Our group studies breast tumor initiation and progression; from the cell of origin in which the first oncogenic events take place, the specific pathways and processes that are deregulated in the further progression of the tumors, to the specific events that are essential for the transition from in situ to invasive cancer. We use patient cohorts and animal models (transgenic and patient-derived xenograft - PDX). We apply high-throughput genomic technologies, functional assays, lineage-tracing, in situ hybridization techniques and statistical and bioinformatics methods in our research.
Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer
Cancer Discov (in press)
RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
NPJ Breast Cancer, 8 (1), 94
Comparative analysis of the molecular subtype landscape in canine and human mammary gland tumors
J Mammary Gland Biol Neoplasia, 27 (2), 171-183