Publications

Publications from OUS - Genome Biology Group (Skotheim)

87 publications found

Publications 2019

  1. Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
    Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
    Oncogenesis, 8 (6), 35
    DOI 10.1038/s41389-019-0141-3, PubMed 31092812

Publications 2018

  1. Celestino R, Nome T, Pestana A, Hoff AM, Gonçalves AP, Pereira L, Cavadas B, Eloy C, Bjøro T, Sobrinho-Simões M, Skotheim RI, Soares P (2018)
    CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension
    BMC Cancer, 18 (1), 68
    DOI 10.1186/s12885-017-3948-3, PubMed 29321030
  2. Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA (2018)
    Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
    Int J Cancer, 144 (4), 841-847
    DOI 10.1002/ijc.31809, PubMed 30121958
  3. Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
    Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
    Eur Urol, 75 (3), 498-505
    DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
  4. Rajpert-De Meyts E, Skotheim RI (2018)
    Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology
    Eur Urol, 73 (6), 832-833
    DOI 10.1016/j.eururo.2018.02.023, PubMed 29530636
  5. Viswanathan SR, Ha G, Hoff AM, Wala JA, Carrot-Zhang J, Whelan CW, Haradhvala NJ, Freeman SS, Reed SC, Rhoades J, Polak P, Cipicchio M, Wankowicz SA, Wong A, Kamath T, Zhang Z, Gydush GJ, Rotem D, PCF/SU2C International Prostate Cancer Dream Team, Love JC, Getz G, Gabriel S, Zhang CZ, Dehm SM, Nelson PS et al. (2018)
    Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing
    Cell, 174 (2), 433-447.e19
    DOI 10.1016/j.cell.2018.05.036, PubMed 29909985

Publications 2017

  1. Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
    Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
    Mol Cancer, 16 (1), 116
    DOI 10.1186/s12943-017-0691-y, PubMed 28683746
  2. Lågstad S, Zhao S, Hoff AM, Johannessen B, Lingjærde OC, Skotheim RI (2017)
    chimeraviz: a tool for visualizing chimeric RNA
    Bioinformatics, 33 (18), 2954-2956
    DOI 10.1093/bioinformatics/btx329, PubMed 28525538
  3. Smebye ML, Agostini A, Johannessen B, Thorsen J, Davidson B, Tropé CG, Heim S, Skotheim RI, Micci F (2017)
    Involvement of DPP9 in gene fusions in serous ovarian carcinoma
    BMC Cancer, 17 (1), 642
    DOI 10.1186/s12885-017-3625-6, PubMed 28893231
  4. Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
    Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
    Genome Med, 9 (1), 46
    DOI 10.1186/s13073-017-0434-0, PubMed 28539123
  5. Zhao S, Løvf M, Carm KT, Bakken AC, Hoff AM, Skotheim RI (2017)
    Novel transcription-induced fusion RNAs in prostate cancer
    Oncotarget, 8 (30), 49133-49143
    DOI 10.18632/oncotarget.17099, PubMed 28467780

Publications 2016

  1. Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA (2016)
    MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
    Oncotarget, 7 (6), 6476-505
    DOI 10.18632/oncotarget.6390, PubMed 26623728
  2. Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
    Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
    Oncotarget, 7 (5), 5273-88
    DOI 10.18632/oncotarget.6567, PubMed 26672768
  3. Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
    Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
    Urol Oncol, 35 (3), 111.e1-111.e8
    DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142
  4. Ramberg H, Grytli HH, Nygård S, Wang W, Ögren O, Zhao S, Løvf M, Katz B, Skotheim RI, Bjartell A, Eri LM, Berge V, Svindland A, Taskén KA (2016)
    PBX3 is a putative biomarker of aggressive prostate cancer
    Int J Cancer, 139 (8), 1810-20
    DOI 10.1002/ijc.30220, PubMed 27273830
  5. Smebye ML, Haugom L, Davidson B, Trope CG, Heim S, Skotheim RI, Micci F (2016)
    Bilateral ovarian carcinomas differ in the expression of metastasis-related genes
    Oncol Lett, 13 (1), 184-190
    DOI 10.3892/ol.2016.5384, PubMed 28123539

