Therapeutic Drug Monitoring and Clincial Toxicology

Publications 2026

Bialer M, Johannessen Landmark C, Koepp MJ, Perucca E, Perucca P, Tomson T, White HS, Wirrell E (2026)
Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development
Epilepsia (in press)
DOI 10.1002/epi.70354, PubMed 42470358

Bialer M, Johannessen Landmark C, Koepp MJ, Perucca E, Perucca P, Tomson T, White HS, Wirrell E (2026)
Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development
Epilepsia (in press)
DOI 10.1002/epi.70346, PubMed 42470359

Bruun LD, Andersen GØ, Myhre PL, Halvorsen S, Kringen MK, Hansen CH, Molden E, Øie E (2026)
Prognostic relevance of β1-adrenergic receptor polymorphisms on cardiovascular outcome in patients treated with metoprolol after acute myocardial infarction - an observational study
Eur J Clin Pharmacol, 82 (7)
DOI 10.1007/s00228-026-04091-x, PubMed 42271119

Franco V, Dattrino F, Palmisani M, Tacchella F, Tartara E, De Giorgis V, Quaranta CA, Pasca L, Rota P, Russo E, Romigi A, Johannessen Landmark C, Fedele G, Tassorelli C, Nicotera P (2026)
Clinical validation of a patient-friendly saliva microsampling approach to monitor perampanel levels in people with epilepsy
Epilepsia, 67 (7), e102-e108
DOI 10.1002/epi.70302, PubMed 42171659

Gervin K, Kverneland M, Nakken KO, Rudi K, Iversen PO, Landmark CJ, Selmer KK (2026)
DNA methylation of antiseizure medication metabolism genes and pharmacokinetic changes in adult epilepsy patients treated with the modified Atkins diet
Genes Nutr, 21 (1)
DOI 10.1186/s12263-026-00796-x, PubMed 41826818

Gjerulfsen CE, Liao VWY, Mieszczanek TS, Jakobsen AV, Gardella E, Olofsson K, Nikanorova M, Bayat A, Ortiz S, Weckhuysen S, Landmark CJ, Devinsky O, Chebib M, Ahring PK, Rubboli G, Møller RS (2026)
Add-on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss-of-function γ-aminobutyric acid type A receptor variants
Epilepsia, 67 (8), 4051-4064
DOI 10.1002/epi.70310, PubMed 42227896

Helmstaedter C, Alfstad KA, Dahl-Hansen E, Henning O, Landmark CJ, Kälviäinen R, Kyte EB, Marusic P, Mula M, Myren S, Peltola J, Rubboli G, Strzelczyk A, Jozwiak S, Lossius MI (2026)
Proceedings from ERN EpiCARE "BEYOND SEIZURES" meeting, Aalesund, Norway, May the 27th. Advancing holistic care for rare and complex epilepsies in adults
Epilepsy Behav, 178, 110879
DOI 10.1016/j.yebeh.2025.110879, PubMed 41719739

Johannessen Landmark C, Belkilani H, Awad L, Burns ML, Gottås A, Svendsen T, Sætre E (2026)
Pharmacokinetic variability and complex two-way interactions with cenobamate in patients with refractory epilepsy
Epilepsia, 67 (6), 2820-2835
DOI 10.1002/epi.70184, PubMed 41874535

Publications 2025

Berman E, Pariente G, Erenburg N, Hamed R, Landmark CJ, Kovo M, Eyal S (2025)
Folate transfer across the placenta during late pregnancy in women with epilepsy: A cross-sectional, two-center study
Epilepsia, 66 (12), 4752-4763
DOI 10.1111/epi.18575, PubMed 40782172

Bratberg A, Nygaard I, Løhne K, Gustavsen I, Opdal MS (2025)
Serum Ethanol Concentrations in Relation to Sex and Age in Patients Admitted to a Large Emergency Department During 2015-2020
Basic Clin Pharmacol Toxicol, 136 (1), e14118
DOI 10.1111/bcpt.14118, PubMed 39722461

Bruun LD, Andersen GØ, Kringen MK, Myhre PL, Halvorsen S, Hansen CH, Molden E, Øie E (2025)
Effect of metoprolol exposure following myocardial infarction on future cardiovascular events: a Mendelian randomization study
Eur J Clin Pharmacol, 81 (4), 551-560
DOI 10.1007/s00228-025-03806-w, PubMed 39900827

Gjerulfsen CE, Oudin MJ, Furia F, Gverdtsiteli S, Landmark CJ, Trivisano M, Balestrini S, Guerrini R, Aledo-Serrano A, Morcos R, Previtali R, Veggiotti P, Ricci E, Rubboli G, Gardella E, Møller RS (2025)
Cenobamate as add-on treatment for SCN8A developmental and epileptic encephalopathy
Epilepsia, 66 (4), 1119-1128
DOI 10.1111/epi.18257, PubMed 39812613

Johannessen Landmark C, Mashal S, Boldingh Debernard KA, Sannes ER, Heger K, Burns ML, Henning O (2025)
What do pharmacists know about epilepsy and antiseizure medications? - A survey among pharmacists in Norway
Epilepsy Behav, 165, 110340
DOI 10.1016/j.yebeh.2025.110340, PubMed 40015058

Johannessen Landmark C, Sætre J, Gottås A, Wolden M, McQuade TA, Kjeldsen SF, Våtevik A, Sætre E, Svendsen T, Burns ML, Øiestad EL, Johannessen SI (2025)
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy
Epilepsia, 66 (5), 1477-1491
DOI 10.1111/epi.18284, PubMed 39985501

Johannessen Landmark C, Wolden M, Sætre J, Burns ML, Heger K, Kjeldsen SF, Johannessen SI, Sætre E (2025)
A precision approach to therapeutic drug monitoring of valproate to evaluate markers of toxicity
Epilepsia, 66 (10), 3741-3756
DOI 10.1111/epi.18508, PubMed 40538198

Larsen RE, Karimi A, Krogstad T, Landmark CJ, Holm LB (2025)
High Medication Non-Adherence Rates and its Drivers in the General Population: A Cross-sectional Study Using the OMAS-37 Adherence Survey Tool
Inquiry, 62, 469580251321596
DOI 10.1177/00469580251321596, PubMed 39995052

McBride A, Henning OJ, Johannessen Landmark C, Watkins L, Tromans S, Basset P, Triantafyllopoulou P, Shankar R (2025)
Rescue epilepsy medication and training: A comparison between midazolam use, guidelines, clinical practice, and possibilities in the UK and Norway
Epilepsia Open, 10 (6), 1824-1834
DOI 10.1002/epi4.70145, PubMed 41051929

