The role of CD45 phosphatase activity and its regulation via natural ligands to control BCR signaling strength in normal B cell development
To decipher how the BCR signal strength controls fate decision of autoreactive clones in central and peripheral tolerance mechanisms in autoimmunity/autoimmune diseases
To delineate how the B cells proliferation capacity and longevity is -along with other factors- regulated by the BCR signaling strength in immunodeficiencies and hematological malignancies
To investigate CD45 phosphatase activity regulation of BCR signaling strength in the development of effective humoral immune response against viruses
Bazsó A, Szodoray P, Shoenfeld Y, Nagy G, Kiss E(2026) Targeting autoimmunity: Phosphodiesterase inhibitors as immunomodulators-a review of current insights and future direction Autoimmun Rev, 25(4), 104035 DOI 10.1016/j.autrev.2026.104035, PubMed 41839428
Blomberg B, Myklebust NN, Oppegaard O, Tøndel C, Cox RJ, Iversen A, Lehmann ME, Sandvig A, Dahl TB, Valderhaug VD, Szodoray P, Wilhelmsen M, Kirsebom BE, Glambek M, Kaarbøe O, Aukrust P, Lie RT, Langeland N(2025) Randomized trial of nirmatrelvir/ritonavir versus placebo for adults with acute COVID-19 to prevent long COVID: PanoramicNOR Trial Trials, 26(1), 477 DOI 10.1186/s13063-025-09226-6, PubMed 41199272
