Publications
Publications published since 2003 from OUS - Dept. of Microbiology, Tønjum - Genome dynamics
79 publications found
Publications 2024
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Activity against Mycobacterium tuberculosis of a new class of spirooxindolopyrrolidine embedded chromanone hybrid heterocycles
RSC Adv, 14 (17), 11604-11613
DOI 10.1039/d4ra01501k, PubMed 38605893 -
Differential Abundance of Protein Acylation in Mycobacterium tuberculosis Under Exposure to Nitrosative Stress
Proteomics Clin Appl, e202300212 (in press)
DOI 10.1002/prca.202300212, PubMed 39082596 -
Identification of essential oils with strong activity against stationary phase Mycobacterium abscessus
Heliyon, 10 (5), e27073
DOI 10.1016/j.heliyon.2024.e27073, PubMed 38463856 -
Antimicrobial and Antibiofilm Effects of Bithionol against Mycobacterium abscessus
Antibiotics (Basel), 13 (6)
DOI 10.3390/antibiotics13060529, PubMed 38927195 -
Design and Synthesis of the Linezolid Bioisosteres to Resolve the Serotonergic Toxicity Associated with Linezolid
ACS Med Chem Lett, 15 (6), 924-937
DOI 10.1021/acsmedchemlett.4c00114, PubMed 38894926
Publications 2023
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Repurposing Azoles to Resolve Serotogenic Toxicity Associated with Linezolid to Combat Multidrug-Resistant Tuberculosis
ACS Med Chem Lett, 14 (12), 1754-1759
DOI 10.1021/acsmedchemlett.3c00406, PubMed 38116435 -
Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant
J Med Chem, 66 (16), 11056-11077
DOI 10.1021/acs.jmedchem.3c00358, PubMed 37485869 -
Novel Quinoline-Based Thiosemicarbazide Derivatives: Synthesis, DFT Calculations, and Investigation of Antitubercular, Antibacterial, and Antifungal Activities
ACS Omega, 8 (43), 40140-40152
DOI 10.1021/acsomega.3c03018, PubMed 37929089
Publications 2022
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Proteome Profiling of Mycobacterium tuberculosis Cells Exposed to Nitrosative Stress
ACS Omega, 7 (4), 3470-3482
DOI 10.1021/acsomega.1c05923, PubMed 35128256 -
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities
Drug Dev Res, 83 (6), 1292-1304
DOI 10.1002/ddr.21958, PubMed 35769019 -
Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity
Pharmaceuticals (Basel), 15 (10)
DOI 10.3390/ph15101301, PubMed 36297413 -
Linking azoles to isoniazid via hydrazone bridge: Synthesis, crystal structure determination, antitubercular evaluation and computational studies
Journal of Molecular Liquids, 354, 118873
DOI 10.1016/j.molliq.2022.118873, PublikaID 422 -
Synthesis, characterization, anti-tuberculosis activity and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety
Journal of Molecular Structure, 1270, 133899
DOI 10.1016/j.molstruc.2022.133899, PublikaID 421
Publications 2021
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[Pregnant women should be screened for asymptomatic bacteriuria]
Tidsskr Nor Laegeforen, 141 (11)
DOI 10.4045/tidsskr.21.0379, PubMed 34423934 -
Lipid droplets and the transcriptome of Mycobacterium tuberculosis from direct sputa: a literature review
Lipids Health Dis, 20 (1), 129
DOI 10.1186/s12944-021-01550-5, PubMed 34602073 -
Correction: Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study
PLoS One, 16 (10), e0258457
DOI 10.1371/journal.pone.0258457, PubMed 34614019 -
Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia
Front Microbiol, 12, 743198
DOI 10.3389/fmicb.2021.743198, PubMed 34938276
Publications 2020
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Antibiotic resistance: turning evolutionary principles into clinical reality
FEMS Microbiol Rev, 44 (2), 171-188
DOI 10.1093/femsre/fuaa001, PubMed 31981358 -
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
iScience, 23 (10), 101556
DOI 10.1016/j.isci.2020.101556, PubMed 33083725 -
Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study
PLoS One, 15 (8), e0236362
DOI 10.1371/journal.pone.0236362, PubMed 32797053 -
Frequency and patterns of first- and second-line drug resistance-conferring mutations in Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in a cross-sectional study in Tigray Region, Ethiopia
J Glob Antimicrob Resist, 24, 6-13
DOI 10.1016/j.jgar.2020.11.017, PubMed 33279682 -
Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism
Front Microbiol, 11, 550760
DOI 10.3389/fmicb.2020.550760, PubMed 33072011
Publications 2019
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Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide
Antimicrob Agents Chemother, 63 (6)
DOI 10.1128/AAC.02681-18, PubMed 30858213
Publications 2018
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A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis
