OUH - Group members

Anne-Lise Børresen-Dale

Professor emerita; PhD, MD (h.c.)
+47 22 78 13 73

Born 030746, Molde, Norway

Addresses:

1. Department of Genetics, Institute for Cancer Research, Oslo University Hospital The Norwegian Radiumhospital.

2. Institute for Clinical Medicine, Faculty of Medicine University of Oslo, Norway.

Phone: +4722781373, Fax: +4722781395 Cell phone: +4792854455

Email: a.l.borresen-dale@medisin.uio.no

Anne-Lise Børresen-Dale is Professor Emerita at University of Oslo and previous head of Department of Cancer Genetics, Oslo University Hospital Radiumhospitalet. She is among the leading geneticists in research on molecular biology of breast cancer, and her group was among the pioneers in expression profiling of breast carcinomas in collaboration with groups at Stanford, demonstrating that breast cancer can be divided into distinct sub-groups with differences in molecular profiles and in overall and relapse-free survival. Her achievements are seminal for understanding breast cancer evolution, and have had an enormous impact on our view of the complexity of breast cancer. She is author of more than 500 published scientific papers, books chapters and invited reviews.

Børresen-Dale was director of the K.G. Jebsen Center for Breast Cancer Research with a major funding from the K.G. Jebsen Foundation in the period 2011-2016. (http://stiftkgj.no/hva-vi-gjor/k-g-jebsen-medisinske-sentre/k-g-jebsen-senter-for-brystkreftforskning/)

Børresen-Dale has received several prizes and awards, some of the most prestigious being the Swiss Bridge Award for Outstanding Cancer Research in 2004, the Möbius prize for outstanding Research from the Research Council of Norway in 2008, The Mildred Scheel Lecturership in 2015, the Fritjof Nansen medal and award for Outstanding Research from the Academy of Science and Letters, Norway in 2015, the AACR Distinguished Lectureship in Breast Cancer Research in 2015 and the AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship and award in 2017. She was appointed to Commander of the Royal Norwegian St. Olavs Order by the King of Norway in 2017. Børresen-Dale has been Member of the Board of Directors of both AACR and ECCO, is past president of EACR, and is Elected Member of The Royal Academy of Science, Norway, The Norwegian Academy of Science and Letters and the European Academy of Cancer Sciences.

Børresen-Dale's research has been focusing on Exploring the Systems Biology of Breast Cancer using high dimensional data in integrated approaches aiming at identification of genotypes and gene expression profiles contributing to elevated cancer risk, radiation sensitivity, tumor aggressiveness and therapy resistance. The goal has been to follow the linear time course of predisposition, initiation, early stages and advanced disease and to dissect the molecular mechanisms triggered at each stage and to follow the multidimensional interactions at various levels in a systems biology approach to be able to better do risk estimation, prognostication and prediction.

Ongoing external activities:

Member of External Advisory Group of the EU7FP project REQUITE: Validating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-Effects and Improve Quality of Life in Cancer Survivors. https://www.requite.eu/
Scientific Advisory Board member of the Center of Molecular Medicine, Umeå University, Sweden. http://www.ucmm.umu.se/english/
Scientific Advisory Board member, German Consortium for Translational Cancer Research (DKTK). https://dktk.dkfz.de/en/home
Scientific Council member, Deutsches Krebsforschungszentrum (DKZF) Heidelberg, Germany. https://www.dkfz.de/en/index.html
Scientific Advisory Board member of the cancer genomics research program CIT (Tumor Identity Cards) of the French League Against Cancer.http://cit.ligue-cancer.net
Academic committee member, Aker Scholarship. http://www.akerscholarship.no/akademisk-komite/
Scientific Advisory Board member of SAGA Diagnostics. http://sagadiagnostics.com/
Member of the Board of Arctic Pharma. http://www.arcticpharma.com/
Member of the nomination committee, Oslo Cancer Cluster OCC http://oslocancercluster.no/
Chairman of Sigurd K Thoresens Legacy. http://www.thoresenslegat.no/
Scientific Advisory Board member of the EU2020 project MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks (Breast cancer metabolism- a new concept for patient stratification). https://mesi-strat.eu/
Member of the FEBS/EMBO Women in Science Award committee. http://www.embo.org/funding-awards/women-in-science-award

Academic Degrees.

1970 M.Sc. Biochemistry, Technical University of Norway, Trondheim, Norway.

1978 Doctor of Science in Medical Biochemical Genetics, University of Oslo, Norway.

1987 Judged qualified as a professor in gene technology, University of Oslo, Norway.

1992 Professor in Molecular Tumor biology, Univ. of Oslo, Norway (still holding)

Main Positions held

1970-72 Research assistant, Institute of Medical Genetics, University of Oslo.

1972-78 Research Fellow, Institute of Medical Genetics, University of Oslo.

1978-82 Senior Research Fellow, Institute of Medical Genetics, University of Oslo

1982-86 Senior Biochemist, Head, section for prenatal diagnosis, Department of Medical Genetics, UiO

1987-99 Senior Scientist, Dept. of Genetics, Inst. for Cancer Research, DNR, Norway

1999-present Head of Department, Dept. Genetics, Inst. for Cancer Research, OUS/DNR, Norway

Honors and awards

1989 Prof.Olav Torgersens Prize and Memorial Lecture: Gene tech. in the fight against cancer.

1989 Honorary lecturer at the 175th anniversary of the Medical Faculty, Univ.Oslo.

1994 King Olav V's Cancer Research Prize

1998 Member of The Royal Academy of Science, Norway

2001 Honorary member of The Norwegian Biochemical Society

2002 University of Oslo's Research Prize for Outstanding Research

2002 SalusAnsvar Medical prize for Outstanding Research in Tumor biology

2002 The Employer of the year at The Norwegian Raduimhospital

2004 Member of The Norwegian Academy of Science and Letters

2004 Swiss Bridge Award for outstanding Cancer Research

2008 Doctor medicinae honoris causa, University of Copenhagen

2008 The Möbius prize for outstanding Research from The Research Council of Norway

2009 ESTRO Honorary member award

2009 International Journal of Cancer/ Meyenburg-Stiftung Joint Lectureship distinguished speaker

2009 Elected member of the European Academy of Cancer Sciences

2009 Associate Investigator of Centre for Molecular medicine (NCMM), Nordic EMBL Partnership

2010 Honorary ambassador of the Norwegian Cancer Society

2012 Honorary member of The Hungarian Cancer Societ

Research work abroad (3-6 months)

1972: Dep. Hum.Biol.Chem& Gen, Univ. Texas, (Barbara Bowman), protein sequencing.

1977: The Rockefeller University, New York (Thomas Kindt), protein sequencing

1985: EMBL (Hans Lerach), recombinant DNA‑techniques

1986: Recombinant DNA Tech. Lab, Helsinki, Finland (Leena Peltonen,)

1990: Harvard Med. Sch., Mass. (David Yandell), PCR/SSCP on Rb,

1992: MIT, Cent. Envir. Health Sci. MA (William Thilly), mutation assay systems

1992: MGH Cancer Cent and Harvard Med. Sch, Boston, MA (Stephen Friend)

2002: Visiting Prof, Dept of Genetics, Stanford Univ.CA (David Botstein), Microarray analyses.

Teaching responsibilities

Supervised: 40 PhD stud (22 as main supervisor, 5 ongoing, 3 as main), 18 MSc stud. (10 as main superv)

PBL Medical Students since 96.

Selective Administrative Experience on national and international Boards

1986-91: Secretary General, The Norwegian Biochemical Society.

1989-1993: PI of a Nordic technology development project financed by Nordisk Industrifond

1995-00: Chair of expert committee on Biotech. and Genetics. Norwegian Board of Health.

1995-00: Chairman of the program committee, MedKap, NFR

1999-02: Member of the Scientific Council, International .Agency for Res. of Cancer, IARC, Lyon

2002-03: Vice-Chairman of the Scientific Council, IACR, Lyon

2001-04: Board member of the National Committee for Functional Genomics, FUGE

2003-06: Member of The Board of Directors, American Ass. for Cancer Res. (AACR)

1996-06 Member of The Scientific Board "Forskningutvalget" DNR/RR-HF.

2004-08 One of the PI's in the EU Integrated project on "Mutant TP53 and Cancer"

2000 Member of the Scientific Committees for the 2^nd ESF conference, and ECCO 13

2006- 08 President Elect, European Association for Cancer Research, EACR

2007- Scientific Advisory Board, CREATE HEALTH Consortium Lund Sweden

2008-10 President EACR

2008-12 Board of Directors and Executive committee as Treasure, ECCO (European CanCer Organization)

2008-10 Member of the Nomination Committee, AACR

2008- External Advisory Board (EAB) of the SPORE in Breast Cancer at Univ. of North Carolina

2010-13 Scientific Advisory Board member, DKZF, Heidelberg, Germany'

2011-13 Council of Scientific Advisors, AACR (American Association for Cancer Research)

2011 Scientific co-chair, ECCO16 Conference, Stockholm

2011- Senior Associated Editor, Molecular Oncology

2011-16 Director of the K.G.Jebsen Centre for Breast Cancer Research

2011-14 Chair of Scientific Advisory Board for TRANSCAN ERA-net

2012 Chair and organizer of International Symposium on Personalized Cancer Care

2013- Scientific Board of the Pezcoller Foundation

2013-16 Scientific Advisory Board, German Consortium for Translational Cancer Research (DKTK)

2013 Basic Science track chair, ECCO17 Conference, Amsterdam

2013-18 External Advisory Group, ReQuiTe: Radiotherapy for Quality of life through reduced Toxicity

2014-15 Breast Cancer track chair, ECCO18 Conference, Vienna

Publications:

Author of 438 published/in press scientific papers, 40 chapters in books and invited reviews, 33 articles in Nordic journals and books

Main funding

1) Annually from the Cancer Society of Norway, on Exploring the Systems Biology of Breast Cancer.

Pt: One postdoc (50%, ending march 2015) one postdoc 100% ( to start August 2014), 2 technicians and laboratory expenses

2) 2011-2015: Funding for a K.G Jebsen Center for Breast Cancer Research

3) 2013-2017: Funding from HSØ for a PhD student and a post doc in the project : Exploring the Systems Biology of Breast Cancer, focusing on noncoding RNA and its role in breast cancer progression

4) 2012-2015: NFR grant together with GM Mælansdmo, MetAction: Actionable Targets in Cancer Metastasis - from Bed to Bench to Byte to Bedside

5) EU-7FP: BASIS: Breast Cancer Somatic Genetics Study under HEALTH-2009-2.1.1-2: Large-scale functional genomics efforts to identify molecular determinants of cancer:

6) EU-7FP: "GlycoHIT: Glycomics by High-throughput Integrated Technologies: Development and validation of complementary and integrated technologies for glycomic analysis of serum in cancer glycobiomarker discovery, diagnostics and glycotherapeutic monitoring" under HEALTH 2010.1.1-3: High-throughput analysis of posttranslational modifications of proteins.

7) EU-7FP: "EUROCANPLATFORM" A European Platform for Translational Cancer Research: Network of Excellence under HEALTH 2.4.1-2 .

Selected peer-reviewed publications (from a total of 458)

Citations(>10) per May 28. 2014 marked in blue

1. Perou, CM., Sørlie, T., Eisen, MB., van de Rijn, M., Jeffrey, S. S., Pollack, JR., Rees, CA., Ross, DT., Johnsen, H., Akslen, LA., Pergamenschikov, CW., Zhu, SX., Lønning, PE., Børresen-Dale, AL., Brown, PO. and Botstein, D.: Molecular portraits of human breast tumours. Nature 406: 747-52, 2000. 7724 citations

2. Sørlie, T., Perou, C. M., Tibshirani, R., Aas, T., Geisler, S., Hastie, T., Johnsen, H., Eisen, M.B., Thorsen, T., Rijn, M. van der., Jeffrey, S., Quist, H., Rees, C. A., Brown, P.O., Botstein, D., Lønning, P.E. and Børresen-Dale, A.-L.: Gene expression patterns of breast carcinomas distinguish tumor subclasses with potential clinical implications. PNAS 98 (19): 10869-74, 2001. 5980 citations

3. Sørlie, T., Tibshirani, R., Parker, J., Hastie, T., Marron, J. S., Nobel, A., Deng, S., Johnsen, H., Pesich, R., Geisler, S., Perou, C. M., Lønning, P. E., Brown, P. O., Børresen-Dale, A.-L., and Botstein, D.: Repeated observation of breast tumor subtypes in independent gene expression data sets. PNAS., 100 (14): 8418-8423, 2003. 3387 citations

4. Hicks, J., Krasnitz, A., et al and Børresen-Dale, A.-L., Naume, B., Schlicting, E., Norton, L., Hagerstrøm,T., Skoog,L., Auer, G,. Måner, S., Lundin, P. and Zetterberg, A.: Novel patterns of genome rearrangements and their association with survival in breast cancer. Genome Res. 16(12):1465-79, 2006. 209 citations

5. Horlings H.M., Bergamaschi A., Nordgard, S H., Kim Y H., Han W., Noh DY., Salary, K., Joosse, S. A., Reyal, F., Lingjaerde, O. C., Kristensen V.N., Børresen-Dale A-L., Pollack J.R. and van de Vijver M.J.: ESR1 gene amplification in breast cancer: a common phenomenon? Letter to editor of Nature Genetics on the publication of Frederik Holst et al. in Nature Genetics 39, 655 - 660 (2007), Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nature Genetics 40(7): 807-808, 2008. 85 citations

6. Stephens, P. J., McBride, D. J., et al and, Børresen-Dale, A.-L., Campbell, P. J., Futreal, P. A. and Stratton, M. R.: Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature, 462(7276):1005-10, 2009. 450 citations

7. Russnes, H. G., Vollan, H. K. M., Lingjærde, O. C., Krasnitz, A., Lundin, P., Naume, B., Sørlie, T., Borgen, E., Rye, I. H., Langerød, A., Chin, S-F., Teschendorff, A. E., Stephens, P. J., Månèr, S., Schlichting, E., Baumbusch, L. O., Kåresen, R., Stratton, M. P., Wigler, M., Caldas, C., Zetterberg, A., Hicks, J. and Børresen-Dale, A.-L.: Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Science Translation Medicine, 2, 38ra47 (2010) 78 citations

8. Van Loo, P., Nordgard, S. H., Lingjærde, O. C., Russnes, H. G., Rye, I. H., Sun, W., Weigman, V. J., Marynen, P., Zetterberg, A., Naume, B., Perou, C. M., Børresen-Dale, A.-L. and Kristensen, V. N.: Allele specific copy number analysis in tumors (ASCAT). 2010. PNAS 107 (39) 16910-16915 Sep.28, 2010, www.pnas.org/cgi/doi/10.1073/pnas.100984310 118 citations

9. Potapenko, I. O., Haakensen, V. D., Lüders, T., Helland, Å., Bukholm, I. R., Sørlie, T., Kristensen, V.N., Lingjærde, O. C. and Børresen-Dale, A.-L.: Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression. 2009. Molecular Oncol. 4(2):98-118, 2010. 39 citations

10. Hennessy, B. T., Lu, Y., Gonzalez-Angulo, A.M., Carey , M. S., Myhre, S., Ju, Z., Davies, M. A., Liu, W., Coombes, K., Meric-Bernstam, F., Bedrosian, I., McGahren, M., Agarwal, M., Zhang, F., Overgaard, J., Alsner, J., Neve, R. M., Kuo, W.-L., Gray, J. W. , Borresen-Dale, A.-L. and Mills, G. B.: A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin.Proteom 6:129-151, 2010. 54 citations

11. Enerly, E., Steinfeld, I., Kleivi, G. K., Leivonen, S. K., Aure, M. R., Russnes, H. G., Rønneberg, J. O., Johnsen, H., Navon, R., Rødland, E., Mäkalä, R., Naume, B., Perälä, M., Kallioniemi, O., Kristensen, V. N., Yakhini, Z. and Børresen-Dale, A.-L.: miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors. Plos One, 2011 Feb 22:6 (2) e16915 100 citations

12. Edgren H, Murumägi A, Kangaspeska S, Nicorici D, Hongisto V, Kleivi K, Rye IH, Wolf M,Børresen-Dale, A.-L. and Kallioniemi O.: Identification of fusion genes in breast cancer by paired- end RNA-sequencing. Genome Biology, 2011 jan.19:12(1):R6. 72 citation

13. Zhao X, Rødland EA, Sørlie T, Naume B, Langerød A, Frigessi A, Kristensen VN, Børresen-Dale, A.-L., and Lindgjærde OC.: Combining gene signatures improves prediction of breast cancer survival. PLoS One, 2011 Mar.10;6(3) e17845. 22 citation

14. Russnes HG, Navin N, Hicks J, Borresen-Dale A.-L.: Insight into the Heterogeneity of Breast Cancer through Next-Generation Sequencing. JCI, Oct 3; 121(10) 3810-8, 2011 70 citation

15. Kristensen, V.N., Vaske, C et al and Børresen-Dale, A.-L.: Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling. PNAS Sep 9, 2011 42 citations

16. Curtis C., Shah S.P., Chin S.-F. et al and Børresen-Dale, Brenton J.D., Tavare´S., Caldas C. & Aparicio S.: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature, 486 (7403), 346-52, 2012. 484 citations

17. Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale A.-L., Levine AJ, Bargonetti J and Prives C. Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway. Cell.;148(1-2):244-58, 2012. 99 citations

18. Stephens, P.J., Tarpe P et al and, Børresen- Dale,A.-L., Richardson,A.L., Campbell,P.J., P Andrew Futreal,P.A. and Stratton,M.R. The landscape of cancer genes and mutational processes in breast cancer. Nature 486 (7403), 400-4, 2012. 325 citations

19. Nik-Zainal S, van Loo P, Wedge DC et al and Børresen-Dale A.-L, Futreal PA, Stratton MR and Campbell PJ: The Life History of 21 Breast Cancers. Cell, 149 (5), 994-100, 2012. 242 citations

20. A. Margolin, E. Bilal, E. Huang, T. C. Norman, L. Ottestad, et al and The Sage DREAM Breast Cancer Challenge Consortium, V. N. Kristensen, J. Hellerstein, S. Friend, G. Stolovitzky, S.Aparicio, C. Caldas, A.L. Børresen-Dale Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer 2013 Science Translational Medicine, 17 April 2013 Vol 5 Issue 181 181re1.

21. Aure, M. R., Steinfeld, I., Baumbusch, L.O., Lilestøl, K., Lipson, D., Nyberg, S., Naume, B., Sahlberg, K. K., Kristensen, V. N., Børresen-Dale, A.-L., Lingjærde, O.C. and Yakhini, S.: Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data. PlosOne, 2013(8)1e53014

22. Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio S, Behjati S,. Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale A.-L... Pfister SM, Campbell PJ, and Stratton MR: Signatures of mutational processes in human cancer. Nature. 2013 Aug 22;500(7463):415-21. doi: 10.1038/nature12477. Epub 2013 Aug 14. 128 citations

23. Engebraaten, Vollan, H.K.M., and Børresen-Dale, A.L.:Triple-negative breast cancer and the need for new therapeutic targets. Am J Pathol. 2013 Aug 3. piiS0002-9440(13)00461-6. doi: 10.1016/j.ajpath.2013.05.033

24. Aure MR, Leivonen SK, Fleischer T, Zhu Q, Overgaard J, Alsner J, Tramm T, Louhimo R, Alnæs GI, Perälä M, Busato F, Touleimat N, Tost J, Børresen-Dale AL, Hautaniemi S, Troyanskaya OG, Lingjærde OC, Sahlberg KK, Kristensen VN Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors. Genome Biol, 14 (11), R126 PubMed 24257477

25. Vessela N. Kristensen, Ole Christian Lingjærde, Hege G. Russnes, Hans Kristian M. Vollan, Arnoldo Frigessi, and Anne-Lise Børresen-Dale: Principles and methods of integrative genomic analyses in cancer, Nature Cancer Reviews, VOLUME 14 | MAY 2014 | 303

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Publications 2009-2014 - download in Word format

Publications 2025

Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q, Delgado MK, Lee JM, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Bandera EV, Barile M, Barkardottir RB, Barrowdale D, Beckmann MW, Benitez J, Berchuck A, Bisogna M et al. (2025)
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Nat Commun, 16 (1), 8237
DOI 10.1038/s41467-025-63507-x, PubMed 40925936

Publications 2024

Fleischer T, Haugen MH, Ankill J, Silwal-Pandit L, Børresen-Dale AL, Hedenfalk I, Hatschek T, Tost J, Engebraaten O, Kristensen VN (2024)
An integrated omics approach highlights how epigenetic events can explain and predict response to neoadjuvant chemotherapy and bevacizumab in breast cancer
Mol Oncol, 18 (8), 2042-2059
DOI 10.1002/1878-0261.13656, PubMed 38671580

Publications 2023

Nygaard V, Ree AH, Dagenborg VJ, Børresen-Dale AL, Edwin B, Fretland ÅA, Grzyb K, Haugen MH, Mælandsmo GM, Flatmark K (2023)
A PRRX1 Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases
Cancer Res Commun, 3 (2), 235-244
DOI 10.1158/2767-9764.CRC-22-0295, PubMed 36968142

Publications 2022

Ahearn TU, Zhang H, Michailidou K, Milne RL, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Augustinsson A, Baten A, Becher H, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H et al. (2022)
Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Breast Cancer Res, 24 (1), 2
DOI 10.1186/s13058-021-01484-x, PubMed 34983606

Castro-Mondragon JA, Aure MR, Lingjærde OC, Langerød A, Martens JWM, Børresen-Dale AL, Kristensen VN, Mathelier A (2022)
Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers
Nucleic Acids Res, 50 (21), 12131-12148
DOI 10.1093/nar/gkac1143, PubMed 36477895

Publications 2021

Aure MR, Fleischer T, Bjørklund S, Ankill J, Castro-Mondragon JA, OSBREAC, Børresen-Dale AL, Tost J, Sahlberg KK, Mathelier A, Tekpli X, Kristensen VN (2021)
Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer
Genome Med, 13 (1), 72
DOI 10.1186/s13073-021-00880-4, PubMed 33926515

Breast Cancer Association Consortium, Dorling L, Carvalho S, Allen J, González-Neira A, Luccarini C, Wahlström C, Pooley KA, Parsons MT, Fortuno C, Wang Q, Bolla MK, Dennis J, Keeman R, Alonso MR, Álvarez N, Herraez B, Fernandez V, Núñez-Torres R, Osorio A, Valcich J, Li M, Törngren T, Harrington PA, Baynes C et al. (2021)
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
N Engl J Med, 384 (5), 428-439
DOI 10.1056/NEJMoa1913948, PubMed 33471991

Erdélyi K, Ditrói T, Johansson HJ, Czikora Á, Balog N, Silwal-Pandit L, Ida T, Olasz J, Hajdú D, Mátrai Z, Csuka O, Uchida K, Tóvári J, Engebraten O, Akaike T, Børresen Dale AL, Kásler M, Lehtiö J, Nagy P (2021)
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
Proc Natl Acad Sci U S A, 118 (45)
DOI 10.1073/pnas.2100050118, PubMed 34737229

Fores-Martos J, Cervera-Vidal R, Sierra-Roca J, Lozano-Asencio C, Fedele V, Cornelissen S, Edvarsen H, Tadeo-Cervera I, Eroles P, Lluch A, Tabares-Seisdedos R, Falcó A, Van't Veer LJ, Schmidt M, Quigley DA, Børresen-Dale AL, Kristensen VN, Balmain A, Climent J (2021)
Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3^VNTR polymorphisms and gene co-expression
NPJ Breast Cancer, 7 (1), 118
DOI 10.1038/s41523-021-00329-2, PubMed 34508103

Haugen MH, Lingjærde OC, Hedenfalk I, Garred Ø, Borgen E, Loman N, Hatschek T, Børresen-Dale AL, Naume B, Mills GB, Mælandsmo GM, Engebraaten O (2021)
Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers
JCO Precis Oncol, 5
DOI 10.1200/PO.20.00086, PubMed 34036235

Publications 2020

Escala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Ashworth A, Auer PL, Auvinen P, Beckmann MW, Beesley J, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Blot W, Bogdanova NV, Bojesen SE, Bolla MK, Børresen-Dale AL, Brauch H, Brenner H, Brucker SY, Burwinkel B, Caldas C, Canzian F et al. (2020)
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Nat Commun, 11 (1), 312
DOI 10.1038/s41467-019-14100-6, PubMed 31949161

Pladsen AV, Nilsen G, Rueda OM, Aure MR, Borgan Ø, Liestøl K, Vitelli V, Frigessi A, Langerød A, Mathelier A, OSBREAC, Engebråten O, Kristensen V, Wedge DC, Van Loo P, Caldas C, Børresen-Dale AL, Russnes HG, Lingjærde OC (2020)
DNA copy number motifs are strong and independent predictors of survival in breast cancer
Commun Biol, 3 (1), 153
DOI 10.1038/s42003-020-0884-6, PubMed 32242091

Ree AH, Nygaard V, Boye K, Heinrich D, Dueland S, Bergheim IR, Johansen C, Beiske K, Negård A, Lund-Iversen M, Nygaard V, Hovig E, Nakken S, Nasser S, Julsrud L, Reisse CH, Ruud EA, Kristensen VN, Flørenes VA, Geitvik GA, Lingjærde OC, Børresen-Dale AL, Russnes HG, Mælandsmo GM, Flatmark K (2020)
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study
Acta Oncol, 59 (7), 733-740
DOI 10.1080/0284186X.2020.1742377, PubMed 32208873

von der Lippe Gythfeldt H, Lien T, Tekpli X, Silwal-Pandit L, Borgen E, Garred Ø, Skjerven H, Schlichting E, Lundgren S, Wist E, Naume B, Kristensen V, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2020)
Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer
Int J Cancer, 147 (9), 2515-2525
DOI 10.1002/ijc.33108, PubMed 32488909

Publications 2019

Brinkman AB, Nik-Zainal S, Simmer F, Rodríguez-González FG, Smid M, Alexandrov LB, Butler A, Martin S, Davies H, Glodzik D, Zou X, Ramakrishna M, Staaf J, Ringnér M, Sieuwerts A, Ferrari A, Morganella S, Fleischer T, Kristensen V, Gut M, van de Vijver MJ, Børresen-Dale AL, Richardson AL, Thomas G, Gut IG et al. (2019)
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Nat Commun, 10 (1), 1749
DOI 10.1038/s41467-019-09828-0, PubMed 30988298

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P (2019)
Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 10 (1), 525
DOI 10.1038/s41467-019-08512-7, PubMed 30692535

Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R, Dennis J, Beesley J, Lecarpentier J, Bolla MK, Wang Q, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Boeckx B, Bojesen SE, Bonanni B, Børresen-Dale AL et al. (2019)
Genome-wide association study of germline variants and breast cancer-specific mortality
Br J Cancer, 120 (6), 647-657
DOI 10.1038/s41416-019-0393-x, PubMed 30787463

Johansson HJ, Socciarelli F, Vacanti NM, Haugen MH, Zhu Y, Siavelis I, Fernandez-Woodbridge A, Aure MR, Sennblad B, Vesterlund M, Branca RM, Orre LM, Huss M, Fredlund E, Beraki E, Garred Ø, Boekel J, Sauer T, Zhao W, Nord S, Höglander EK, Jans DC, Brismar H, Haukaas TH, Bathen TF et al. (2019)
Breast cancer quantitative proteome and proteogenomic landscape
Nat Commun, 10 (1), 1600
DOI 10.1038/s41467-019-09018-y, PubMed 30962452

