Publications
Publications 2023
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Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies
Front Mol Biosci, 10, 980433
DOI 10.3389/fmolb.2023.980433, PubMed 36818049 -
Efficient chimeric antigen receptor (CAR) targeting of a central epitope of CD22
J Biol Chem, 104883 (in press)
DOI 10.1016/j.jbc.2023.104883, PubMed 37269947 -
screenwerk: a modular tool for the design and analysis of drug combination screens
Bioinformatics, 39 (1)
DOI 10.1093/bioinformatics/btac840, PubMed 36573326 -
siRNA screening reveals that SNAP29 contributes to exosome release
Cell Mol Life Sci, 80 (7), 177
DOI 10.1007/s00018-023-04822-8, PubMed 37285022 -
Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse
Proc Natl Acad Sci U S A, 120 (6), e2211368120
DOI 10.1073/pnas.2211368120, PubMed 36730202 -
Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data
Cell Rep Methods, 3 (3), 100417
DOI 10.1016/j.crmeth.2023.100417, PubMed 37056380 -
Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer
Cell Commun Signal, 21 (1), 50
DOI 10.1186/s12964-023-01062-y, PubMed 36882786 -
Microbiota-Associated HAF-EVs Regulate Monocytes by Triggering or Inhibiting Inflammasome Activation
Int J Mol Sci, 24 (3)
DOI 10.3390/ijms24032527, PubMed 36768851 -
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Circ Res, 132 (11), e188-e205
DOI 10.1161/CIRCRESAHA.122.321732, PubMed 37139790 -
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
Proc Natl Acad Sci U S A, 120 (4), e2210593120
DOI 10.1073/pnas.2210593120, PubMed 36656860 -
Lipid Biomarkers in Liquid Biopsies: Novel Opportunities for Cancer Diagnosis
Pharmaceutics, 15 (2)
DOI 10.3390/pharmaceutics15020437, PubMed 36839759 -
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?
Cold Spring Harb Perspect Biol (in press)
DOI 10.1101/cshperspect.a041415, PubMed 37277192 -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Nat Commun, 14 (1), 115
DOI 10.1038/s41467-022-35624-4, PubMed 36611026 -
Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Nat Commun, 14 (1), 1767
DOI 10.1038/s41467-023-37488-8, PubMed 36997540 -
CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side
J Cell Biol, 222 (4)
DOI 10.1083/jcb.202208062, PubMed 36752787 -
The quick reference card "Storage of urinary EVs" - A practical guideline tool for research and clinical laboratories
J Extracell Vesicles, 12 (3), e12286
DOI 10.1002/jev2.12286, PubMed 36916183 -
Autophagosome Biogenesis
Cells, 12 (4)
DOI 10.3390/cells12040668, PubMed 36831335 -
A phosphoinositide kinase triggers migrasome formation
Cell Res (in press)
DOI 10.1038/s41422-023-00822-2, PubMed 37165066
Publications 2022
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Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
Cell Mol Life Sci, 79 (4), 220
DOI 10.1007/s00018-022-04251-z, PubMed 35368213 -
Extracellular Vesicles as Novel Players in Kidney Disease
J Am Soc Nephrol, 33 (3), 467-471
DOI 10.1681/ASN.2021091232, PubMed 35131841 -
SILAC-based quantitative proteomics and microscopy analysis of cancer cells treated with the N-glycolyl GM3-specific anti-tumor antibody 14F7
Front Immunol, 13, 994790
DOI 10.3389/fimmu.2022.994790, PubMed 36439103 -
Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix
Front Mol Biosci, 9, 763750
DOI 10.3389/fmolb.2022.763750, PubMed 35495628 -
Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report
Ann N Y Acad Sci, 1510 (1), 79-99
DOI 10.1111/nyas.14745, PubMed 35000205 -
Regulation of autophagosome biogenesis and mitochondrial bioenergetics by the cholesterol transport protein GRAMD1C
Autophagy, 1-3 (in press)
DOI 10.1080/15548627.2022.2155020, PubMed 36469687 -
Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight
Acta Physiol (Oxf), 236 (4), e13862
DOI 10.1111/apha.13862, PubMed 36377504 -
"Double-punch" strategy against triple-negative breast cancer via a synergistic therapy of magneto-mechanical force enhancing NIR-II hypothermal ablation
Biomaterials, 291, 121868
DOI 10.1016/j.biomaterials.2022.121868, PubMed 36332286 -
Multifunctional Modulation of High-Performance Znx Fe3-x O4 Nanoparticles by Precisely Tuning the Zinc Doping Content
Small, 18 (42), e2201669
DOI 10.1002/smll.202201669, PubMed 36101918 -
Measuring Autophagic Cargo Flux with Keima-Based Probes
Methods Mol Biol, 2445, 99-115
DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988 -
The SUMO stress response in transcriptional regulation: Causal relationships or secondary bystander effects?
