002, PubMed 26321095

Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
Oncogene, 35 (19), 2413-27
DOI 10.1038/onc.2015.318, PubMed 26300000

Goodridge JP, Önfelt B, Malmberg KJ (2015)
Newtonian cell interactions shape natural killer cell education
Immunol Rev, 267 (1), 197-213
DOI 10.1111/imr.12325, PubMed 26284479

Nygaard V, Rødland EA, Hovig E (2015)
Methods that remove batch effects while retaining group differences may lead to exaggerated confidence in downstream analyses
Biostatistics, 17 (1), 29-39
DOI 10.1093/biostatistics/kxv027, PubMed 26272994

Zhen Y, Stenmark H (2015)
Cellular functions of Rab GTPases at a glance
J Cell Sci, 128 (17), 3171-6
DOI 10.1242/jcs.166074, PubMed 26272922

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
DOI 10.1093/nar/gkv744, PubMed 26250117

Hektoen HH, Ree AH, Redalen KR, Flatmark K (2015)
Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells
J Enzyme Inhib Med Chem, 31 (5), 779-86
DOI 10.3109/14756366.2015.1069286, PubMed 26244271

Kolstad A, Olweus J (2015)
"In situ" vaccination for systemic effects in follicular lymphoma
Oncoimmunology, 4 (7), e1014773
DOI 10.1080/2162402X.2015.1014773, PubMed 26140239

Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H (2015)
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443

Bettum IJ, Gorad SS, Barkovskaya A, Pettersen S, Moestue SA, Vasiliauskaite K, Tenstad E, Øyjord T, Risa Ø, Nygaard V, Mælandsmo GM, Prasmickaite L (2015)
Metabolic reprogramming supports the invasive phenotype in malignant melanoma
Cancer Lett, 366 (1), 71-83
DOI 10.1016/j.canlet.2015.06.006, PubMed 26095603

Flåtten I, Fossum-Raunehaug S, Taipale R, Martinsen S, Skarstad K (2015)
The DnaA Protein Is Not the Limiting Factor for Initiation of Replication in Escherichia coli
PLoS Genet, 11 (6), e1005276
DOI 10.1371/journal.pgen.1005276, PubMed 26047361

Raiborg C, Wenzel EM, Stenmark H (2015)
ER-endosome contact sites: molecular compositions and functions
EMBO J, 34 (14), 1848-58
DOI 10.15252/embj.201591481, PubMed 26041457

Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H (2015)
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
Nature, 522 (7555), 231-5
DOI 10.1038/nature14408, PubMed 26040712

Mills IG (2015)
Molecular subtyping of prostate cancer: a partnership model
Eur Urol, 68 (4), 568-9
DOI 10.1016/j.eururo.2015.05.012, PubMed 26001612

Lund KV, Simonsen TG, Hompland T, Kristensen GB, Rofstad EK (2015)
Short-term pretreatment DCE-MRI in prediction of outcome in locally advanced cervical cancer
Radiother Oncol, 115 (3), 379-85
DOI 10.1016/j.radonc.2015.05.001, PubMed 25998804

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952

Aure MR, Jernström S, Krohn M, Vollan HK, Due EU, Rødland E, Kåresen R, Oslo Breast Cancer Research Consortium (OSBREAC), Ram P, Lu Y, Mills GB, Sahlberg KK, Børresen-Dale AL, Lingjærde OC, Kristensen VN (2015)
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer
Genome Med, 7 (1), 21
DOI 10.1186/s13073-015-0135-5, PubMed 25873999

Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H (2015)
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
Nature, 520 (7546), 234-8
DOI 10.1038/nature14359, PubMed 25855459

Grigalavicius M, Moan J, Dahlback A, Juzeniene A (2015)
Vitamin D and ultraviolet phototherapy in Caucasians
J Photochem Photobiol B, 147, 69-74
DOI 10.1016/j.jphotobiol.2015.03.009, PubMed 25846579

