Elisabeth Gjefsen

  • PhD student; MD
  • +47 924 90 884

Background: 
Elisabeth Gjefsen has a medical doctor degree from University of Oslo in 2007.  She has been working at the neurologic department at Oslo University Hospital since 2011, and is Consultant of Neurology 

Research Project:
Elisabeth Gjefsen started the project denoted «BacktoBasic» in 2018, a randomized double blind placebo-controlled mutisenter trial where the overall concept is to assess whether a TNF-alfa inhibitor is an effective treatment in patients with chronic LBP with concomitant Modic Changes. 

Main supervisor:  Professor John-Anker Zwart, FORMI, Nevroklinikken, OUS

Co-supervisors: Kjersti Storheim, FORMI, Nevroklinikken, OUS and MD, PhD Guro Løvik Goll, Diakonhjemmet hospital,

 

Publications 2025

Dagestad MH, Vetti N, Haugli Bråten LC, Gjefsen E, Grøvle L, Gervin K, Haugen AJ, Bakland G, Marchand GH, Kadar T, Storheim K, Zwart JA, Assmus J, Espeland A (2025)
Modic Change Edema in Chronic Low Back Pain Treated with Infliximab or Placebo: The BackToBasic Trial
Spine (Phila Pa 1976) (in press)
DOI 10.1097/BRS.0000000000005391, PubMed 40358067

Gjefsen E, Bråten LC, Espeland A, Goll GL, Storheim K, Zwart JA (2025)
Reply: Correspondence to Efficacy of a Tumor necrosis Factor Inhibitor in Chronic Low-Back Pain with Modic type 1 Changes: A Randomized Controlled Trial
Arthritis Rheumatol (in press)
DOI 10.1002/art.43309, PubMed 40621716

Gjefsen E, Bråten LC, Ponzi E, Dagestad MH, Marchand GH, Kadar T, Bakland G, Haugen AJ, Granviken F, Flørenes TW, Vetti N, Grøvle L, Nilsen AT, Lunestad A, Holmgard TE, Valberg M, Bolstad N, Espeland A, Brox JI, Goll GL, Storheim K, Zwart JA (2025)
Efficacy of a Tumor Necrosis Factor Inhibitor in Chronic Low-Back Pain With Modic Type 1 Changes: A Randomized Controlled Trial
Arthritis Rheumatol, 77 (5), 615-623
DOI 10.1002/art.43073, PubMed 39624017

Vigeland MD, Flåm ST, Vigeland MD, Zucknick M, Wigemyr M, Bråten LCH, Gjefsen E, Zwart JA, Storheim K, Pedersen LM, Lie BA, The Aim Study Group (2025)
Gene Expression Correlates with Disability and Pain Intensity in Patients with Chronic Low Back Pain and Modic Changes in a Sex-Specific Manner
Int J Mol Sci, 26 (2)
DOI 10.3390/ijms26020800, PubMed 39859512

Publications 2023

Bråten LCH, Gjefsen E, Gervin K, Pripp AH, Skouen JS, Schistad E, Pedersen LM, Wigemyr M, Selmer KK, Aass HCD, Goll G, Brox JI, Espeland A, Grøvle L, Zwart JA, Storheim K, AIM-study group (2023)
Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study)
J Pain Res, 16, 1713-1724
DOI 10.2147/JPR.S406079, PubMed 37252109

Gjefsen E, Gervin K, Bråten LCH, Goll GL, Aass HCD, Schistad EI, Wigemyr M, Pedersen LM, Skouen JS, Vigeland MD, Selmer KK, Storheim K, Zwart JA (2023)
Longitudinal changes of serum cytokines in patients with chronic low back pain and Modic changes
Osteoarthritis Cartilage, 31 (4), 543-547
DOI 10.1016/j.joca.2023.01.001, PubMed 36640896

Vigeland MD, Flåm ST, Vigeland MD, Espeland A, Zucknick M, Wigemyr M, Bråten LCH, Gjefsen E, Zwart JA, Storheim K, Pedersen LM, Selmer K, Lie BA, Gervin K, The Aim Study Group (2023)
Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
Antibiotics (Basel), 12 (7)
DOI 10.3390/antibiotics12071217, PubMed 37508313

Publications 2022

Bråten LCH, Grøvle L, Wigemyr M, Wilhelmsen M, Gjefsen E, Espeland A, Haugen AJ, Skouen JS, Brox JI, Zwart JA, Storheim K, Ostelo RW, Grotle M (2022)
Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain
J Clin Epidemiol, 151, 75-87
DOI 10.1016/j.jclinepi.2022.07.012, PubMed 35926821

Dagestad MH, Toppe MK, Kristoffersen PM, Gjefsen E, Andersen E, Assmus J, Vetti N, Espeland A (2022)
Dixon T2 imaging of vertebral bone edema: reliability and comparison with short tau inversion recovery
Acta Radiol, 65 (3), 273-283
DOI 10.1177/02841851221146130, PubMed 36560906

Vigeland MD, Flåm ST, Vigeland MD, Espeland A, Kristoffersen PM, Vetti N, Wigemyr M, Bråten LCH, Gjefsen E, Schistad EI, Haugen AJ, Froholdt A, Skouen JS, Zwart JA, Storheim K, Pedersen LM, Lie BA, AIM Study Group (2022)
Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement
Sci Rep, 12 (1), 215
DOI 10.1038/s41598-021-04189-5, PubMed 34997115

Publications 2021

Gjefsen E, Gervin K, Goll G, Bråten LCH, Wigemyr M, Aass HCD, Vigeland MD, Schistad E, Pedersen LM, Pripp AH, Storheim K, Selmer KK, Zwart JA (2021)
Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes
RMD Open, 7 (2)
DOI 10.1136/rmdopen-2021-001726, PubMed 34344830

Publications 2020

Gjefsen E, Bråten LCH, Goll GL, Wigemyr M, Bolstad N, Valberg M, Schistad EI, Marchand GH, Granviken F, Selmer KK, Froholdt A, Haugen AJ, Dagestad MH, Vetti N, Bakland G, Lie BA, Haavardsholm EA, Nilsen AT, Holmgard TE, Kadar TI, Kvien T, Skouen JS, Grøvle L, Brox JI, Espeland A et al. (2020)
The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial
BMC Musculoskelet Disord, 21 (1), 698
DOI 10.1186/s12891-020-03720-5, PubMed 33087100

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