Bioessays, 44 (7), e2200065
DOI 10.1002/bies.202200065, PubMed 35655365 -
Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries
Int J Mol Sci, 23 (3)
DOI 10.3390/ijms23031293, PubMed 35163213 -
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells
Biomedicines, 10 (2)
DOI 10.3390/biomedicines10020232, PubMed 35203441 -
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178 -
How CAR T Cells Breathe
Cells, 11 (9)
DOI 10.3390/cells11091454, PubMed 35563759 -
3D-Structured Illumination Microscopy of Centrosomes in Human Cell Lines
Bio Protoc, 12 (6), e4360
DOI 10.21769/BioProtoc.4360, PubMed 35434191 -
Corrigendum to "Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft", [Journal of Control Release, 293 (2019) 183-192]
J Control Release, 349, 1
DOI 10.1016/j.jconrel.2022.06.040, PubMed 35792388 -
Diversity of mitophagy pathways at a glance
J Cell Sci, 135 (23)
DOI 10.1242/jcs.259748, PubMed 36504076 -
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
FEBS J, 290 (4), 1096-1116
DOI 10.1111/febs.16628, PubMed 36111389 -
Computed tomography with segmentation and quantification of individual organs in a D. melanogaster tumor model
Sci Rep, 12 (1), 2056
DOI 10.1038/s41598-022-05991-5, PubMed 35136137 -
Autophagy power expands: fuse those cells!
EMBO J, 41 (12), e111424
DOI 10.15252/embj.2022111424, PubMed 35561082 -
Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells
Cells, 11 (3)
DOI 10.3390/cells11030522, PubMed 35159330 -
PHLPP1 regulates CFTR activity and lumen expansion through AMPK
Development, 149 (20)
DOI 10.1242/dev.200955, PubMed 35997536 -
FGF-FGFR signaling promotes the development of invasive cervical cancer
FEBS J, 289 (12), 3419-3421
DOI 10.1111/febs.16384, PubMed 35146913 -
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection
EMBO J, 41 (23), e111289
DOI 10.15252/embj.2022111289, PubMed 36221902 -
Amniotic fluid stem cell-derived extracellular vesicles are independent metabolic units capable of modulating inflammasome activation in THP-1 cells
FASEB J, 36 (4), e22218
DOI 10.1096/fj.202101657R, PubMed 35218567 -
ESCRTed resistance to T cell attack
Trends Immunol, 43 (8), 598-600
DOI 10.1016/j.it.2022.06.007, PubMed 35810056 -
Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
Curr Opin Cell Biol, 75, 102062
DOI 10.1016/j.ceb.2022.01.007, PubMed 35248976 -
GAK and PRKCD kinases regulate basal mitophagy
Autophagy, 18 (2), 467-469
DOI 10.1080/15548627.2021.2015154, PubMed 35001811 -
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
Nat Commun, 13 (1), 6283
DOI 10.1038/s41467-022-33933-2, PubMed 36270994 -
Are doping tests in sports trustworthy?: Athletes suffer from insufficiently defined criteria for doping tests: Athletes suffer from insufficiently defined criteria for doping tests
EMBO Rep, 23 (3), e54431
DOI 10.15252/embr.202154431, PubMed 35156749 -
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828 -
Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
Front Cell Dev Biol, 10, 1022191
DOI 10.3389/fcell.2022.1022191, PubMed 36619857 -
Analysis of the pheromone signaling pathway by RT-qPCR in the budding yeast Saccharomyces cerevisiae
STAR Protoc, 3 (1), 101210
DOI 10.1016/j.xpro.2022.101210, PubMed 35265859 -
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
DOI 10.1152/ajpheart.00635.2021, PubMed 35522553 -
Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC
Toxins (Basel), 14 (5)
DOI 10.3390/toxins14050360, PubMed 35622606 -
STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway
Am J Cancer Res, 12 (1), 327-336