Prasmickaite L, Berge G, Bettum IJ, Aamdal S, Hansson J, Bastholt L, Øijordsbakken M, Boye K, Mælandsmo GM (2015)
Evaluation of serum osteopontin level and gene polymorphism as biomarkers: analyses from the Nordic Adjuvant Interferon alpha Melanoma trial
Cancer Immunol Immunother, 64 (6), 769-76
DOI 10.1007/s00262-015-1686-4, PubMed 25832001

Generalov R, Kuan WB, Chen W, Kristensen S, Juzenas P (2015)
Radiosensitizing effect of zinc oxide and silica nanocomposites on cancer cells
Colloids Surf B Biointerfaces, 129, 79-86
DOI 10.1016/j.colsurfb.2015.03.026, PubMed 25829130

Enqvist M, Ask EH, Forslund E, Carlsten M, Abrahamsen G, Béziat V, Andersson S, Schaffer M, Spurkland A, Bryceson Y, Önfelt B, Malmberg KJ (2015)
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells
J Immunol, 194 (9), 4518-27
DOI 10.4049/jimmunol.1401972, PubMed 25825444

Saetre F, Hagen LK, Engedal N, Seglen PO (2015)
Novel steps in the autophagic-lysosomal pathway
FEBS J, 282 (11), 2202-14
DOI 10.1111/febs.13268, PubMed 25779646

Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
Mol Oncol, 9 (6), 1129-39
DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404

Bostad M, Olsen CE, Peng Q, Berg K, Høgset A, Selbo PK (2015)
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J Control Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331

Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
Neoplasia, 17 (2), 167-74
DOI 10.1016/j.neo.2014.12.005, PubMed 25748235

Helgesen E, Fossum-Raunehaug S, Sætre F, Schink KO, Skarstad K (2015)
Dynamic Escherichia coli SeqA complexes organize the newly replicated DNA at a considerable distance from the replisome
Nucleic Acids Res, 43 (5), 2730-43
DOI 10.1093/nar/gkv146, PubMed 25722374

Berstad MB, Cheung LH, Berg K, Peng Q, Fremstedal AS, Patzke S, Rosenblum MG, Weyergang A (2015)
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy
Oncogene, 34 (44), 5582-92
DOI 10.1038/onc.2015.15, PubMed 25684137

Potapenko IO, Lüders T, Russnes HG, Helland Å, Sørlie T, Kristensen VN, Nord S, Lingjærde OC, Børresen-Dale AL, Haakensen VD (2015)
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival
Mol Oncol, 9 (4), 861-76
DOI 10.1016/j.molonc.2014.12.013, PubMed 25655580

Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE (2015)
Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma
Hepatology, 61 (5), 1651-9
DOI 10.1002/hep.27707, PubMed 25644509

Eikenes ÅH, Malerød L, Christensen AL, Steen CB, Mathieu J, Nezis IP, Liestøl K, Huynh JR, Stenmark H, Haglund K (2015)
ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo
PLoS Genet, 11 (1), e1004904
DOI 10.1371/journal.pgen.1004904, PubMed 25635693

Braadland PR, Ramberg H, Grytli HH, Taskén KA (2015)
β-Adrenergic Receptor Signaling in Prostate Cancer
Front Oncol, 4, 375
DOI 10.3389/fonc.2014.00375, PubMed 25629002

Blaker YN, Brodtkorb M, Maddison J, Hveem TS, Nesheim JA, Mohn HM, Kolstad A, Geisler CH, Liestøl K, Smeland EB, Holte H, Delabie J, Danielsen H (2015)
Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma
Histopathology, 67 (1), 62-9
DOI 10.1111/his.12624, PubMed 25431344

Skotland T, Sandvig K (2021)
Transport of nanoparticles across the endothelial cell layer
Nano Today, 36, 101029
DOI 10.1016/j.nantod.2020.101029

Tan KW (2021)
First person - Kia Wee Tan
J. Cell Sci., 134 (14), jcs259055
DOI 10.1242/jcs.259055