Rognstad S, Søraas CL, Brunborg C, Halvorsen LV, Brobak KM, Olsen E, Bergland OU, Aune A, Tuv SS, Svarstad AC, Clasen PE, Haldsrud R, Larstorp ACK, Helland A, Opdal MS (2025)
Pharmacokinetic Variability of Amlodipine Serum Concentration and Effect on Blood Pressure in Patients Treated for Hypertension
Pharmacol Res Perspect, 13 (4), e70140
DOI 10.1002/prp2.70140, PubMed 40616336

Vinayan KP, Asadi-Pooya AA, Jyotsna AS, Kumar NN, Elsas SM, Johannessen Landmark C, Matsabisa M, Mesraoua B, O'Callaghan F, Thiele E, Zhang C, Riney K (2025)
Availability and affordability of cannabinoids for epilepsy treatment across different geographic settings-A survey from the ILAE Plant-Based Therapy Task Force
Epilepsia, 66 (12), 4639-4653
DOI 10.1111/epi.18622, PubMed 40986286

Publications 2024

Asadi-Pooya AA, Johannessen Landmark C, Mirzaei Damabi N, Fazelian K (2024)
Interactions between antiseizure medications and foods and drinks: A systematic review
Epilepsia Open, 9 (2), 475-485
DOI 10.1002/epi4.12918, PubMed 38345419

Aune A, Ohldieck A, Halvorsen LV, Brobak KM, Olsen E, Rognstad S, Larstorp ACK, Søraas CL, Rossebø AB, Rösner A, Grytaas MA, Gerdts E (2024)
Gender Differences in Cardiac Organ Damage in Arterial Hypertension: Assessing the Role of Drug Nonadherence
High Blood Press Cardiovasc Prev, 31 (2), 157-166
DOI 10.1007/s40292-024-00632-6, PubMed 38530572

Brobak KM, Halvorsen LV, Aass HCD, Søraas CL, Aune A, Olsen E, Bergland OU, Rognstad S, Blom KB, Birkeland JAK, Høieggen A, Larstorp ACK, Solbu MD (2024)
Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage
Blood Press, 33 (1), 2323980
DOI 10.1080/08037051.2024.2323980, PubMed 38606688

Ghannoum M, Waters PJ, Hovda KE, Choquette G, Elgstøen KBP, Nygaard I, Rootwelt H, Hickey D, Yazdani M, Bourque DK (2024)
Can endogenous ethylene glycol production occur in humans? A detailed investigation of adult monozygotic twin sisters
Clin Toxicol (Phila), 62 (11), 698-706
DOI 10.1080/15563650.2024.2401076, PubMed 39327950

Gjerulfsen CE, Nikanorova M, Olofsson K, Johannessen Landmark C, Rubboli G, Møller RS (2024)
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real-world study
Epilepsia Open, 9 (5), 1891-1900
DOI 10.1002/epi4.13029, PubMed 39140199

Halvorsen LV, Søraas CL, Larstorp ACK, Hjørnholm U, Kjær VN, Liestøl K, Aune A, Olsen E, Brobak KM, Bergland OU, Rognstad S, Aarskog NR, Heimark S, Fadl Elmula FEM, Gerdts E, Mo R, Solbu MD, Opdal MS, Kjeldsen SE, Rostrup M, Høieggen A (2024)
Effect of Therapeutic Drug Monitoring on Adherence and Blood Pressure: A Multicenter Randomized Clinical Trial
Am J Hypertens, 37 (10), 826-836
DOI 10.1093/ajh/hpae059, PubMed 38713475

Havig SM, Berg-Pedersen RM, Krabseth HM, Müller LD, Haugaa K, Zare HK, Gjesdal K, Krajci P, Opdal MS (2024)
Effect on QTc interval by switching from methadone to equipotent R-methadone dose in methadone maintenance treatment patients
Basic Clin Pharmacol Toxicol, 134 (4), 519-530
DOI 10.1111/bcpt.13982, PubMed 38308508

Heger K, Burns ML, Nikanorova M, Johannessen SI, Johannessen Landmark C (2024)
Pharmacokinetic Variability of Rufinamide and Stiripentol in Children With Refractory Epilepsy: A Retrospective Study of Therapeutic Drug Monitoring From the National Epilepsy Centers in Denmark and Norway
Ther Drug Monit, 46 (5), 664-671
DOI 10.1097/FTD.0000000000001219, PubMed 38758628

Kirkeby K, Cockerell I, Christensen J, Hoei-Hansen CE, Holst L, Fredriksen MG, Lund C, Johannessen Landmark C (2024)
Pharmacokinetic variability of everolimus and impact of concomitant antiseizure medications in patients with tuberous sclerosis complex: A retrospective study of therapeutic drug monitoring data in Denmark and Norway
Medicine (Baltimore), 103 (32), e39244
DOI 10.1097/MD.0000000000039244, PubMed 39121325

Larsen RE, Hole K, Selle ML, Johannessen Landmark C, Krogstad T, Holm LB (2024)
Access to a tailored mobile application enhances medication adherence among young users of antidepressants
Front Pharmacol, 15, 1379700
DOI 10.3389/fphar.2024.1379700, PubMed 38659579

Opdal MS, Rognstad S, Edvardsen F, Halvorsen LV, Mo R, Gustavsen I, Larstorp ACK, Søraas CL, Helland A (2024)
[Correction: Usefulness of measuring the serum concentration of antihypertensive drugs in uncontrolled hypertension]
Tidsskr Nor Laegeforen, 144
DOI 10.4045/tidsskr.24.0407, PubMed 39149754

Opdal MS, Rognstad S, Edvardsen F, Halvorsen LV, Mo R, Gustavsen I, Larstorp ACK, Søraas CL, Helland A (2024)
Usefulness of measuring the serum concentration of antihypertensive drugs in uncontrolled hypertension
Tidsskr Nor Laegeforen, 144 (9)
DOI 10.4045/tidsskr.24.0167, PubMed 39167005

Publications 2023

Cockerell I, Christensen J, Hoei-Hansen CE, Holst L, Grenaa Frederiksen M, Issa-Epe AI, Nedregaard B, Solhoff R, Heimdal K, Johannessen Landmark C, Lund C, Nærland T (2023)
Effectiveness and safety of everolimus treatment in patients with tuberous sclerosis complex in real-world clinical practice
Orphanet J Rare Dis, 18 (1), 377
DOI 10.1186/s13023-023-02982-1, PubMed 38042867

Heger K, Kjeldstadli K, Ring N, Aaberg KM, Kjeldsen SF, Burns ML, Johannessen SI, Johannessen Landmark C (2023)
Pharmacokinetic Variability of Sulthiame: The Impact of Age, Drug-Drug Interactions, and Biochemical Markers of Toxicity in Patients with Epilepsy
Ther Drug Monit, 46 (2), 237-245
DOI 10.1097/FTD.0000000000001146, PubMed 38158595