PubMed 35141021 -
Don't forget to be picky - selective autophagy of protein aggregates in neurodegenerative diseases
Curr Opin Cell Biol, 75, 102064
DOI 10.1016/j.ceb.2022.01.009, PubMed 35240373 -
Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges
Adv Drug Deliv Rev, 186, 114326
DOI 10.1016/j.addr.2022.114326, PubMed 35588953 -
Need for more focus on lipid species in studies of biological and model membranes
Prog Lipid Res, 86, 101160
DOI 10.1016/j.plipres.2022.101160, PubMed 35288150 -
Super-resolution re-scan second harmonic generation microscopy
Proc Natl Acad Sci U S A, 119 (47), e2214662119
DOI 10.1073/pnas.2214662119, PubMed 36375085 -
Scattering-type Scanning Near-Field Optical Microscopy of Polymer-Coated Gold Nanoparticles
ACS Omega, 7 (13), 11353-11362
DOI 10.1021/acsomega.2c00410, PubMed 35415325 -
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
J Cell Sci, 135 (4)
DOI 10.1242/jcs.259138, PubMed 35099014 -
ER as master regulator of membrane trafficking and organelle function
J Cell Biol, 221 (10)
DOI 10.1083/jcb.202205135, PubMed 36108241 -
ER-endosome contacts master the ins and outs of secretory endosomes
J Cell Biol, 221 (12)
DOI 10.1083/jcb.202210033, PubMed 36355088 -
Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations
Autophagy, 18 (11), 2547-2560
DOI 10.1080/15548627.2022.2039535, PubMed 35220892 -
On the surface-to-bulk partition of proteins in extracellular vesicles
Colloids Surf B Biointerfaces, 218, 112728
DOI 10.1016/j.colsurfb.2022.112728, PubMed 35969923 -
Waves of sumoylation support transcription dynamics during adipocyte differentiation
Nucleic Acids Res, 50 (3), 1351-1369
DOI 10.1093/nar/gkac027, PubMed 35100417
Publications 2021
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Wetting regulates autophagy of phase-separated compartments and the cytosol
Nature, 591 (7848), 142-146
DOI 10.1038/s41586-020-2992-3, PubMed 33473217 -
Autophagy in healthy aging and disease
Nat Aging, 1 (8), 634-650
DOI 10.1038/s43587-021-00098-4, PubMed 34901876 -
Cosegregation of asymmetric features during cell division
Open Biol, 11 (8), 210116
DOI 10.1098/rsob.210116, PubMed 34343465 -
Uptake of circulating extracellular vesicles from rectal cancer patients and differential responses by human monocyte cultures
FEBS Open Bio, 11 (3), 724-740
DOI 10.1002/2211-5463.13098, PubMed 33512765 -
Lipotoxic stress alters the membrane lipid profile of extracellular vesicles released by Huh-7 hepatocarcinoma cells
Sci Rep, 11 (1), 4613
DOI 10.1038/s41598-021-84268-9, PubMed 33633289 -
Pharmacologic Control of CAR T Cells
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094320, PubMed 33919245 -
RasV12; scrib-/- Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
Int J Mol Sci, 22 (16)
DOI 10.3390/ijms22168873, PubMed 34445578 -
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
J Extracell Vesicles, 10 (7), e12093
DOI 10.1002/jev2.12093, PubMed 34035881 -
FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
Commun Biol, 4 (1), 127
DOI 10.1038/s42003-021-01647-8, PubMed 33514811 -
A phase 2a randomized clinical trial of intravenous vedolizumab for the treatment of steroid-refractory intestinal acute graft-versus-host disease
Bone Marrow Transplant, 56 (10), 2477-2488
DOI 10.1038/s41409-021-01356-0, PubMed 34108672 -
V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis
Autophagy, 17 (12), 4442-4452
DOI 10.1080/15548627.2021.1918915, PubMed 33978540 -
Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
Cell Rep, 37 (13), 110186
