An article describing a novel microarray design making it possible to detect fusion genes was published by Skotheim and colleagues in Molecular Cancer this week.
With the new array design one can screen for all known oncogenic fusion transcripts in a single experiment. Proof of principle was shown by detection of known fusion genes (i.e. TCF3:PBX1, ETV6:RUNX1, and TMPRSS2:ERG) from six positive control samples consisting of leukemia cell lines and prostate cancer biopsies.
-I'm excited about this technology and hope to soon show the value of this array in both diagnostics and further research, says Skotheim.
A patent has been filed.
For the full article, click here.