Publications 2015

  1. Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
    Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
    Neoplasia, 17 (2), 167-74
    DOI 10.1016/j.neo.2014.12.005, PubMed 25748235
  2. Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
    Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
    Clin Cancer Res, 21 (16), 3759-70
    DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952
  3. Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
    Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
    Cancer Res, 76 (1), 108-16
    DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575
  4. Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
    Novel RNA variants in colorectal cancers
    Oncotarget, 6 (34), 36587-602
    DOI 10.18632/oncotarget.5500, PubMed 26474385
  5. Johannessen B, Sveen A, Skotheim RI (2015)
    TIN: An R Package for Transcriptome Instability Analysis
    Cancer Inform, 14, 109-12
    DOI 10.4137/CIN.S31363, PubMed 26448683
  6. Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
    Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
    Mol Oncol, 9 (6), 1129-39
    DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404
  7. Kumar S, Krabberød AK, Neumann RS, Michalickova K, Zhao S, Zhang X, Shalchian-Tabrizi K (2015)
    BIR Pipeline for Preparation of Phylogenomic Data
    Evol Bioinform Online, 11, 79-83
    DOI 10.4137/EBO.S10189, PubMed 25987827
  8. Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
    Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
    Oncotarget, 6 (7), 5217-36
    DOI 10.18632/oncotarget.2847, PubMed 25595908
  9. Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ (2015)
    The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
    Oncotarget, 6 (33), 34358-74
    DOI 10.18632/oncotarget.6024, PubMed 26452038
  10. Rounge TB, Furu K, Skotheim RI, Haugen TB, Grotmol T, Enerly E (2015)
    Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs
    Mol Cancer, 14, 153
    DOI 10.1186/s12943-015-0411-4, PubMed 26265322
  11. Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
    Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
    Oncogene, 35 (19), 2413-27
    DOI 10.1038/onc.2015.318, PubMed 26300000

Publications 2014

  1. Løvf M, Nome T, Bruun J, Eknaes M, Bakken AC, Mpindi JP, Kilpinen S, Rognum TO, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2014)
    A novel transcript, VNN1-AB, as a biomarker for colorectal cancer
    Int J Cancer, 135 (9), 2077-84
    DOI 10.1002/ijc.28855, PubMed 24687856
  2. Nome T, Hoff AM, Bakken AC, Rognum TO, Nesbakken A, Skotheim RI (2014)
    High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants
    PLoS One, 9 (3), e91264
    DOI 10.1371/journal.pone.0091264, PubMed 24608966
  3. Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J (2014)
    PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
    Biochem J, 461 (3), 383-90
    DOI 10.1042/BJ20140132, PubMed 24840251
  4. Smebye ML, Sveen A, Haugom L, Davidson B, Tropé CG, Lothe RA, Heim S, Skotheim RI, Micci F (2014)
    Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted
    Genes Chromosomes Cancer, 53 (7), 558-67
    DOI 10.1002/gcc.22166, PubMed 24634323
  5. Sveen A, Johannessen B, Teixeira MR, Lothe RA, Skotheim RI (2014)
    Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
    BMC Genomics, 15, 672
    DOI 10.1186/1471-2164-15-672, PubMed 25109687
  6. Vedeld HM, Skotheim RI, Lothe RA, Lind GE (2014)
    The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
    Epigenetics, 9 (3), 346-50
    DOI 10.4161/epi.27582, PubMed 24384857

Publications 2013

  1. Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
    Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
    Stem Cells Dev, 22 (7), 1136-46
    DOI 10.1089/scd.2012.0369, PubMed 23137282
  2. Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P, Andrews PW, Knowles BB (2013)
    BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures
    Stem Cell Reports, 1 (5), 379-86
    DOI 10.1016/j.stemcr.2013.10.005, PubMed 24286026
  3. Barros-Silva JD, Paulo P, Bakken AC, Cerveira N, Løvf M, Henrique R, Jerónimo C, Lothe RA, Skotheim RI, Teixeira MR (2013)
    Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer
    Neoplasia, 15 (7), 720-6
    DOI 10.1593/neo.13232, PubMed 23814484
  4. Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR et al. (2013)
    Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Nat Genet, 45 (6), 680-5
    DOI 10.1038/ng.2634, PubMed 23666239
  5. Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (2013)
    Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
    Endocr Rev, 34 (3), 339-76
    DOI 10.1210/er.2012-1045, PubMed 23575763
  6. Løvf M, Thomassen GO, Mertens F, Cerveira N, Teixeira MR, Lothe RA, Skotheim RI (2013)
    Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray
    PLoS One, 8 (8), e70649
    DOI 10.1371/journal.pone.0070649, PubMed 23967081
  7. Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
    Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
    Transl Oncol, 6 (5), 546-53
    DOI 10.1593/tlo.13457, PubMed 24151535
  8. Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Greene MH, Jacobs KB, Kanetsky PA, Kolonel LN, Loud JT, Korde LA, Le Marchand L, Lewinger JP, Lothe RA, Pike MC, Rahman N, Rubertone MV, Schwartz SM et al. (2013)
    Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23
    Hum Mol Genet, 22 (13), 2748-53
    DOI 10.1093/hmg/ddt109, PubMed 23462292