DOI 10.1016/j.celrep.2021.110186, PubMed 34965431 -
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Autophagy, 18 (7), 1486-1502
DOI 10.1080/15548627.2021.1988359, PubMed 34740308 -
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
PLoS One, 16 (3), e0248140
DOI 10.1371/journal.pone.0248140, PubMed 33690666 -
Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells
PLoS One, 16 (6), e0253828
DOI 10.1371/journal.pone.0253828, PubMed 34191854 -
Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo
BMC Biol, 19 (1), 85
DOI 10.1186/s12915-021-01012-5, PubMed 33966633 -
Ebulin l Is Internalized in Cells by Both Clathrin-Dependent and -Independent Mechanisms and Does Not Require Clathrin or Dynamin for Intoxication
Toxins (Basel), 13 (2)
DOI 10.3390/toxins13020102, PubMed 33573355 -
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
EMBO J, 40 (18), e107336
DOI 10.15252/embj.2020107336, PubMed 34309071 -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751 -
Autophagy in major human diseases
EMBO J, 40 (19), e108863
DOI 10.15252/embj.2021108863, PubMed 34459017 -
Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
Int J Mol Sci, 22 (8)
DOI 10.3390/ijms22083887, PubMed 33918699 -
Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model
Biomacromolecules, 22 (10), 4169-4180
DOI 10.1021/acs.biomac.1c00662, PubMed 34542998 -
Urinary Extracellular Vesicles in Urology: Current Successes and Challenges Ahead
Eur Urol, 81 (1), 127-128
DOI 10.1016/j.eururo.2021.09.025, PubMed 34625312 -
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol Oncol, 16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096 -
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015 -
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
iScience, 24 (7), 102807
DOI 10.1016/j.isci.2021.102807, PubMed 34337362 -
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice
Int J Mol Sci, 22 (12)
DOI 10.3390/ijms22126309, PubMed 34208396 -
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Nanomaterials (Basel), 11 (5)
DOI 10.3390/nano11051140, PubMed 33924869 -
Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research
Br J Cancer, 126 (3), 331-350
DOI 10.1038/s41416-021-01610-8, PubMed 34811504 -
Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients
Br J Cancer, 126 (3), 492-501
DOI 10.1038/s41416-021-01598-1, PubMed 34811506 -
The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy
J Cell Sci, 134 (3)
DOI 10.1242/jcs.250670, PubMed 33468622 -
Structural Analysis of Toxin-Neutralizing, Single-Domain Antibodies that Bridge Ricin's A-B Subunit Interface
J Mol Biol, 433 (15), 167086
DOI 10.1016/j.jmb.2021.167086, PubMed 34089718 -
bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments
Brief Bioinform, 22 (6)
DOI 10.1093/bib/bbab251, PubMed 34308471 -
The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport
Toxins (Basel), 13 (6)
DOI 10.3390/toxins13060377, PubMed 34070659 -
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
Nat Commun, 12 (1), 6577
DOI 10.1038/s41467-021-26775-x, PubMed 34772942 -
Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation
Autophagy, 17 (4), 1046-1048
DOI 10.1080/15548627.2021.1887548, PubMed 33629888 -
Autophagy modulates cell fate decisions during lineage commitment
Autophagy, 18 (8), 1915-1931
DOI 10.1080/15548627.2021.2008691, PubMed 34923909 -
Characterization of mechanisms positioning costimulatory complexes in immune synapses
iScience, 24 (10), 103100
DOI 10.1016/j.isci.2021.103100, PubMed 34622155 -
Cellular uptake of nanoparticles: Involvement of caveolae?