Johannessen Landmark C, Eyal S, Burns ML, Franco V, Johannessen SI (2023)
Pharmacological aspects of antiseizure medications: From basic mechanisms to clinical considerations of drug interactions and use of therapeutic drug monitoring
Epileptic Disord, 25 (4), 454-471
DOI 10.1002/epd2.20069, PubMed 37259844

Palmisani M, Tartara E, Johannessen Landmark C, Crema F, De Giorgis V, Varesio C, Fattore C, Rota P, Russo E, Franco V (2023)
Therapeutic Salivary Monitoring of Perampanel in Patients with Epilepsy Using a Volumetric Absorptive Microsampling Technique
Pharmaceutics, 15 (8)
DOI 10.3390/pharmaceutics15082030, PubMed 37631244

Pedersen S, Kverneland M, Rudi K, Gervin K, Landmark CJ, Iversen PO, Selmer KK (2023)
Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet
Epilepsia Open, 8 (3), 858-866
DOI 10.1002/epi4.12746, PubMed 37057954

Smith RL, Molden E, Bernard JP (2023)
Effect of CYP2D6 and CYP2C19 genotypes on atomoxetine serum levels: A study based on therapeutic drug monitoring data
Br J Clin Pharmacol, 89 (7), 2246-2253
DOI 10.1111/bcp.15706, PubMed 36851891

Publications 2022

Halvorsen LV, Bergland OU, Søraas CL, Larstorp ACK, Hjørnholm U, Kjær VN, Kringen MK, Clasen PE, Haldsrud R, Kjeldsen SE, Rostrup M, Fadl Elmula FEM, Opdal MS, Høieggen A (2022)
Nonadherence by Serum Drug Analyses in Resistant Hypertension: 7-Year Follow-Up of Patients Considered Adherent by Directly Observed Therapy
J Am Heart Assoc, 11 (18), e025879
DOI 10.1161/JAHA.121.025879, PubMed 36073648

Heger K, Skipsfjord J, Kiselev Y, Burns ML, Aaberg KM, Johannessen SI, Skurtveit S, Johannessen Landmark C (2022)
Changes in the use of antiseizure medications in children and adolescents in Norway, 2009-2018
Epilepsy Res, 181, 106872
DOI 10.1016/j.eplepsyres.2022.106872, PubMed 35180640

Henning O, Alfstad KÅ, Johannessen Landmark C, Helmstaedter C, Lossius MI, Holth Skogan A (2022)
Use of screening tools to assess comorbidities and adverse events in patients with epilepsy. A European Reference Network for Rare and Complex Epilepsies (EpiCARE) survey
Seizure, 101, 237-243
DOI 10.1016/j.seizure.2022.09.008, PubMed 36115293

Larsen RE, Pripp AH, Krogstad T, Johannessen Landmark C, Holm LB (2022)
Development and validation of a new non-disease-specific survey tool to assess self-reported adherence to medication
Front Pharmacol, 13, 981368
DOI 10.3389/fphar.2022.981368, PubMed 36569319

Larsson D, Baftiu A, Johannessen Landmark C, von Euler M, Kumlien E, Åsberg S, Zelano J (2022)
Association Between Antiseizure Drug Monotherapy and Mortality for Patients With Poststroke Epilepsy
JAMA Neurol, 79 (2), 169-175
DOI 10.1001/jamaneurol.2021.4584, PubMed 34902006

Revdal E, Morken G, Bakken IJ, Bråthen G, Landmark CJ, Brodtkorb E (2022)
Bidirectionality of antiseizure and antipsychotic treatment: A population-based study
Epilepsy Behav, 136, 108911
DOI 10.1016/j.yebeh.2022.108911, PubMed 36126553

Svendsen T, Brodtkorb E, Linge HL, Burns ML, Johannessen SI, Nakken KO, Lossius MI, Landmark CJ (2022)
Efficacy, tolerability and pharmacokinetic variability of brivaracetam in adults with difficult-to-treat epilepsy
Epilepsy Res, 183, 106946
DOI 10.1016/j.eplepsyres.2022.106946, PubMed 35609355

Thorstensen CW, Clasen PE, Rognstad S, Haldsrud R, Føreid S, Helstrøm T, Bergland OU, Halvorsen LV, Aune A, Olsen E, Brobak KM, Høieggen A, Gustavsen I, Larstorp ACK, Søraas CL, Opdal MS (2022)
Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension
J Pharm Biomed Anal, 219, 114908
DOI 10.1016/j.jpba.2022.114908, PubMed 35803015

Publications 2021

Baumgartner T, Carreño M, Rocamora R, Bisulli F, Boni A, Brázdil M, Horak O, Craiu D, Pereira C, Guerrini R, San Antonio-Arce V, Schulze-Bonhage A, Zuberi SM, Hallböök T, Kalviainen R, Lagae L, Nguyen S, Quintas S, Franco A, Cross JH, Walker M, Arzimanoglou A, Rheims S, Granata T, Canafoglia L, Johannessen Landmark C, Sen A, Rattihalli R, Nabbout R, Tartara E et al. (2021)
A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies
Epilepsia Open, 6 (1), 160-170
DOI 10.1002/epi4.12459, PubMed 33681659

Bergland OU, Halvorsen LV, Søraas CL, Hjørnholm U, Kjær VN, Rognstad S, Brobak KM, Aune A, Olsen E, Fauchald YM, Heimark S, Thorstensen CW, Liestøl K, Solbu MD, Gerdts E, Mo R, Rostrup M, Kjeldsen SE, Høieggen A, Opdal MS, Larstorp ACK, Fadl Elmula FEM (2021)
Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations
Hypertension, 78 (3), 617-628
DOI 10.1161/HYPERTENSIONAHA.121.17514, PubMed 34275336

Johannessen Landmark C, Potschka H, Auvin S, Wilmshurst JM, Johannessen SI, Kasteleijn-Nolst Trenité D, Wirrell EC (2021)
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
Epilepsia, 62 (4), 857-873
DOI 10.1111/epi.16849, PubMed 33638459

Landmark CJ, Rektorli L, Burns ML, Revdal E, Johannessen SI, Brodtkorb E (2021)
Pharmacokinetic data on brivaracetam, lacosamide and perampanel during pregnancy and lactation
Epileptic Disord, 23 (2), 426-431
DOI 10.1684/epd.2021.1273, PubMed 33935028

Midtlyng L, Høiseth G, Luytkis H, Kristoffersen L, Le Nygaard I, Strand MC, Arnestad M, Vevelstad M (2021)
Relationship between betahydroxybutyrate (BHB) and acetone concentrations in postmortem blood and cause of death
Forensic Sci Int, 321, 110726
DOI 10.1016/j.forsciint.2021.110726, PubMed 33631622