Lai X, Geier OM, Fleischer T, Garred Ø, Borgen E, Funke SW, Kumar S, Rognes ME, Seierstad T, Børresen-Dale AL, Kristensen VN, Engebraaten O, Köhn-Luque A, Frigessi A (2019)
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Cancer Res, 79 (16), 4293-4304
DOI 10.1158/0008-5472.CAN-18-1804, PubMed 31118201

Lindholm EM, Leivonen SK, Undlien E, Nebdal D, Git A, Caldas C, Børresen-Dale AL, Kleivi K (2019)
miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth
Microrna, 8 (2), 155-165
DOI 10.2174/2211536608666181206124922, PubMed 30520388

Lindholm EM, Ragle Aure M, Haugen MH, Kleivi Sahlberg K, Kristensen VN, Nebdal D, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2019)
miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer
Mol Oncol, 13 (10), 2278-2296
DOI 10.1002/1878-0261.12561, PubMed 31402562

Mukhopadhyay UK, Oturkar CC, Adams C, Wickramasekera N, Bansal S, Medisetty R, Miller A, Swetzig WM, Silwal-Pandit L, Børresen-Dale AL, Creighton CJ, Park JH, Konduri SD, Mukhopadhyay A, Caradori A, Omilian A, Bshara W, Kaipparettu BA, Das GM (2019)
TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer
J Natl Cancer Inst, 111 (11), 1202-1215
DOI 10.1093/jnci/djz051, PubMed 30990221

Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C et al. (2019)
Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Nature, 566 (7742), E1
DOI 10.1038/s41586-019-0883-2, PubMed 30659290

Nygård S, Lingjærde OC, Caldas C, Hovig E, Børresen-Dale AL, Helland Å, Haakensen VD (2019)
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995

Ree AH, Nygaard V, Russnes HG, Heinrich D, Nygaard V, Johansen C, Bergheim IR, Hovig E, Beiske K, Negård A, Børresen-Dale AL, Flatmark K, Mælandsmo GM (2019)
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006

Smid M, Wilting SM, Uhr K, Rodríguez-González FG, de Weerd V, Prager-Van der Smissen WJC, van der Vlugt-Daane M, van Galen A, Nik-Zainal S, Butler A, Martin S, Davies HR, Staaf J, van de Vijver MJ, Richardson AL, MacGrogan G, Salgado R, van den Eynden GGGM, Purdie CA, Thompson AM, Caldas C, Span PN, Sweep FCGJ, Simpson PT, Lakhani SR et al. (2019)
The circular RNome of primary breast cancer
Genome Res, 29 (3), 356-366
DOI 10.1101/gr.238121.118, PubMed 30692147

Publications 2018

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P (2018)
Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 9 (1), 5397
DOI 10.1038/s41467-018-07842-2, PubMed 30559362

Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Schmidt MK, Shah M, Luben R, Brown J, Czene K, Darabi H, Eriksson M, Klevebring D, Bojesen SE et al. (2018)
Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Nat Commun, 9, 16193
DOI 10.1038/ncomms16193, PubMed 29633761

Höglander EK, Nord S, Wedge DC, Lingjærde OC, Silwal-Pandit L, Gythfeldt HV, Vollan HKM, Fleischer T, Krohn M, Schlitchting E, Borgen E, Garred Ø, Holmen MM, Wist E, Naume B, Van Loo P, Børresen-Dale AL, Engebraaten O, Kristensen V (2018)
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
Genome Med, 10 (1), 92
DOI 10.1186/s13073-018-0601-y, PubMed 30497530

Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Lüders T, Engebraaten O, Børresen-Dale AL, Kyte JA, Gromov P, Naume B, Kristensen V, Gromova I, Tekpli X (2018)
Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
Oncoimmunology, 8 (2), e1537691
DOI 10.1080/2162402X.2018.1537691, PubMed 30713794

Jabeen S, Zucknick M, Nome M, Dannenfelser R, Fleischer T, Kumar S, Lüders T, von der Lippe Gythfeldt H, Troyanskaya O, Kyte JA, Børresen-Dale AL, Naume B, Tekpli X, Engebraaten O, Kristensen V (2018)
Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab
Oncoimmunology, 7 (11), e1457598
DOI 10.1080/2162402X.2018.1457598, PubMed 30377556

Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK (2018)
Correction to: A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 18 (1), 80
DOI 10.1186/s12885-017-3766-7, PubMed 29338700

Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen TH, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Aittomäki K, Allen J, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Auvinen P, Barrdahl M, Beane Freeman LE, Beckmann MW et al. (2018)
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
Am J Hum Genet, 104 (1), 21-34
DOI 10.1016/j.ajhg.2018.11.002, PubMed 30554720

Prasmickaite L, Tenstad EM, Pettersen S, Jabeen S, Egeland EV, Nord S, Pandya A, Haugen MH, Kristensen VN, Børresen-Dale AL, Oslo Breast Cancer Research Consortium (OSBREAC), Engebråten O, Maelandsmo GM (2018)
Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4
Mol Oncol, 12 (9), 1540-1558
DOI 10.1002/1878-0261.12319, PubMed 29741811

Rye IH, Trinh A, Saetersdal AB, Nebdal D, Lingjaerde OC, Almendro V, Polyak K, Børresen-Dale AL, Helland Å, Markowetz F, Russnes HG (2018)
Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors
Mol Oncol, 12 (11), 1838-1855
DOI 10.1002/1878-0261.12375, PubMed 30133130

Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I (2018)
N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome
Mol Oncol, 12 (6), 972-990
DOI 10.1002/1878-0261.12312, PubMed 29698574

Publications 2017

Alves CP, Dey-Guha I, Kabraji S, Yeh AC, Talele NP, Solé X, Chowdhury J, Mino-Kenudson M, Loda M, Sgroi D, Borresen-Dale AL, Russnes HG, Ross KN, Ramaswamy S (2017)
AKT1^low Quiescent Cancer Cells Promote Solid Tumor Growth
Mol Cancer Ther, 17 (1), 254-263
DOI 10.1158/1535-7163.MCT-16-0868, PubMed 29054988

Aure MR, Vitelli V, Jernström S, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Lüders T, Rødland E, Vaske CJ, Zhao W, Møller EK, Nord S, Giskeødegård GF, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Geisler J, Bukholm IR, Naume B, Schlichting E et al. (2017)
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Breast Cancer Res, 19 (1), 44
DOI 10.1186/s13058-017-0812-y, PubMed 28356166

Bjørklund SS, Panda A, Kumar S, Seiler M, Robinson D, Gheeya J, Yao M, Alnæs GIG, Toppmeyer D, Riis M, Naume B, Børresen-Dale AL, Kristensen VN, Ganesan S, Bhanot G (2017)
Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma
Sci Rep, 7 (1), 5568
DOI 10.1038/s41598-017-05537-0, PubMed 28717182

Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P (2017)
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 8 (1), 1221
DOI 10.1038/s41467-017-01355-0, PubMed 29089486

Dannenfelser R, Nome M, Tahiri A, Ursini-Siegel J, Vollan HKM, Haakensen VD, Helland Å, Naume B, Caldas C, Børresen-Dale AL, Kristensen VN, Troyanskaya OG (2017)
Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity
Oncotarget, 8 (34), 57121-57133
DOI 10.18632/oncotarget.19078, PubMed 28915659

Davies H, Glodzik D, Morganella S, Yates LR, Staaf J, Zou X, Ramakrishna M, Martin S, Boyault S, Sieuwerts AM, Simpson PT, King TA, Raine K, Eyfjord JE, Kong G, Borg Å, Birney E, Stunnenberg HG, van de Vijver MJ, Børresen-Dale AL, Martens JW, Span PN, Lakhani SR, Vincent-Salomon A, Sotiriou C et al. (2017)
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
Nat Med, 23 (4), 517-525
DOI 10.1038/nm.4292, PubMed 28288110

Davies H, Morganella S, Purdie CA, Jang SJ, Borgen E, Russnes H, Glodzik D, Zou X, Viari A, Richardson AL, Børresen-Dale AL, Thompson A, Eyfjord JE, Kong G, Stratton MR, Nik-Zainal S (2017)
Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency
Cancer Res, 77 (18), 4755-4762
DOI 10.1158/0008-5472.CAN-17-1083, PubMed 28904067

Dumeaux V, Fjukstad B, Fjosne HE, Frantzen JO, Holmen MM, Rodegerdts E, Schlichting E, Børresen-Dale AL, Bongo LA, Lund E, Hallett M (2017)
Interactions between the tumor and the blood systemic response of breast cancer patients
PLoS Comput Biol, 13 (9), e1005680
DOI 10.1371/journal.pcbi.1005680, PubMed 28957325

Euceda LR, Haukaas TH, Giskeodegard GF, Vettukattil R, Engel J, Silwal-Pandit L, Lundgren S, Borgen E, Garred O, Postma G, Buydens LMC, Borresen-Dale AL, Engebraaten O, Bathen TF (2017)
Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using MR spectroscopy
Metabolomics, 13 (4), 37
DOI 10.1007/s11306-017-1168-0

Fleischer T, Klajic J, Aure MR, Louhimo R, Pladsen AV, Ottestad L, Touleimat N, Laakso M, Halvorsen AR, Grenaker Alnæs GI, Riis ML, Helland Å, Hautaniemi S, Lønning PE, Naume B, Børresen-Dale AL, Tost J, Kristensen VN (2017)
DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival
Oncotarget, 8 (1), 1074-1082
DOI 10.18632/oncotarget.13718, PubMed 27911866

Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E, Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN (2017)
DNA methylation at enhancers identifies distinct breast cancer lineages
Nat Commun, 8 (1), 1379
DOI 10.1038/s41467-017-00510-x, PubMed 29123100

Glodzik D, Morganella S, Davies H, Simpson PT, Li Y, Zou X, Diez-Perez J, Staaf J, Alexandrov LB, Smid M, Brinkman AB, Rye IH, Russnes H, Raine K, Purdie CA, Lakhani SR, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Viari A et al. (2017)
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Nat Genet, 49 (3), 341-348
DOI 10.1038/ng.3771, PubMed 28112740

Glodzik D, Morganella S, Davies H, Simpson PT, Li Y, Zou X, Diez-Perez J, Staaf J, Alexandrov LB, Smid M, Brinkman AB, Rye IH, Russnes H, Raine K, Purdie CA, Lakhani SR, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JWM, Børresen-Dale AL, Richardson AL, Kong G, Viari A et al. (2017)
Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Nat Genet, 49 (11), 1661
DOI 10.1038/ng1117-1661a, PubMed 29074948

Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB, Rahbari R, Wedge DC, Davies HR, Ramakrishna M, Fullam A, Martin S, Alder C, Patel N, Gamble S, O'Meara S, Giri DD, Sauer T, Pinder SE, Purdie CA, Borg Å, Stunnenberg H, van de Vijver M, Tan BK, Caldas C, Tutt A et al. (2017)
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
Nature, 543 (7647), 714-718
DOI 10.1038/nature21703, PubMed 28329761

Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, Lemaçon A, Soucy P, Glubb D, Rostamianfar A, Bolla MK, Wang Q, Tyrer J, Dicks E, Lee A, Wang Z, Allen J, Keeman R, Eilber U, French JD, Qing Chen X, Fachal L, McCue K, McCart Reed AE, Ghoussaini M et al. (2017)
Association analysis identifies 65 new breast cancer risk loci
Nature, 551 (7678), 92-94
DOI 10.1038/nature24284, PubMed 29059683

Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J, Agata S, Ahmed S, Ahsan H, Aittomäki K, Al-Ejeh F et al. (2017)
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Nat Genet, 49 (12), 1767-1778
DOI 10.1038/ng.3785, PubMed 29058716

Quigley DA, Tahiri A, Lüders T, Riis MH, Balmain A, Børresen-Dale AL, Bukholm I, Kristensen V (2017)
Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue
Oncoimmunology, 6 (11), e1356142
DOI 10.1080/2162402X.2017.1356142, PubMed 29147603

Ree AH, Russnes HG, Heinrich D, Dueland S, Boye K, Nygaard V, Silwal-Pandit L, Østrup O, Hovig E, Nygaard V, Rødland EA, Nakken S, Øien JT, Johansen C, Bergheim IR, Skarpeteig V, Sathermugathevan M, Sauer T, Lund-Iversen M, Beiske K, Nasser S, Julsrud L, Reisse CH, Ruud EA, Flørenes VA et al. (2017)
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
ESMO Open, 2 (2), e000158
DOI 10.1136/esmoopen-2017-000158, PubMed 28761742

Russnes HG, Lingjærde OC, Børresen-Dale AL, Caldas C (2017)
Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters
Am J Pathol, 187 (10), 2152-2162
DOI 10.1016/j.ajpath.2017.04.022, PubMed 28733194

Saldova R, Haakensen VD, Rødland E, Walsh I, Stöckmann H, Engebraaten O, Børresen-Dale AL, Rudd PM (2017)
Serum N-glycome alterations in breast cancer during multimodal treatment and follow-up
Mol Oncol, 11 (10), 1361-1379
DOI 10.1002/1878-0261.12105, PubMed 28657165

Shimelis H, Mesman RLS, Von Nicolai C, Ehlen A, Guidugli L, Martin C, Calléja FMGR, Meeks H, Hallberg E, Hinton J, Lilyquist J, Hu C, Aalfs CM, Aittomäki K, Andrulis I, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV, Bojesen SE, Bolla MK, Borresen-Dale AL, Brauch H, Brennan P et al. (2017)
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Cancer Res, 77 (11), 2789-2799
DOI 10.1158/0008-5472.CAN-16-2568, PubMed 28283652

Silwal-Pandit L, Langerød A, Børresen-Dale AL (2017)
TP53 Mutations in Breast and Ovarian Cancer
Cold Spring Harb Perspect Med, 7 (1)
DOI 10.1101/cshperspect.a026252, PubMed 27815305

Silwal-Pandit L, Nord S, von der Lippe Gythfeldt H, Møller EK, Fleischer T, Rødland E, Krohn M, Borgen E, Garred Ø, Olsen T, Vu P, Skjerven H, Fangberget A, Holmen MM, Schlitchting E, Wille E, Nordberg Stokke M, Moen Vollan HK, Kristensen V, Langerød A, Lundgren S, Wist E, Naume B, Lingjærde OC, Børresen-Dale AL et al. (2017)
The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer
Clin Cancer Res, 23 (16), 4662-4670
DOI 10.1158/1078-0432.CCR-17-0160, PubMed 28487444

Østrup O, Dagenborg VJ, Rødland EA, Skarpeteig V, Silwal-Pandit L, Grzyb K, Berstad AE, Fretland ÅA, Mælandsmo GM, Børresen-Dale AL, Ree AH, Edwin B, Nygaard V, Flatmark K (2017)
Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases
Oncotarget, 8 (44), 76290-76304
DOI 10.18632/oncotarget.19350, PubMed 29100312

Publications 2016

Demeulemeester J, Kumar P, Møller EK, Nord S, Wedge DC, Peterson A, Mathiesen RR, Fjelldal R, Zamani Esteki M, Theunis K, Fernandez Gallardo E, Grundstad AJ, Borgen E, Baumbusch LO, Børresen-Dale AL, White KP, Kristensen VN, Van Loo P, Voet T, Naume B (2016)
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Genome Biol, 17 (1), 250
DOI 10.1186/s13059-016-1109-7, PubMed 27931250

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis J et al. (2016)
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Nat Genet, 48 (4), 374-86
DOI 10.1038/ng.3521, PubMed 26928228

Espinoza JA, Jabeen S, Batra R, Papaleo E, Haakensen V, Timmermans Wielenga V, Møller Talman ML, Brunner N, Børresen-Dale AL, Gromov P, Helland Å, Kristensen VN, Gromova I (2016)
Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics
Oncoimmunology, 5 (12), e1248015
DOI 10.1080/2162402X.2016.1248015, PubMed 28123884

Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Dennis J, Bolla MK, Wang Q, Dicks E, Milne RL, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O et al. (2016)
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation
Am J Hum Genet, 99 (4), 903-911
DOI 10.1016/j.ajhg.2016.07.017, PubMed 27640304

Guo Y, Warren Andersen S, Shu XO, Michailidou K, Bolla MK, Wang Q, Garcia-Closas M, Milne RL, Schmidt MK, Chang-Claude J, Dunning A, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bogdanova NV, Bonanni B, Børresen-Dale AL, Brand J, Brauch H et al. (2016)
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
PLoS Med, 13 (8), e1002105
DOI 10.1371/journal.pmed.1002105, PubMed 27551723

Halvorsen AR, Helland Å, Gromov P, Wielenga VT, Talman MM, Brunner N, Sandhu V, Børresen-Dale AL, Gromova I, Haakensen VD (2016)
Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer
Mol Oncol, 11 (2), 220-234
DOI 10.1002/1878-0261.12025, PubMed 28145100

Halvorsen AR, Silwal-Pandit L, Meza-Zepeda LA, Vodak D, Vu P, Sagerup C, Hovig E, Myklebost O, Børresen-Dale AL, Brustugun OT, Helland Å (2016)
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894

Hamdi Y, Soucy P, Adoue V, Michailidou K, Canisius S, Lemaçon A, Droit A, Andrulis IL, Anton-Culver H, Arndt V, Baynes C, Blomqvist C, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Borresen-Dale AL, Brand JS, Brauch H, Brenner H, Broeks A, Burwinkel B, Chang-Claude J, NBCS Collaborators, Couch FJ et al. (2016)
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21
Oncotarget, 7 (49), 80140-80163
DOI 10.18632/oncotarget.12818, PubMed 27792995

Haukaas TH, Euceda LR, Giskeødegård GF, Lamichhane S, Krohn M, Jernström S, Aure MR, Lingjærde OC, Schlichting E, Garred Ø, Due EU, Mills GB, Sahlberg KK, Børresen-Dale AL, Bathen TF, Oslo Breast Cancer Consortium (OSBREAC) (2016)
Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes
Cancer Metab, 4, 12
DOI 10.1186/s40170-016-0152-x, PubMed 27350877

Horne HN, Chung CC, Zhang H, Yu K, Prokunina-Olsson L, Michailidou K, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O, Johnson N, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel P, Truong T et al. (2016)
Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus
PLoS One, 11 (8), e0160316
DOI 10.1371/journal.pone.0160316, PubMed 27556229

Haakensen VD, Nygaard V, Greger L, Aure MR, Fromm B, Bukholm IR, Lüders T, Chin SF, Git A, Caldas C, Kristensen VN, Brazma A, Børresen-Dale AL, Hovig E, Helland Å (2016)
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer, 139 (5), 1117-28
DOI 10.1002/ijc.30142, PubMed 27082076

Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR, Ramakrishna M, Li Y, Yates L, Gundem G, Tarpey PS, Behjati S, Papaemmanuil E, Martin S, Fullam A, Gerstung M, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group, Nangalia J, Green AR, Caldas C, Borg Å, Tutt A, Lee MT, Van't Veer LJ et al. (2016)
Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Genome Res, 26 (5), 717.2
DOI 10.1101/gr.206557.116, PubMed 27197245

Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK (2016)
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16 (1), 913
DOI 10.1186/s12885-016-2899-4, PubMed 27876019

Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q, Delgado MK, Lee JM, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Bandera EV, Barile M, Barkardottir RB, Barrowdale D, Beckmann MW, Benitez J, Berchuck A, Bisogna M et al. (2016)
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Nat Commun, 7, 12675
DOI 10.1038/ncomms12675, PubMed 27601076

Lesurf R, Aure MR, Mørk HH, Vitelli V, Oslo Breast Cancer Research Consortium (OSBREAC), Lundgren S, Børresen-Dale AL, Kristensen V, Wärnberg F, Hallett M, Sørlie T (2016)
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
Cell Rep, 16 (4), 1166-1179
DOI 10.1016/j.celrep.2016.06.051, PubMed 27396337

Morganella S, Alexandrov LB, Glodzik D, Zou X, Davies H, Staaf J, Sieuwerts AM, Brinkman AB, Martin S, Ramakrishna M, Butler A, Kim HY, Borg Å, Sotiriou C, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL et al. (2016)
The topography of mutational processes in breast cancer genomes
Nat Commun, 7, 11383
DOI 10.1038/ncomms11383, PubMed 27136393

Muranen TA, Greco D, Blomqvist C, Aittomäki K, Khan S, Hogervorst F, Verhoef S, Pharoah PDP, Dunning AM, Shah M, Luben R, Bojesen SE, Nordestgaard BG, Schoemaker M, Swerdlow A, García-Closas M, Figueroa J, Dörk T, Bogdanova NV, Hall P, Li J, Khusnutdinova E, Bermisheva M, Kristensen V, Borresen-Dale AL et al. (2016)
Genetic modifiers of CHEK2*1100delC-associated breast cancer risk
Genet Med, 19 (5), 599-603
DOI 10.1038/gim.2016.147, PubMed 27711073

Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C et al. (2016)
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Nature, 534 (7605), 47-54
DOI 10.1038/nature17676, PubMed 27135926

Papp J, Kovacs ME, Matrai Z, Orosz E, Kásler M, Børresen-Dale AL, Olah E (2016)
Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary
Fam Cancer, 15 (1), 85-97
DOI 10.1007/s10689-015-9845-5, PubMed 26446593

Pelttari LM, Khan S, Vuorela M, Kiiski JI, Vilske S, Nevanlinna V, Ranta S, Schleutker J, Winqvist R, Kallioniemi A, Dörk T, Bogdanova NV, Figueroa J, Pharoah PD, Schmidt MK, Dunning AM, García-Closas M, Bolla MK, Dennis J, Michailidou K, Wang Q, Hopper JL, Southey MC, Rosenberg EH, Fasching PA et al. (2016)
RAD51B in Familial Breast Cancer
PLoS One, 11 (5), e0153788
DOI 10.1371/journal.pone.0153788, PubMed 27149063

Pereira B, Chin SF, Rueda OM, Vollan HK, Provenzano E, Bardwell HA, Pugh M, Jones L, Russell R, Sammut SJ, Tsui DW, Liu B, Dawson SJ, Abraham J, Northen H, Peden JF, Mukherjee A, Turashvili G, Green AR, McKinney S, Oloumi A, Shah S, Rosenfeld N, Murphy L, Bentley DR et al. (2016)
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
Nat Commun, 7, 11479
DOI 10.1038/ncomms11479, PubMed 27161491

Pereira B, Chin SF, Rueda OM, Vollan HK, Provenzano E, Bardwell HA, Pugh M, Jones L, Russell R, Sammut SJ, Tsui DW, Liu B, Dawson SJ, Abraham J, Northen H, Peden JF, Mukherjee A, Turashvili G, Green AR, McKinney S, Oloumi A, Shah S, Rosenfeld N, Murphy L, Bentley DR et al. (2016)
Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
Nat Commun, 7, 11908
DOI 10.1038/ncomms11908, PubMed 27264733

Petridis C, Brook MN, Shah V, Kohut K, Gorman P, Caneppele M, Levi D, Papouli E, Orr N, Cox A, Cross SS, Dos-Santos-Silva I, Peto J, Swerdlow A, Schoemaker MJ, Bolla MK, Wang Q, Dennis J, Michailidou K, Benitez J, González-Neira A, Tessier DC, Vincent D, Li J, Figueroa J et al. (2016)
Genetic predisposition to ductal carcinoma in situ of the breast
Breast Cancer Res, 18 (1), 22
DOI 10.1186/s13058-016-0675-7, PubMed 26884359

Robles AI, Olsen KS, Tsui DW, Georgoulias V, Creaney J, Dobra K, Vyberg M, Minato N, Anders RA, Børresen-Dale AL, Zhou J, Sætrom P, Nielsen BS, Kirschner MB, Krokan HE, Papadimitrakopoulou V, Tsamardinos I, Røe OD (2016)
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
J Transl Med, 14 (1), 295
DOI 10.1186/s12967-016-1059-6, PubMed 27756323

Sandhu V, Wedge DC, Bowitz Lothe IM, Labori KJ, Dentro SC, Buanes T, Skrede ML, Dalsgaard AM, Munthe E, Myklebost O, Lingjærde OC, Børresen-Dale AL, Ikdahl T, Van Loo P, Nord S, Kure EH (2016)
The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Cancer Res, 76 (17), 5092-102
DOI 10.1158/0008-5472.CAN-16-0658, PubMed 27488532

Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Körner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, Yuan J, Azuaje F, Oslo Breast Cancer Research Consortium (OSBREAC)SauerTorillGeislerJürgenHofvindSolveigBathenTone FBorgenElinEngebråtenOlavFodstadØysteinGarredØysteinGeitvikGry AarumKåresenRolfNaumeBjørnMælandsmoGunhild MariRussnesHege GSchlichtingEllenSørlieThereseLingjærdeOle ChristianSahlbergKristine KleiviSkjervenHelle KristineFritzmanBritt, Ulitsky I, Diederichs S, Wiemann S, Yakhini Z, Kristensen VN, Børresen-Dale AL, Yarden Y (2016)
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer
EMBO Mol Med, 8 (9), 1052-64
DOI 10.15252/emmm.201606198, PubMed 27485121

Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Dennis J, Lush M, Milne RL, Shu XO, Beesley J, Kar S, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Zhao Z, Guo X, Benitez J, Beeghly-Fadiel A, Blot W, Bogdanova NV, Bojesen SE, Brauch H et al. (2016)
Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
Int J Cancer, 139 (6), 1303-1317
DOI 10.1002/ijc.30150, PubMed 27087578

Shlien A, Raine K, Fuligni F, Arnold R, Nik-Zainal S, Dronov S, Mamanova L, Rosic A, Ju YS, Cooke SL, Ramakrishna M, Papaemmanuil E, Davies HR, Tarpey PS, Van Loo P, Wedge DC, Jones DR, Martin S, Marshall J, Anderson E, Hardy C, ICGC Breast Cancer Working Group, Oslo Breast Cancer Research Consortium, Barbashina V, Aparicio SA, Sauer T et al. (2016)
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Rep, 16 (7), 2032-46
DOI 10.1016/j.celrep.2016.07.028, PubMed 27498871

Smid M, Rodríguez-González FG, Sieuwerts AM, Salgado R, Prager-Van der Smissen WJ, Vlugt-Daane MV, van Galen A, Nik-Zainal S, Staaf J, Brinkman AB, van de Vijver MJ, Richardson AL, Fatima A, Berentsen K, Butler A, Martin S, Davies HR, Debets R, Gelder ME, van Deurzen CH, MacGrogan G, Van den Eynden GG, Purdie C, Thompson AM, Caldas C et al. (2016)
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Nat Commun, 7, 12910
DOI 10.1038/ncomms12910, PubMed 27666519

Tinholt M, Sandset PM, Mowinckel MC, Garred Ø, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Jacobsen AF, Skretting G, Iversen N (2016)
Determinants of acquired activated protein C resistance and D-dimer in breast cancer
Thromb Res, 145, 78-83
DOI 10.1016/j.thromres.2016.08.003, PubMed 27505249