Precis Nanomed, 4 (2), 782-786
DOI 10.33218/001c.22201, PublikaID 365 -
Transport of nanoparticles across the endothelial cell layer
Nano Today, 36, 101029
DOI 10.1016/j.nantod.2020.101029 -
Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling
Cells, 10 (6)
DOI 10.3390/cells10061342, PubMed 34071546 -
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
Cells, 10 (12)
DOI 10.3390/cells10123432, PubMed 34943939 -
First person - Kia Wee Tan
J. Cell Sci., 134 (14), jcs259055
DOI 10.1242/jcs.259055 -
JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes
J Cell Sci, 134 (14)
DOI 10.1242/jcs.258495, PubMed 34109410 -
Adaptation to hypoxia in Drosophila melanogaster requires autophagy
Autophagy, 18 (4), 909-920
DOI 10.1080/15548627.2021.1991191, PubMed 34793268 -
Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells
Int J Pharm, 597, 120217
DOI 10.1016/j.ijpharm.2021.120217, PubMed 33486035 -
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy
Biochem Pharmacol, 194, 114837
DOI 10.1016/j.bcp.2021.114837, PubMed 34780750 -
Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation
Cells, 10 (9)
DOI 10.3390/cells10092231, PubMed 34571880 -
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
J Mol Biol, 433 (15), 167049
DOI 10.1016/j.jmb.2021.167049, PubMed 34052024 -
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
J Mol Biol, 433 (13), 166987
DOI 10.1016/j.jmb.2021.166987, PubMed 33845085 -
The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion
Proc Natl Acad Sci U S A, 118 (28)
DOI 10.1073/pnas.2024596118, PubMed 34244439 -
Sealing holes in cellular membranes
EMBO J, 40 (7), e106922
DOI 10.15252/embj.2020106922, PubMed 33644904 -
Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: toxicity and changes in the proteome of breast, colon and prostate cancer cells
Nanotoxicology, 15 (7), 865-884
DOI 10.1080/17435390.2021.1924888, PubMed 34047629
Publications 2020
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Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular
Int J Mol Sci, 21 (7)
DOI 10.3390/ijms21072576, PubMed 32276321 -
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 23 (6), 101154
DOI 10.1016/j.isci.2020.101154, PubMed 32450518 -
Colorectal cysts as a validating tool for CAR therapy
BMC Biotechnol, 20 (1), 30
DOI 10.1186/s12896-020-00623-0, PubMed 32487146 -
HLA-DPB1 mismatch reduce relapse and improve survival in T-cell replete unrelated donor allogeneic stem cell transplantation
Bone Marrow Transplant, 55 (8), 1658-1661
DOI 10.1038/s41409-020-0827-3, PubMed 32054997 -
Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
Life Sci Alliance, 4 (2)
DOI 10.26508/lsa.202000965, PubMed 33318080 -
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
Cell Rep, 31 (8), 107695
DOI 10.1016/j.celrep.2020.107695, PubMed 32460019 -
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
Nat Commun, 11 (1), 440
DOI 10.1038/s41467-020-14343-8, PubMed 31974402 -
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response
EMBO Rep, 21 (9), e50051
DOI 10.15252/embr.202050051, PubMed 32715615 -
FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1
Cancers (Basel), 12 (10)
DOI 10.3390/cancers12102992, PubMed 33076489 -
RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression
Cancer Res, 81 (2), 315-331
DOI 10.1158/0008-5472.CAN-20-1871, PubMed 33067265 -
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (8), 973-985
DOI 10.1038/s41556-020-0549-1, PubMed 32753672 -
Author Correction: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Nat Cell Biol, 22 (10), 1286
DOI 10.1038/s41556-020-0574-0, PubMed 32788721 -
Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB
Autophagy, 16 (12), 2305-2306
DOI 10.1080/15548627.2020.1837423, PubMed 33070669 -
RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism
Curr Biol, 30 (7), 1177-1188.e5
DOI 10.1016/j.cub.2020.01.048, PubMed 32059769 -
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
Proc Natl Acad Sci U S A, 117 (46), 28614-28624
DOI 10.1073/pnas.2014228117, PubMed 33139578 -
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus
Cell Mol Life Sci, 78 (3), 985-1009
DOI 10.1007/s00018-020-03551-6, PubMed 32447426 -
Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies
J Mater Chem B, 8 (31), 6710-6738
DOI 10.1039/d0tb00861c, PubMed 32627783 -
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
Cancer Rep (Hoboken), 5 (12), e1278
DOI 10.1002/cnr2.1278, PubMed 32737955 -
Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