Publications 2012

  1. Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
    ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
    Gut, 61 (11), 1560-7
    DOI 10.1136/gutjnl-2011-301179, PubMed 22213796
  2. Camões MJ, Paulo P, Ribeiro FR, Barros-Silva JD, Almeida M, Costa VL, Cerveira N, Skotheim RI, Lothe RA, Henrique R, Jerónimo C, Teixeira MR (2012)
    Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
    PLoS One, 7 (11), e49819
    DOI 10.1371/journal.pone.0049819, PubMed 23185447
  3. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2012)
    MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
    Neoplasia, 14 (9), 868-79
    DOI 10.1593/neo.121094, PubMed 23019418
  4. Celestino R, Sigstad E, Løvf M, Thomassen GO, Grøholt KK, Jørgensen LH, Berner A, Castro P, Lothe RA, Bjøro T, Sobrinho-Simões M, Soares P, Skotheim RI (2012)
    Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes
    Genes Chromosomes Cancer, 51 (12), 1154-64
    DOI 10.1002/gcc.22003, PubMed 22961909
  5. Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R (2012)
    Oncogenicity of the developmental transcription factor Sox9
    Cancer Res, 72 (5), 1301-15
    DOI 10.1158/0008-5472.CAN-11-3660, PubMed 22246670
  6. Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012)
    Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    PLoS One, 7 (11), e49705
    DOI 10.1371/journal.pone.0049705, PubMed 23185413
  7. Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR (2012)
    Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
    Neoplasia, 14 (7), 600-11
    DOI 10.1593/neo.12600, PubMed 22904677
  8. Sveen A, Bakken AC, Ågesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI (2012)
    The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
    Int J Cancer, 131 (6), 1479-85
    DOI 10.1002/ijc.27399, PubMed 22173985
  9. Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA (2012)
    ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients
    Clin Cancer Res, 18 (21), 6001-10
    DOI 10.1158/1078-0432.CCR-11-3302, PubMed 22991413

Publications 2011

  1. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
    The testicular germ cell tumour transcriptome
    Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
    DOI 10.1111/j.1365-2605.2011.01169.x, PubMed 21651573
  2. Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
    Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
    PLoS One, 6 (9), e24419
    DOI 10.1371/journal.pone.0024419, PubMed 21909432
  3. Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
    Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
    Mol Cancer, 10, 85
    DOI 10.1186/1476-4598-10-85, PubMed 21777459
  4. Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011)
    Fusion gene microarray reveals cancer type-specificity among fusion genes
    Genes Chromosomes Cancer, 50 (5), 348-57
    DOI 10.1002/gcc.20860, PubMed 21305644
  5. Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
    Genes Chromosomes Cancer, 51 (3), 240-9
    DOI 10.1002/gcc.20948, PubMed 22081504
  6. Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
    PLoS One, 6 (7), e22317
    DOI 10.1371/journal.pone.0022317, PubMed 21814574
  7. Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H (2011)
    A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
    PLoS One, 6 (3), e17086
    DOI 10.1371/journal.pone.0017086, PubMed 21455500
  8. Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI (2011)
    Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
    Genome Med, 3 (5), 32
    DOI 10.1186/gm248, PubMed 21619627
  9. Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
    CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
    Genes Immun, 12 (8), 653-62
    DOI 10.1038/gene.2011.43, PubMed 21716316

Publications 2010

  1. Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
    Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
    Mol Cancer, 9, 100
    DOI 10.1186/1476-4598-9-100, PubMed 20459617
  2. Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
    Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    J Clin Oncol, 28 (9), 1573-82
    DOI 10.1200/JCO.2009.24.8989, PubMed 20159821
  3. Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP (2010)
    Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
    J Carcinog, 9, 1
    DOI 10.4103/1477-3163.60358, PubMed 20411023
  4. Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE (2010)
    Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
    Clin Cancer Res, 16 (23), 5842-51
    DOI 10.1158/1078-0432.CCR-10-1312, PubMed 20975101
  5. Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S (2010)
    Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
    Genes Chromosomes Cancer, 49 (11), 1046-53
    DOI 10.1002/gcc.20813, PubMed 20725991
  6. Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010)
    PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
    Nat Cell Biol, 12 (4), 362-71
    DOI 10.1038/ncb2036, PubMed 20208530

Publications 2009

  1. Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
    Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
    Neuro Oncol, 11 (5), 514-28
    DOI 10.1215/15228517-2008-127, PubMed 19182148
  2. Godmann M, Gashaw I, Eildermann K, Schweyer S, Bergmann M, Skotheim RI, Behr R (2009)
    The pluripotency transcription factor Krüppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma
    Mol Hum Reprod, 15 (8), 479-88
    DOI 10.1093/molehr/gap040, PubMed 19505997
  3. Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S (2009)
    Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
    Genes Chromosomes Cancer, 48 (2), 184-93
    DOI 10.1002/gcc.20628, PubMed 18973136
  4. Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA (2009)
    A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
    Mol Cancer, 8, 5
    DOI 10.1186/1476-4598-8-5, PubMed 19152679