Zeng C, Guo X, Long J, Kuchenbaecker KB, Droit A, Michailidou K, Ghoussaini M, Kar S, Freeman A, Hopper JL, Milne RL, Bolla MK, Wang Q, Dennis J, Agata S, Ahmed S, Aittomäki K, Andrulis IL, Anton-Culver H, Antonenkova NN, Arason A, Arndt V, Arun BK, Arver B, Bacot F et al. (2016)
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
Breast Cancer Res, 18 (1), 64
DOI 10.1186/s13058-016-0718-0, PubMed 27459855

Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, Zhang B, Long J, Shu XO, Schmidt MK, Milne RL, García-Closas M, Chang-Claude J, Lindstrom S, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Blomqvist C, Bogdanova NV, Børresen-Dale AL et al. (2016)
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry
Cancer Causes Control, 27 (5), 679-93
DOI 10.1007/s10552-016-0741-6, PubMed 27053251

Zänker KS, Borresen-Dale AL, Huber HP (2016)
Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression, and Therapy
Biomed Hub, 1 (3), 1-9
DOI 10.1159/000453253, PubMed 31988890

Publications 2015

Aure MR, Jernström S, Krohn M, Vollan HK, Due EU, Rødland E, Kåresen R, Oslo Breast Cancer Research Consortium (OSBREAC), Ram P, Lu Y, Mills GB, Sahlberg KK, Børresen-Dale AL, Lingjærde OC, Kristensen VN (2015)
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer
Genome Med, 7 (1), 21
DOI 10.1186/s13073-015-0135-5, PubMed 25873999

Bjørklund SS, Kristensen VN, Seiler M, Kumar S, Alnæs GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Børresen-Dale AL, Ganesan S (2015)
Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas
BMC Cancer, 15, 524
DOI 10.1186/s12885-015-1510-8, PubMed 26183823

Bjaanæs MM, Fleischer T, Halvorsen AR, Daunay A, Busato F, Solberg S, Jørgensen L, Kure E, Edvardsen H, Børresen-Dale AL, Brustugun OT, Tost J, Kristensen V, Helland Å (2015)
Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
Mol Oncol, 10 (2), 330-43
DOI 10.1016/j.molonc.2015.10.021, PubMed 26601720

Borge KS, Nord S, Van Loo P, Lingjærde OC, Gunnes G, Alnæs GI, Solvang HK, Lüders T, Kristensen VN, Børresen-Dale AL, Lingaas F (2015)
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN
PLoS One, 10 (5), e0126371
DOI 10.1371/journal.pone.0126371, PubMed 25955013

Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S, Humphreys K, Thompson D, Ghoussaini M, Bolla MK, Dennis J, Wang Q, Canisius S, Scott CG, Apicella C, Hopper JL, Southey MC, Stone J, Broeks A, Schmidt MK, Scott RJ, Lophatananon A, Muir K, Beckmann MW, Ekici AB et al. (2015)
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
Am J Hum Genet, 97 (1), 22-34
DOI 10.1016/j.ajhg.2015.05.002, PubMed 26073781

Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF, McArdle PF, Nutile T, Porcu E, Robino A, Rose LM et al. (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Nat Genet, 47 (11), 1294-1303
DOI 10.1038/ng.3412, PubMed 26414677

Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF, McArdle PF, Nutile T, Porcu E, Robino A, Rose LM et al. (2015)
Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT
Obstet. Gynecol. Surv., 70 (12), 758-762
DOI 10.1097/01.ogx.0000473766.71624.99

Grawenda AM, Møller EK, Lam S, Repapi E, Teunisse AF, Alnæs GI, Børresen-Dale AL, Kristensen VN, Goding CR, Jochemsen AG, Edvardsen H, Bond GL (2015)
Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer
Cancer Res, 75 (4), 698-708
DOI 10.1158/0008-5472.CAN-14-2637, PubMed 25649770

Győrffy B, Bottai G, Fleischer T, Munkácsy G, Budczies J, Paladini L, Børresen-Dale AL, Kristensen VN, Santarpia L (2015)
Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes
Int J Cancer, 138 (1), 87-97
DOI 10.1002/ijc.29684, PubMed 26174627

Haakensen VD, Steinfeld I, Saldova R, Shehni AA, Kifer I, Naume B, Rudd PM, Børresen-Dale AL, Yakhini Z (2015)
Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome
Mol Oncol, 10 (1), 59-72
DOI 10.1016/j.molonc.2015.08.002, PubMed 26321095

Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR, Ramakrishna M, Li Y, Yates L, Gundem G, Tarpey PS, Behjati S, Papaemmanuil E, Martin S, Fullam A, Gerstung M, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group, Nangalia J, Green AR, Caldas C, Borg Å, Tutt A, Lee MT, van't Veer LJ et al. (2015)
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Genome Res, 25 (6), 814-24
DOI 10.1101/gr.190470.115, PubMed 25963125

Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, Bolla MK, Dennis J, Dunning AM, Easton DF, Wang Q, Benitez J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Fasching PA, Haeberle L, Peto J, Dos-Santos-Silva I, Sawyer EJ, Tomlinson I, Burwinkel B, Marmé F, Guénel P, Truong T et al. (2015)
Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium
Hum Genet, 135 (1), 137-54
DOI 10.1007/s00439-015-1616-8, PubMed 26621531

Lei J, Rudolph A, Moysich KB, Rafiq S, Behrens S, Goode EL, Pharoah PP, Seibold P, Fasching PA, Andrulis IL, Kristensen VN, Couch FJ, Hamann U, Hooning MJ, Nevanlinna H, Eilber U, Bolla MK, Dennis J, Wang Q, Lindblom A, Mannermaa A, Lambrechts D, García-Closas M, Hall P, Chenevix-Trench G et al. (2015)
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy
Breast Cancer Res, 17 (1), 18
DOI 10.1186/s13058-015-0522-2, PubMed 25849327

Mavaddat N, Pharoah PD, Michailidou K, Tyrer J, Brook MN, Bolla MK, Wang Q, Dennis J, Dunning AM, Shah M, Luben R, Brown J, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Czene K, Darabi H, Eriksson M, Peto J, Dos-Santos-Silva I, Dudbridge F, Johnson N, Schmidt MK, Broeks A et al. (2015)
Prediction of breast cancer risk based on profiling with common genetic variants
J Natl Cancer Inst, 107 (5)
DOI 10.1093/jnci/djv036, PubMed 25855707

Meeks HD, Song H, Michailidou K, Bolla MK, Dennis J, Wang Q, Barrowdale D, Frost D, EMBRACE, McGuffog L, Ellis S, Feng B, Buys SS, Hopper JL, Southey MC, Tesoriero A, kConFab Investigators, James PA, Bruinsma F, Campbell IG, Australia Ovarian Cancer Study Group, Broeks A, Schmidt MK, Hogervorst FB, HEBON et al. (2015)
BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers
J Natl Cancer Inst, 108 (2)
DOI 10.1093/jnci/djv315, PubMed 26586665

Mäki-Jouppila JH, Pruikkonen S, Tambe MB, Aure MR, Halonen T, Salmela AL, Laine L, Børresen-Dale AL, Kallio MJ (2015)
MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase
Mol Oncol, 9 (6), 1056-70
DOI 10.1016/j.molonc.2015.01.005, PubMed 25682900

Orr N, Dudbridge F, Dryden N, Maguire S, Novo D, Perrakis E, Johnson N, Ghoussaini M, Hopper JL, Southey MC, Apicella C, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Hogervorst FB, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Gibson L, Aitken Z, Warren H, Sawyer E, Tomlinson I et al. (2015)
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Hum Mol Genet, 24 (10), 2966-84
DOI 10.1093/hmg/ddv035, PubMed 25652398

Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, Freed-Pastor WA, Laptenko O, Neo SP, Bargonetti J, Hoque M, Tian B, Gunaratne J, Engebraaten O, Manley JL, Børresen-Dale AL, Neilsen PM, Prives C (2015)
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells
Genes Dev, 29 (12), 1298-315
DOI 10.1101/gad.263202.115, PubMed 26080815

Potapenko IO, Lüders T, Russnes HG, Helland Å, Sørlie T, Kristensen VN, Nord S, Lingjærde OC, Børresen-Dale AL, Haakensen VD (2015)
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival
Mol Oncol, 9 (4), 861-76
DOI 10.1016/j.molonc.2014.12.013, PubMed 25655580

Sandhu V, Bowitz Lothe IM, Labori KJ, Skrede ML, Hamfjord J, Dalsgaard AM, Buanes T, Dube G, Kale MM, Sawant S, Kulkarni-Kale U, Børresen-Dale AL, Lingjærde OC, Kure EH (2015)
Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma
Mol Oncol, 10 (2), 303-16
DOI 10.1016/j.molonc.2015.10.011, PubMed 26590090

Seibold P, Schmezer P, Behrens S, Michailidou K, Bolla MK, Wang Q, Flesch-Janys D, Nevanlinna H, Fagerholm R, Aittomäki K, Blomqvist C, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Lambrechts D, Wildiers H, Kristensen V, Alnæs GG, Nord S, Borresen-Dale AL, Hooning MJ, Hollestelle A, Jager A et al. (2015)
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients
BMC Cancer, 15, 978
DOI 10.1186/s12885-015-1957-7, PubMed 26674097

Silwal-Pandit L, Russnes H, Borgen E, Skarpeteig V, Moen Vollan HK, Schlichting E, Kåresen R, Naume B, Børresen-Dale AL, Farnebo M, Langerød A (2015)
The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer
PLoS One, 10 (10), e0139965
DOI 10.1371/journal.pone.0139965, PubMed 26460974

Stone J, Thompson DJ, Dos Santos Silva I, Scott C, Tamimi RM, Lindstrom S, Kraft P, Hazra A, Li J, Eriksson L, Czene K, Hall P, Jensen M, Cunningham J, Olson JE, Purrington K, Couch FJ, Brown J, Leyland J, Warren RM, Luben RN, Khaw KT, Smith P, Wareham NJ, Jud SM et al. (2015)
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures
Cancer Res, 75 (12), 2457-67
DOI 10.1158/0008-5472.CAN-14-2012, PubMed 25862352

Tinholt M, Vollan HK, Sahlberg KK, Jernström S, Kaveh F, Lingjærde OC, Kåresen R, Sauer T, Kristensen V, Børresen-Dale AL, Sandset PM, Iversen N (2015)
Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF
Breast Cancer Res, 17 (1), 44
DOI 10.1186/s13058-015-0548-5, PubMed 25882602

Aakula A, Leivonen SK, Hintsanen P, Aittokallio T, Ceder Y, Børresen-Dale AL, Perälä M, Östling P, Kallioniemi O (2015)
MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth
Mol Oncol, 9 (7), 1287-300
DOI 10.1016/j.molonc.2015.03.001, PubMed 25907805

Publications 2014

Almendro V, Cheng YK, Randles A, Itzkovitz S, Marusyk A, Ametller E, Gonzalez-Farre X, Muñoz M, Russnes HG, Helland A, Rye IH, Borresen-Dale AL, Maruyama R, van Oudenaarden A, Dowsett M, Jones RL, Reis-Filho J, Gascon P, Gönen M, Michor F, Polyak K (2014)
Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity
Cell Rep, 6 (3), 514-27
DOI 10.1016/j.celrep.2013.12.041, PubMed 24462293

Askautrud HA, Gjernes E, Gunnes G, Sletten M, Ross DT, Børresen-Dale AL, Iversen N, Tranulis MA, Frengen E (2014)
Global gene expression analysis reveals a link between NDRG1 and vesicle transport
PLoS One, 9 (1), e87268
DOI 10.1371/journal.pone.0087268, PubMed 24498060

Bjaanaes MM, Halvorsen AR, Solberg S, Jørgensen L, Dragani TA, Galvan A, Colombo F, Anderlini M, Pastorino U, Kure E, Børresen-Dale AL, Brustugun OT, Helland A (2014)
Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas
Int J Cancer, 135 (8), 1812-21
DOI 10.1002/ijc.28828, PubMed 24599520

Carvajal-Carmona LG, O'Mara TA, Painter JN, Lose FA, Dennis J, Michailidou K, Tyrer JP, Ahmed S, Ferguson K, Healey CS, Pooley K, Beesley J, Cheng T, Jones A, Howarth K, Martin L, Gorman M, Hodgson S, National Study of Endometrial Cancer Genetics Group (NSECG), Australian National Endometrial Cancer Study Group (ANECS), Wentzensen N, Fasching PA, Hein A, Beckmann MW, Renner SP et al. (2014)
Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk
Hum Genet, 134 (2), 231-45
DOI 10.1007/s00439-014-1515-4, PubMed 25487306

Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K et al. (2014)
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers
Cancer Cell, 26 (6), 863-879
DOI 10.1016/j.ccell.2014.10.010, PubMed 25490449

Fleischer T, Edvardsen H, Solvang HK, Daviaud C, Naume B, Børresen-Dale AL, Kristensen VN, Tost J (2014)
Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
Int J Cancer, 134 (11), 2615-25
DOI 10.1002/ijc.28606, PubMed 24395279

Fleischer T, Frigessi A, Johnson KC, Edvardsen H, Touleimat N, Klajic J, Riis ML, Haakensen VD, Wärnberg F, Naume B, Helland A, Børresen-Dale AL, Tost J, Christensen BC, Kristensen VN (2014)
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
Genome Biol, 15 (8), 435
DOI 10.1186/PREACCEPT-2333349012841587, PubMed 25146004

Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Schmidt MK, Shah M, Luben R, Brown J, Czene K, Darabi H, Eriksson M, Klevebring D, Bojesen SE et al. (2014)
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Nat Commun, 4, 4999
DOI 10.1038/ncomms5999, PubMed 25248036

Grinde MT, Skrbo N, Moestue SA, Rødland EA, Borgan E, Kristian A, Sitter B, Bathen TF, Børresen-Dale AL, Mælandsmo GM, Engebraaten O, Sørlie T, Marangoni E, Gribbestad IS (2014)
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts
Breast Cancer Res, 16 (1), R5
DOI 10.1186/bcr3597, PubMed 24447408

Halvorsen AR, Helland A, Fleischer T, Haug KM, Grenaker Alnaes GI, Nebdal D, Syljuåsen RG, Touleimat N, Busato F, Tost J, Saetersdal AB, Børresen-Dale AL, Kristensen V, Edvardsen H (2014)
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy
Int J Cancer, 135 (9), 2085-95
DOI 10.1002/ijc.28862, PubMed 24658971

Johnson N, Dudbridge F, Orr N, Gibson L, Jones ME, Schoemaker MJ, Folkerd EJ, Haynes BP, Hopper JL, Southey MC, Dite GS, Apicella C, Schmidt MK, Broeks A, Van't Veer LJ, Atsma F, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Ekici AB, Renner SP, Sawyer E, Tomlinson I, Kerin M et al. (2014)
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Breast Cancer Res, 16 (3), R51
DOI 10.1186/bcr3662, PubMed 24887515

Klajic J, Busato F, Edvardsen H, Touleimat N, Fleischer T, Bukholm I, Børresen-Dale AL, Lønning PE, Tost J, Kristensen VN (2014)
DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors
Clin Cancer Res, 20 (24), 6357-66
DOI 10.1158/1078-0432.CCR-14-0297, PubMed 25294903

Kleivi Sahlberg K, Bottai G, Naume B, Burwinkel B, Calin GA, Børresen-Dale AL, Santarpia L (2014)
A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients
Clin Cancer Res, 21 (5), 1207-14
DOI 10.1158/1078-0432.CCR-14-2011, PubMed 25547678

Kristensen VN, Lingjærde OC, Russnes HG, Vollan HK, Frigessi A, Børresen-Dale AL (2014)
Principles and methods of integrative genomic analyses in cancer
Nat Rev Cancer, 14 (5), 299-313
DOI 10.1038/nrc3721, PubMed 24759209

Li J, Lindström LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PD, Michailidou K, Dennis J, Bolla MK, Wang Q, Van 't Veer LJ, Cornelissen S, Rutgers E, Southey MC, Apicella C, Dite GS, Hopper JL, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Blomqvist C, Muranen TA, Aittomäki K, Lindblom A et al. (2014)
2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Nat Commun, 5, 4051
DOI 10.1038/ncomms5051, PubMed 24937182

Nygren MK, Tekle C, Ingebrigtsen VA, Mäkelä R, Krohn M, Aure MR, Nunes-Xavier CE, Perälä M, Tramm T, Alsner J, Overgaard J, Nesland JM, Borgen E, Børresen-Dale AL, Fodstad Ø, Sahlberg KK, Leivonen SK (2014)
Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c
Br J Cancer, 110 (8), 2072-80
DOI 10.1038/bjc.2014.113, PubMed 24577056

Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, Michailidou K, Tyrer JP, Ahmed S, Ferguson K, Healey CS, Kaufmann S, Hillman KM, Walpole C, Moya L, Pollock P, Jones A, Howarth K, Martin L, Gorman M, Hodgson S, National Study of Endometrial Cancer Genetics Group (NSECG), CHIBCHA Consortium, De Polanco MM, Sans M et al. (2014)
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk
Hum Mol Genet, 24 (5), 1478-92
DOI 10.1093/hmg/ddu552, PubMed 25378557

Quigley D, Silwal-Pandit L, Dannenfelser R, Langerød A, Vollan HK, Vaske C, Siegel JU, Troyanskaya O, Chin SF, Caldas C, Balmain A, Børresen-Dale AL, Kristensen V (2014)
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
Mol Cancer Res, 13 (3), 493-501
DOI 10.1158/1541-7786.MCR-14-0387, PubMed 25351767

Reiche K, Kasack K, Schreiber S, Lüders T, Due EU, Naume B, Riis M, Kristensen VN, Horn F, Børresen-Dale AL, Hackermüller J, Baumbusch LO (2014)
Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes
PLoS One, 9 (9), e106076
DOI 10.1371/journal.pone.0106076, PubMed 25264628

Russnes HG, Lønning PE, Børresen-Dale AL, Lingjærde OC (2014)
The multitude of molecular analyses in cancer: the opening of Pandora’s box
Genome Biol, 15 (9), 447
DOI 10.1186/s13059-014-0447-6, PubMed 25316146

Rye IH, Lundin P, Månér S, Fjelldal R, Naume B, Wigler M, Hicks J, Børresen-Dale AL, Zetterberg A, Russnes HG (2014)
Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors
Genes Chromosomes Cancer, 54 (4), 235-48
DOI 10.1002/gcc.22237, PubMed 25546585

Saldova R, Asadi Shehni A, Haakensen VD, Steinfeld I, Hilliard M, Kifer I, Helland A, Yakhini Z, Børresen-Dale AL, Rudd PM (2014)
Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC
J Proteome Res, 13 (5), 2314-27
DOI 10.1021/pr401092y, PubMed 24669823

Sandhu V, Bowitz Lothe IM, Labori KJ, Lingjærde OC, Buanes T, Dalsgaard AM, Skrede ML, Hamfjord J, Haaland T, Eide TJ, Børresen-Dale AL, Ikdahl T, Kure EH (2014)
Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas
Mol Oncol, 9 (4), 758-71
DOI 10.1016/j.molonc.2014.12.002, PubMed 25579086

Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A (2014)
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance
Clin Cancer Res, 20 (13), 3569-80
DOI 10.1158/1078-0432.CCR-13-2943, PubMed 24803582

Sternemalm J, Russnes HG, Zhao X, Risberg B, Nord S, Caldas C, Børresen-Dale AL, Stokke T, Patzke S (2014)
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer
Br J Cancer, 111 (2), 326-38
DOI 10.1038/bjc.2014.297, PubMed 24901235

Sørlie T, Johnsen H, Vu P, Lind GE, Lothe R, Børresen-Dale AL (2014)
Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE)
Methods Mol Biol, 1105, 315-24
DOI 10.1007/978-1-62703-739-6_25, PubMed 24623239

Tinholt M, Viken MK, Dahm AE, Vollan HK, Sahlberg KK, Garred O, Børresen-Dale AL, Jacobsen AF, Kristensen V, Bukholm I, Kåresen R, Schlichting E, Skretting G, Lie BA, Sandset PM, Iversen N (2014)
Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study
BMC Cancer, 14, 845
DOI 10.1186/1471-2407-14-845, PubMed 25407022

Tramm T, Mohammed H, Myhre S, Kyndi M, Alsner J, Børresen-Dale AL, Sørlie T, Frigessi A, Overgaard J (2014)
Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort
Clin Cancer Res, 20 (20), 5272-80
DOI 10.1158/1078-0432.CCR-14-0458, PubMed 25149560

Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP et al. (2014)
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
Science, 345 (6196), 1251343
DOI 10.1126/science.1251343, PubMed 25082706

Vollan HK, Rueda OM, Chin SF, Curtis C, Turashvili G, Shah S, Lingjærde OC, Yuan Y, Ng CK, Dunning MJ, Dicks E, Provenzano E, Sammut S, McKinney S, Ellis IO, Pinder S, Purushotham A, Murphy LC, Kristensen VN, METABRIC Group, Brenton JD, Pharoah PD, Børresen-Dale AL, Aparicio S, Caldas C (2014)
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer
Mol Oncol, 9 (1), 115-27
DOI 10.1016/j.molonc.2014.07.019, PubMed 25169931

Winsel S, Mäki-Jouppila J, Tambe M, Aure MR, Pruikkonen S, Salmela AL, Halonen T, Leivonen SK, Kallio L, Børresen-Dale AL, Kallio MJ (2014)
Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo
Br J Cancer, 111 (11), 2142-51
DOI 10.1038/bjc.2014.524, PubMed 25268374

Zhao X, Rødland EA, Sørlie T, Vollan HK, Russnes HG, Kristensen VN, Lingjærde OC, Børresen-Dale AL (2014)
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status
BMC Cancer, 14, 211
DOI 10.1186/1471-2407-14-211, PubMed 24645668

Publications 2013

Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjörd JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinski M et al. (2013)
Signatures of mutational processes in human cancer
Nature, 500 (7463), 415-21
DOI 10.1038/nature12477, PubMed 23945592

Aure MR, Leivonen SK, Fleischer T, Zhu Q, Overgaard J, Alsner J, Tramm T, Louhimo R, Alnæs GI, Perälä M, Busato F, Touleimat N, Tost J, Børresen-Dale AL, Hautaniemi S, Troyanskaya OG, Lingjærde OC, Sahlberg KK, Kristensen VN (2013)
Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors
Genome Biol, 14 (11), R126
DOI 10.1186/gb-2013-14-11-r126, PubMed 24257477

Aure MR, Steinfeld I, Baumbusch LO, Liestøl K, Lipson D, Nyberg S, Naume B, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Lingjærde OC, Yakhini Z (2013)
Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data
PLoS One, 8 (1), e53014
DOI 10.1371/journal.pone.0053014, PubMed 23382830

Baumbusch LO, Helland Å, Wang Y, Liestøl K, Schaner ME, Holm R, Etemadmoghadam D, Alsop K, Brown P, Australian Ovarian Cancer Study Group, Mitchell G, Fereday S, DeFazio A, Bowtell DD, Kristensen GB, Lingjærde OC, Børresen-Dale AL (2013)
High levels of genomic aberrations in serous ovarian cancers are associated with better survival
PLoS One, 8 (1), e54356
DOI 10.1371/journal.pone.0054356, PubMed 23372714

Bilal E, Dutkowski J, Guinney J, Jang IS, Logsdon BA, Pandey G, Sauerwine BA, Shimoni Y, Moen Vollan HK, Mecham BH, Rueda OM, Tost J, Curtis C, Alvarez MJ, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Califano A, Friend SH, Ideker T, Schadt EE, Stolovitzky GA, Margolin AA (2013)
Improving breast cancer survival analysis through competition-based multidimensional modeling
PLoS Comput Biol, 9 (5), e1003047
DOI 10.1371/journal.pcbi.1003047, PubMed 23671412

Edvardsen H, Landmark-Høyvik H, Reinertsen KV, Zhao X, Grenaker-Alnæs GI, Nebdal D, Syvänen AC, Rødningen O, Alsner J, Overgaard J, Borresen-Dale AL, Fosså SD, Kristensen VN (2013)
SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling
Int J Radiat Oncol Biol Phys, 86 (4), 791-9
DOI 10.1016/j.ijrobp.2013.02.025, PubMed 23597419

Engebraaten O, Vollan HKM, Børresen-Dale AL (2013)
Triple-negative breast cancer and the need for new therapeutic targets
Am J Pathol, 183 (4), 1064-1074
DOI 10.1016/j.ajpath.2013.05.033, PubMed 23920327

Kalous O, Conklin D, Desai AJ, Dering J, Goldstein J, Ginther C, Anderson L, Lu M, Kolarova T, Eckardt MA, Langerød A, Børresen-Dale AL, Slamon DJ, Finn RS (2013)
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53
Breast Cancer Res Treat, 141 (3), 397-408
DOI 10.1007/s10549-013-2702-z, PubMed 24091768

Klajic J, Fleischer T, Dejeux E, Edvardsen H, Warnberg F, Bukholm I, Lønning PE, Solvang H, Børresen-Dale AL, Tost J, Kristensen VN (2013)
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
BMC Cancer, 13, 456
DOI 10.1186/1471-2407-13-456, PubMed 24093668

Landmark-Høyvik H, Dumeaux V, Nebdal D, Lund E, Tost J, Kamatani Y, Renault V, Børresen-Dale AL, Kristensen V, Edvardsen H (2013)
Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II
Genomics, 102 (4), 278-87
DOI 10.1016/j.ygeno.2013.07.006, PubMed 23880221

Leivonen SK, Sahlberg KK, Mäkelä R, Due EU, Kallioniemi O, Børresen-Dale AL, Perälä M (2013)
High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
Mol Oncol, 8 (1), 93-104
DOI 10.1016/j.molonc.2013.10.001, PubMed 24148764

Liu Y, Zhou R, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Aarøe J, Wärnberg F, Børresen-Dale AL, Mills GB, Thompson PA, Bondy ML (2013)
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
Breast Cancer Res Treat, 143 (1), 189-201
DOI 10.1007/s10549-013-2796-3, PubMed 24305980

Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, Sauerwine B, Kellen MR, Mangravite LM, Furia MD, Vollan HK, Rueda OM, Guinney J, Deflaux NA, Hoff B, Schildwachter X, Russnes HG, Park D, Vang VO, Pirtle T, Youseff L, Citro C, Curtis C, Kristensen VN, Hellerstein J et al. (2013)
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer
Sci Transl Med, 5 (181), 181re1
DOI 10.1126/scitranslmed.3006112, PubMed 23596205

Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD, Prathalingham R, Dennis J, Bolla MK, Wang Q, de Santiago I, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Hogervorst FB, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Fasching PA, Lux MP et al. (2013)
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1
Am J Hum Genet, 93 (6), 1046-60
DOI 10.1016/j.ajhg.2013.10.026, PubMed 24290378

Milne RL, Herranz J, Michailidou K, Dennis J, Tyrer JP, Zamora MP, Arias-Perez JI, González-Neira A, Pita G, Alonso MR, Wang Q, Bolla MK, Czene K, Eriksson M, Humphreys K, Darabi H, Li J, Anton-Culver H, Neuhausen SL, Ziogas A, Clarke CA, Hopper JL, Dite GS, Apicella C, Southey MC et al. (2013)
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium
Hum Mol Genet, 23 (7), 1934-46
DOI 10.1093/hmg/ddt581, PubMed 24242184