Mochol M, Whatmore P, Taubøll E, Landmark CJ, Ropstad E, Svalheim S, Fraser TWK (2021)
Lamotrigine effects on immune gene expression in larval zebrafish
Epilepsy Res, 178, 106823
DOI 10.1016/j.eplepsyres.2021.106823, PubMed 34844088

Rognstad S, Søraas CL, Bergland OU, Høieggen A, Strømmen M, Helland A, Opdal MS (2021)
Establishing Serum Reference Ranges for Antihypertensive Drugs
Ther Drug Monit, 43 (1), 116-125
DOI 10.1097/FTD.0000000000000806, PubMed 32881780

Publications 2020

Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O, The Cannabinoids International Experts Panel, Collaborators (2020)
Epilepsy and cannabidiol: a guide to treatment
Epileptic Disord, 22 (1), 1-14
DOI 10.1684/epd.2020.1141, PubMed 32096470

Franco V, Gatti G, Mazzucchelli I, Marchiselli R, Fattore C, Rota P, Galimberti CA, Capovilla G, Beccaria F, De Giorgis V, Johannessen Landmark C, Perucca E (2020)
Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy
Epilepsia, 61 (7), e79-e84
DOI 10.1111/epi.16584, PubMed 32562438

Heger K, Lund C, Larsen Burns M, Bjørnvold M, Sætre E, Johannessen SI, Johannessen Landmark C (2020)
A retrospective review of changes and challenges in the use of antiseizure medicines in Dravet syndrome in Norway
Epilepsia Open, 5 (3), 432-441
DOI 10.1002/epi4.12413, PubMed 32913951

Johannessen Landmark C, Heger K, Lund C, Burns ML, Bjørnvold M, Sætre E, Johannessen SI (2020)
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome
Ther Drug Monit, 42 (5), 744-753
DOI 10.1097/FTD.0000000000000781, PubMed 32558674

Johannessen Landmark C, Johannessen SI, Patsalos PN (2020)
Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
Expert Opin Drug Metab Toxicol, 16 (3), 227-238
DOI 10.1080/17425255.2020.1724956, PubMed 32054370

Landmark CJ, Brandl U (2020)
Pharmacology and drug interactions of cannabinoids
Epileptic Disord, 22 (S1), 16-22
DOI 10.1684/epd.2019.1123, PubMed 31941642

Svendsen T, Brodtkorb E, Baftiu A, Lossius MI, Nakken KO, Johannessen SI, Johannessen Landmark C (2020)
Clinical experience combined with therapeutic drug monitoring of lacosamide
Acta Neurol Scand, 141 (4), 279-286
DOI 10.1111/ane.13206, PubMed 31853958

Publications 2019

Alvestad S, Bjørnvold M, Molteberg E, Lossius M, Landmark CJ (2019)
[Continued importance of valproate for women with generalised epilepsy]
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.19.0220, PubMed 30969058

Baftiu A, Lima MH, Svendsen K, Larsson PG, Johannessen SI, Landmark CJ (2019)
Safety aspects of antiepileptic drugs-a population-based study of adverse effects relative to changes in utilisation
Eur J Clin Pharmacol, 75 (8), 1153-1160
DOI 10.1007/s00228-019-02678-1, PubMed 31001654

Bruun LD, Kjeldstadli K, Temte V, Birdal M, Bachs L, Langødegård M, Strand DH, Gaare KI, Øiestad E, Høiseth G (2019)
Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing
J Anal Toxicol, 43 (5), 369-377
DOI 10.1093/jat/bky083, PubMed 30615130

Frost J, Bernard JP, Dietrichs ES, Kjeldstadli K, Riedel B, Skrastad RB, Vevelstad M, Helland A (2019)
New recommendations for serum concentration measurements of central stimulant drugs
Tidsskr. Nor. Laegeforen., 139 (13), 1230-1231

Granas AG, Halvorsen KH, Wendelbo J, Johannessen Landmark C (2019)
Interdisciplinary medication review to improve pharmacotherapy for patients with intellectual disabilities
Int J Clin Pharm, 41 (6), 1516-1525
DOI 10.1007/s11096-019-00914-3, PubMed 31729635

Henning O, Johannessen Landmark C, Nakken KO, Lossius MI (2019)
Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence
Epilepsia, 60 (5), e58-e62
DOI 10.1111/epi.14734, PubMed 30980675

Henning O, Johannessen Landmark C, Traeen B, Svendsen T, Farmen A, Nakken KO, Lossius M (2019)
Sexual function in people with epilepsy: Similarities and differences with the general population
Epilepsia, 60 (9), 1984-1992
DOI 10.1111/epi.16311, PubMed 31407332

Henning O, Landmark CJ, Henning D, Nakken KO, Lossius MI (2019)
Challenges in epilepsy-The perspective of Norwegian epilepsy patients
Acta Neurol Scand, 140 (1), 40-47
DOI 10.1111/ane.13098, PubMed 30963535

Henning O, Lossius MI, Lima M, Mevåg M, Villagran A, Nakken KO, Johannessen Landmark C (2019)
Refractory epilepsy and nonadherence to drug treatment
Epilepsia Open, 4 (4), 618-623
DOI 10.1002/epi4.12367, PubMed 31819918

Johannessen Landmark C, Fløgstad I, Baftiu A, Syvertsen M, Enger U, Koht J, Johannessen SI (2019)
Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Res, 155, 106148
DOI 10.1016/j.eplepsyres.2019.05.016, PubMed 31195184

Johannessen Landmark C, Fløgstad I, Syvertsen M, Baftiu A, Enger U, Koht J, Johannessen SI (2019)
Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Behav, 98 (Pt A), 110-116
DOI 10.1016/j.yebeh.2019.05.021, PubMed 31330379

Larsen Burns M, Kinge E, Stokke Opdal M, Johannessen SI, Johannessen Landmark C (2019)
Therapeutic drug monitoring of gabapentin in various indications
Acta Neurol Scand, 139 (5), 446-454
DOI 10.1111/ane.13075, PubMed 30710348

Larsen Burns M, Nikanorova M, Baftiu A, Borg Rasmussen J, Johannessen SI, Johannessen Landmark C (2019)
Pharmacokinetic Variability and Clinical Use of Lacosamide in Children and Adolescents in Denmark and Norway
Ther Drug Monit, 41 (3), 340-347
DOI 10.1097/FTD.0000000000000599, PubMed 30688870

Temte V, Kjeldstadli K, Bruun LD, Birdal M, Bachs L, Karinen R, Middelkoop G, Øiestad E, Høiseth G (2019)
An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses
J Anal Toxicol, 43 (2), 104-111
DOI 10.1093/jat/bky062, PubMed 30517712

Publications 2018

Johannessen Landmark C, Farmen AH, Burns ML, Baftiu A, Lossius MI, Johannessen SI, Tomson T (2018)
Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring
Epilepsy Res, 141, 31-37
DOI 10.1016/j.eplepsyres.2018.02.004, PubMed 29453075