Publications 2008

  1. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
    Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
    Mol Cancer, 7, 94
    DOI 10.1186/1476-4598-7-94, PubMed 19117505
  2. Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008)
    TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
    Mol Cell Endocrinol, 306 (1-2), 75-80
    DOI 10.1016/j.mce.2008.10.043, PubMed 19041365
  3. Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O (2008)
    Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
    Genome Biol, 9 (9), R139
    DOI 10.1186/gb-2008-9-9-r139, PubMed 18803840
  4. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
    Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
    J Transl Med, 6, 13
    DOI 10.1186/1479-5876-6-13, PubMed 18346269

Publications 2007

  1. Almstrup K, Leffers H, Lothe RA, Skakkebaek NE, Sonne SB, Nielsen JE, Rajpert-De Meyts E, Skotheim RI (2007)
    Improved gene expression signature of testicular carcinoma in situ
    Int J Androl, 30 (4), 292-302; discussion 303
    DOI 10.1111/j.1365-2605.2007.00758.x, PubMed 17488342
  2. Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
    Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
    Mol Cancer, 6, 2
    DOI 10.1186/1476-4598-6-2, PubMed 17201907
  3. Lind GE, Skotheim RI, Lothe RA (2007)
    The epigenome of testicular germ cell tumors
    APMIS, 115 (10), 1147-60
    DOI 10.1111/j.1600-0463.2007.apm_660.xml.x, PubMed 18042148
  4. Skotheim RI, Nees M (2007)
    Alternative splicing in cancer: noise, functional, or systematic?
    Int J Biochem Cell Biol, 39 (7-8), 1432-49
    DOI 10.1016/j.biocel.2007.02.016, PubMed 17416541

Publications 2006

  1. Iljin K, Wolf M, Edgren H, Gupta S, Kilpinen S, Skotheim RI, Peltola M, Smit F, Verhaegh G, Schalken J, Nees M, Kallioniemi O (2006)
    TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
    Cancer Res, 66 (21), 10242-6
    DOI 10.1158/0008-5472.CAN-06-1986, PubMed 17079440
  2. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
    Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
    J Pathol, 210 (4), 441-9
    DOI 10.1002/path.2064, PubMed 17029216
  3. Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O, Lothe RA (2006)
    Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
    Cell Oncol, 28 (5-6), 315-26
    PubMed 17167184
  4. von Eyben FE, Jacobsen GK, Skotheim RI, von der Maase H, Rorth M (2006)
    Precursor lesions in testis and dysgenetic gonads
    Hum Pathol, 37 (6), 773; author reply 774
    DOI 10.1016/j.humpath.2006.01.006, PubMed 16733221

Publications 2005

  1. Hofer MD, Browne TJ, He L, Skotheim RI, Lothe RA, Rubin MA (2005)
    Identification of two molecular groups of seminomas by using expression and tissue microarrays
    Clin Cancer Res, 11 (16), 5722-9
    DOI 10.1158/1078-0432.CCR-05-0533, PubMed 16115909
  2. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Henrique R, Saatcioglu F, Esteller M, Teixeira MR, Lothe RA (2005)
    The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
    Mol Cancer, 4 (1), 8
    DOI 10.1186/1476-4598-4-8, PubMed 15691383
  3. von Eyben FE, Jacobsen GK, Skotheim RI (2005)
    Microinvasive germ cell tumor of the testis
    Virchows Arch, 447 (3), 610-25
    DOI 10.1007/s00428-005-1257-8, PubMed 15968545

Publications 2003

  1. Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fosså SD, Feinberg AP, Lothe RA (2003)
    Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
    Cancer Genet Cytogenet, 147 (1), 1-8
    DOI 10.1016/S0165-4608(03)00160-2, PubMed 14580764

Publications 2002

  1. Kraggerud SM, Skotheim RI, Szymanska J, Eknaes M, Fosså SD, Stenwig AE, Peltomäki P, Lothe RA (2002)
    Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
    Genes Chromosomes Cancer, 34 (2), 168-74
    DOI 10.1002/gcc.10058, PubMed 11979550
  2. Smith-Sørensen B, Lind GE, Skotheim RI, Fosså SD, Fodstad Ø, Stenwig AE, Jakobsen KS, Lothe RA (2002)
    Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
    Oncogene, 21 (57), 8878-84
    DOI 10.1038/sj.onc.1205978, PubMed 12483540
 
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