Myhre S, Lingjærde OC, Hennessy BT, Aure MR, Carey MS, Alsner J, Tramm T, Overgaard J, Mills GB, Børresen-Dale AL, Sørlie T (2013)
Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
Mol Oncol, 7 (3), 704-18
DOI 10.1016/j.molonc.2013.02.018, PubMed 23562353

Møller EK, Kumar P, Voet T, Peterson A, Van Loo P, Mathiesen RR, Fjelldal R, Grundstad J, Borgen E, Baumbusch LO, Naume B, Børresen-Dale AL, White KP, Nord S, Kristensen VN (2013)
Next-generation sequencing of disseminated tumor cells
Front Oncol, 3, 320
DOI 10.3389/fonc.2013.00320, PubMed 24427740

Quigley DA, Fiorito E, Nord S, Van Loo P, Alnæs GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, Børresen-Dale AL, Kristensen V (2013)
The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors
Mol Oncol, 8 (2), 273-84
DOI 10.1016/j.molonc.2013.11.008, PubMed 24388359

Tahiri A, Leivonen SK, Lüders T, Steinfeld I, Ragle Aure M, Geisler J, Mäkelä R, Nord S, Riis ML, Yakhini Z, Kleivi Sahlberg K, Børresen-Dale AL, Perälä M, Bukholm IR, Kristensen VN (2013)
Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors
Carcinogenesis, 35 (1), 76-85
DOI 10.1093/carcin/bgt333, PubMed 24104550

Zänker KS, Mihich E, Huber HP, Borresen-Dale AL (2013)
Personalized cancer care conference
J Pers Med, 3 (2), 70-81
DOI 10.3390/jpm3020070, PubMed 25562519

Publications 2012

Bilal E, Vassallo K, Toppmeyer D, Barnard N, Rye IH, Almendro V, Russnes H, Børresen-Dale AL, Levine AJ, Bhanot G, Ganesan S (2012)
Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers
PLoS One, 7 (6), e38575
DOI 10.1371/journal.pone.0038575, PubMed 22719901

Borgan E, Lindholm EM, Moestue S, Mælandsmo GM, Lingjærde OC, Gribbestad IS, Børresen-Dale AL, Engebraaten O, Sørlie T (2012)
Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts
Mol Oncol, 7 (1), 130-42
DOI 10.1016/j.molonc.2012.10.005, PubMed 23142657

Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L et al. (2012)
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Nature, 486 (7403), 346-52
DOI 10.1038/nature10983, PubMed 22522925

Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C (2012)
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Cell, 148 (1-2), 244-58
DOI 10.1016/j.cell.2011.12.017, PubMed 22265415

Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Driver K, Johnson N, Orr N, dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON), Hall P, Czene K et al. (2012)
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Nat Genet, 44 (3), 312-8
DOI 10.1038/ng.1049, PubMed 22267197

Hein R, Maranian M, Hopper JL, Kapuscinski MK, Southey MC, Park DJ, Schmidt MK, Broeks A, Hogervorst FB, Bueno-de-Mesquita HB, Muir KR, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching PA, Hein A, Ekici AB, Beckmann MW, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Sawyer E, Tomlinson I, Kerin M et al. (2012)
Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)
PLoS One, 7 (8), e42380
DOI 10.1371/journal.pone.0042380, PubMed 22879957

Joshi H, Bhanot G, Børresen-Dale AL, Kristensen V (2012)
Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway
Br J Cancer, 107 (10), 1722-8
DOI 10.1038/bjc.2012.461, PubMed 23079576

Joshi H, Nord SH, Frigessi A, Børresen-Dale AL, Kristensen VN (2012)
Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes
BMC Genomics, 13, 199
DOI 10.1186/1471-2164-13-199, PubMed 22616941

Kim J, Villadsen R, Sørlie T, Fogh L, Grønlund SZ, Fridriksdottir AJ, Kuhn I, Rank F, Wielenga VT, Solvang H, Edwards PA, Børresen-Dale AL, Rønnov-Jessen L, Bissell MJ, Petersen OW (2012)
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity
Proc Natl Acad Sci U S A, 109 (16), 6124-9
DOI 10.1073/pnas.1203203109, PubMed 22454501

Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI, Benítez J, Hamann U, Ko YD, Brüning T, GENICA Network et al. (2012)
11q13 is a susceptibility locus for hormone receptor positive breast cancer
Hum Mutat, 33 (7), 1123-32
DOI 10.1002/humu.22089, PubMed 22461340

Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, Jones D, Hinton J, Marshall J, Stebbings LA, Menzies A, Martin S, Leung K, Chen L, Leroy C, Ramakrishna M, Rance R, Lau KW, Mudie LJ, Varela I, McBride DJ, Bignell GR, Cooke SL, Shlien A, Gamble J et al. (2012)
Mutational processes molding the genomes of 21 breast cancers
Cell, 149 (5), 979-93
DOI 10.1016/j.cell.2012.04.024, PubMed 22608084

Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD, Lau KW, Raine K, Jones D, Marshall J, Ramakrishna M, Shlien A, Cooke SL, Hinton J, Menzies A, Stebbings LA, Leroy C, Jia M, Rance R, Mudie LJ, Gamble SJ, Stephens PJ, McLaren S, Tarpey PS, Papaemmanuil E, Davies HR et al. (2012)
The life history of 21 breast cancers
Cell, 149 (5), 994-1007
DOI 10.1016/j.cell.2012.04.023, PubMed 22608083

Nilsen G, Liestøl K, Van Loo P, Moen Vollan HK, Eide MB, Rueda OM, Chin SF, Russell R, Baumbusch LO, Caldas C, Børresen-Dale AL, Lingjaerde OC (2012)
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591, PubMed 23442169

Sahlberg KK, Hongisto V, Edgren H, Mäkelä R, Hellström K, Due EU, Moen Vollan HK, Sahlberg N, Wolf M, Børresen-Dale AL, Perälä M, Kallioniemi O (2012)
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells
Mol Oncol, 7 (3), 392-401
DOI 10.1016/j.molonc.2012.10.012, PubMed 23253899

Stavnes HT, Nymoen DA, Langerød A, Holth A, Børresen Dale AL, Davidson B (2012)
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma
Virchows Arch, 462 (2), 163-73
DOI 10.1007/s00428-012-1347-3, PubMed 23242172

Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, Nik-Zainal S, Martin S, Varela I, Bignell GR, Yates LR, Papaemmanuil E, Beare D, Butler A, Cheverton A, Gamble J, Hinton J, Jia M, Jayakumar A, Jones D, Latimer C, Lau KW, McLaren S, McBride DJ, Menzies A et al. (2012)
The landscape of cancer genes and mutational processes in breast cancer
Nature, 486 (7403), 400-4
DOI 10.1038/nature11017, PubMed 22722201

Stevens KN, Fredericksen Z, Vachon CM, Wang X, Margolin S, Lindblom A, Nevanlinna H, Greco D, Aittomäki K, Blomqvist C, Chang-Claude J, Vrieling A, Flesch-Janys D, Sinn HP, Wang-Gohrke S, Nickels S, Brauch H, GENICA Network, Ko YD, Fischer HP, Schmutzler RK, Meindl A, Bartram CR, Schott S, Engel C et al. (2012)
19p13.1 is a triple-negative-specific breast cancer susceptibility locus
Cancer Res, 72 (7), 1795-803
DOI 10.1158/0008-5472.CAN-11-3364, PubMed 22331459

Vachon CM, Scott CG, Fasching PA, Hall P, Tamimi RM, Li J, Stone J, Apicella C, Odefrey F, Gierach GL, Jud SM, Heusinger K, Beckmann MW, Pollan M, Fernández-Navarro P, Gonzalez-Neira A, Benitez J, van Gils CH, Lokate M, Onland-Moret NC, Peeters PH, Brown J, Leyland J, Varghese JS, Easton DF et al. (2012)
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk
Cancer Epidemiol Biomarkers Prev, 21 (7), 1156-66
DOI 10.1158/1055-9965.EPI-12-0066, PubMed 22454379

Van Loo P, Nilsen G, Nordgard SH, Vollan HK, Børresen-Dale AL, Kristensen VN, Lingjærde OC (2012)
Analyzing cancer samples with SNP arrays
Methods Mol Biol, 802, 57-72
DOI 10.1007/978-1-61779-400-1_4, PubMed 22130873

Weischer M, Nordestgaard BG, Pharoah P, Bolla MK, Nevanlinna H, Van't Veer LJ, Garcia-Closas M, Hopper JL, Hall P, Andrulis IL, Devilee P, Fasching PA, Anton-Culver H, Lambrechts D, Hooning M, Cox A, Giles GG, Burwinkel B, Lindblom A, Couch FJ, Mannermaa A, Grenaker Alnæs G, John EM, Dörk T, Flyger H et al. (2012)
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer
J Clin Oncol, 30 (35), 4308-16
DOI 10.1200/JCO.2012.42.7336, PubMed 23109706

Publications 2011

Akslen LA, Straume O, Geisler S, Sørlie T, Chi JT, Aas T, Børresen-Dale AL, Lønning PE (2011)
Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer
Br J Cancer, 105 (1), 9-12
DOI 10.1038/bjc.2011.203, PubMed 21673677

Borgan E, Navon R, Vollan HK, Schlichting E, Sauer T, Yakhini Z, Lingjærde OC, Sørlie T, Børresen-Dale AL (2011)
Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue
Mol Oncol, 5 (6), 564-76
DOI 10.1016/j.molonc.2011.08.004, PubMed 21917534

Borge KS, Børresen-Dale AL, Lingaas F (2011)
Identification of genetic variation in 11 candidate genes of canine mammary tumour
Vet Comp Oncol, 9 (4), 241-50
DOI 10.1111/j.1476-5829.2010.00250.x, PubMed 22077404

Broeks A, Schmidt MK, Sherman ME, Couch FJ, Hopper JL, Dite GS, Apicella C, Smith LD, Hammet F, Southey MC, Van 't Veer LJ, de Groot R, Smit VT, Fasching PA, Beckmann MW, Jud S, Ekici AB, Hartmann A, Hein A, Schulz-Wendtland R, Burwinkel B, Marme F, Schneeweiss A, Sinn HP, Sohn C et al. (2011)
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Hum Mol Genet, 20 (16), 3289-303
DOI 10.1093/hmg/ddr228, PubMed 21596841

Edgren H, Murumagi A, Kangaspeska S, Nicorici D, Hongisto V, Kleivi K, Rye IH, Nyberg S, Wolf M, Borresen-Dale AL, Kallioniemi O (2011)
Identification of fusion genes in breast cancer by paired-end RNA-sequencing
Genome Biol, 12 (1), R6
DOI 10.1186/gb-2011-12-1-r6, PubMed 21247443

Enerly E, Steinfeld I, Kleivi K, Leivonen SK, Aure MR, Russnes HG, Rønneberg JA, Johnsen H, Navon R, Rødland E, Mäkelä R, Naume B, Perälä M, Kallioniemi O, Kristensen VN, Yakhini Z, Børresen-Dale AL (2011)
miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors
PLoS One, 6 (2), e16915
DOI 10.1371/journal.pone.0016915, PubMed 21364938

Gonzalez-Angulo AM, Hennessy BT, Meric-Bernstam F, Sahin A, Liu W, Ju Z, Carey MS, Myhre S, Speers C, Deng L, Broaddus R, Lluch A, Aparicio S, Brown P, Pusztai L, Symmans WF, Alsner J, Overgaard J, Borresen-Dale AL, Hortobagyi GN, Coombes KR, Mills GB (2011)
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
Clin Proteomics, 8 (1), 11
DOI 10.1186/1559-0275-8-11, PubMed 21906370

Helland Å, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ, Australian Ovarian Cancer Study Group, Pearson RB, Børresen-Dale AL, Huntsman DG, deFazio A, Creighton CJ, Smyth GK, Bowtell DD (2011)
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers
PLoS One, 6 (4), e18064
DOI 10.1371/journal.pone.0018064, PubMed 21533284

Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerød A, Børresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY (2011)
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Nat Genet, 43 (7), 621-9
DOI 10.1038/ng.848, PubMed 21642992

Haakensen VD, Bjøro T, Lüders T, Riis M, Bukholm IK, Kristensen VN, Troester MA, Homen MM, Ursin G, Børresen-Dale AL, Helland Å (2011)
Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas
BMC Cancer, 11, 332
DOI 10.1186/1471-2407-11-332, PubMed 21812955

Haakensen VD, Lingjaerde OC, Lüders T, Riis M, Prat A, Troester MA, Holmen MM, Frantzen JO, Romundstad L, Navjord D, Bukholm IK, Johannesen TB, Perou CM, Ursin G, Kristensen VN, Børresen-Dale AL, Helland A (2011)
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
BMC Med Genomics, 4, 77
DOI 10.1186/1755-8794-4-77, PubMed 22044755

Kaveh F, Edvardsen H, Børresen-Dale AL, N Kristensen V, Solvang HK (2011)
Allele-specific disparity in breast cancer
BMC Med Genomics, 4, 85
DOI 10.1186/1755-8794-4-85, PubMed 22188678

Knappskog S, Bjørnslett M, Myklebust LM, Huijts PE, Vreeswijk MP, Edvardsen H, Guo Y, Zhang X, Yang M, Ylisaukko-Oja SK, Alhopuro P, Arola J, Tollenaar RA, van Asperen CJ, Seynaeve C, Staalesen V, Chrisanthar R, Løkkevik E, Salvesen HB, Evans DG, Newman WG, Lin D, Aaltonen LA, Børresen-Dale AL, Tell GS et al. (2011)
The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians
Cancer Cell, 19 (2), 273-82
DOI 10.1016/j.ccr.2010.12.019, PubMed 21316605

Kristensen VN, Vaske CJ, Ursini-Siegel J, Van Loo P, Nordgard SH, Sachidanandam R, Sørlie T, Wärnberg F, Haakensen VD, Helland Å, Naume B, Perou CM, Haussler D, Troyanskaya OG, Børresen-Dale AL (2011)
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
Proc Natl Acad Sci U S A, 109 (8), 2802-7
DOI 10.1073/pnas.1108781108, PubMed 21908711

Mathiesen RR, Fjelldal R, Liestøl K, Due EU, Geigl JB, Riethdorf S, Borgen E, Rye IH, Schneider IJ, Obenauf AC, Mauermann O, Nilsen G, Christian Lingjaerde O, Børresen-Dale AL, Pantel K, Speicher MR, Naume B, Baumbusch LO (2011)
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Int J Cancer, 131 (4), E405-15
DOI 10.1002/ijc.26444, PubMed 21935921

Perou CM, Børresen-Dale AL (2011)
Systems biology and genomics of breast cancer
Cold Spring Harb Perspect Biol, 3 (2)
DOI 10.1101/cshperspect.a003293, PubMed 21047916

Russnes HG, Kuligina ESh, Suspitsin EN, Voskresenskiy DA, Jordanova ES, Cornelisse CJ, Borresen-Dale AL, Imyanitov EN (2011)
Paired distribution of molecular subtypes in bilateral breast carcinomas
Cancer Genet, 204 (2), 96-102
DOI 10.1016/j.cancergencyto.2010.09.012, PubMed 21504707

Russnes HG, Navin N, Hicks J, Borresen-Dale AL (2011)
Insight into the heterogeneity of breast cancer through next-generation sequencing
J Clin Invest, 121 (10), 3810-8
DOI 10.1172/JCI57088, PubMed 21965338

Solvang HK, Lingjærde OC, Frigessi A, Børresen-Dale AL, Kristensen VN (2011)
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer
BMC Bioinformatics, 12, 197
DOI 10.1186/1471-2105-12-197, PubMed 21609452

Weigman VJ, Chao HH, Shabalin AA, He X, Parker JS, Nordgard SH, Grushko T, Huo D, Nwachukwu C, Nobel A, Kristensen VN, Børresen-Dale AL, Olopade OI, Perou CM (2011)
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival
Breast Cancer Res Treat, 133 (3), 865-80
DOI 10.1007/s10549-011-1846-y, PubMed 22048815

Westbury CB, Sahlberg KK, Borresen-Dale AL, Isacke CM, Yarnold JR (2011)
Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients
Radiat Oncol, 6, 42
DOI 10.1186/1748-717X-6-42, PubMed 21521514

Zhao X, Rødland EA, Sørlie T, Naume B, Langerød A, Frigessi A, Kristensen VN, Børresen-Dale AL, Lingjærde OC (2011)
Combining gene signatures improves prediction of breast cancer survival
PLoS One, 6 (3), e17845
DOI 10.1371/journal.pone.0017845, PubMed 21423775

Publications 2010

Avraham R, Sas-Chen A, Manor O, Steinfeld I, Shalgi R, Tarcic G, Bossel N, Zeisel A, Amit I, Zwang Y, Enerly E, Russnes HG, Biagioni F, Mottolese M, Strano S, Blandino G, Børresen-Dale AL, Pilpel Y, Yakhini Z, Segal E, Yarden Y (2010)
EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors
Sci Signal, 3 (124), ra43
DOI 10.1126/scisignal.2000876, PubMed 20516477

Berge EO, Knappskog S, Geisler S, Staalesen V, Pacal M, Børresen-Dale AL, Puntervoll P, Lillehaug JR, Lønning PE (2010)
Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers
Mol Cancer, 9, 173
DOI 10.1186/1476-4598-9-173, PubMed 20594292

Bernstein JL, Haile RW, Stovall M, Boice JD, Shore RE, Langholz B, Thomas DC, Bernstein L, Lynch CF, Olsen JH, Malone KE, Mellemkjaer L, Borresen-Dale AL, Rosenstein BS, Teraoka SN, Diep AT, Smith SA, Capanu M, Reiner AS, Liang X, Gatti RA, Concannon P, WECARE Study Collaborative Group (2010)
Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study
J Natl Cancer Inst, 102 (7), 475-83
DOI 10.1093/jnci/djq055, PubMed 20305132

Borg A, Haile RW, Malone KE, Capanu M, Diep A, Törngren T, Teraoka S, Begg CB, Thomas DC, Concannon P, Mellemkjaer L, Bernstein L, Tellhed L, Xue S, Olson ER, Liang X, Dolle J, Børresen-Dale AL, Bernstein JL (2010)
Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study
Hum Mutat, 31 (3), E1200-40
DOI 10.1002/humu.21202, PubMed 20104584

Borgan E, Sitter B, Lingjærde OC, Johnsen H, Lundgren S, Bathen TF, Sørlie T, Børresen-Dale AL, Gribbestad IS (2010)
Merging transcriptomics and metabolomics--advances in breast cancer profiling
BMC Cancer, 10, 628
DOI 10.1186/1471-2407-10-628, PubMed 21080935

Borresen-Dale AL (2010)
Europe's largest Member Association for Cancer Research
Period. Biol., 112 (4), 483-485

Børresen-Dale AL, Sørlie T, Kristensen VN (2010)
On the molecular biology of breast cancer
Mol Oncol, 4 (3), 171-3
DOI 10.1016/j.molonc.2010.04.007, PubMed 20483673

de Neergaard M, Kim J, Villadsen R, Fridriksdottir AJ, Rank F, Timmermans-Wielenga V, Langerød A, Børresen-Dale AL, Petersen OW, Rønnov-Jessen L (2010)
Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment
Am J Pathol, 176 (3), 1229-40
DOI 10.2353/ajpath.2010.090648, PubMed 20133812

Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J (2010)
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
Mol Cancer, 9, 68
DOI 10.1186/1476-4598-9-68, PubMed 20338046

Dumeaux V, Olsen KS, Nuel G, Paulssen RH, Børresen-Dale AL, Lund E (2010)
Deciphering normal blood gene expression variation--The NOWAC postgenome study
PLoS Genet, 6 (3), e1000873
DOI 10.1371/journal.pgen.1000873, PubMed 20300640

Edvardsen H, Brunsvig PF, Solvang H, Tsalenko A, Andersen A, Syvanen AC, Yakhini Z, Børresen-Dale AL, Olsen H, Aamdal S, Kristensen VN (2010)
SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance
Pharmacogenomics J, 10 (6), 513-23
DOI 10.1038/tpj.2010.6, PubMed 20157331

Fu YP, Edvardsen H, Kaushiva A, Arhancet JP, Howe TM, Kohaar I, Porter-Gill P, Shah A, Landmark-Høyvik H, Fosså SD, Ambs S, Naume B, Børresen-Dale AL, Kristensen VN, Prokunina-Olsson L (2010)
NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
Mol Cancer, 9, 113
DOI 10.1186/1476-4598-9-113, PubMed 20482849

Hennessy BT, Lu Y, Gonzalez-Angulo AM, Carey MS, Myhre S, Ju Z, Davies MA, Liu W, Coombes K, Meric-Bernstam F, Bedrosian I, McGahren M, Agarwal R, Zhang F, Overgaard J, Alsner J, Neve RM, Kuo WL, Gray JW, Borresen-Dale AL, Mills GB (2010)
A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers
Clin Proteomics, 6 (4), 129-51
DOI 10.1007/s12014-010-9055-y, PubMed 21691416

Holstege H, Horlings HM, Velds A, Langerød A, Børresen-Dale AL, van de Vijver MJ, Nederlof PM, Jonkers J (2010)
BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations
BMC Cancer, 10, 654
DOI 10.1186/1471-2407-10-654, PubMed 21118481

Haakensen VD, Biong M, Lingjærde OC, Holmen MM, Frantzen JO, Chen Y, Navjord D, Romundstad L, Lüders T, Bukholm IK, Solvang HK, Kristensen VN, Ursin G, Børresen-Dale AL, Helland A (2010)
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
Breast Cancer Res, 12 (4), R65
DOI 10.1186/bcr2632, PubMed 20799965

International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J et al. (2010)
International network of cancer genome projects
Nature, 464 (7291), 993-8
DOI 10.1038/nature08987, PubMed 20393554

Kamalakaran S, Varadan V, Giercksky Russnes HE, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, Kåresen R, Shama Prasada K, Rotti H, Rao R, Rao L, Eric Tang MH, Satyamoorthy K, Lucito R, Wigler M, Dimitrova N, Naume B, Borresen-Dale AL, Hicks JB (2010)
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables
Mol Oncol, 5 (1), 77-92
DOI 10.1016/j.molonc.2010.11.002, PubMed 21169070

Kristensen V, Borresen-Dale AL (2010)
Mutations for the people
EMBO Mol Med, 2 (5), 143-5
DOI 10.1002/emmm.201000071, PubMed 20461736

Landmark-Høyvik H, Dumeaux V, Reinertsen KV, Edvardsen H, Fosså SD, Børresen-Dale AL (2010)
Blood gene expression profiling of breast cancer survivors experiencing fibrosis
Int J Radiat Oncol Biol Phys, 79 (3), 875-83
DOI 10.1016/j.ijrobp.2010.09.052, PubMed 21129856

Landmark-Høyvik H, Reinertsen KV, Loge JH, Kristensen VN, Dumeaux V, Fosså SD, Børresen-Dale AL, Edvardsen H (2010)
The genetics and epigenetics of fatigue
PM R, 2 (5), 456-65
DOI 10.1016/j.pmrj.2010.04.003, PubMed 20656628

Moestue SA, Borgan E, Huuse EM, Lindholm EM, Sitter B, Børresen-Dale AL, Engebraaten O, Maelandsmo GM, Gribbestad IS (2010)
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
BMC Cancer, 10, 433
DOI 10.1186/1471-2407-10-433, PubMed 20716336

Muggerud AA, Hallett M, Johnsen H, Kleivi K, Zhou W, Tahmasebpoor S, Amini RM, Botling J, Børresen-Dale AL, Sørlie T, Wärnberg F (2010)
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
Mol Oncol, 4 (4), 357-68
DOI 10.1016/j.molonc.2010.06.007, PubMed 20663721

Muggerud AA, Rønneberg JA, Wärnberg F, Botling J, Busato F, Jovanovic J, Solvang H, Bukholm I, Børresen-Dale AL, Kristensen VN, Sørlie T, Tost J (2010)
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
Breast Cancer Res, 12 (1), R3
DOI 10.1186/bcr2466, PubMed 20056007

Myhre S, Mohammed H, Tramm T, Alsner J, Finak G, Park M, Overgaard J, Børresen-Dale AL, Frigessi A, Sørlie T (2010)
In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome
PLoS One, 5 (11), e14002
DOI 10.1371/journal.pone.0014002, PubMed 21124964

Naume B, Zhao X, Synnestvedt M, Borgen E, Russnes HG, Lingjaerde OC, Stromberg M, Wiedswang G, Kvalheim G, Karesen R, Nesland JM, Borresen-Dale AL, Sorlie T (2010)
Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer (vol 1, pg 160, 2007)
Mol. Oncol., 4 (2), 169
DOI 10.1016/j.molonc.2010.01.003

Papp J, Kovacs ME, Solyom S, Kasler M, Børresen-Dale AL, Olah E (2010)
High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients
BMC Med Genet, 11, 169
DOI 10.1186/1471-2350-11-169, PubMed 21118512

Podo F, Buydens LM, Degani H, Hilhorst R, Klipp E, Gribbestad IS, Van Huffel S, van Laarhoven HW, Luts J, Monleon D, Postma GJ, Schneiderhan-Marra N, Santoro F, Wouters H, Russnes HG, Sørlie T, Tagliabue E, Børresen-Dale AL, FEMME Consortium (2010)
Triple-negative breast cancer: present challenges and new perspectives
Mol Oncol, 4 (3), 209-29
DOI 10.1016/j.molonc.2010.04.006, PubMed 20537966

Russnes HG, Vollan HKM, Lingjærde OC, Krasnitz A, Lundin P, Naume B, Sørlie T, Borgen E, Rye IH, Langerød A, Chin SF, Teschendorff AE, Stephens PJ, Månér S, Schlichting E, Baumbusch LO, Kåresen R, Stratton MP, Wigler M, Caldas C, Zetterberg A, Hicks J, Børresen-Dale AL (2010)
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Sci Transl Med, 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611, PubMed 20592421

Rønneberg JA, Fleischer T, Solvang HK, Nordgard SH, Edvardsen H, Potapenko I, Nebdal D, Daviaud C, Gut I, Bukholm I, Naume B, Børresen-Dale AL, Tost J, Kristensen V (2010)
Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer
Mol Oncol, 5 (1), 61-76
DOI 10.1016/j.molonc.2010.11.004, PubMed 21212030

Sørlie T, Borgan E, Myhre S, Vollan HK, Russnes H, Zhao X, Nilsen G, Lingjaerde OC, Børresen-Dale AL, Rødland E (2010)
The importance of gene-centring microarray data
Lancet Oncol, 11 (8), 719-20; author reply 720-1
DOI 10.1016/S1470-2045(10)70174-1, PubMed 20688275

Van Loo P, Nordgard SH, Lingjærde OC, Russnes HG, Rye IH, Sun W, Weigman VJ, Marynen P, Zetterberg A, Naume B, Perou CM, Børresen-Dale AL, Kristensen VN (2010)
Allele-specific copy number analysis of tumors
Proc Natl Acad Sci U S A, 107 (39), 16910-5
DOI 10.1073/pnas.1009843107, PubMed 20837533

Aarøe J, Lindahl T, Dumeaux V, Saebø S, Tobin D, Hagen N, Skaane P, Lönneborg A, Sharma P, Børresen-Dale AL (2010)
Gene expression profiling of peripheral blood cells for early detection of breast cancer
Breast Cancer Res, 12 (1), R7
DOI 10.1186/bcr2472, PubMed 20078854