Müller LD, Opdal MS (2018)
Developing a rapid semi-automated sample preparation with alkaline hydrolysis in a 96-well plate for quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in urine samples by UHPLC-MS/MS
J Pharm Biomed Anal, 161, 296-304
DOI 10.1016/j.jpba.2018.08.045, PubMed 30189411

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C (2018)
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines
Drug Des Devel Ther, 12, 271-280
DOI 10.2147/DDDT.S154388, PubMed 29467570

Serk TT, Le Nygaard I, Kvan E, Frost J, Aronsen L, Narum S, Bjanes T (2018)
Immediate telephonic alerting of deviating pharmacological test results
Tidsskr. Nor. Laegeforen., 138 (18), 1694-1695

Serkland TT, Nygaard IL, Kvan E, Frost J, Aronsen L, Narum S, Bjånes T (2018)
Immediate telephonic alerting of deviating pharmacological test results
Tidsskr Nor Laegeforen, 138 (18)
DOI 10.4045/tidsskr.18.0776, PubMed 30421739

Syvertsen M, Fløgstad I, Enger U, Landmark CJ, Koht J (2018)
Antiepileptic drug withdrawal in juvenile myoclonic epilepsy
Acta Neurol Scand, 139 (2), 192-198
DOI 10.1111/ane.13042, PubMed 30378684

Publications 2017

Baftiu A, Feet SA, Larsson PG, Burns ML, Henning O, Sætre E, Molden E, Granas AG, Johannessen SI, Landmark CJ (2017)
Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015
Epilepsy Res, 139, 35-42
DOI 10.1016/j.eplepsyres.2017.11.001, PubMed 29175562

Baftiu A, Landmark CJ, Rusten IR, Feet SA, Johannessen SI, Larsson PG (2017)
Erratum to: Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders-A pharmacoepidemiological study and clinical implications
Eur J Clin Pharmacol, 73 (6), 791-792
DOI 10.1007/s00228-017-2252-0, PubMed 28389679

Burns ML, Lang AM (2017)
The authors reply
Pediatr Crit Care Med, 18 (1), 98
DOI 10.1097/PCC.0000000000001023, PubMed 28060165

Høiseth G, Gottås A, Berg T, Arnestad M, Halvorsen PS, Bachs LC (2017)
Urinary Kinetics of Heroin Metabolites in Pigs Shortly After Intake
J Anal Toxicol, 41 (5), 451-454
DOI 10.1093/jat/bkx017, PubMed 28335030

Johannessen Landmark C, Burns ML, Baftiu A, Farmen AH, Lossius MI, Johannessen SI, Tomson T (2017)
Pharmacokinetic variability of valproate in women of childbearing age
Epilepsia, 58 (10), e142-e146
DOI 10.1111/epi.13872, PubMed 28833045

Kringen MK, Chalabianloo F, Bernard JP, Bramness JG, Molden E, Høiseth G (2017)
Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment
Ther Drug Monit, 39 (5), 550-555
DOI 10.1097/FTD.0000000000000437, PubMed 28723731

Pisani LR, Nikanorova M, Landmark CJ, Johannessen SI, Pisani F (2017)
Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities
Curr Pharm Des, 23 (37), 5639-5648
DOI 10.2174/1381612823666170926103631, PubMed 28950817

Reimers A, Berg JA, Burns ML, Landmark CJ (2017)
Harmonised reference ranges for antiepileptic drugs
Tidsskr Nor Laegeforen, 137 (12-13), 864-865
DOI 10.4045/tidsskr.17.0392, PubMed 28655236

Reimers A, Berg JA, Burns ML, Landmark CJ (2017)
Common reference range for antiepileptics
Tidsskr. Nor. Laegeforen., 137 (12-13), 864-865

Svendsen T, Brodtkorb E, Baftiu A, Burns ML, Johannessen SI, Johannessen Landmark C (2017)
Therapeutic Drug Monitoring of Lacosamide in Norway: Focus on Pharmacokinetic Variability, Efficacy and Tolerability
Neurochem Res, 42 (7), 2077-2083
DOI 10.1007/s11064-017-2234-8, PubMed 28349359

Publications 2016

Baftiu A, Johannessen Landmark C, Rusten IR, Feet SA, Johannessen SI, Larsson PG (2016)
Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders-a pharmacoepidemiological study and clinical implications
Eur J Clin Pharmacol, 72 (10), 1245-1254
DOI 10.1007/s00228-016-2092-3, PubMed 27411937

Burns ML, Baftiu A, Opdal MS, Johannessen SI, Landmark CJ (2016)
Therapeutic Drug Monitoring of Clobazam and Its Metabolite-Impact of Age and Comedication on Pharmacokinetic Variability
Ther Drug Monit, 38 (3), 350-7
DOI 10.1097/FTD.0000000000000272, PubMed 26751267

Burns ML, Stensvold HJ, Risnes K, Guthe HJ, Astrup H, Nordhov SM, Selberg TR, Rønnestad A, Lang AM, Norwegian Neonatal Network (2016)
Inotropic Therapy in Newborns, A Population-Based National Registry Study
Pediatr Crit Care Med, 17 (10), 948-956
DOI 10.1097/PCC.0000000000000898, PubMed 27500723

Gottås A, Arnestad M, Halvorsen PS, Bachs LC, Høiseth G (2016)
Pharmacokinetics of heroin and its metabolites in vitreous humor and blood in a living pig model
Forensic Toxicol, 34 (2), 277-285
DOI 10.1007/s11419-016-0315-z, PubMed 27660664

Haga C, Opdal MS, Tuv SS, Zahl PH, Stenberg-Nilsen H (2016)
[Drug safety associated with the change of digitalis drug in Norway]
Tidsskr Nor Laegeforen, 136 (20), 1714-1718
DOI 10.4045/tidsskr.15.0161, PubMed 27830905

Halvorsen KH, Johannessen Landmark C, Granas AG (2016)
Prevalence of Different Combinations of Antiepileptic Drugs and CNS Drugs in Elderly Home Care Service and Nursing Home Patients in Norway
Epilepsy Res Treat, 2016, 5153093
DOI 10.1155/2016/5153093, PubMed 27525114

Johannessen Landmark C, Henning O, Johannessen SI (2016)
Proconvulsant effects of antidepressants - What is the current evidence?
Epilepsy Behav, 61, 287-291
DOI 10.1016/j.yebeh.2016.01.029, PubMed 26926001

Johannessen Landmark C, Svendsen T, Dinarevic J, Kufaas RF, Reimers A, Brodtkorb E, Baftiu A, Burns ML, Johannessen SI (2016)
The Impact of Pharmacokinetic Interactions With Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice
Ther Drug Monit, 38 (4), 499-505
DOI 10.1097/FTD.0000000000000306, PubMed 27414974