Microb Genom, 4 (11)
DOI 10.1099/mgen.0.000222, PubMed 30251949 -
The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease
Curr Med Chem, 25 (40), 5578-5587
DOI 10.2174/0929867324666170616110111, PubMed 28618998 -
Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood
Neurosci Lett, 672, 53-58
DOI 10.1016/j.neulet.2018.02.043, PubMed 29474873
Publications 2017
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Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis
BMC Microbiol, 17 (1), 96
DOI 10.1186/s12866-017-1004-8, PubMed 28431522 -
Nε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains: Proteins Involved in Bioenergetics, Virulence, and Antimicrobial Resistance Are Acetylated
J Proteome Res, 16 (11), 4045-4059
DOI 10.1021/acs.jproteome.7b00429, PubMed 28920697 -
A non-canonical mismatch repair pathway in prokaryotes
Nat Commun, 8, 14246
DOI 10.1038/ncomms14246, PubMed 28128207 -
The helicase DinG responds to stress due to DNA double strand breaks
PLoS One, 12 (11), e0187900
DOI 10.1371/journal.pone.0187900, PubMed 29121674 -
DprA from Neisseria meningitidis: properties and role in natural competence for transformation
Microbiology (Reading), 163 (7), 1016-1029
DOI 10.1099/mic.0.000489, PubMed 28696187 -
Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance
Neurosci Lett, 645, 46-52
DOI 10.1016/j.neulet.2017.02.062, PubMed 28242328 -
Tuberculosis Outbreak in an Educational Institution in Norway
J Clin Microbiol, 55 (5), 1327-1333
DOI 10.1128/JCM.01152-16, PubMed 28202795 -
Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence
Front Microbiol, 8, 795
DOI 10.3389/fmicb.2017.00795, PubMed 28536560
Publications 2016
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Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
DOI 10.1371/journal.pone.0164588, PubMed 27736945 -
Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease
Mol Brain, 9 (1), 61
DOI 10.1186/s13041-016-0237-z, PubMed 27234294 -
The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
BMC Genomics, 17 (1), 791
DOI 10.1186/s12864-016-3132-1, PubMed 27724857 -
Deciphering the recent phylogenetic expansion of the originally deeply rooted Mycobacterium tuberculosis lineage 7
BMC Evol Biol, 16 (1), 146
DOI 10.1186/s12862-016-0715-z, PubMed 27363525 -
Throat culture positivity rate and antibiotic susceptibility pattern of beta-hemolytic streptococci in children on secondary prophylaxis for rheumatic heart disease
BMC Infect Dis, 16 (1), 510
DOI 10.1186/s12879-016-1841-3, PubMed 27663649
Publications 2015
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Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro
Neurotoxicology, 48, 61-7
DOI 10.1016/j.neuro.2015.03.001, PubMed 25757835 -
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
DOI 10.1371/journal.pone.0134954, PubMed 26248334 -
Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Clin Exp Gastroenterol, 8, 49-67
DOI 10.2147/CEG.S70119, PubMed 25624769 -
Mycobacterium tuberculosis lineage 7 strains are associated with prolonged patient delay in seeking treatment for pulmonary tuberculosis in Amhara Region, Ethiopia
J Clin Microbiol, 53 (4), 1301-9
DOI 10.1128/JCM.03566-14, PubMed 25673798
Publications 2014
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Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations
PLoS One, 9 (7), e101637
DOI 10.1371/journal.pone.0101637, PubMed 24999629 -
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc
J Neurosci Res, 92 (12), 1792-800
DOI 10.1002/jnr.23444, PubMed 25043715 -
[A knot on the aquarium owner's hand]
Tidsskr Nor Laegeforen, 134 (7), 715
DOI 10.4045/tidsskr.13.1425, PubMed 24721859 -
Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility
Biophys J, 107 (7), 1523-31
DOI 10.1016/j.bpj.2014.07.061, PubMed 25296304
Publications 2013
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Dialects of the DNA uptake sequence in Neisseriaceae
PLoS Genet, 9 (4), e1003458
DOI 10.1371/journal.pgen.1003458, PubMed 23637627
Publications 2012
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Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis
PLoS One, 7 (7), e39742
DOI 10.1371/journal.pone.0039742, PubMed 22768309 -
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB
PLoS One, 7 (5), e36960
DOI 10.1371/journal.pone.0036960, PubMed 22615856 -
Gut bacterial profile in patients newly diagnosed with treatment-naïve Crohn's disease
Clin Exp Gastroenterol, 5, 173-86
DOI 10.2147/CEG.S33858, PubMed 23049264 -
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions
Microbiology (Reading), 158 (Pt 8), 1982-1993
DOI 10.1099/mic.0.058693-0, PubMed 22628485
Publications 2011
