New book on RNA Interference edited by Mouldy Sioud recently published
Mouldy Sioud from Department of Immunology at the Institute for Cancer Research is the editor of a new book published November 10th entitled "RNA Interference: Challenges and Therapeutic Opportunities". The book is included in the series "Methods in Molecular Biology, Vol. 1218" and provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA's unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes.
These excellent chapters will assist researchers, clinicians, teachers and biotechnologists interested in the power of RNA-based therapies.
Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Includes cutting-edge techniques in using RNA interference for therapeutic purposes
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Published in major journals, first or last author from Oslo University Hospital.
Ghanima W, Khelif A, Waage A, Michel M, Tjønnfjord GE, Romdhan NB, Kahrs J, Darne B, Holme PA, RITP study group(2015) Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial Lancet, 385(9978), 1653-61 DOI 10.1016/S0140-6736(14)61495-1, PubMed 25662413
Berntsen NL, Klingenberg O, Juran BD, Benito de Valle M, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR(2015) Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis Gastroenterology, 148(5), 924-927.e2 DOI 10.1053/j.gastro.2015.01.041, PubMed 25655558
Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE(2015) Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma Hepatology, 61(5), 1651-9 DOI 10.1002/hep.27707, PubMed 25644509