Publications 2009

Agarwal R, Gonzalez-Angulo AM, Myhre S, Carey M, Lee JS, Overgaard J, Alsner J, Stemke-Hale K, Lluch A, Neve RM, Kuo WL, Sorlie T, Sahin A, Valero V, Keyomarsi K, Gray JW, Borresen-Dale AL, Mills GB, Hennessy BT (2009)
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
Clin Cancer Res, 15 (11), 3654-62
DOI 10.1158/1078-0432.CCR-08-3293, PubMed 19470724

Bergamaschi A, Hjortland GO, Triulzi T, Sørlie T, Johnsen H, Ree AH, Russnes HG, Tronnes S, Maelandsmo GM, Fodstad O, Borresen-Dale AL, Engebraaten O (2009)
Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
Mol Oncol, 3 (5-6), 469-82
DOI 10.1016/j.molonc.2009.07.003, PubMed 19713161

Bocanegra M, Bergamaschi A, Kim YH, Miller MA, Rajput AB, Kao J, Langerød A, Han W, Noh DY, Jeffrey SS, Huntsman DG, Børresen-Dale AL, Pollack JR (2009)
Focal amplification and oncogene dependency of GAB2 in breast cancer
Oncogene, 29 (5), 774-9
DOI 10.1038/onc.2009.364, PubMed 19881546

Dunning AM, Healey CS, Baynes C, Maia AT, Scollen S, Vega A, Rodríguez R, Barbosa-Morais NL, Ponder BA, SEARCH, Low YL, Bingham S, EPIC, Haiman CA, Le Marchand L, MEC, Broeks A, Schmidt MK, ABCS, Hopper J, Southey M, ABCFS, Beckmann MW, Fasching PA, BBCC et al. (2009)
Association of ESR1 gene tagging SNPs with breast cancer risk
Hum Mol Genet, 18 (6), 1131-9
DOI 10.1093/hmg/ddn429, PubMed 19126777

Figueiredo JC, Haile RW, Bernstein L, Malone KE, Largent J, Langholz B, Lynch CF, Bertelsen L, Capanu M, Concannon P, Borg A, Børresen-Dale AL, Diep A, Teraoka S, Torngren T, Xue S, Bernstein JL (2009)
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
Breast Cancer Res Treat, 120 (1), 175-83
DOI 10.1007/s10549-009-0455-5, PubMed 19597986

Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale AL, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S (2009)
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide
Clin Cancer Res, 15 (12), 4165-73
DOI 10.1158/1078-0432.CCR-09-0119, PubMed 19509150

Kamalakaran S, Kendall J, Zhao X, Tang C, Khan S, Ravi K, Auletta T, Riggs M, Wang Y, Helland A, Naume B, Dimitrova N, Børresen-Dale AL, Hicks J, Lucito R (2009)
Methylation detection oligonucleotide microarray analysis: a high-resolution method for detection of CpG island methylation
Nucleic Acids Res, 37 (12), e89
DOI 10.1093/nar/gkp413, PubMed 19474344

Landmark-Høyvik H, Reinertsen KV, Loge JH, Fosså SD, Børresen-Dale AL, Dumeaux V (2009)
Alterations of gene expression in blood cells associated with chronic fatigue in breast cancer survivors
Pharmacogenomics J, 9 (5), 333-40
DOI 10.1038/tpj.2009.27, PubMed 19546881

Leivonen SK, Mäkelä R, Ostling P, Kohonen P, Haapa-Paananen S, Kleivi K, Enerly E, Aakula A, Hellström K, Sahlberg N, Kristensen VN, Børresen-Dale AL, Saviranta P, Perälä M, Kallioniemi O (2009)
Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines
Oncogene, 28 (44), 3926-36
DOI 10.1038/onc.2009.241, PubMed 19684618

Lönneborg A, Aarøe J, Dumeaux V, Børresen-Dale AL (2009)
Found in transcription: gene expression and other novel blood biomarkers for the early detection of breast cancer
Expert Rev Anticancer Ther, 9 (8), 1115-23
DOI 10.1586/era.09.31, PubMed 19671031

Murph MM, Liu W, Yu S, Lu Y, Hall H, Hennessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Børresen-Dale AL, Mills GB (2009)
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis
PLoS One, 4 (5), e5583
DOI 10.1371/journal.pone.0005583, PubMed 19440550

Potapenko IO, Haakensen VD, Lüders T, Helland A, Bukholm I, Sørlie T, Kristensen VN, Lingjaerde OC, Børresen-Dale AL (2009)
Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
Mol Oncol, 4 (2), 98-118
DOI 10.1016/j.molonc.2009.12.001, PubMed 20060370

Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C, Edkins S, Mudie LJ, Greenman CD, Jia M, Latimer C, Teague JW, Lau KW, Burton J, Quail MA, Swerdlow H, Churcher C, Natrajan R, Sieuwerts AM, Martens JW, Silver DP, Langerød A, Russnes HE et al. (2009)
Complex landscapes of somatic rearrangement in human breast cancer genomes
Nature, 462 (7276), 1005-10
DOI 10.1038/nature08645, PubMed 20033038

Zhou W, Muggerud AA, Vu P, Due EU, Sørlie T, Børresen-Dale AL, Wärnberg F, Langerød A (2009)
Full sequencing of TP53 identifies identical mutations within in situ and invasive components in breast cancer suggesting clonal evolution
Mol Oncol, 3 (3), 214-9
DOI 10.1016/j.molonc.2009.03.001, PubMed 19403344

Publications 2008

Alsner J, Jensen V, Kyndi M, Offersen BV, Vu P, Børresen-Dale AL, Overgaard J (2008)
A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients
Acta Oncol, 47 (4), 600-7
DOI 10.1080/02841860802047411, PubMed 18465328

Baumbusch LO, Aarøe J, Johansen FE, Hicks J, Sun H, Bruhn L, Gunderson K, Naume B, Kristensen VN, Liestøl K, Børresen-Dale AL, Lingjaerde OC (2008)
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
BMC Genomics, 9, 379
DOI 10.1186/1471-2164-9-379, PubMed 18691401

Bergamaschi A, Kim YH, Kwei KA, La Choi Y, Bocanegra M, Langerød A, Han W, Noh DY, Huntsman DG, Jeffrey SS, Børresen-Dale AL, Pollack JR (2008)
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
Mol Oncol, 2 (4), 327-39
DOI 10.1016/j.molonc.2008.09.004, PubMed 19383354

Bergamaschi A, Tagliabue E, Sørlie T, Naume B, Triulzi T, Orlandi R, Russnes HG, Nesland JM, Tammi R, Auvinen P, Kosma VM, Ménard S, Børresen-Dale AL (2008)
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
J Pathol, 214 (3), 357-67
DOI 10.1002/path.2278, PubMed 18044827

Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V (2008)
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
Mol Syst Biol, 4, 229
DOI 10.1038/msb.2008.65, PubMed 19034270

Concannon P, Haile RW, Børresen-Dale AL, Rosenstein BS, Gatti RA, Teraoka SN, Diep TA, Jansen L, Atencio DP, Langholz B, Capanu M, Liang X, Begg CB, Thomas DC, Bernstein L, Olsen JH, Malone KE, Lynch CF, Anton-Culver H, Bernstein JL, Women's Environment, Cancer, and Radiation Epidemiology Study Collaborative Group (2008)
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
Cancer Res, 68 (16), 6486-91
DOI 10.1158/0008-5472.CAN-08-0134, PubMed 18701470

Dumeaux V, Børresen-Dale AL, Frantzen JO, Kumle M, Kristensen VN, Lund E (2008)
Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study
Breast Cancer Res, 10 (1), R13
DOI 10.1186/bcr1859, PubMed 18271962

Dumeaux V, Lund E, Børresen-Dale AL (2008)
Comparison of globin RNA processing methods for genome-wide transcriptome analysis from whole blood
Biomark Med, 2 (1), 11-21
DOI 10.2217/17520363.2.1.11, PubMed 20477359

Horlings HM, Bergamaschi A, Nordgard SH, Kim YH, Han W, Noh DY, Salari K, Joosse SA, Reyal F, Lingjaerde OC, Kristensen VN, Børresen-Dale AL, Pollack J, van de Vijver MJ (2008)
ESR1 gene amplification in breast cancer: a common phenomenon?
Nat Genet, 40 (7), 807-8; author reply 810-2
DOI 10.1038/ng0708-807, PubMed 18583965

Kristensen VN, Børresen-Dale AL (2008)
SNPs associated with molecular subtypes of breast cancer: on the usefulness of stratified Genome-wide Association Studies (GWAS) in the identification of novel susceptibility loci
Mol Oncol, 2 (1), 12-5
DOI 10.1016/j.molonc.2008.02.003, PubMed 19383324

Mellemkjaer L, Dahl C, Olsen JH, Bertelsen L, Guldberg P, Christensen J, Børresen-Dale AL, Stovall M, Langholz B, Bernstein L, Lynch CF, Malone KE, Haile RW, Andersson M, Thomas DC, Concannon P, Capanu M, Boice JD, WECARE Study Collaborative Group, Bernstein JL (2008)
Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study
Br J Cancer, 98 (4), 728-33
DOI 10.1038/sj.bjc.6604228, PubMed 18253122

Nordgard SH, Alnaes GI, Hihn B, Lingjaerde OC, Liestøl K, Tsalenko A, Sørlie T, Lønning PE, Børresen-Dale AL, Kristensen VN (2008)
Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
Int J Cancer, 123 (3), 577-85
DOI 10.1002/ijc.23541, PubMed 18498133

Nordgard SH, Johansen FE, Alnaes GI, Bucher E, Syvänen AC, Naume B, Børresen-Dale AL, Kristensen VN (2008)
Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients
Genes Chromosomes Cancer, 47 (8), 680-96
DOI 10.1002/gcc.20569, PubMed 18398821

Rønneberg JA, Tost J, Solvang HK, Alnaes GI, Johansen FE, Brendeford EM, Yakhini Z, Gut IG, Lønning PE, Børresen-Dale AL, Gabrielsen OS, Kristensen VN (2008)
GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas
Cancer Res, 68 (14), 5562-71
DOI 10.1158/0008-5472.CAN-07-5828, PubMed 18632608

Suspitsin EN, Due EU, Vu P, Hirvonen A, Børresen-Dale AL, Imyanitov EN (2008)
TP53 mutations in synchronous and metachronous bilateral breast carcinomas
Cancer Genet Cytogenet, 184 (2), 119-21
DOI 10.1016/j.cancergencyto.2008.03.005, PubMed 18617062

Tongbai R, Idelman G, Nordgard SH, Cui W, Jacobs JL, Haggerty CM, Chanock SJ, Børresen-Dale AL, Livingston G, Shaunessy P, Chiang CH, Kristensen VN, Bilke S, Gardner K (2008)
Transcriptional networks inferred from molecular signatures of breast cancer
Am J Pathol, 172 (2), 495-509
DOI 10.2353/ajpath.2008.061079, PubMed 18187569

Publications 2007

Casalini P, Iorio MV, Berno V, Bergamaschi A, Børresen Dale AL, Gasparini P, Orlandi R, Casati B, Tagliabue E, Ménard S (2007)
Relationship between p53 and p27 expression following HER2 signaling
Breast, 16 (6), 597-605
DOI 10.1016/j.breast.2007.05.007, PubMed 17604627

Chanock SJ, Burdett L, Yeager M, Llaca V, Langerød A, Presswalla S, Kaaresen R, Strausberg RL, Gerhard DS, Kristensen V, Perou CM, Børresen-Dale AL (2007)
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas
Breast Cancer Res, 9 (1), R5
DOI 10.1186/bcr1637, PubMed 17224074

Edvardsen H, Kristensen VN, Grenaker Alnaes GI, Bøhn M, Erikstein B, Helland A, Børresen-Dale AL, Fosså SD (2007)
Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy
Int J Radiat Oncol Biol Phys, 67 (4), 1163-71
DOI 10.1016/j.ijrobp.2006.11.009, PubMed 17336217

Edvardsen H, Tefre T, Jansen L, Vu P, Haffty BG, Fosså SD, Kristensen VN, Børresen-Dale AL (2007)
Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence
Radiat Oncol, 2, 25
DOI 10.1186/1748-717X-2-25, PubMed 17623063

Garcia-Closas M, Kristensen V, Langerød A, Qi Y, Yeager M, Burdett L, Welch R, Lissowska J, Peplonska B, Brinton L, Gerhard DS, Gram IT, Perou CM, Børresen-Dale AL, Chanock S (2007)
Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
Int J Cancer, 121 (11), 2532-8
DOI 10.1002/ijc.22985, PubMed 17683073

Garcia-Closas M, Troester MA, Qi Y, Langerød A, Yeager M, Lissowska J, Brinton L, Welch R, Peplonska B, Gerhard DS, Gram IT, Kristensen V, Børresen-Dale AL, Chanock S, Perou CM (2007)
Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status
Cancer Epidemiol Biomarkers Prev, 16 (11), 2269-75
DOI 10.1158/1055-9965.EPI-07-0449, PubMed 18006915

Kapp AV, Jeffrey SS, Langerod A, Borresen-Dale AL, Han W, Noh DY, Bukholm IRK, Nicolau M, Brown PO, Tibshirani R (2007)
Discovery and validation of breast cancer subtypes (vol 8, pg 101, 2007)
BMC Genomics, 8, 101
DOI 10.1186/1471-2164-8-101

Knappskog S, Chrisanthar R, Staalesen V, Børresen-Dale AL, Gram IT, Lillehaug JR, Lønning PE (2007)
Mutations and polymorphisms of the p21B transcript in breast cancer
Int J Cancer, 121 (4), 908-10
DOI 10.1002/ijc.22777, PubMed 17443496

Landmark H, Nahas SA, Aarøe J, Gatti R, Børresen-Dale AL, Rødningen OK (2007)
Transcriptional response to ionizing radiation in human radiation sensitive cell lines
Radiother Oncol, 83 (3), 256-60
DOI 10.1016/j.radonc.2007.04.017, PubMed 17512073

Langerød A, Zhao H, Borgan Ø, Nesland JM, Bukholm IR, Ikdahl T, Kåresen R, Børresen-Dale AL, Jeffrey SS (2007)
TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Breast Cancer Res, 9 (3), R30
DOI 10.1186/bcr1675, PubMed 17504517

Naume B, Zhao X, Synnestvedt M, Borgen E, Russnes HG, Lingjaerde OC, Strømberg M, Wiedswang G, Kvalheim G, Kåresen R, Nesland JM, Børresen-Dale AL, Sørlie T (2007)
Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer
Mol Oncol, 1 (2), 160-71
DOI 10.1016/j.molonc.2007.03.004, PubMed 19383292

Nicolau M, Tibshirani R, Børresen-Dale AL, Jeffrey SS (2007)
Disease-specific genomic analysis: identifying the signature of pathologic biology
Bioinformatics, 23 (8), 957-65
DOI 10.1093/bioinformatics/btm033, PubMed 17277331

Nordgard SH, Johansen FE, Alnaes GI, Naume B, Børresen-Dale AL, Kristensen VN (2007)
Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes
Breast Cancer Res, 9 (6), 113
DOI 10.1186/bcr1784, PubMed 18036273

Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lønning PE, Børresen-Dale AL, Kristensen VN (2007)
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
Pharmacogenet Genomics, 17 (2), 127-36
DOI 10.1097/FPC.0b013e328011abaa, PubMed 17301692

Petitjean A, Achatz MI, Borresen-Dale AL, Hainaut P, Olivier M (2007)
TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
Oncogene, 26 (15), 2157-65
DOI 10.1038/sj.onc.1210302, PubMed 17401424

Roca X, Olson AJ, Rao AR, Enerly E, Kristensen VN, Børresen-Dale AL, Andresen BS, Krainer AR, Sachidanandam R (2007)
Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics
Genome Res, 18 (1), 77-87
DOI 10.1101/gr.6859308, PubMed 18032726

Rødningen OK, Børresen-Dale AL, Alsner J, Hastie T, Overgaard J (2007)
Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis
Radiother Oncol, 86 (3), 314-20
DOI 10.1016/j.radonc.2007.09.013, PubMed 17963910

Stray-Pedersen A, Borresen-Dale AL, Paus E, Lindman CR, Burgers T, Abrahamsen TG (2007)
Alpha fetoprotein is increasing with age in ataxia-telangiectasia
Eur J Paediatr Neurol, 11 (6), 375-80
DOI 10.1016/j.ejpn.2007.04.001, PubMed 17540590

Størvold GL, Gjernes E, Askautrud HA, Børresen-Dale AL, Perou CM, Frengen E (2007)
A retroviral vector for siRNA expression in mammalian cells
Mol Biotechnol, 35 (3), 275-82
DOI 10.1007/BF02686013, PubMed 17652791

Suspitsin EN, Sokolenko AP, Togo AV, Lazareva YR, Turkevich EA, Matsko DE, Henrich KO, Borresen-Dale AL, Schwab M, Cornelisse CJ, Imyanitov EN (2007)
Nonrandom distribution of oncogene amplifications in bilateral breast carcinomas: Possible role of host factors and survival bias
Int J Cancer, 120 (2), 297-302
DOI 10.1002/ijc.22265, PubMed 17066426

Wang Y, Kristensen GB, Børresen-Dale AL, Helland A (2007)
TP53 mutations and codon 72 genotype--impact on survival among ovarian cancer patients
Ann Oncol, 18 (5), 964-6
DOI 10.1093/annonc/mdm134, PubMed 17488735

Yosef N, Yakhini Z, Tsalenko A, Kristensen V, Børresen-Dale AL, Ruppin E, Sharan R (2007)
A supervised approach for identifying discriminating genotype patterns and its application to breast cancer data
Bioinformatics, 23 (2), e91-8
DOI 10.1093/bioinformatics/btl298, PubMed 17237111

Publications 2006

Anensen N, Skavland J, Stapnes C, Ryningen A, Børresen-Dale AL, Gjertsen BT, Bruserud Ø (2006)
Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report
Leukemia, 20 (4), 734-6
DOI 10.1038/sj.leu.2404117, PubMed 16437140

Baumbusch LO, Myhre S, Langerød A, Bergamaschi A, Geisler SB, Lønning PE, Deppert W, Dornreiter I, Børresen-Dale AL (2006)
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters
Mol Cancer, 5, 47
DOI 10.1186/1476-4598-5-47, PubMed 17054774

Bergamaschi A, Kim YH, Wang P, Sørlie T, Hernandez-Boussard T, Lonning PE, Tibshirani R, Børresen-Dale AL, Pollack JR (2006)
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
Genes Chromosomes Cancer, 45 (11), 1033-40
DOI 10.1002/gcc.20366, PubMed 16897746

Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Børresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, Brown PO (2006)
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers
PLoS Med, 3 (3), e47
DOI 10.1371/journal.pmed.0030047, PubMed 16417408

Dumeaux V, Johansen J, Børresen-Dale AL, Lund E (2006)
Gene expression profiling of whole-blood samples from women exposed to hormone replacement therapy
Mol Cancer Ther, 5 (4), 868-76
DOI 10.1158/1535-7163.MCT-05-0329, PubMed 16648556

Edvardsen H, Irene Grenaker Alnaes G, Tsalenko A, Mulcahy T, Yuryev A, Lindersson M, Lien S, Omholt S, Syvänen AC, Børresen-Dale AL, Kristensen VN (2006)
Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds
Pharmacogenet Genomics, 16 (3), 207-17
DOI 10.1097/01.fpc.0000194422.12770.fb, PubMed 16495780

Heikkinen K, Rapakko K, Karppinen SM, Erkko H, Knuutila S, Lundán T, Mannermaa A, Børresen-Dale AL, Borg A, Barkardottir RB, Petrini J, Winqvist R (2006)
RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability
Carcinogenesis, 27 (8), 1593-9
DOI 10.1093/carcin/bgi360, PubMed 16474176

Helland A, Johnsen H, Frøyland C, Landmark HB, Saetersdal AB, Holmen MM, Gjertsen T, Nesland JM, Ottestad W, Jeffrey SS, Ottestad LO, Rodningen OK, Sherlock G, Børresen-Dale AL (2006)
Radiation-induced effects on gene expression: an in vivo study on breast cancer
Radiother Oncol, 80 (2), 230-5
DOI 10.1016/j.radonc.2006.07.007, PubMed 16890317

Hicks J, Krasnitz A, Lakshmi B, Navin NE, Riggs M, Leibu E, Esposito D, Alexander J, Troge J, Grubor V, Yoon S, Wigler M, Ye K, Børresen-Dale AL, Naume B, Schlicting E, Norton L, Hägerström T, Skoog L, Auer G, Månér S, Lundin P, Zetterberg A (2006)
Novel patterns of genome rearrangement and their association with survival in breast cancer
Genome Res, 16 (12), 1465-79
DOI 10.1101/gr.5460106, PubMed 17142309

Irish JM, Anensen N, Hovland R, Skavland J, Børresen-Dale AL, Bruserud O, Nolan GP, Gjertsen BT (2006)
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53
Blood, 109 (6), 2589-96
DOI 10.1182/blood-2006-02-004234, PubMed 17105820

Kapp AV, Jeffrey SS, Langerød A, Børresen-Dale AL, Han W, Noh DY, Bukholm IR, Nicolau M, Brown PO, Tibshirani R (2006)
Discovery and validation of breast cancer subtypes
BMC Genomics, 7, 231
DOI 10.1186/1471-2164-7-231, PubMed 16965636

Kristensen VN, Edvardsen H, Tsalenko A, Nordgard SH, Sørlie T, Sharan R, Vailaya A, Ben-Dor A, Lønning PE, Lien S, Omholt S, Syvänen AC, Yakhini Z, Børresen-Dale AL (2006)
Genetic variation in putative regulatory loci controlling gene expression in breast cancer
Proc Natl Acad Sci U S A, 103 (20), 7735-40
DOI 10.1073/pnas.0601893103, PubMed 16684880

Kristensen VN, Tsalenko A, Geisler J, Faldaas A, Grenaker GI, Lingjaerde OC, Fjeldstad S, Yakhini Z, Lønning PE, Børresen-Dale AL (2006)
Multilocus analysis of SNP and metabolic data within a given pathway
BMC Genomics, 7, 5
DOI 10.1186/1471-2164-7-5, PubMed 16412218

Langholz B, Bernstein JL, Bernstein L, Olsen JH, Børresen-Dale AL, Rosenstein BS, Gatti RA, WECARE Study Collaborative Group, Concannon P (2006)
On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancer
Int J Cancer, 119 (3), 724-5
DOI 10.1002/ijc.21876, PubMed 16496408

Lønning PE, Børresen-Dale AL (2006)
Interaction between p53 staining and high-dose chemotherapy in breast cancer
Clin Cancer Res, 12 (7 Pt 1), 2289
DOI 10.1158/1078-0432.CCR-06-0129, PubMed 16609046

Muggerud AA, Johnsen H, Barnes DA, Steel A, Lønning PE, Naume B, Sørlie T, Børresen-Dale AL (2006)
Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes
BMC Cancer, 6, 59
DOI 10.1186/1471-2407-6-59, PubMed 16536878

Olivier M, Langerød A, Carrieri P, Bergh J, Klaar S, Eyfjord J, Theillet C, Rodriguez C, Lidereau R, Bièche I, Varley J, Bignon Y, Uhrhammer N, Winqvist R, Jukkola-Vuorinen A, Niederacher D, Kato S, Ishioka C, Hainaut P, Børresen-Dale AL (2006)
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
Clin Cancer Res, 12 (4), 1157-67
DOI 10.1158/1078-0432.CCR-05-1029, PubMed 16489069

Staalesen V, Knappskog S, Chrisanthar R, Nordgard SH, Løkkevik E, Anker G, Ostenstad B, Lundgren S, Risberg T, Mjaaland I, Gram IT, Kristensen VN, Børresen-Dale AL, Lillehaug JR, Lønning PE (2006)
The novel p21 polymorphism p21G251A is associated with locally advanced breast cancer
Clin Cancer Res, 12 (20 Pt 1), 6000-4
DOI 10.1158/1078-0432.CCR-05-2822, PubMed 17062672

Sørlie T, Perou CM, Fan C, Geisler S, Aas T, Nobel A, Anker G, Akslen LA, Botstein D, Børresen-Dale AL, Lønning PE (2006)
Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
Mol Cancer Ther, 5 (11), 2914-8
DOI 10.1158/1535-7163.MCT-06-0126, PubMed 17121939

Sørlie T, Wang Y, Xiao C, Johnsen H, Naume B, Samaha RR, Børresen-Dale AL (2006)
Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
BMC Genomics, 7, 127
DOI 10.1186/1471-2164-7-127, PubMed 16729877

Tavtigian SV, Pierotti MA, Børresen-Dale AL (2006)
International Agency for Research on Cancer workshop on 'Expression array analyses in breast cancer taxonomy'
Breast Cancer Res, 8 (6), 303
DOI 10.1186/bcr1609, PubMed 17096863

Tommiska J, Jansen L, Kilpivaara O, Edvardsen H, Kristensen V, Tamminen A, Aittomäki K, Blomqvist C, Børresen-Dale AL, Nevanlinna H (2006)
ATM variants and cancer risk in breast cancer patients from Southern Finland
BMC Cancer, 6, 209
DOI 10.1186/1471-2407-6-209, PubMed 16914028

Tsalenko A, Sharan R, Kristensen V, Edvardsen H, Børresen-Dale AL, Ben-Dor A, Yakhini Z (2006)
Analysis of SNP-expression association matrices
J Bioinform Comput Biol, 4 (2), 259-74
DOI 10.1142/s0219720006001953, PubMed 16819783

Publications 2005

Benetkiewicz M, Wang Y, Schaner M, Wang P, Mantripragada KK, Buckley PG, Kristensen G, Børresen-Dale AL, Dumanski JP (2005)
High-resolution gene copy number and expression profiling of human chromosome 22 in ovarian carcinomas
Genes Chromosomes Cancer, 42 (3), 228-37
DOI 10.1002/gcc.20128, PubMed 15578687

Kringen P, Bergamaschi A, Due EU, Wang Y, Tagliabue E, Nesland JM, Nehman A, Tönisson N, Børresen-Dale AL (2005)
Evaluation of arrayed primer extension for TP53 mutation detection in breast and ovarian carcinomas
Biotechniques, 39 (5), 755-61
DOI 10.2144/000112000, PubMed 16312222

Kringen P, Wang Y, Dumeaux V, Nesland JM, Kristensen G, Borresen-Dale AL, Dorum A (2005)
TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival
BMC Cancer, 5, 134
DOI 10.1186/1471-2407-5-134, PubMed 16229746

Kristensen VN, Sørlie T, Geisler J, Langerød A, Yoshimura N, Kåresen R, Harada N, Lønning PE, Børresen-Dale AL (2005)
Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
Clin Cancer Res, 11 (2 Pt 2), 878s-83s
PubMed 15701881

Kristensen VN, Sørlie T, Geisler J, Yoshimura N, Linegjaerde OC, Glad I, Frigessi A, Harada N, Lønning PE, Børresen-Dale AL (2005)
Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
J Steroid Biochem Mol Biol, 95 (1-5), 105-11
DOI 10.1016/j.jsbmb.2005.04.028, PubMed 16023338