Landmark CJ, Johannessen SI, Tomson T (2016)
Dosing strategies for antiepileptic drugs: from a standard dose for all to individualised treatment by implementation of therapeutic drug monitoring
Epileptic Disord, 18 (4), 367-383
DOI 10.1684/epd.2016.0880, PubMed 27965183

Mevaag M, Henning O, Baftiu A, Granas AG, Johannessen SI, Nakken KO, Johannessen Landmark C (2016)
Discrepancies between physicians' prescriptions and patients' use of antiepileptic drugs
Acta Neurol Scand, 135 (1), 80-87
DOI 10.1111/ane.12578, PubMed 26923477

Opdal MS, Johansen PW (2016)
Useful and necessary about new anticoagulants
Tidsskr Nor Laegeforen, 136 (18), 1505
DOI 10.4045/tidsskr.16.0786, PubMed 27731583

Svendsen T, Brodtkorb E, Reimers A, Molden E, Sætre E, Johannessen SI, Johannessen Landmark C (2016)
Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate-A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome
Epilepsy Res, 129, 125-131
DOI 10.1016/j.eplepsyres.2016.12.001, PubMed 28043062

Publications 2015

Baftiu A, Johannessen Landmark C, Nikaj V, Neslein IL, Johannessen SI, Perucca E (2015)
Availability of antiepileptic drugs across Europe
Epilepsia, 56 (12), e191-7
DOI 10.1111/epi.13210, PubMed 26477534

Beiske GA, Holmøy T, Beiske AG, Johannessen SI, Johannessen Landmark C (2015)
Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis
Mult Scler Int, 2015, 317859
DOI 10.1155/2015/317859, PubMed 26221541

Bernard JP, Khiabani HZ, Hilberg T, Karinen R, Slørdal L, Waal H, Mørland J (2015)
Characteristics of methadone-related fatalities in Norway
J Forensic Leg Med, 36, 114-20
DOI 10.1016/j.jflm.2015.09.011, PubMed 26439870

Gottås A, Ripel Å, Boix F, Vindenes V, Mørland J, Øiestad EL (2015)
Determination of dopamine concentrations in brain extracellular fluid using microdialysis with short sampling intervals, analyzed by ultra high performance liquid chromatography tandem mass spectrometry
J Pharmacol Toxicol Methods, 74, 75-9
DOI 10.1016/j.vascn.2015.06.002, PubMed 26123500

Hjelmeland K, Gustavsen I, Bernard JP, Mørland J (2015)
Can a simple clinical test detect impairment of zopiclone and alcohol? - A randomized controlled trial
Forensic Sci Int, 248, 129-33
DOI 10.1016/j.forsciint.2014.12.028, PubMed 25617762

Johannessen Landmark C, Beiske G, Baftiu A, Burns ML, Johannessen SI (2015)
Experience from therapeutic drug monitoring and gender aspects of gabapentin and pregabalin in clinical practice
Seizure, 28, 88-91
DOI 10.1016/j.seizure.2015.02.017, PubMed 25758302

Johannessen Landmark C, I Johannessen S (2015)
Pharmacotherapy in epilepsy - does gender affect safety?
Expert Opin Drug Saf, 15 (1), 1-4
DOI 10.1517/14740338.2016.1117606, PubMed 26650146

Karlsen Bjånes T, Mjåset Hjertø E, Lønne L, Aronsen L, Andsnes Berg J, Bergan S, Otto Berg-Hansen G, Bernard JP, Larsen Burns M, Toralf Fosen J, Frost J, Hilberg T, Krabseth HM, Kvan E, Narum S, Austgulen Westin A (2015)
Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services
Clin Ther, 38 (1), 222-6
DOI 10.1016/j.clinthera.2015.10.015, PubMed 26546404

Opdal MS, Arnesen M, Müller LD, Hullstein I, Sayed K, Brørs O, Kringen M, Sagedal S, Gjesdal K, Krajci P (2015)
Effects of Hemodialysis on Methadone Pharmacokinetics and QTc
Clin Ther, 37 (7), 1594-9
DOI 10.1016/j.clinthera.2015.04.009, PubMed 25963997

Publications 2014

Gottås A, Boix F, Øiestad EL, Vindenes V, Mørland J (2014)
Role of 6-monoacetylmorphine in the acute release of striatal dopamine induced by intravenous heroin
Int J Neuropsychopharmacol, 17 (9), 1357-65
DOI 10.1017/S1461145714000169, PubMed 24576415

Høiseth G, Fjeld B, Burns ML, Strand DH, Vindenes V (2014)
Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20°C
Forensic Sci Int, 239, 6-10
DOI 10.1016/j.forsciint.2014.03.008, PubMed 24709028

Kringen MK, Piehler AP, Grimholt RM, Opdal MS, Haug KB, Urdal P (2014)
Serum bilirubin concentration in healthy adult North-Europeans is strictly controlled by the UGT1A1 TA-repeat variants
PLoS One, 9 (2), e90248
DOI 10.1371/journal.pone.0090248, PubMed 24587300

Publications 2013

Al-Samarraie MS, Vevelstad M, Nygaard IL, Bachs L, Mørland J (2013)
[Intoxation with paramethoxymethamphetamine]
Tidsskr Nor Laegeforen, 133 (9), 966-9
DOI 10.4045/tidsskr.12.0417, PubMed 23652145

Gottås A, Øiestad EL, Boix F, Vindenes V, Ripel Å, Thaulow CH, Mørland J (2013)
Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats
Br J Pharmacol, 170 (3), 546-56
DOI 10.1111/bph.12305, PubMed 23865556

Henning O, Baftiu A, Johannessen SI, Landmark CJ (2013)
Withdrawal of antiepileptic drugs during presurgical video-EEG monitoring: an observational study for evaluation of current practice at a referral center for epilepsy
Acta Neurol Scand, 129 (4), 243-51
DOI 10.1111/ane.12179, PubMed 23980664

Karinen R, Vindenes V, Morild I, Johnsen L, Le Nygaard I, Christophersen AS (2013)
Methyl tert-butyl ether (MTBE) detected in abnormally high concentrations in postmortem blood and urine from two persons found dead inside a car containing a gasoline spill
J Forensic Sci, 58 (5), 1393-1396
DOI 10.1111/1556-4029.12208, PubMed 23879346

Karouni M, Henning O, Larsson PG, Johannessen SI, Johannessen Landmark C (2013)
Pharmacological treatment of psychiatric comorbidity in patients with refractory epilepsy
Epilepsy Behav, 29 (1), 77-81
DOI 10.1016/j.yebeh.2013.06.031, PubMed 23939032

