Developing Precision Medicine Approaches: To create personalized treatment plans for patients with Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB) by integrating genetic, biomarker, and clinical data.
Innovative Therapeutic Strategies: To identify new drug targets and therapeutic interventions aimed at enhancing cellular clearance mechanisms in neurodegenerative diseases.
Early Diagnosis and Prevention: To develop reliable biomarkers and advanced imaging techniques for early diagnosis and potential prevention strategies for neurodegenerative diseases.
Understanding Disease Mechanisms: To elucidate the molecular and cellular pathways involved in the onset and progression of neurodegenerative diseases, with an emphasis on translational research.
Enhancing Patient Outcomes: To improve the quality of life and clinical outcomes for patients through the development of novel diagnostic tools and therapeutic strategies.
Collaborative Research Networks: To establish and expand collaborative research networks between different institutions and disciplines, fostering a multidisciplinary approach to tackling neurodegeneration.
Kirsebom BE, Nilsson J, Vromen E, Arnesen PM, Bjørnerud A, Brinkmalm A, Bråthen G, Grøntvedt GR, Jarholm J, Nordengen K, Pålhaugen L, Selnes P, Siafarikas N, Skogseth RE, Tecelão S, Waterloo K, You P, Zetterberg H, Aarsland D, Tijms B, Visser PJ, Blennow K, Fladby T(2025) Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer's disease genetic pathways Mol Neurodegener, 20(1), 107 DOI 10.1186/s13024-025-00899-w, PubMed 41084010
Knudtzon S, Nordengen K, Pålhaugen L, Gísladóttir B, Jarholm J, Bråthen G, Skogseth RE, Waterloo K, Selnes P, Fladby T, Kirsebom BE(2025) Sexual dimorphisms in innate immune activation markers in predementia Alzheimer's disease Brain Commun, 7(3), fcaf161 DOI 10.1093/braincomms/fcaf161, PubMed 40322776
Richter G, Kirsebom BE, Jarholm JA, Pålhaugen L, Gísladóttir B, Aarsland D, Grøntvedt GR, Skogseth RE, Waterloo K, Fladby T, Nordengen K(2025) Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes Neurobiol Aging, 155, 13-23 DOI 10.1016/j.neurobiolaging.2025.07.005, PubMed 40669105