Lønning PE, Sørlie T, Børresen-Dale AL (2005)
Genomics in breast cancer-therapeutic implications
Nat Clin Pract Oncol, 2 (1), 26-33
DOI 10.1038/ncponc0072, PubMed 16264853

Maguire P, Margolin S, Skoglund J, Sun XF, Gustafsson JA, Børresen-Dale AL, Lindblom A (2005)
Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer
Breast Cancer Res Treat, 94 (2), 145-52
DOI 10.1007/s10549-005-7697-7, PubMed 16261413

Olsen JH, Hahnemann JM, Børresen-Dale AL, Tretli S, Kleinerman R, Sankila R, Hammarström L, Robsahm TE, Kääriäinen H, Bregård A, Brøndum-Nielsen K, Yuen J, Tucker M (2005)
Breast and other cancers in 1445 blood relatives of 75 Nordic patients with ataxia telangiectasia
Br J Cancer, 93 (2), 260-5
DOI 10.1038/sj.bjc.6602658, PubMed 15942625

Rødningen OK, Overgaard J, Alsner J, Hastie T, Børresen-Dale AL (2005)
Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts
Radiother Oncol, 77 (3), 231-40
DOI 10.1016/j.radonc.2005.09.020, PubMed 16297999

Schaner ME, Davidson B, Skrede M, Reich R, Flørenes VA, Risberg B, Berner A, Goldberg I, Givant-Horwitz V, Tropè CG, Kristensen GB, Nesland JM, Børresen-Dale AL (2005)
Variation in gene expression patterns in effusions and primary tumors from serous ovarian cancer patients
Mol Cancer, 4, 26
DOI 10.1186/1476-4598-4-26, PubMed 16042759

Sharma P, Sahni NS, Tibshirani R, Skaane P, Urdal P, Berghagen H, Jensen M, Kristiansen L, Moen C, Sharma P, Zaka A, Arnes J, Sauer T, Akslen LA, Schlichting E, Børresen-Dale AL, Lönneborg A (2005)
Early detection of breast cancer based on gene-expression patterns in peripheral blood cells
Breast Cancer Res, 7 (5), R634-44
DOI 10.1186/bcr1203, PubMed 16168108

Sørlie T, Johnsen H, Vu P, Lind GE, Lothe R, Børresen-Dale AL (2005)
Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
Methods Mol Biol, 291, 207-16
DOI 10.1385/1-59259-840-4:207, PubMed 15502225

Tsalenko A, Sharan R, Edvardsen H, Kristensen V, Børresen-Dale AL, Ben-Dor A, Yakhini Z (2005)
Analysis of SNP-expression association matrices
Proc IEEE Comput Syst Bioinform Conf, 135-43
DOI 10.1109/csb.2005.14, PubMed 16447971

Wang Y, Helland A, Holm R, Kristensen GB, Børresen-Dale AL (2005)
PIK3CA mutations in advanced ovarian carcinomas
Hum Mutat, 25 (3), 322
DOI 10.1002/humu.9316, PubMed 15712344

Wang Y, Kristensen GB, Helland A, Nesland JM, Børresen-Dale AL, Holm R (2005)
Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas
Am J Clin Pathol, 124 (3), 392-401
DOI 10.1309/BL7E-MW66-LQX6-GFRP, PubMed 16191507

Aas T, Geisler S, Helle H, Børresen-Dale AL, Lønning PE, Akslen LA (2005)
Prognostic and predictive value of changes in tumour cell proliferation in locally advanced breast cancer primarily treated with doxorubicin
Oncol Rep, 13 (3), 525-30
PubMed 15706428

Publications 2004

Bernstein JL, Langholz B, Haile RW, Bernstein L, Thomas DC, Stovall M, Malone KE, Lynch CF, Olsen JH, Anton-Culver H, Shore RE, Boice JD, Berkowitz GS, Gatti RA, Teitelbaum SL, Smith SA, Rosenstein BS, Børresen-Dale AL, Concannon P, Thompson WD, WECARE study (2004)
Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
Breast Cancer Res, 6 (3), R199-214
DOI 10.1186/bcr771, PubMed 15084244

Lingjaerde OC, Baumbusch LO, Liestøl K, Glad IK, Børresen-Dale AL (2004)
CGH-Explorer: a program for analysis of array-CGH data
Bioinformatics, 21 (6), 821-2
DOI 10.1093/bioinformatics/bti113, PubMed 15531610

Stray-Pedersen A, Jónsson T, Heiberg A, Lindman CR, Widing E, Aaberge IS, Borresen-Dale AL, Abrahamsen TG (2004)
The impact of an early truncating founder ATM mutation on immunoglobulins, specific antibodies and lymphocyte populations in ataxia-telangiectasia patients and their parents
Clin Exp Immunol, 137 (1), 179-86
DOI 10.1111/j.1365-2249.2004.02492.x, PubMed 15196260

Staalesen V, Falck J, Geisler S, Bartkova J, Børresen-Dale AL, Lukas J, Lillehaug JR, Bartek J, Lønning PE (2004)
Alternative splicing and mutation status of CHEK2 in stage III breast cancer
Oncogene, 23 (52), 8535-44
DOI 10.1038/sj.onc.1207928, PubMed 15361853

Sørlie T, Børresen-Dale AL, Lønning PE, Brown PO, Botstein D (2004)
Expression profiling of breast cancer: From molecular portraits to clinical utility.
In Oncogenomics: Molecular approaches to cancer (Brenner C, Duggan DJ, eds.), John Wiley & Sons, Inc., New York
PublikaID 67, ISBN 0-471-22592-4

Troester MA, Hoadley KA, Sørlie T, Herbert BS, Børresen-Dale AL, Lønning PE, Shay JW, Kaufmann WK, Perou CM (2004)
Cell-type-specific responses to chemotherapeutics in breast cancer
Cancer Res, 64 (12), 4218-26
DOI 10.1158/0008-5472.CAN-04-0107, PubMed 15205334

Usary J, Llaca V, Karaca G, Presswala S, Karaca M, He X, Langerød A, Kåresen R, Oh DS, Dressler LG, Lønning PE, Strausberg RL, Chanock S, Børresen-Dale AL, Perou CM (2004)
Mutation of GATA3 in human breast tumors
Oncogene, 23 (46), 7669-78
DOI 10.1038/sj.onc.1207966, PubMed 15361840

Wang Y, Helland A, Holm R, Skomedal H, Abeler VM, Danielsen HE, Tropé CG, Børresen-Dale AL, Kristensen GB (2004)
TP53 mutations in early-stage ovarian carcinoma, relation to long-term survival
Br J Cancer, 90 (3), 678-85
DOI 10.1038/sj.bjc.6601537, PubMed 14760384

Wang Y, Kringen P, Kristensen GB, Holm R, Baekelandt MM, Olivier M, Skomedal H, Hainaut P, Tropé CG, Abeler VM, Nesland JM, Børresen-Dale AL, Helland A (2004)
Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
Hum Mutat, 24 (1), 21-34
DOI 10.1002/humu.20055, PubMed 15221786

Zhao H, Langerød A, Ji Y, Nowels KW, Nesland JM, Tibshirani R, Bukholm IK, Kåresen R, Botstein D, Børresen-Dale AL, Jeffrey SS (2004)
Different gene expression patterns in invasive lobular and ductal carcinomas of the breast
Mol Biol Cell, 15 (6), 2523-36
DOI 10.1091/mbc.e03-11-0786, PubMed 15034139

Publications 2003

Bernstein JL, Bernstein L, Thompson WD, Lynch CF, Malone KE, Teitelbaum SL, Olsen JH, Anton-Culver H, Boice JD, Rosenstein BS, Børresen-Dale AL, Gatti RA, Concannon P, Haile RW, WECARE Study Collaborative Group (2003)
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer
Br J Cancer, 89 (8), 1513-6
DOI 10.1038/sj.bjc.6601289, PubMed 14562025

Bernstein JL, Teraoka S, Haile RW, Børresen-Dale AL, Rosenstein BS, Gatti RA, Diep AT, Jansen L, Atencio DP, Olsen JH, Bernstein L, Teitelbaum SL, Thompson WD, Concannon P, WECARE Study Collaborative Group (2003)
Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer
Hum Mutat, 21 (5), 542-50
DOI 10.1002/humu.10206, PubMed 12673797

Børresen-Dale AL (2003)
TP53 and breast cancer
Hum Mutat, 21 (3), 292-300
DOI 10.1002/humu.10174, PubMed 12619115

Børresen-Dale AL (2003)
Genetic profiling of breast cancer: from molecular portraits to clinical utility
Int J Biol Markers, 18 (1), 54-6
DOI 10.1177/172460080301800109, PubMed 12699064

Geisler S, Børresen-Dale AL, Johnsen H, Aas T, Geisler J, Akslen LA, Anker G, Lønning PE (2003)
TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer
Clin Cancer Res, 9 (15), 5582-8
PubMed 14654539

Kristiansen M, Helland A, Kristensen GB, Olsen AO, Lønning PE, Børresen-Dale AL, Ørstavik KH (2003)
X chromosome inactivation in cervical cancer patients
Cancer Genet Cytogenet, 146 (1), 73-6
DOI 10.1016/s0165-4608(03)00152-3, PubMed 14499700

Langerød A, Strømberg M, Chin K, Kristensen VN, Børresen-Dale AL (2003)
BUB1 infrequently mutated in human breast carcinomas
Hum Mutat, 22 (5), 420
DOI 10.1002/humu.9194, PubMed 14517964

Pan-Hammarström Q, Dai S, Zhao Y, van Dijk-Härd IF, Gatti RA, Børresen-Dale AL, Hammarström L (2003)
ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region
J Immunol, 170 (7), 3707-16
DOI 10.4049/jimmunol.170.7.3707, PubMed 12646636

Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O'Dwyer PJ, Fero MJ, Kristensen GB, Borresen-Dale AL, Hastie T, Tibshirani R, van de Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO et al. (2003)
Gene expression patterns in ovarian carcinomas
Mol Biol Cell, 14 (11), 4376-86
DOI 10.1091/mbc.e03-05-0279, PubMed 12960427

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lønning PE, Brown PO, Børresen-Dale AL, Botstein D (2003)
Repeated observation of breast tumor subtypes in independent gene expression data sets
Proc Natl Acad Sci U S A, 100 (14), 8418-23
DOI 10.1073/pnas.0932692100, PubMed 12829800

Soucek P, Gut I, Trneny M, Skovlund E, Grenaker Alnaes G, Kristensen T, Børresen-Dale AL, Kristensen VN (2003)
Multiplex single-tube screening for mutations in the Nijmegen Breakage Syndrome (NBS1) gene in Hodgkin's and non-Hodgkin's lymphoma patients of Slavic origin
Eur J Hum Genet, 11 (5), 416-9
DOI 10.1038/sj.ejhg.5200972, PubMed 12734548

Yoshimura N, Harada N, Bukholm I, Kåresen R, Børresen-Dale AL, Kristensen VN (2003)
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer
Breast Cancer Res, 6 (2), R46-55
DOI 10.1186/bcr746, PubMed 14979917

Aas T, Geisler S, Eide GE, Haugen DF, Varhaug JE, Bassøe AM, Thorsen T, Berntsen H, Børresen-Dale AL, Akslen LA, Lønning PE (2003)
Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy
Eur J Cancer, 39 (4), 438-46
DOI 10.1016/s0959-8049(02)00732-3, PubMed 12751373

Publications 2002

Allinen M, Launonen V, Laake K, Jansen L, Huusko P, Kääriäinen H, Børresen-Dale AL, Winqvist R (2002)
ATM mutations in Finnish breast cancer patients
J Med Genet, 39 (3), 192-6
DOI 10.1136/jmg.39.3.192, PubMed 11897822

Bernstein JL, Seminara D, Børresen-Dale AL (2002)
Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002
Breast Cancer Res, 4 (6), 249-52
DOI 10.1186/bcr551, PubMed 12473172

Børresen AL (2002)
Mismatch detection using heteroduplex analysis
Curr Protoc Hum Genet, Chapter 7, Unit 7.3
DOI 10.1002/0471142905.hg0703s33, PubMed 18428333

Jeffrey SS, Fero MJ, Børresen-Dale AL, Botstein D (2002)
Expression array technology in the diagnosis and treatment of breast cancer
Mol Interv, 2 (2), 101-9
DOI 10.1124/mi.2.2.101, PubMed 14993355

Kringen P, Egedal S, Pedersen JC, Harbitz TB, Tveit KM, Berg K, Børresen-Dale AL, Andersen TI (2002)
BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system
Electrophoresis, 23 (24), 4085-91
DOI 10.1002/elps.200290025, PubMed 12481264

Kristiansen M, Langerød A, Knudsen GP, Weber BL, Børresen-Dale AL, Orstavik KH (2002)
High frequency of skewed X inactivation in young breast cancer patients
J Med Genet, 39 (1), 30-3
DOI 10.1136/jmg.39.1.30, PubMed 11826021

Langerød A, Bukholm IR, Bregård A, Lønning PE, Andersen TI, Rognum TO, Meling GI, Lothe RA, Børresen-Dale AL (2002)
The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas
Cancer Epidemiol Biomarkers Prev, 11 (12), 1684-8
PubMed 12496062

Passarino G, Cavalleri GL, Lin AA, Cavalli-Sforza LL, Børresen-Dale AL, Underhill PA (2002)
Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms
Eur J Hum Genet, 10 (9), 521-9
DOI 10.1038/sj.ejhg.5200834, PubMed 12173029

Pollack JR, Sørlie T, Perou CM, Rees CA, Jeffrey SS, Lonning PE, Tibshirani R, Botstein D, Børresen-Dale AL, Brown PO (2002)
Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors
Proc Natl Acad Sci U S A, 99 (20), 12963-8
DOI 10.1073/pnas.162471999, PubMed 12297621

Zhao H, Hastie T, Whitfield ML, Børresen-Dale AL, Jeffrey SS (2002)
Optimization and evaluation of T7 based RNA linear amplification protocols for cDNA microarray analysis
BMC Genomics, 3 (1), 31
DOI 10.1186/1471-2164-3-31, PubMed 12445333

Publications 2001

Bjørheim J, Ekstrøm PO, Fossberg E, Børresen-Dale AL, Gaudernack G (2001)
Automated constant denaturant capillary electrophoresis applied for detection of KRAS exon 1 mutations
Biotechniques, 30 (5), 972-5
DOI 10.2144/01305st01, PubMed 11355359

Børresen-Dale AL, Hovig E, Smith-Sørensen B (2001)
Detection of mutations by denaturing gradient gel electrophoresis
Curr Protoc Hum Genet, Chapter 7, Unit 7.5
DOI 10.1002/0471142905.hg0705s17, PubMed 18428306

Dai H, Holm R, Kristensen GB, Abeler VM, Børresen-Dale AL, Helland A (2001)
Fibroblast growth factor receptor 3 (FGFR3) - analyses of the S249C mutation and protein expression in primary cervical carcinomas
Anal Cell Pathol, 23 (2), 45-9
DOI 10.1155/2001/521873, PubMed 11904459

Forus A, Sørlie T, Børresen-Dale AL, Myklebost O (2001)
[Microarray technology--potential in cancer research]
Tidsskr Nor Laegeforen, 121 (21), 2498-503
PubMed 11875927

Geisler S, Lønning PE, Aas T, Johnsen H, Fluge O, Haugen DF, Lillehaug JR, Akslen LA, Børresen-Dale AL (2001)
Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
Cancer Res, 61 (6), 2505-12
PubMed 11289122

Helland Å, Børresen-Dale AL (2001)
Livmorhalskreft og arvelighet med fokus på HLA-systemet
In Medicinsk årbog, Norli, Oslo, 2001, s. 121-128
BIBSYS 042195993

Jain AN, Chin K, Børresen-Dale AL, Erikstein BK, Eynstein Lonning P, Kaaresen R, Gray JW (2001)
Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival
Proc Natl Acad Sci U S A, 98 (14), 7952-7
DOI 10.1073/pnas.151241198, PubMed 11438741

Kristensen VN, Børresen-Dale AL, Kristensen T (2001)
Hypervariable area in the 5' flanking region of GSTP1, previously reported as a minisatellite ATAAA repeat
Hum Mutat, 17 (3), 238-9
DOI 10.1002/humu.17, PubMed 11241854

Kristensen VN, Harada N, Kristensen T, Borresen-Dale AL (2001)
[Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]
Vopr Onkol, 47 (2), 156-9
PubMed 11383450

Kristensen VN, Kelefiotis D, Kristensen T, Børresen-Dale AL (2001)
High-throughput methods for detection of genetic variation
Biotechniques, 30 (2), 318-22, 324, 326 passim
DOI 10.2144/01302tt01, PubMed 11233601

Kristensen VN, Kure EH, Erikstein B, Harada N, Børresen-Dale A (2001)
Genetic susceptibility and environmental estrogen-like compounds
Mutat Res, 482 (1-2), 77-82
DOI 10.1016/s0027-5107(01)00212-3, PubMed 11535251

Lønning PE, Sørlie T, Perou CM, Brown PO, Botstein D, Børresen-Dale AL (2001)
Microarrays in primary breast cancer--lessons from chemotherapy studies
Endocr Relat Cancer, 8 (3), 259-63
DOI 10.1677/erc.0.0080259, PubMed 11566617

Olsen JH, Hahnemann JM, Børresen-Dale AL, Brøndum-Nielsen K, Hammarström L, Kleinerman R, Kääriäinen H, Lönnqvist T, Sankila R, Seersholm N, Tretli S, Yuen J, Boice JD, Tucker M (2001)
Cancer in patients with ataxia-telangiectasia and in their relatives in the nordic countries
J Natl Cancer Inst, 93 (2), 121-7
DOI 10.1093/jnci/93.2.121, PubMed 11208881

Salahshor S, Haixin L, Huo H, Kristensen VN, Loman N, Sjöberg-Margolin S, Borg A, Børresen-Dale AL, Vorechovsky I, Lindblom A (2001)
Low frequency of E-cadherin alterations in familial breast cancer
Breast Cancer Res, 3 (3), 199-207
DOI 10.1186/bcr295, PubMed 11305955

Sandvik AK, Støren O, Nørsett K, Laegreid A, Børresen-Dale AL, Myklebost O (2001)
[Measurement of gene activity by DNA microarrays]
Tidsskr Nor Laegeforen, 121 (10), 1225-8
PubMed 11402749

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL (2001)
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Proc Natl Acad Sci U S A, 98 (19), 10869-74
DOI 10.1073/pnas.191367098, PubMed 11553815

Warren W, Hovig E, Smith-Sørensen B, Børresen AL, Fujimura FK, Liu Q, Feng J, Sommer SS (2001)
Detection of mutations by single-strand conformation polymorphism (SSCP) analysis and SSCP-hybrid methods
Curr Protoc Hum Genet, Chapter 7, Unit 7.4
DOI 10.1002/0471142905.hg0704s15, PubMed 18428305

Publications 2000

Bukholm IK, Nesland JM, Børresen-Dale AL (2000)
Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [seecomments]
J Pathol, 190 (1), 15-9
DOI 10.1002/(SICI)1096-9896(200001)190:1<15::AID-PATH489>3.0.CO;2-L, PubMed 10640987

Helland A, Kraggerud SM, Kristensen GB, Holm R, Abeler VM, Huebner K, Borresen-Dale AL, Lothe RA (2000)
Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival
Int J Cancer, 88 (2), 217-22
DOI 10.1002/1097-0215(20001015)88:2<217::aid-ijc11>3.0.co;2-i, PubMed 11004671

Hellström AC, Blegen H, Malec M, Silfverswärd C, Lystad S, Børresen-Dale AL, Auer G (2000)
Recurrent fallopian tube carcinoma: TP53 mutation and clinical course
Int J Gynecol Pathol, 19 (2), 145-51
DOI 10.1097/00004347-200004000-00008, PubMed 10782411

Hou SM, Ryberg D, Fält S, Deverill A, Tefre T, Børresen AL, Haugen A, Lambert B (2000)
GSTM1 and NAT2 polymorphisms in operable and non-operable lung cancer patients
Carcinogenesis, 21 (1), 49-54
DOI 10.1093/carcin/21.1.49, PubMed 10607733

Jugessur A, Frost P, Andersen TI, Steine S, Lindblom A, Børresen-Dale AL, Eiken HG (2000)
Enhanced detection of mutations in BRCA1 exon 11 using restriction endonuclease fingerprinting-single-strand conformation polymorphism
J Mol Med (Berl), 78 (10), 580-7
DOI 10.1007/s001090000147, PubMed 11199332

Kristensen VN, Borresen-Dale AL (2000)
Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism
Mutat Res, 462 (2-3), 323-33
DOI 10.1016/s1383-5742(00)00018-1, PubMed 10767642

Kristensen VN, Harada N, Yoshimura N, Haraldsen E, Lonning PE, Erikstein B, Kåresen R, Kristensen T, Børresen-Dale AL (2000)
Genetic variants of CYP19 (aromatase) and breast cancer risk
Oncogene, 19 (10), 1329-33
DOI 10.1038/sj.onc.1203425, PubMed 10713674

Liestøl K, Kvittingen EA, Rootwelt H, Dunlop O, Goplen AK, Pedersen JC, Brorson SH, Børresen-Dale AL, Myrvang B, Maehlen J (2000)
Association between apolipoprotein E genotypes and cancer risk in patients with acquired immunodeficiency syndrome
Cancer Detect Prev, 24 (5), 496-9
PubMed 11129992

Laake K, Jansen L, Hahnemann JM, Brondum-Nielsen K, Lönnqvist T, Kääriäinen H, Sankila R, Lähdesmäki A, Hammarström L, Yuen J, Tretli S, Heiberg A, Olsen JH, Tucker M, Kleinerman R, Børresen-Dale AL (2000)
Characterization of ATM mutations in 41 Nordic families with ataxia telangiectasia
Hum Mutat, 16 (3), 232-46
DOI 10.1002/1098-1004(200009)16:3<232::AID-HUMU6>3.0.CO;2-L, PubMed 10980530

Laake K, Vu P, Andersen TI, Erikstein B, Kåresen R, Lonning PE, Skovlund E, Børresen-Dale AL (2000)
Screening breast cancer patients for Norwegian ATM mutations
Br J Cancer, 83 (12), 1650-3
DOI 10.1054/bjoc.2000.1519, PubMed 11104561

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale AL, Brown PO, Botstein D (2000)
Molecular portraits of human breast tumours
Nature, 406 (6797), 747-52
DOI 10.1038/35021093, PubMed 10963602

Stokke T, Galteland E, Holte H, Smedshammer L, Suo Z, Smeland EB, Børresen-Dale AL, DeAngelis P, Steen HB (2000)
Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma
Int J Cancer, 89 (4), 313-24
DOI 10.1002/1097-0215(20000720)89:4<313::aid-ijc1>3.0.co;2-d, PubMed 10956404

Publications 1999

Arver B, Claro A, Langerød A, Børresen-Dale AL, Lindblom A (1999)
BRCA1 screening in patients with a family history of breast or ovarian cancer
Genet Test, 3 (2), 223-6
DOI 10.1089/gte.1999.3.223, PubMed 10464672

Danielsen T, Smith-Sørensen B, Grønlund HA, Hvidsten M, Børresen-Dale AL, Rofstad EK (1999)
No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines
Int J Radiat Biol, 75 (9), 1149-60
DOI 10.1080/095530099139629, PubMed 10528923

Ekstrøm PO, Børresen-Dale AL, Qvist H, Giercksky KE, Thilly WG (1999)
Detection of low-frequency mutations in exon 8 of the TP53 gene by constant denaturant capillary electrophoresis (CDCE)
Biotechniques, 27 (1), 128-34
DOI 10.2144/99271rr01, PubMed 10407675

Helland A, Børresen-Dale AL (1999)
p53 polymorphism and cervical cancer
Lancet, 354 (9189), 1561-2
DOI 10.1016/S0140-6736(05)76596-X, PubMed 10551531

Högmo A, Börresen-Dale AL, Blegen H, Lindholm J, Kuylenstierna R, Auer G, Munck-Wikland E (1999)
TP53 mutations do not correlate with locoregional recurrence in stage I tongue carcinomas
Anticancer Res, 19 (4C), 3433-8
PubMed 10629631

Laake K, Launonen V, Niederacher D, Gudlaugsdottir S, Seitz S, Rio P, Champème MH, Bièche I, Birnbaum D, White G, Sztan M, Sever N, Plummer S, Osorio A, Broeks A, Huusko P, Spurr N, Borg A, Cleton-Jansen AM, van't Veer L, Benitez J, Casey G, Peterlin B, Olah E, Børresen-Dale AL (1999)
Loss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium
Genes Chromosomes Cancer, 25 (3), 212-21
DOI 10.1002/(SICI)1098-2264(199907)25:3<212::AID-GCC3>3.3.CO;2-7, PubMed 10379867

Nedelcheva Kristensen V, Haraldsen EK, Anderson KB, Lønning PE, Erikstein B, Kåresen R, Gabrielsen OS, Børresen-Dale AL (1999)
CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
Cancer Res, 59 (12), 2825-8
PubMed 10383140

Skomedal H, Helland A, Kristensen GB, Holm R, Børresen-Dale AL (1999)
Allelic imbalance at chromosome region 11q23 in cervical carcinomas
Eur J Cancer, 35 (4), 659-63
DOI 10.1016/s0959-8049(98)00413-4, PubMed 10492643

Skomedal H, Kristensen GB, Nesland JM, Børresen-Dale AL, Tropé C, Holm R (1999)
TP53 alterations in relation to the cell cycle-associated proteins p21, cyclin D1, CDK4, RB, MDM2, and EGFR in cancers of the uterine corpus
J Pathol, 187 (5), 556-62
DOI 10.1002/(SICI)1096-9896(199904)187:5<556::AID-PATH294>3.0.CO;2-Y, PubMed 10398121

van Slooten HJ, van De Vijver MJ, Borresen AL, Eyfjörd JE, Valgardsdóttir R, Scherneck S, Nesland JM, Devilee P, Cornelisse CJ, van Dierendonck JH (1999)
Mutations in exons 5-8 of the p53 gene, independent of their type and location, are associated with increased apoptosis and mitosis in invasive breast carcinoma
J Pathol, 189 (4), 504-13
DOI 10.1002/(SICI)1096-9896(199912)189:4<504::AID-PATH483>3.0.CO;2-A, PubMed 10629550

Publications 1998

Adélaïde J, Chaffanet M, Imbert A, Allione F, Geneix J, Popovici C, van Alewijk D, Trapman J, Zeillinger R, Børresen-Dale AL, Lidereau R, Birnbaum D, Pébusque MJ (1998)
Chromosome region 8p11-p21: refined mapping and molecular alterations in breast cancer
Genes Chromosomes Cancer, 22 (3), 186-99
DOI 10.1002/(sici)1098-2264(199807)22:3<186::aid-gcc4>3.0.co;2-s, PubMed 9624530

Andersen TI, Børresen-Dale AL (1998)
[Diagnostic molecular biology in breast cancer]
Tidsskr Nor Laegeforen, 118 (15), 2366-9
PubMed 9691806