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Considered "negative" for MAP, these results would be very "positive" for tuberculoid leprosy Reply
J. Crohns Colitis, 5 (4), 374
DOI 10.1016/j.crohns.2011.04.007 -
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
DOI 10.1016/j.dnarep.2011.03.007, PubMed 21570366
Publications 2010
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Paucity of mycobacteria in mucosal bowel biopsies from adults and children with early inflammatory bowel disease
J Crohns Colitis, 4 (5), 561-6
DOI 10.1016/j.crohns.2010.05.003, PubMed 21122560
Publications 2009
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Genome dynamics in major bacterial pathogens
FEMS Microbiol Rev, 33 (3), 453-70
DOI 10.1111/j.1574-6976.2009.00173.x, PubMed 19396949 -
Molecular diagnostics in tuberculosis: basis and implications for therapy
Mol Diagn Ther, 13 (3), 137-51
DOI 10.1007/BF03256322, PubMed 19650669 -
DNA repair in Mycobacterium tuberculosis revisited
FEMS Microbiol Rev, 33 (3), 471-87
DOI 10.1111/j.1574-6976.2009.00170.x, PubMed 19385996 -
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
FEMS Immunol Med Microbiol, 56 (2), 151-61
DOI 10.1111/j.1574-695X.2009.00562.x, PubMed 19496823 -
Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair
BMC Microbiol, 9, 7
DOI 10.1186/1471-2180-9-7, PubMed 19134198
Publications 2008
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Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis
PLoS One, 3 (2), e1538
DOI 10.1371/journal.pone.0001538, PubMed 18253486 -
Infections due to various atypical mycobacteria in a Norwegian multiplex family with dominant interferon-gamma receptor deficiency
Clin Infect Dis, 46 (3), e23-7
DOI 10.1086/525855, PubMed 18171304 -
The impact of the neisserial DNA uptake sequences on genome evolution and stability
Genome Biol, 9 (3), R60
DOI 10.1186/gb-2008-9-3-r60, PubMed 18366792
Publications 2007
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Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidis
J Bacteriol, 189 (15), 5716-27
DOI 10.1128/JB.00060-07, PubMed 17526700 -
Genome instability and DNA repair in brain, ageing and neurological disease
Neuroscience, 145 (4), 1183-6
DOI 10.1016/j.neuroscience.2007.03.015, PubMed 17400394 -
DNA repair profiles of disease-associated isolates of Neisseria meningitidis
FEMS Immunol Med Microbiol, 49 (2), 243-51
DOI 10.1111/j.1574-695X.2006.00195.x, PubMed 17284282 -
Microbial genome dynamics in CNS pathogenesis
Neuroscience, 145 (4), 1375-87
DOI 10.1016/j.neuroscience.2007.01.059, PubMed 17367950 -
Genetic interactions of DNA repair pathways in the pathogen Neisseria meningitidis
J Bacteriol, 189 (15), 5728-37
DOI 10.1128/JB.00161-07, PubMed 17513474
Publications 2006
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New functional identity for the DNA uptake sequence in transformation and its presence in transcriptional terminators
J Bacteriol, 189 (5), 2077-85
DOI 10.1128/JB.01408-06, PubMed 17194793 -
Meningococcal genome dynamics
Nat Rev Microbiol, 4 (1), 11-22
DOI 10.1038/nrmicro1324, PubMed 16357857 -
Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis
J Biomol NMR, 36 Suppl 1, 68
DOI 10.1007/s10858-006-9054-5, PubMed 16933020 -
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold
J Mol Biol, 364 (2), 186-95
DOI 10.1016/j.jmb.2006.08.078, PubMed 17007878 -
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?
FEMS Microbiol Rev, 30 (6), 841-52
DOI 10.1111/j.1574-6976.2006.00038.x, PubMed 17064283 -
Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions
Mol Microbiol, 63 (1), 69-85
DOI 10.1111/j.1365-2958.2006.05482.x, PubMed 17140412
Publications 2005
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Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ
J Biol Chem, 280 (19), 18923-30
DOI 10.1074/jbc.M411603200, PubMed 15753075 -
Antimutator role of DNA glycosylase MutY in pathogenic Neisseria species
J Bacteriol, 187 (8), 2801-9
DOI 10.1128/JB.187.8.2801-2809.2005, PubMed 15805527
Publications 2004
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Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution
J Biol Chem, 279 (38), 39750-6
DOI 10.1074/jbc.M405971200, PubMed 15254043 -
Biased distribution of DNA uptake sequences towards genome maintenance genes
Nucleic Acids Res, 32 (3), 1050-8
DOI 10.1093/nar/gkh255, PubMed 14960717
Publications 2003
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Three-dimensional structure of the Neisseria meningitidis secretin PilQ determined from negative-stain transmission electron microscopy
J Bacteriol, 185 (8), 2611-7
DOI 10.1128/JB.185.8.2611-2617.2003, PubMed 12670986