Korczyn AD, Schachter SC, Brodie MJ, Dalal SS, Engel J, Guekht A, Hecimovic H, Jerbi K, Kanner AM, Johannessen Landmark C, Mares P, Marusic P, Meletti S, Mula M, Patsalos PN, Reuber M, Ryvlin P, Štillová K, Tuchman R, Rektor I (2013)
Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)
Epilepsy Behav, 28 (2), 283-302
DOI 10.1016/j.yebeh.2013.03.012, PubMed 23764496

Sørgaard G, Landmark CJ (2013)
[Electronic prescriptions and cooperation]
Tidsskr Nor Laegeforen, 133 (2), 133
DOI 10.4045/tidsskr.12.1471, PubMed 23344589

Tomson T, Landmark CJ, Battino D (2013)
Antiepileptic drug treatment in pregnancy: changes in drug disposition and their clinical implications
Epilepsia, 54 (3), 405-14
DOI 10.1111/epi.12109, PubMed 23360413

Publications 2012

Bernard JP, Havnes I, Slørdal L, Waal H, Mørland J, Khiabani HZ (2012)
Methadone-related deaths in Norway
Forensic Sci Int, 224 (1-3), 111-6
DOI 10.1016/j.forsciint.2012.11.010, PubMed 23246070

Fjeld B, Burns ML, Karinen R, Larssen B, Smith-Kielland A, Vindenes V (2012)
Long-term stability of GHB in post-mortem samples and samples from living persons, stored at -20°C, using fluoride preservatives
Forensic Sci Int, 222 (1-3), 47-51
DOI 10.1016/j.forsciint.2012.04.033, PubMed 22648054

Gottas A, Oiestad EL, Boix F, Ripel A, Thaulow CH, Pettersen BS, Vindenes V, Morland J (2012)
Simultaneous measurement of heroin and its metabolites in brain extracellular fluid by microdialysis and ultra performance liquid chromatography tandem mass spectrometry
J Pharmacol Toxicol Methods, 66 (1), 14-21
DOI 10.1016/j.vascn.2012.04.009, PubMed 22561414

Gustavsen I, Hjelmeland K, Bernard JP, Mørland J (2012)
Individual psychomotor impairment in relation to zopiclone and ethanol concentrations in blood--a randomized controlled double-blinded trial
Addiction, 107 (5), 925-32
DOI 10.1111/j.1360-0443.2011.03693.x, PubMed 22008377

Johannessen Landmark C, Baftiu A, Tysse I, Valsø B, Larsson PG, Rytter E, Johannessen SI (2012)
Pharmacokinetic variability of four newer antiepileptic drugs, lamotrigine, levetiracetam, oxcarbazepine, and topiramate: a comparison of the impact of age and comedication
Ther Drug Monit, 34 (4), 440-5
DOI 10.1097/FTD.0b013e31825ee389, PubMed 22777154

Johannessen Landmark C, Patsalos PN (2012)
Methodologies used to identify and characterize interactions among antiepileptic drugs
Expert Rev Clin Pharmacol, 5 (3), 281-92
DOI 10.1586/ecp.12.10, PubMed 22697591

Opdal MS (2012)
[Sick from sickness, substance abuse or medicine]
Tidsskr Nor Laegeforen, 132 (1), 52
DOI 10.4045/tidsskr.11.0906, PubMed 22240832

Publications 2011

Bogstrand ST, Normann PT, Rossow I, Larsen M, Mørland J, Ekeberg Ø (2011)
Prevalence of alcohol and other substances of abuse among injured patients in a Norwegian emergency department
Drug Alcohol Depend, 117 (2-3), 132-8
DOI 10.1016/j.drugalcdep.2011.01.007, PubMed 21316163

Gustavsen I, Hjelmeland K, Bernard JP, Mørland J (2011)
Psychomotor performance after intake of zopiclone compared with intake of ethanol: a randomized, controlled, double-blinded trial
J Clin Psychopharmacol, 31 (4), 481-8
DOI 10.1097/JCP.0b013e3182214be6, PubMed 21694628

Johannessen Landmark C, Johannessen SI, Tomson T (2011)
Host factors affecting antiepileptic drug delivery-pharmacokinetic variability
Adv Drug Deliv Rev, 64 (10), 896-910
DOI 10.1016/j.addr.2011.10.003, PubMed 22063021

Landmark CJ, Fossmark H, Larsson PG, Rytter E, Johannessen SI (2011)
[The prescription registry and abuse of pregabalin]
Tidsskr Nor Laegeforen, 131 (3), 223
DOI 10.4045/tidsskr.10.1328, PubMed 21304565

Landmark CJ, Fossmark H, Larsson PG, Rytter E, Johannessen SI (2011)
Prescription patterns of antiepileptic drugs in patients with epilepsy in a nation-wide population
Epilepsy Res, 95 (1-2), 51-9
DOI 10.1016/j.eplepsyres.2011.02.012, PubMed 21435840

Landmark CJ, Johannessen SI (2011)
Safety aspects of antiepileptic drugs--focus on pharmacovigilance
Pharmacoepidemiol Drug Saf, 21 (1), 11-20
DOI 10.1002/pds.2269, PubMed 22069221

Landmark CJ, Larsson PG, Rytter E, Johannessen SI (2011)
[Clarification about pregabalin and the Norwegian Prescription Database]
Tidsskr Nor Laegeforen, 131 (8), 800-1
DOI 10.4045/tidsskr.11.0292, PubMed 21556068

Vindenes V, Yttredal B, Oiestad EL, Waal H, Bernard JP, Mørland JG, Christophersen AS (2011)
Oral fluid is a viable alternative for monitoring drug abuse: detection of drugs in oral fluid by liquid chromatography-tandem mass spectrometry and comparison to the results from urine samples from patients treated with Methadone or Buprenorphine
J Anal Toxicol, 35 (1), 32-9
DOI 10.1093/anatox/35.1.32, PubMed 21219701

Publications 2010

Al-Samarraie MS, Karinen R, Mørland J, Stokke Opdal M (2010)
Blood GHB concentrations and results of medical examinations in 25 car drivers in Norway
Eur J Clin Pharmacol, 66 (10), 987-98
DOI 10.1007/s00228-010-0870-x, PubMed 20717656

Gjerde H, Øiestad EL, Øiestad ÅM, Langødegård M, Gustavsen I, Hjelmeland K, Bernard JP, Christophersen AS (2010)
Comparison of zopiclone concentrations in oral fluid sampled with Intercept(®) oral specimen collection device and Statsure Saliva Sampler™ and concentrations in blood
J Anal Toxicol, 34 (9), 590-3
DOI 10.1093/jat/34.9.590, PubMed 21073813

Johannessen Landmark C, Patsalos PN (2010)
Drug interactions involving the new second- and third-generation antiepileptic drugs
Expert Rev Neurother, 10 (1), 119-40
DOI 10.1586/ern.09.136, PubMed 20021326