Andersen TI, Eiken HG, Couch F, Kaada G, Skrede M, Johnsen H, Aloysius TA, Tveit KM, Tranebjaerg L, Dørum A, Møller P, Weber BL, Børresen-Dale AL (1998)
Constant denaturant gel electrophoresis (CDGE) in BRCA1 mutation screening
Hum Mutat, 11 (2), 166-74
DOI 10.1002/(SICI)1098-1004(1998)11:2<166::AID-HUMU10>3.0.CO;2-X, PubMed 9482581

Bjørheim J, Lystad S, Lindblom A, Kressner U, Westring S, Wahlberg S, Lindmark G, Gaudernack G, Ekstrøm P, Røe J, Thilly WG, Børresen-Dale AL (1998)
Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillary electrophoresis and allele specific polymerase chain reaction
Mutat Res, 403 (1-2), 103-12
DOI 10.1016/s0027-5107(98)00057-8, PubMed 9726011

Bukholm IK, Berner JM, Nesland JM, Børresen-Dale AL (1998)
Expression of cyclin Ds in relation to p53 status in human breast carcinomas
Virchows Arch, 433 (3), 223-8
DOI 10.1007/s004280050240, PubMed 9769125

Bukholm IK, Nesland JM, Kåresen R, Jacobsen U, Børresen-Dale AL (1998)
E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma
J Pathol, 185 (3), 262-6
DOI 10.1002/(SICI)1096-9896(199807)185:3<262::AID-PATH97>3.0.CO;2-Y, PubMed 9771479

Børresen-Dale AL, Boman H (1998)
[Hereditary cancer]
Tidsskr Nor Laegeforen, 118 (12), 1873-7
PubMed 9638057

Børresen-Dale AL, Lothe RA, Meling GI, Hainaut P, Rognum TO, Skovlund E (1998)
TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival
Clin Cancer Res, 4 (1), 203-10
PubMed 9516972

Børresen-Dale AL, Lothe RA, Nesland JM (1998)
[Molecular biology. Basis for increased understanding of diseases and improved diagnostics]
Tidsskr Nor Laegeforen, 118 (11), 1681
PubMed 9621751

Clausen OP, Lothe RA, Børresen-Dale AL, De Angelis P, Chen Y, Rognum TO, Meling GI (1998)
Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas
Diagn Mol Pathol, 7 (4), 215-23
DOI 10.1097/00019606-199808000-00006, PubMed 9917132

Eiken HG, Børresen-Dale AL (1998)
[Molecular genetic diagnostics. Technology for detecting mutations in DNA]
Tidsskr Nor Laegeforen, 118 (11), 1730-6
PubMed 9621763

Helland A, Langerød A, Johnsen H, Olsen AO, Skovlund E, Børresen-Dale AL (1998)
p53 polymorphism and risk of cervical cancer
Nature, 396 (6711), 530-1; author reply 532
DOI 10.1038/25034, PubMed 9859987

Helland A, Olsen AO, Gjøen K, Akselsen HE, Sauer T, Magnus P, Børresen-Dale AL, Rønningen KS (1998)
An increased risk of cervical intra-epithelial neoplasia grade II-III among human papillomavirus positive patients with the HLA-DQA1*0102-DQB1*0602 haplotype: a population-based case-control study of Norwegian women
Int J Cancer, 76 (1), 19-24
DOI 10.1002/(sici)1097-0215(19980330)76:1<19::aid-ijc4>3.0.co;2-0, PubMed 9533756

Kressner U, Bjørheim J, Westring S, Wahlberg SS, Påhlman L, Glimelius B, Lindmark G, Lindblom A, Børresen-Dale AL (1998)
Ki-ras mutations and prognosis in colorectal cancer
Eur J Cancer, 34 (4), 518-21
DOI 10.1016/s0959-8049(97)10111-3, PubMed 9713302

Kristensen T, Kristensen VN, Børresen-Dale AL (1998)
High-throughput screening for known mutations by automated analysis of single sequencing reactions
Biotechniques, 24 (5), 832-5
DOI 10.2144/98245dt04, PubMed 9591134

Kristensen VN, Andersen TI, Lindblom A, Erikstein B, Magnus P, Børresen-Dale AL (1998)
A rare CYP19 (aromatase) variant may increase the risk of breast cancer
Pharmacogenetics, 8 (1), 43-8
DOI 10.1097/00008571-199802000-00006, PubMed 9511180

Lothe RA, Hektoen M, Johnsen H, Meling GI, Andersen TI, Rognum TO, Lindblom A, Børresen-Dale AL (1998)
The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer
Cancer Res, 58 (14), 2923-4
PubMed 9679946

Laake K, Telatar M, Geitvik GA, Hansen RO, Heiberg A, Andresen AM, Gatti R, Børresen-Dale AL (1998)
Identical mutation in 55% of the ATM alleles in 11 Norwegian AT families: evidence for a founder effect
Eur J Hum Genet, 6 (3), 235-44
DOI 10.1038/sj.ejhg.5200181, PubMed 9781027

Nedelcheva Kristensen V, Andersen TI, Erikstein B, Geitvik G, Skovlund E, Nesland JM, Børresen-Dale AL (1998)
Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinicopathological variables in breast cancer patients
Pharmacogenetics, 8 (5), 441-7
DOI 10.1097/00008571-199810000-00009, PubMed 9825836

Phelan CM, Borg A, Cuny M, Crichton DN, Baldersson T, Andersen TI, Caligo MA, Lidereau R, Lindblom A, Seitz S, Kelsell D, Hamann U, Rio P, Thorlacius S, Papp J, Olah E, Ponder B, Bignon YJ, Scherneck S, Barkardottir R, Borresen-Dale AL, Eyfjörd J, Theillet C, Thompson AM, Larsson C (1998)
Consortium study on 1280 breast carcinomas: allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters
Cancer Res, 58 (5), 1004-12
PubMed 9500463

Smith-Sørensen B, Kaern J, Holm R, Dørum A, Tropé C, Børresen-Dale AL (1998)
Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients with epithelial ovarian cancer and relation to TP53 gene status
Br J Cancer, 78 (3), 375-81
DOI 10.1038/bjc.1998.502, PubMed 9703286

Sørlie T, Andersen TI, Bukholm I, Børresen-Dale AL (1998)
Mutation screening of BRCA1 using PTT and LOH analysis at 17q21 in breast carcinomas from familial and non-familial cases
Breast Cancer Res Treat, 48 (3), 259-64
DOI 10.1023/a:1005953519972, PubMed 9598872

Sørlie T, Bukholm I, Børresen-Dale AL (1998)
Truncating somatic mutation in exon 15 of the APC gene is a rare event in human breast carcinomas. Mutations in brief no. 179. Online
Hum Mutat, 12 (3), 215
PubMed 10660330

Sørlie T, Martel-Planche G, Hainaut P, Lewalter J, Holm R, Børresen-Dale AL, Montesano R (1998)
Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines
Br J Cancer, 77 (10), 1573-9
DOI 10.1038/bjc.1998.259, PubMed 9635831

Telatar M, Teraoka S, Wang Z, Chun HH, Liang T, Castellvi-Bel S, Udar N, Borresen-Dale AL, Chessa L, Bernatowska-Matuszkiewicz E, Porras O, Watanabe M, Junker A, Concannon P, Gatti RA (1998)
Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations
Am J Hum Genet, 62 (1), 86-97
DOI 10.1086/301673, PubMed 9443866

Publications 1997

Anderson TI, Wooster R, Laake K, Collins N, Warren W, Skrede M, Elles R, Tveit KM, Johnston SR, Dowsett M, Olsen AO, Møller P, Stratton MR, Børresen-Dale AL (1997)
Screening for ESR mutations in breast and ovarian cancer patients
Hum Mutat, 9 (6), 531-6
DOI 10.1002/(SICI)1098-1004(1997)9:6<531::AID-HUMU6>3.0.CO;2-4, PubMed 9195227

Breivik J, Lothe RA, Meling GI, Rognum TO, Børresen-Dale AL, Gaudernack G (1997)
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors
Int J Cancer, 74 (6), 664-9
DOI 10.1002/(sici)1097-0215(19971219)74:6<664::aid-ijc18>3.0.co;2-5, PubMed 9421366

Bukholm IK, Nesland JM, Kåresen R, Jacobsen U, Børresen-Dale AL (1997)
Interaction between bcl-2 and p21 (WAF1/CIP1) in breast carcinomas with wild-type p53
Int J Cancer, 73 (1), 38-41
DOI 10.1002/(sici)1097-0215(19970926)73:1<38::aid-ijc7>3.0.co;2-2, PubMed 9334807

Bukholm IK, Nesland JM, Kåresen R, Jacobsen U, Børresen-Dale AL (1997)
Expression of E-cadherin and its relation to the p53 protein status in human breast carcinomas
Virchows Arch, 431 (5), 317-21
DOI 10.1007/s004280050105, PubMed 9463572

Bukholm IK, Nesland JM, Kåresen R, Jacobsen U, Børresen AL (1997)
Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas
J Pathol, 181 (2), 140-5
DOI 10.1002/(SICI)1096-9896(199702)181:2<140::AID-PATH745>3.0.CO;2-A, PubMed 9120716

Børresen-Dale AL, Lystad S, Langerød A (1997)
Temporal Temperature Gradient Gel Electrophoresis on the DCode™ System A Comparison to DGGE and CDGE in Mutation Screening
In Bio Rad Bulletin, BioRad, 2133, 12-13
PublikaID 33

Devilee P, Hermans J, Eyfjörd J, Bøorresen AL, Lidereau R, Sobol H, Borg A, Cleton-Jansen AM, Oláh E, Cohen BB, Scherneck S, Hamann U, Peterlin B, Caligo M, Bignon YJ, Maugard C (1997)
Loss of heterozygosity at 7q31 in breast cancer: results from an International Collaborative Study Group. The Breast Cancer Somatic Genetics Consortium
Genes Chromosomes Cancer, 18 (3), 193-9
PubMed 9071572

Ellis PA, Lonning PE, Borresen-Dale A, Aas T, Geisler S, Akslen LA, Salter I, Smith IE, Dowsett M (1997)
Absence of p21 expression is associated with abnormal p53 in human breast carcinomas
Br J Cancer, 76 (4), 480-5
DOI 10.1038/bjc.1997.413, PubMed 9275025

Heimdal K, Olsson H, Tretli S, Fosså SD, Børresen AL, Bishop DT (1997)
A segregation analysis of testicular cancer based on Norwegian and Swedish families
Br J Cancer, 75 (7), 1084-7
DOI 10.1038/bjc.1997.185, PubMed 9083348

Helland A, Børresen-Dale AL, Peltomäki P, Hektoen M, Kristensen GB, Nesland JM, de la Chapelle A, Lothe RA (1997)
Microsatellite instability in cervical and endometrial carcinomas
Int J Cancer, 70 (5), 499-501
DOI 10.1002/(sici)1097-0215(19970304)70:5<499::aid-ijc1>3.0.co;2-t, PubMed 9052745

Kraggerud SM, Jacobsen KD, Berner A, Stokke T, Holm R, Smedshammer L, Børresen-Dale AL, Fosså SD (1997)
A comparison of different modes for the detection of p53 protein accumulation. A study of bladder cancer
Pathol Res Pract, 193 (7), 471-8
DOI 10.1016/s0344-0338(97)80099-4, PubMed 9342752

Kristensen VN, Børresen-Dale AL (1997)
Improved electrophoretic separation of polymorphic short tandem repeats in agarose gels using bis-benzimide
Biotechniques, 23 (4), 634-6
DOI 10.2144/97234bm18, PubMed 9343680

Laake K, Odegård A, Andersen TI, Bukholm IK, Kåresen R, Nesland JM, Ottestad L, Shiloh Y, Børresen-Dale AL (1997)
Loss of heterozygosity at 11q23.1 in breast carcinomas: indication for involvement of a gene distal and close to ATM
Genes Chromosomes Cancer, 18 (3), 175-80
DOI 10.1002/(SICI)1098-2264(199703)18:3<175::AID-GCC4>3.3.CO;2-R, PubMed 9071570

Paulsen T, Aas T, Børresen AL, Varhaug JE, Lønning PE, Akslen LA (1997)
Angiogenesis does not predict clinical response to doxorubicin monotherapy in patients with locally advanced breast cancer
Int J Cancer, 74 (1), 138-40
DOI 10.1002/(sici)1097-0215(19970220)74:1<138::aid-ijc23>3.0.co;2-a, PubMed 9036883

Skomedal H, Kristensen GB, Abeler VM, Børresen-Dale AL, Tropé C, Holm R (1997)
TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas
J Pathol, 181 (2), 158-65
DOI 10.1002/(SICI)1096-9896(199702)181:2<158::AID-PATH742>3.0.CO;2-8, PubMed 9120719

Tranebjaerg L, Børresen-Dale AL, Hansteen IL, Heim S, Kvittingen EA, Møller P (1997)
Genetic services in Norway
Eur J Hum Genet, 5 Suppl 2, 130-4
PubMed 9450210

Zelada-Hedman M, Børresen-Dale AL, Claro A, Chen J, Skoog L, Lindblom A (1997)
Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families
Br J Cancer, 75 (8), 1201-4
DOI 10.1038/bjc.1997.205, PubMed 9099970

Zelada-Hedman M, Børresen-Dale AL, Lindblom A (1997)
Screening of 229 family cancer patients for a germline estrogen receptor gene (ESR) base mutation
Hum Mutat, 9 (3), 289
DOI 10.1002/(SICI)1098-1004(1997)9:3<289::AID-HUMU15>3.0.CO;2-Z, PubMed 9090537

Zelada-Hedman M, Wasteson Arver B, Claro A, Chen J, Werelius B, Kok H, Sandelin K, Håkansson S, Andersen TI, Borg A, Børresen Dale AL, Lindblom A (1997)
A screening for BRCA1 mutations in breast and breast-ovarian cancer families from the Stockholm region
Cancer Res, 57 (12), 2474-7
PubMed 9192828

Publications 1996

Andersen TI, Børresen AL, Møller P (1996)
A common BRCA1 mutation in Norwegian breast and ovarian cancer families?
Am J Hum Genet, 59 (2), 486-7
PubMed 8755943

Chitemerere M, Andersen TI, Holm R, Karlsen F, Børresen AL, Nesland JM (1996)
TP53 alterations in atypical ductal hyperplasia and ductal carcinoma in situ of the breast
Breast Cancer Res Treat, 41 (2), 103-9
DOI 10.1007/BF01807155, PubMed 8944328

Heimdal K, Olsson H, Tretli S, Flodgren P, Børresen AL, Fossa SD (1996)
Familial testicular cancer in Norway and southern Sweden
Br J Cancer, 73 (7), 964-9
DOI 10.1038/bjc.1996.173, PubMed 8611416

Heimdal K, Olsson H, Tretli S, Flodgren P, Børresen AL, Fossa SD (1996)
Risk of cancer in relatives of testicular cancer patients
Br J Cancer, 73 (7), 970-3
DOI 10.1038/bjc.1996.174, PubMed 8611417

Lothe RA, Karhu R, Mandahl N, Mertens F, Saeter G, Heim S, Borresen-Dale AL, Kallioniemi OP (1996)
Gain of 17q24-qter detected by comparative genomic hybridization in malignant tumors from patients with von Recklinghausen's neurofibromatosis
Cancer Res, 56 (20), 4778-81
PubMed 8840998

Maelandsmo GM, Flørenes VA, Hovig E, Oyjord T, Engebraaten O, Holm R, Børresen AL, Fodstad O (1996)
Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas
Br J Cancer, 73 (8), 909-16
DOI 10.1038/bjc.1996.181, PubMed 8611425

Zedenius J, Larsson C, Wallin G, Bäckdahl M, Aspenblad U, Höög A, Børresen AL, Auer G (1996)
Alterations of p53 and expression of WAF1/p21 in human thyroid tumors
Thyroid, 6 (1), 1-9
DOI 10.1089/thy.1996.6.1, PubMed 8777377

Aas T, Børresen AL, Geisler S, Smith-Sørensen B, Johnsen H, Varhaug JE, Akslen LA, Lønning PE (1996)
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
Nat Med, 2 (7), 811-4
DOI 10.1038/nm0796-811, PubMed 8673929

Aas T, Geisler S, Paulsen T, Børresen-Dale AL, Varhaug JE, Lønning PE, Akslen LA (1996)
Primary systemic treatment with weekly doxorubicin monotherapy in women with locally advanced breast cancer; clinical experience and parameters predicting outcome
Acta Oncol, 35 Suppl 5, 5-8
DOI 10.3109/02841869609083960, PubMed 9142957

Publications 1995

Andersen TI, Børresen AL (1995)
Alterations of the TP53 gene as a potential prognostic marker in breast carcinomas. Advantages of using constant denaturant gel electrophoresis in mutation detection
Diagn Mol Pathol, 4 (3), 203-11
DOI 10.1097/00019606-199509000-00008, PubMed 7493140

Andersen TI, Paus E, Nesland JM, McKenzie SJ, Børresen AL (1995)
Detection of c-erbB-2 related protein in sera from breast cancer patients. Relationship to ERBB2 gene amplification and c-erbB-2 protein overexpression in tumour
Acta Oncol, 34 (4), 499-504
DOI 10.3109/02841869509094014, PubMed 7605658

Berner A, Geitvik G, Karlsen F, Fosså SD, Nesland JM, Børresen AL (1995)
TP53 mutations in prostatic cancer. Analysis of pre- and post-treatment archival formalin-fixed tumour tissue
J Pathol, 176 (3), 299-308
DOI 10.1002/path.1711760312, PubMed 7674092

Børresen AL, Andersen TI, Eyfjörd JE, Cornelis RS, Thorlacius S, Borg A, Johansson U, Theillet C, Scherneck S, Hartman S (1995)
TP53 mutations and breast cancer prognosis: particularly poor survival rates for cases with mutations in the zinc-binding domains
Genes Chromosomes Cancer, 14 (1), 71-5
DOI 10.1002/gcc.2870140113, PubMed 8527388

Børresen AL, Lothe RA, Meling GI, Lystad S, Morrison P, Lipford J, Kane MF, Rognum TO, Kolodner RD (1995)
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas
Hum Mol Genet, 4 (11), 2065-72
DOI 10.1093/hmg/4.11.2065, PubMed 8589682

Friend S, Borresen AL, Brody L, Casey G, Devilee P, Gayther S, Goldgar D, Murphy P, Weber BL, Wiseman R (1995)
Breast cancer information on the web
Nat Genet, 11 (3), 238-9
DOI 10.1038/ng1195-238, PubMed 7581445

Heimdal K, Andersen TI, Skrede M, Fosså SD, Berg K, Børresen AL (1995)
Association studies of estrogen receptor polymorphisms in a Norwegian testicular cancer population
Cancer Epidemiol Biomarkers Prev, 4 (2), 123-6
PubMed 7742719

Lange E, Borresen AL, Chen X, Chessa L, Chiplunkar S, Concannon P, Dandekar S, Gerken S, Lange K, Liang T (1995)
Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium
Am J Hum Genet, 57 (1), 112-9
PubMed 7611279

Lothe RA, Andersen SN, Hofstad B, Meling GI, Peltomäki P, Heim S, Brøgger A, Vatn M, Rognum TO, Børresen AL (1995)
Deletion of 1p loci and microsatellite instability in colorectal polyps
Genes Chromosomes Cancer, 14 (3), 182-8
DOI 10.1002/gcc.2870140305, PubMed 8589034

Lothe RA, Børresen AL (1995)
[Early diagnosis of colorectal tumors]
Tidsskr Nor Laegeforen, 115 (26), 3231-2
PubMed 7482447

Lothe RA, Peltomäki P, Tommerup N, Fosså SD, Stenwig AE, Børresen AL, Nesland JM (1995)
Molecular genetic changes in human male germ cell tumors
Lab Invest, 73 (5), 606-14
PubMed 7474934

Lothe RA, Slettan A, Saeter G, Brøgger A, Børresen AL, Nesland JM (1995)
Alterations at chromosome 17 loci in peripheral nerve sheath tumors
J Neuropathol Exp Neurol, 54 (1), 65-73
DOI 10.1097/00005072-199501000-00008, PubMed 7815081

Skomedal H, Kristensen G, Helland A, Nesland JM, Kooi S, Børresen AL, Holm R (1995)
TP53 gene mutations and protein accumulation in primary vaginal carcinomas
Br J Cancer, 72 (1), 129-33
DOI 10.1038/bjc.1995.288, PubMed 7599041

Steen VM, Andreassen OA, Daly AK, Tefre T, Børresen AL, Idle JR, Gulbrandsen AK (1995)
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
Pharmacogenetics, 5 (4), 215-23
DOI 10.1097/00008571-199508000-00005, PubMed 8528268

Thorlacius S, Thorgilsson B, Björnsson J, Tryggvadottir L, Börresen AL, Ogmundsdottir HM, Eyfjörd JE (1995)
TP53 mutations and abnormal p53 protein staining in breast carcinomas related to prognosis
Eur J Cancer, 31A (11), 1856-61
DOI 10.1016/0959-8049(95)00399-4, PubMed 8541113

Publications 1994

Andersen TI, Heimdal KR, Skrede M, Tveit K, Berg K, Børresen AL (1994)
Oestrogen receptor (ESR) polymorphisms and breast cancer susceptibility
Hum Genet, 94 (6), 665-70
DOI 10.1007/BF00206961, PubMed 7989041

Cornelis RS, van Vliet M, Vos CB, Cleton-Jansen AM, van de Vijver MJ, Peterse JL, Khan PM, Børresen AL, Cornelisse CJ, Devilee P (1994)
Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations
Cancer Res, 54 (15), 4200-6
PubMed 8033152

Flørenes VA, Oyjord T, Holm R, Skrede M, Børresen AL, Nesland JM, Fodstad O (1994)
TP53 allele loss, mutations and expression in malignant melanoma
Br J Cancer, 69 (2), 253-9
DOI 10.1038/bjc.1994.48, PubMed 7905277

Gatti RA, Lange E, Rotman G, Chen X, Uhrhammer N, Liang T, Chiplunkar S, Yang L, Udar N, Dandekar S, Sheikhavandi S, Wang Z, Yang HM, Polikow J, Elashoff M, Teletar M, Sanal O, Chessa L, McConville C, Taylor M, Shiloh Y, Porras O, Borresen AL, Wegner RD, Curry C et al. (1994)
Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an approximately 850 kb region on chromosome 11q23.1
Int J Radiat Biol, 66 (6 Suppl), S57-62
DOI 10.1080/09553009414551861, PubMed 7836853

Heimdal KR, Lothe RA, Fosså SD, Børresen AL (1994)
Association studies of a polymorphism in the Wilms' tumor 1 locus in Norwegian patients with testicular cancer
Int J Cancer, 58 (4), 523-6
DOI 10.1002/ijc.2910580412, PubMed 8056449

Helland A, Børresen AL, Kristensen G, Rønningen KS (1994)
DQA1 and DQB1 genes in patients with squamous cell carcinoma of the cervix: relationship to human papillomavirus infection and prognosis
Cancer Epidemiol Biomarkers Prev, 3 (6), 479-86
PubMed 8000298

McIntyre JF, Smith-Sorensen B, Friend SH, Kassell J, Borresen AL, Yan YX, Russo C, Sato J, Barbier N, Miser J (1994)
Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma
J Clin Oncol, 12 (5), 925-30
DOI 10.1200/JCO.1994.12.5.925, PubMed 8164043

Nesland JM, Børresen AL, Andersson LC (1994)
[Molecular pathology. A new diagnostic dimension]
Tidsskr Nor Laegeforen, 114 (26), 3047-8
PubMed 7974419

Rosenberg C, Andersen TI, Nesland JM, Lier ME, Brøgger A, Børresen AL (1994)
Genetic alterations of chromosome 17 in human breast carcinoma studied by fluorescence in situ hybridization and molecular DNA techniques
Cancer Genet Cytogenet, 75 (1), 1-5
DOI 10.1016/0165-4608(94)90207-0, PubMed 8039157

Rosenberg C, Janson M, Nordeskjöld M, Børresen AL, Vianna-Morgante AM (1994)
Intragenic reorganization of RB1 in a complex (4;13) rearrangement demonstrated by FISH
Cytogenet Cell Genet, 65 (4), 268-71
DOI 10.1159/000133645, PubMed 8258302

Ryberg D, Kure E, Lystad S, Skaug V, Stangeland L, Mercy I, Børresen AL, Haugen A (1994)
p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer
Cancer Res, 54 (6), 1551-5
PubMed 8137262

Seruca R, David L, Castedo S, Veiga I, Børresen AL, Sobrinho-Simões M (1994)
p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases
Cancer Genet Cytogenet, 75 (1), 45-50
DOI 10.1016/0165-4608(94)90214-3, PubMed 8039163

Tefre T, Daly AK, Armstrong M, Leathart JB, Idle JR, Brøgger A, Børresen AL (1994)
Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controls
Pharmacogenetics, 4 (2), 47-57
PubMed 8081413

Verwest AM, de Leeuw WJ, Molijn AC, Andersen TI, Börresen AL, Mullaart E, Uitterlinden AG, Vijg J (1994)
Genome scanning of breast cancers by two-dimensional DNA typing
Br J Cancer, 69 (1), 84-92
DOI 10.1038/bjc.1994.13, PubMed 8286216

Publications 1993

Andersen TI, Holm R, Nesland JM, Heimdal KR, Ottestad L, Børresen AL (1993)
Prognostic significance of TP53 alterations in breast carcinoma
Br J Cancer, 68 (3), 540-8
DOI 10.1038/bjc.1993.383, PubMed 8102535

Andreassen A, Oyjord T, Hovig E, Holm R, Flørenes VA, Nesland JM, Myklebost O, Høie J, Bruland OS, Børresen AL (1993)
p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179

Børresen AL (1993)
[The 1993 Nobel Prize in chemistry--polymerase chain reaction and directed mutagenesis]
Tidsskr Nor Laegeforen, 113 (30), 3668-9
PubMed 8278946

Condie A, Eeles R, Borresen AL, Coles C, Cooper C, Prosser J (1993)
Detection of point mutations in the p53 gene: comparison of single-strand conformation polymorphism, constant denaturant gel electrophoresis, and hydroxylamine and osmium tetroxide techniques
Hum Mutat, 2 (1), 58-66
DOI 10.1002/humu.1380020111, PubMed 8477265

Heimdal K, Lothe RA, Lystad S, Holm R, Fosså SD, Børresen AL (1993)
No germline TP53 mutations detected in familial and bilateral testicular cancer
Genes Chromosomes Cancer, 6 (2), 92-7
DOI 10.1002/gcc.2870060205, PubMed 7680893

Helland A, Holm R, Kristensen G, Kaern J, Karlsen F, Trope C, Nesland JM, Børresen AL (1993)
Genetic alterations of the TP53 gene, p53 protein expression and HPV infection in primary cervical carcinomas
J Pathol, 171 (2), 105-14
DOI 10.1002/path.1711710207, PubMed 8283348

Holm R, Skomedal H, Helland A, Kristensen G, Børresen AL, Nesland JM (1993)
Immunohistochemical analysis of p53 protein overexpression in normal, premalignant, and malignant tissues of the cervix uteri
J Pathol, 169 (1), 21-6
DOI 10.1002/path.1711690105, PubMed 8433212

Hovig E, Mullaart E, Børresen AL, Uitterlinden AG, Vijg J (1993)
Genome scanning of human breast carcinomas using micro- and minisatellite core probes
Genomics, 17 (1), 66-75
DOI 10.1006/geno.1993.1284, PubMed 8104870