Johannessen SI, Landmark CJ (2010)
Antiepileptic drug interactions - principles and clinical implications
Curr Neuropharmacol, 8 (3), 254-67
DOI 10.2174/157015910792246254, PubMed 21358975

Karouni M, Arulthas S, Larsson PG, Rytter E, Johannessen SI, Landmark CJ (2010)
Psychiatric comorbidity in patients with epilepsy: a population-based study
Eur J Clin Pharmacol, 66 (11), 1151-60
DOI 10.1007/s00228-010-0861-y, PubMed 20669014

Kringen MK, Haug KB, Grimholt RM, Stormo C, Narum S, Opdal MS, Fosen JT, Piehler AP, Johansen PW, Seljeflot I, Berg JP, Brørs O (2010)
Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction
J Biomed Biotechnol, 2011, 739751
DOI 10.1155/2011/739751, PubMed 21127708

Publications 2009

Al-Samarraie MS, Karinen R, Rognum T, Hasvold I, Opdal Stokke M, Christophersen AS (2009)
Lethal poisoning with ethiofencarb and ethanol
J Anal Toxicol, 33 (7), 389-92
DOI 10.1093/jat/33.7.389, PubMed 19796510

Bernard JP, Mørland J, Krogh M, Khiabani HZ (2009)
Methadone and impairment in apprehended drivers
Addiction, 104 (3), 457-64
DOI 10.1111/j.1360-0443.2008.02470.x, PubMed 19207356

Johannessen Landmark C, Larsson PG, Rytter E, Johannessen SI (2009)
Antiepileptic drugs in epilepsy and other disorders--a population-based study of prescriptions
Epilepsy Res, 87 (1), 31-9
DOI 10.1016/j.eplepsyres.2009.07.005, PubMed 19679449

Oiestad EL, Johansen U, Stokke Opdal M, Bergan S, Christophersen AS (2009)
Determination of digoxin and digitoxin in whole blood
J Anal Toxicol, 33 (7), 372-8
DOI 10.1093/jat/33.7.372, PubMed 19796507

Rytter E, Landmark CJ, Johannessen SI (2009)
Antiepileptic drug treatment of children at a referral centre for epilepsy--does admission make a difference?
Seizure, 18 (8), 573-9
DOI 10.1016/j.seizure.2009.05.011, PubMed 19576793

Vindenes V, Pettersen BS, Gottås A, Christiansen NL, Boix F, Mørland J (2009)
Different effects on dopamine release in nucleus accumbens in mice by the morphine metabolites morphine-6-glucuronide and morphine-3-glucuronide
Basic Clin Pharmacol Toxicol, 105 (5), 357-60
DOI 10.1111/j.1742-7843.2009.00451.x, PubMed 19663818

Publications 2008

Høiseth G, Bernard JP, Stephanson N, Normann PT, Christophersen AS, Mørland J, Helander A (2008)
Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment
Alcohol Alcohol, 43 (2), 187-91
DOI 10.1093/alcalc/agm175, PubMed 18230699

Johannessen Landmark C (2008)
Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy
CNS Drugs, 22 (1), 27-47
DOI 10.2165/00023210-200822010-00003, PubMed 18072813

Johannessen Landmark C, Johannessen SI (2008)
Pharmacological management of epilepsy: recent advances and future prospects
Drugs, 68 (14), 1925-39
DOI 10.2165/00003495-200868140-00001, PubMed 18778117

Johannessen SI, Landmark CJ (2008)
Value of therapeutic drug monitoring in epilepsy
Expert Rev Neurother, 8 (6), 929-39
DOI 10.1586/14737175.8.6.929, PubMed 18505358

Khiabani HZ, Opdal MS, Mørland J (2008)
Blood alcohol concentrations in apprehended drivers of cars and boats suspected to be impaired by the police
Traffic Inj Prev, 9 (1), 31-6
DOI 10.1080/15389580701737629, PubMed 18338292

Landmark CJ (2008)
Antiepileptic drugs in non-epilepsy disorders - Relations between mechanisms of action and clinical efficacy
CNS Drugs, 22 (1), 27-47

Landmark CJ, Johannessen SI (2008)
Modifications of antiepileptic drugs for improved tolerability and efficacy
Perspect Medicin Chem, 2, 21-39
PubMed 19787095

Landmark CJ, Johannessen SI (2008)
Pharmacological Management of Epilepsy Recent Advances and Future Prospects
Drugs, 68 (14), 1925-1939

Landmark CJ, Patsalos PN (2008)
Interactions between antiepileptic drugs and herbal medicines
Bol. Latinoam. Caribe Plantas M., 7 (2), 108-118

Vindenes V, Karinen R, Hasvold I, Bernard JP, Mørland JG, Christophersen AS (2008)
Bromadiolone poisoning: LC-MS method and pharmacokinetic data
J Forensic Sci, 53 (4), 993-6
DOI 10.1111/j.1556-4029.2008.00737.x, PubMed 18482378

Publications 2007

Al-Samarraie M, Khiabani HZ, Opdal MS (2007)
[Khat--a new drug of abuse in Norway]
Tidsskr Nor Laegeforen, 127 (5), 574-6
PubMed 17332809

Bernard JP, Opdal MS, Karinen R, Mørland J, Khiabani HZ (2007)
Relationship between methadone and EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in urine samples from Norwegian prisons
Eur J Clin Pharmacol, 63 (8), 777-82
DOI 10.1007/s00228-007-0314-4, PubMed 17576548

Landmark CJ, Rytter E, Johannessen SI (2007)
Clinical use of antiepileptic drugs at a referral centre for epilepsy
Seizure, 16 (4), 356-64
DOI 10.1016/j.seizure.2007.02.006, PubMed 17420145

Publications 2006

Bernard JP, Opdal MS, Khiabani H (2006)
[General pharmacodynamic principles]
Tidsskr Nor Laegeforen, 126 (16), 2107-9
PubMed 16932780

Kristoffersen L, Øiestad EL, Opdal MS, Krogh M, Lundanes E, Christophersen AS (2006)
Simultaneous determination of 6 beta-blockers, 3 calcium-channel antagonists, 4 angiotensin-II antagonists and 1 antiarrhythmic drug in post-mortem whole blood by automated solid phase extraction and liquid chromatography mass spectrometry. Method development and robustness testing by experimental design
J Chromatogr B Analyt Technol Biomed Life Sci, 850 (1-2), 147-60
DOI 10.1016/j.jchromb.2006.11.030, PubMed 17175206

Landmark CJ (2006)
Targets for antiepileptic drugs in the synapse
Med Sci Monit, 13 (1), RA1-7
PubMed 17179916

Publications 2004

Opdal MS (2004)
[Clinical pharmacology education and internship]
Tidsskr Nor Laegeforen, 124 (13-14), 1828-9
PubMed 15229693