Lothe RA, Hastie N, Heimdal K, Fosså SD, Stenwig AE, Børresen AL (1993)
Frequent loss of 11p13 and 11p15 loci in male germ cell tumours
Genes Chromosomes Cancer, 7 (2), 96-101
DOI 10.1002/gcc.2870070206, PubMed 7687459

Lothe RA, Saeter G, Danielsen HE, Stenwig AE, Høyheim B, O'Connell P, Børresen AL (1993)
Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1)
Pathol Res Pract, 189 (4), 465-71; discussion 471-4
DOI 10.1016/S0344-0338(11)80339-0, PubMed 8351250

Meling GI, Lothe RA, Børresen AL, Graue C, Hauge S, Clausen OP, Rognum TO (1993)
The TP53 tumour suppressor gene in colorectal carcinomas. I. Genetic alterations on chromosome 17
Br J Cancer, 67 (1), 88-92
DOI 10.1038/bjc.1993.14, PubMed 8094008

Meling GI, Lothe RA, Børresen AL, Graue C, Hauge S, Clausen OP, Rognum TO (1993)
The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables
Br J Cancer, 67 (1), 93-8
DOI 10.1038/bjc.1993.15, PubMed 8427784

Ottestad L, Andersen TI, Nesland JM, Skrede M, Tveit KM, Nustad K, Børresen AL (1993)
Amplification of c-erbB-2, int-2 and c-myc genes in node-negative breast carcinomas. Relationship to prognosis
Acta Oncol, 32 (3), 289-94
DOI 10.3109/02841869309093597, PubMed 8100712

Ridanpää M, Lothe RA, Onfelt A, Fosså S, Børresen AL, Husgafvel-Pursiainen K (1993)
K-ras oncogene codon 12 point mutations in testicular cancer
Environ Health Perspect, 101 Suppl 3 (Suppl 3), 185-7
DOI 10.1289/ehp.101-1521158, PubMed 8143614

Ryberg D, Heimdal K, Fosså SD, Børresen AL, Haugen A (1993)
Rare Ha-ras1 alleles and predisposition to testicular cancer
Int J Cancer, 53 (6), 938-40
DOI 10.1002/ijc.2910530612, PubMed 8097187

Smith-Sørensen B, Gebhardt MC, Kloen P, McIntyre J, Aguilar F, Cerutti P, Børresen AL (1993)
Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE)
Hum Mutat, 2 (4), 274-85
DOI 10.1002/humu.1380020407, PubMed 8401536

Thorlacius S, Börresen AL, Eyfjörd JE (1993)
Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor
Cancer Res, 53 (7), 1637-41
PubMed 8453635

Publications 1992

Andersen TI, Gaustad A, Ottestad L, Farrants GW, Nesland JM, Tveit KM, Børresen AL (1992)
Genetic alterations of the tumour suppressor gene regions 3p, 11p, 13q, 17p, and 17q in human breast carcinomas
Genes Chromosomes Cancer, 4 (2), 113-21
DOI 10.1002/gcc.2870040203, PubMed 1373310

Børresen AL (1992)
Oncogenesis in ovarian cancer
Acta Obstet Gynecol Scand Suppl, 155, 25-30
DOI 10.1111/j.1600-0412.1992.tb00004.x, PubMed 1502889

Børresen AL (1992)
Role of genetic factors in breast cancer susceptibility
Acta Oncol, 31 (2), 151-5
DOI 10.3109/02841869209088896, PubMed 1622629

Børresen AL, Andersen TI, Garber J, Barbier-Piraux N, Thorlacius S, Eyfjörd J, Ottestad L, Smith-Sørensen B, Hovig E, Malkin D (1992)
Screening for germ line TP53 mutations in breast cancer patients
Cancer Res, 52 (11), 3234-6
PubMed 1591732

Børresen AL, Helland A, Nesland J, Holm R, Trope C, Kaern J (1992)
Papillomaviruses, p53, and cervical cancer
Lancet, 339 (8805), 1350-1
PubMed 1350005

David L, Seruca R, Nesland JM, Soares P, Sansonetty F, Holm R, Børresen AL, Sobrinho-Simões M (1992)
c-erbB-2 expression in primary gastric carcinomas and their metastases
Mod Pathol, 5 (4), 384-90
PubMed 1353880

Frebourg T, Kassel J, Lam KT, Gryka MA, Barbier N, Andersen TI, Børresen AL, Friend SH (1992)
Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein
Proc Natl Acad Sci U S A, 89 (14), 6413-7
DOI 10.1073/pnas.89.14.6413, PubMed 1631137

Helland A, Børresen AL, Kaern J, Rønningen KS, Thorsby E (1992)
HLA antigens and cervical carcinoma
Nature, 356 (6364), 23
DOI 10.1038/356023a0, PubMed 1538776

Hovig E, Andreassen A, Fangan BM, Børresen AL (1992)
A TP53 mutation detected in cells established from an osteosarcoma, but not in the retinoblastoma of a patient with bilateral retinoblastoma and multiple primary osteosarcomas
Cancer Genet Cytogenet, 64 (2), 178-82
DOI 10.1016/0165-4608(92)90352-9, PubMed 1336709

Hovig E, Smith-Sørensen B, Gebhardt MC, Ryberg D, Lothe R, Børresen AL (1992)
No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung
Genes Chromosomes Cancer, 5 (2), 97-103
DOI 10.1002/gcc.2870050202, PubMed 1381957

Hovig E, Smith-Sørensen B, Uitterlinden AG, Børresen AL (1992)
Detection of DNA variation in cancer
Pharmacogenetics, 2 (6), 317-28
DOI 10.1097/00008571-199212000-00011, PubMed 1306133

Husgafvel-Pursiainen K, Ridanpää M, Hackman P, Anttila S, Karjalainen A, Onfelt A, Børresen AL, Vainio H (1992)
Detection of ras gene mutations in human lung cancer: comparison of two screening assays based on the polymerase chain reaction
Environ Health Perspect, 98, 183-5
DOI 10.1289/ehp.9298183, PubMed 1486847

Lothe RA, Fossli T, Danielsen HE, Stenwig AE, Nesland JM, Gallie B, Børresen AL (1992)
Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors
J Natl Cancer Inst, 84 (14), 1100-8
DOI 10.1093/jnci/84.14.1100, PubMed 1619684

Malkin D, Jolly KW, Barbier N, Look AT, Friend SH, Gebhardt MC, Andersen TI, Børresen AL, Li FP, Garber J (1992)
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms
N Engl J Med, 326 (20), 1309-15
DOI 10.1056/NEJM199205143262002, PubMed 1565144

Peltomäki P, Lothe RA, Børresen AL, Fosså SD, Brøgger A, de la Chapelle A (1992)
Chromosome 12 in human testicular cancer: dosage changes and their parental origin
Cancer Genet Cytogenet, 64 (1), 21-6
DOI 10.1016/0165-4608(92)90316-z, PubMed 1458445

Ryberg D, Tefre T, Skaug V, Stangeland L, Ovrebø S, Naalsund A, Børresen AL, Haugen A (1992)
Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients
Environ Health Perspect, 98, 187-9
DOI 10.1289/ehp.9298187, PubMed 1362538

Seruca R, David L, Holm R, Nesland JM, Fangan BM, Castedo S, Sobrinho-Simões M, Børresen AL (1992)
P53 mutations in gastric carcinomas
Br J Cancer, 65 (5), 708-10
DOI 10.1038/bjc.1992.149, PubMed 1586599

Smith-Sørensen B, Hovig E, Andersson B, Børresen AL (1992)
Screening for mutations in human HPRT cDNA using the polymerase chain reaction (PCR) in combination with constant denaturant gel electrophoresis (CDGE)
Mutat Res, 269 (1), 41-53
DOI 10.1016/0027-5107(92)90159-y, PubMed 1381470

Publications 1991

Børresen AL, Hovig E, Smith-Sørensen B, Malkin D, Lystad S, Andersen TI, Nesland JM, Isselbacher KJ, Friend SH (1991)
Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations
Proc Natl Acad Sci U S A, 88 (19), 8405-9
DOI 10.1073/pnas.88.19.8405, PubMed 1924299

Hovig, Eivind, Smith-Sørensen B, Brøgger A, Børrensen AL (1991)
Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection
Mutat Res, 263 (1), 61
DOI 10.1016/0165-7992(91)90036-4, PubMed 2034242

Hovig E, Lothe R, Farrants G, Brøgger A, Fodstad O, Børresen AL (1991)
Chromosome 13 alterations in osteosarcoma cell lines derived from a patient with previous retinoblastoma
Cancer Genet Cytogenet, 57 (1), 31-40
DOI 10.1016/0165-4608(91)90186-x, PubMed 1684533

Hovig E, Smith-Sørensen B, Brøgger A, Børresen AL (1991)
Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection
Mutat Res, 262 (1), 63-71
DOI 10.1016/0165-7992(91)90108-g, PubMed 1702518

Meling GI, Lothe RA, Børresen AL, Hauge S, Graue C, Clausen OP, Rognum TO (1991)
Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis
Br J Cancer, 64 (3), 475-80
DOI 10.1038/bjc.1991.334, PubMed 1911187

Nesland JM, Ottestad L, Børresen AL, Tvedt KE, Holm R, Heikkilä R, Tveit K (1991)
The c-erbB-2 protein in primary and metastatic breast carcinomas
Ultrastruct Pathol, 15 (3), 281-9
DOI 10.3109/01913129109021890, PubMed 1678562

Nesland JM, Ottestad L, Heikilla R, Holm R, Tveit K, Børresen AL (1991)
C-erbB-2 protein and neuroendocrine expression in breast carcinomas
Anticancer Res, 11 (1), 161-7
PubMed 1673329

Peltomäki P, Lothe R, Børresen AL, Fosså SD, Brøgger A, de la Chapelle A (1991)
Altered dosage of the sex chromosomes in human testicular cancer: a molecular genetic study
Int J Cancer, 47 (4), 518-22
DOI 10.1002/ijc.2910470408, PubMed 1995482

Tefre T, Ryberg D, Haugen A, Nebert DW, Skaug V, Brøgger A, Børresen AL (1991)
Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population
Pharmacogenetics, 1 (1), 20-5
DOI 10.1097/00008571-199110000-00004, PubMed 1726950

Publications 1990

BORRESEN A (1990)
THE USE OF GENE TECHNOLOGY IN THE CLINICAL LABORATORY
Scand. J. Clin. Lab. Invest., 50 202, 9-13

Børresen AL (1990)
The use of gene technology in the clinical laboratory
Scand J Clin Lab Invest Suppl, 202, 9-13
PubMed 2075459

Børresen AL, Andersen TI, Tretli S, Heiberg A, Møller P (1990)
Breast cancer and other cancers in Norwegian families with ataxia-telangiectasia
Genes Chromosomes Cancer, 2 (4), 339-40
DOI 10.1002/gcc.2870020412, PubMed 2268581

Børresen AL, Hovig E, Smith-Sørensen B, Vrieling H, Apold J, Brøgger A (1990)
Screening for base mutations in the PAH and HPRT loci using the polymerase chain reaction (PCR) in combination with denaturing gradient gel electrophoresis (DGGE)
Prog Clin Biol Res, 340A, 389-98
PubMed 2388921

Børresen AL, Ottestad L, Gaustad A, Andersen TI, Heikkilä R, Jahnsen T, Tveit KM, Nesland JM (1990)
Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosis
Br J Cancer, 62 (4), 585-90
DOI 10.1038/bjc.1990.334, PubMed 1977466

Fosså SD, Langmark F, Aass N, Andersen A, Lothe R, Børresen AL (1990)
Second non-germ cell malignancies after radiotherapy of testicular cancer with or without chemotherapy
Br J Cancer, 61 (4), 639-43
DOI 10.1038/bjc.1990.142, PubMed 2109999

Haugen A, Willey J, Børresen AL, Tefre T (1990)
PstI polymorphism at the human P1450 gene on chromosome 15
Nucleic Acids Res, 18 (10), 3114
DOI 10.1093/nar/18.10.3114, PubMed 1971943

Møller P, Moe N, Saugstad OD, Skullerud K, Velken M, Berg K, Nitter-Hauge S, Børresen AL (1990)
Spinal muscular atrophy type I combined with atrial septal defect in three sibs
Clin Genet, 38 (2), 81-3
DOI 10.1111/j.1399-0004.1990.tb03553.x, PubMed 2208769

Ryberg D, Tefre T, Ovrebø S, Skaug V, Stangeland L, Naalsund A, Baera R, Børresen AL, Haugen A (1990)
Ha-ras-1 alleles in Norwegian lung cancer patients
Hum Genet, 86 (1), 40-4
DOI 10.1007/BF00205169, PubMed 1979305

Tefre T, Børresen AL, Aamdal S, Brøgger A (1990)
Studies of the L-myc DNA polymorphism and relation to metastasis in Norwegian lung cancer patients
Br J Cancer, 61 (6), 809-12
DOI 10.1038/bjc.1990.182, PubMed 1973618

Publications 1989

Børresen AL (1989)
[Gene technology in clinical medicine--technics and tools]
Tidsskr Nor Laegeforen, 109 (28), 2882-7
PubMed 2815027

Børresen AL, Berg K (1989)
[Genetic variation and genetic diseases]
Tidsskr Nor Laegeforen, 109 (29), 3003-9
PubMed 2588229

Børresen AL, Brøgger A, Møller P, Smeland E (1989)
[Gene technology in the prevention of cancer]
Tidsskr Nor Laegeforen, 109 (33), 3430-4
PubMed 2609305

Lothe RA, Fosså SD, Stenwig AE, Nakamura Y, White R, Børresen AL, Brøgger A (1989)
Loss of 3p or 11p alleles is associated with testicular cancer tumors
Genomics, 5 (1), 134-8
DOI 10.1016/0888-7543(89)90097-9, PubMed 2767683

Publications 1988

Børresen AL, Boman H, Møller P, Berg K (1988)
Prenatal diagnosis in a female carrying a deletion close to the Duchenne locus
Prenat Diagn, 8 (1), 67-72
DOI 10.1002/pd.1970080110, PubMed 3422736

Børresen AL, Hovig E, Brøgger A (1988)
Detection of base mutations in genomic DNA using denaturing gradient gel electrophoresis (DGGE) followed by transfer and hybridization with gene-specific probes
Mutat Res, 202 (1), 77-83
DOI 10.1016/0027-5107(88)90166-2, PubMed 2903443

Børresen AL, Møller P, Berg K (1988)
Linkage disequilibrium analyses and restriction mapping of four RFLPs at the pro alpha 2(I) collagen locus: lack of correlation between linkage disequilibrium and physical distance
Hum Genet, 78 (3), 216-21
DOI 10.1007/BF00291664, PubMed 2894343

Publications 1987

Børresen AL, Heiberg A, Møller P, Berg K (1987)
Evidence for a sperm mutation resulting in Duchenne muscular dystrophy
Clin Genet, 32 (3), 187-91
DOI 10.1111/j.1399-0004.1987.tb03352.x, PubMed 2887319

Børresen AL, Hellerud C, Møller P, Søvik O, Berg K (1987)
Prenatal diagnosis of glycerol-kinase deficiency associated with a DNA deletion on the short arm of the X-chromosome
Clin Genet, 32 (4), 254-9
DOI 10.1111/j.1399-0004.1987.tb03309.x, PubMed 2890456

Børresen AL, Leren T, Berg K, Solaas MH (1987)
Effect of haptoglobin subtypes on serum lipid levels
Hum Hered, 37 (3), 150-6
DOI 10.1159/000153693, PubMed 3583295

Rivrud GN, Hagen I, Børresen AL (1987)
Mutagenicity testing of human milk from smokers and non-smokers in the Salmonella/microsome test
Life Sci, 41 (21), 2389-96
DOI 10.1016/0024-3205(87)90663-1, PubMed 3316890

Skjørten F, Bakken J, Halvorsen S, Børresen AL (1987)
[Fabry's disease detected by renal biopsy]
Tidsskr Nor Laegeforen, 107 (9), 848, 873
PubMed 3109070

Publications 1986

Børresen AL (1986)
RFLPs in collagen loci and disease
Ann Clin Res, 18 (5-6), 258-63
PubMed 2882728

Dahl LB, Dahl IM, Børresen AL (1986)
The molecular weight of sodium hyaluronate in amniotic fluid
Biochem Med Metab Biol, 35 (2), 219-26
DOI 10.1016/0885-4505(86)90077-0, PubMed 3707753

Tsipouras P, Børresen AL, Bamforth S, Harper PS, Berg K (1986)
Marfan syndrome: exclusion of genetic linkage to the COL1A2 gene
Clin Genet, 30 (5), 428-32
PubMed 2879657

Publications 1985

Børresen AL, Berg K, Tsipouras P, Dickson LA, Prockop DJ, Ramirez F (1985)
DNA polymorphisms in collagen genes: potential use in the study of disease
Prog Clin Biol Res, 177, 37-51
PubMed 2989837

Børresen AL, Jordfald AB, Berg K (1985)
DNA polymorphism of the RC8 probe on the X-chromosome. Identification of a new DNA variant with the TaqI enzyme
Clin Genet, 27 (4), 411-3
DOI 10.1111/j.1399-0004.1985.tb02285.x, PubMed 2986884

Kvittingen EA, Børresen AL, Stokke O, van der Hagen CB, Lie SO (1985)
Deficiency of fumarylacetoacetase without hereditary tyrosinemia
Clin Genet, 27 (6), 550-4
DOI 10.1111/j.1399-0004.1985.tb02039.x, PubMed 4017276

Kvittingen EA, Steinmann B, Gitzelmann R, Leonard JV, Andria G, Børresen AL, Mossman J, Micara G, Lindblad B (1985)
Prenatal diagnosis of hereditary tyrosinemia by determination of fumarylacetoacetase in cultured amniotic fluid cells
Pediatr Res, 19 (4), 334-7
DOI 10.1203/00006450-198519040-00002, PubMed 4000758

Leren TP, Børresen AL, Berg K, Hjermann I, Leren P (1985)
Increased frequency of the apolipoprotein E-4 isoform in male subjects with multifactorial hypercholesterolemia
Clin Genet, 27 (5), 458-62
DOI 10.1111/j.1399-0004.1985.tb00231.x, PubMed 4006269

Leren TP, Hjermann I, Børresen AL, Berg K, Leren P (1985)
Maximal low density lipoprotein receptor activity and the effect of lipid lowering diet on total serum cholesterol
Clin Genet, 27 (6), 543-9
DOI 10.1111/j.1399-0004.1985.tb02038.x, PubMed 4017275

Publications 1984

Humphries SE, Berg K, Gill L, Cumming AM, Robertson FW, Stalenhoef AF, Williamson R, Børresen AL (1984)
The gene for apolipoprotein C-II is closely linked to the gene for apolipo-protein E on chromosome 19
Clin Genet, 26 (5), 389-96
PubMed 6094053

Magnus P, Børresen AL, Opstad PK, Bugge JF, Berg K (1984)
Increase in the ratio of serum levels of apolipoproteins A-I and A-II during prolonged physical strain and calorie deficiency
Eur J Appl Physiol Occup Physiol, 53 (1), 21-4
DOI 10.1007/BF00964684, PubMed 6439559

Marhaug G, Børresen AL, Husby G, Nordstoga K (1984)
A comparative study of serum amyloid a protein (SAA) from mink and man
Comp Biochem Physiol B, 78 (2), 401-6
DOI 10.1016/0305-0491(84)90049-x, PubMed 6467904

Tsipouras P, Børresen AL, Dickson LA, Berg K, Prockop DJ, Ramirez F (1984)
Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta
Am J Hum Genet, 36 (6), 1172-9
PubMed 6097110

Ziesler O, Hole K, Haugan I, Børresen AL, Gjessing LR, Sjaastad O (1984)
Transport and distribution of homocarnosine after intracerebroventricular and intravenous injection in the rat
Neurochem Res, 9 (5), 637-48
DOI 10.1007/BF00964510, PubMed 6472567

Publications 1982

Børresen AL, Maartmann-Moe K, Berg K (1982)
Serum reserve cholesterol binding capacity (SRCBC) in familial hypercholesterolemia
Clin Genet, 21 (6), 362-5
DOI 10.1111/j.1399-0004.1982.tb01388.x, PubMed 6813000

Fowler B, Børresen AL, Boman N (1982)
Prenatal diagnosis of homocystinuria
Lancet, 2 (8303), 875
DOI 10.1016/s0140-6736(82)90835-2, PubMed 6126732

Publications 1981

Berg K, Børresen AL, Nance WE (1981)
Apparent influence of marker genotypes on variation in serum cholesterol in monozygotic twins
Clin Genet, 19 (1), 67-70
DOI 10.1111/j.1399-0004.1981.tb00670.x, PubMed 6936104

Børresen AL, Berg K (1981)
Serum reserve cholesterol binding capacity (SRCBC): the relative importance of different lipoprotein classes
Artery, 9 (2), 96-119
PubMed 6794547

Børresen AL, Berg K (1981)
The apoE polymorphism studied by two-dimensional, high-resolution gel electrophoresis of serum
Clin Genet, 20 (6), 438-48
DOI 10.1111/j.1399-0004.1981.tb01055.x, PubMed 7199983

Børresen AL, Berg K, Dahlén G, Gillnäs T, Ericson C (1981)
The effect of Gemfibrozil on human serum apolipoproteins and on serum reserve cholesterol binding capacity (SRCBC)
Artery, 9 (1), 77-86
PubMed 7018466

Børresen AL, Berg K, Magnus P (1981)
A twin study of aryl hydrocarbon hydroxylase (AHH) inducibility in cultured lymphocytes
Clin Genet, 19 (4), 281-9
DOI 10.1111/j.1399-0004.1981.tb00710.x, PubMed 6944164

Maartmann-Moe K, Magnus P, Børresen AL, Berg K (1981)
Low density lipoprotein receptor activity in cultured fibroblasts from subjects with or without ischemic heart disease (in the absence of familial hypercholesterolemia)
Clin Genet, 20 (5), 337-46
DOI 10.1111/j.1399-0004.1981.tb01045.x, PubMed 6277536

Publications 1980

Børresen AL, Berg K (1980)
Presence of "free" apoA-I in serum: implications for immunological quantification of HDL and its apoproteins
Artery, 7 (2), 139-60
PubMed 7425861

Dahlén G, Gillnäs T, Børresen AL, Berg K, Ericson C (1980)
Effect of gemfibrozil on serum lipid levels
Artery, 7 (3), 224-31
PubMed 7008748

Skogen B, Natvig JB, Bøorresen AL, Berg K (1980)
Degradation of amyloid-related serum protein SAA by a component present in rabbit and human serum
Scand J Immunol, 11 (6), 643-8
DOI 10.1111/j.1365-3083.1980.tb00033.x, PubMed 6777866

Publications 1979

Berg K, Börresen AL, Dahlen G (1979)
Effect of smoking on serum levels of HDL apoproteins
Atherosclerosis, 34 (3), 339-43
DOI 10.1016/s0021-9150(79)80011-8, PubMed 229876

Berg K, Dahlén G, Børresen AL (1979)
Lp(a) phenotypes, other lipoprotein parameters, and a family history of coronary heart disease in middle-aged males
Clin Genet, 16 (5), 347-52
DOI 10.1111/j.1399-0004.1979.tb01014.x, PubMed 230000

Skogen B, Børresen AL, Natvig JB, Berg K, Michaelsen TE (1979)
High-density lipoprotein as carrier for amyloid-related protein SAA in rabbit serum
Scand J Immunol, 10 (1), 39-45
DOI 10.1111/j.1365-3083.1979.tb01332.x, PubMed 224449

Publications 1978

Børresen AL (1978)
The distribution of the inherited Hl 1 and R 67 antigens on rabbit serum high density lipoprotein (HDL) particles
J Immunogenet, 5 (1), 13-23
DOI 10.1111/j.1744-313x.1978.tb00626.x, PubMed 205613

Børresen AL (1978)
Biochemical and genetic studies of the high density lipoprotein (HDL) polymorphisms in rabbit serum
Institute of Medical Genetics, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 950796719

Børresen AL, Kindt TJ (1978)
Purification and partial characterization of the apoA-I of rabbit high density lipoprotein
J Immunogenet, 5 (1), 5-12
DOI 10.1111/j.1744-313x.1978.tb00625.x, PubMed 205614

Børresen AL, Kindt TJ, Berg K (1978)
Partial purification and characterization of the inherited Hl 1 and R 67 antigens of rabbit serum high density lipoprotein
J Immunogenet, 5 (2), 71-86
DOI 10.1111/j.1744-313x.1978.tb00633.x, PubMed 207781

Publications 1977

Borresen AL (1977)
High densitiy lipoprotein (HDL) polymorphisms in rabbit: production of antibody to rabbit allotype (R 67) in sheep
J Immunogenet, 4 (3), 149-58
PubMed 197172

Borresen AL, Berg K, Kindt TJ (1977)
A linkage study of rabbit serum high density lipoprotein (HDL) allotypes
J Immunogenet, 4 (2), 81-95
DOI 10.1111/j.1744-313x.1977.tb00618.x, PubMed 194985

Publications 1976

Berg K, Borresen AL (1976)
Serum-high-density-lipoprotein and atherosclerotic heart-disease
Lancet, 1 (7958), 499-501
DOI 10.1016/s0140-6736(76)90291-9, PubMed 55778

Berg K, Borresen AL, Frick MH, Dahlén G, Stene J (1976)
Letter: Serum-H.D.L. in a therosclerotic heart-disease
Lancet, 2 (7975), 40-1
DOI 10.1016/s0140-6736(76)92991-3, PubMed 59096

Borresen AL (1976)
High density lipoprotein (HDL) polymorphisms in rabbit. II. A study of the inherited Hl 1 and R 67 antigens in relation to HDL polypeptides
J Immunogenet, 3 (2), 83-9
PubMed 58949

Borresen AL (1976)
High density lipoprotein (HDL) polymorphisms in rabbit. III. Quantitative determination of HDL and the inherited Hl 1 and R 67 antigens
J Immunogenet, 3 (2), 91-103
PubMed 58950

Borresen AL (1976)
High density lipoprotein (HDL) polymorphisms in rabbit. I. A comparative study of rabbit and human serum high density lipoprotein
J Immunogenet, 3 (2), 73-81
PubMed 180184

Borresen AL (1976)
Letter: Prenatal metachromatic leukodystrophy
Helv Paediatr Acta, 30 (6), 553
PubMed 1270328

Publications 1973

Borresen AL, van der Hagen CB (1973)
Metachromatic leukodystrophy. II. Direct determination of arylsulphatase A activity in amniotic fluid
Clin Genet, 4 (5), 442-6
PubMed 4751314

van der Hagen CB, Borresen AL, Molne K, Oftedal G, Bjoro K, Berg K (1973)
Metachromatic leukodystrophy. I. Prenatal detection of arylsulphatase A deficiency
Clin Genet, 4 (3), 256-9
PubMed 4765208

Publications 1972

Torsvik H, Børresen A, Berg K, Boman H (1972)
Preliminary assignment of the inherited Hl 1 antigen to the apoA-I polypeptide of rabbit high density lipoprotein
FEBS Lett, 28 (2), 153-155
DOI 10.1016/0014-5793(72)80699-9, PubMed 11946845