J Cell Sci, 133 (13)
DOI 10.1242/jcs.244467, PubMed 32546530 -
Late awakening, prognostic factors and long-term outcome in out-of-hospital cardiac arrest - results of the prospective Norwegian Cardio-Respiratory Arrest Study (NORCAST)
Resuscitation, 149, 170-179
DOI 10.1016/j.resuscitation.2019.12.031, PubMed 31926258 -
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy
EMBO J, 39 (24), e104948
DOI 10.15252/embj.2020104948, PubMed 33226137 -
Tyrosine kinase inhibitors and interferon-α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines
FASEB J, 34 (3), 3773-3791
DOI 10.1096/fj.201802061RR, PubMed 31945226 -
Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061516, PubMed 32531927 -
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer
Biomacromolecules, 21 (4), 1489-1498
DOI 10.1021/acs.biomac.0c00061, PubMed 32092254 -
Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges
Cells, 9 (5)
DOI 10.3390/cells9051171, PubMed 32397238 -
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion
J Cell Biol, 219 (8)
DOI 10.1083/jcb.202003063, PubMed 32479595 -
LRRK2 to the rescue of damaged endomembranes
EMBO J, 39 (18), e106162
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The CD34+ Cell Dose Matters in Hematopoietic Stem Cell Transplantation with Peripheral Blood Stem Cells from Sibling Donors
Clin Hematol Int, 2 (2), 74-81
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The role of lipid species in membranes and cancer-related changes
Cancer Metastasis Rev, 39 (2), 343-360
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An emerging focus on lipids in extracellular vesicles
Adv Drug Deliv Rev, 159, 308-321
DOI 10.1016/j.addr.2020.03.002, PubMed 32151658 -
The Fusarium mycotoxin, 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) induces vacuolization in HepG2 cells
Toxicology, 433-434, 152405
DOI 10.1016/j.tox.2020.152405, PubMed 32044396 -
Biological response and cytotoxicity induced by lipid nanocapsules
J Nanobiotechnology, 18 (1), 5
DOI 10.1186/s12951-019-0567-y, PubMed 31907052 -
Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation
J Biomed Nanotechnol, 16 (4), 432-445
DOI 10.1166/jbn.2020.2906, PubMed 32970976 -
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632 -
Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin
J Biomed Nanotechnol, 16 (4), 419-431
DOI 10.1166/jbn.2020.2911, PubMed 32970975 -
Mass spectrometry-based measurements of cyclic adenosine monophosphate in cells, simplified using reversed phase liquid chromatography with a polar characterized stationary phase
J Chromatogr B Analyt Technol Biomed Life Sci, 1160, 122384
DOI 10.1016/j.jchromb.2020.122384, PubMed 32971370 -
Analytical techniques for multiplex analysis of protein biomarkers
Expert Rev Proteomics, 17 (4), 257-273
DOI 10.1080/14789450.2020.1763174, PubMed 32427033 -
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol, 22 (7), 856-867
DOI 10.1038/s41556-020-0537-5, PubMed 32601372 -
Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration
J Extracell Vesicles, 9 (1), 1816641
DOI 10.1080/20013078.2020.1816641, PubMed 33062218 -
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965 -
STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (8), 868-879
DOI 10.1038/s41590-020-0730-5, PubMed 32690950 -
Author Correction: STEEP mediates STING ER exit and activation of signaling
Nat Immunol, 21 (11), 1468-1469
DOI 10.1038/s41590-020-0803-5, PubMed 32929276
Publications 2019
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Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
Nat Commun, 10 (1), 5693
DOI 10.1038/s41467-019-13674-5, PubMed 31836700 -
Cell Competition Triggers Suicide by Autophagy
Dev Cell, 51 (1), 4-5
DOI 10.1016/j.devcel.2019.09.014, PubMed 31593651 -
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Nat Commun, 10 (1), 5284
DOI 10.1038/s41467-019-13172-8, PubMed 31754102 -
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
Cell Rep, 28 (7), 1907-1922.e6
DOI 10.1016/j.celrep.2019.07.025, PubMed 31412255 -
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279 -
The FMRpolyGlycine Protein Mediates Aggregate Formation and Toxicity Independent of the CGG mRNA Hairpin in a Cellular Model for FXTAS
Front Genet, 10, 249
DOI 10.3389/fgene.2019.00249, PubMed 30984240 -
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
Nat Commun, 10 (1), 4176
DOI 10.1038/s41467-019-12094-9, PubMed 31519908 -
Autophagy and Tumorigenesis in Drosophila
Adv Exp Med Biol, 1167, 113-127
DOI 10.1007/978-3-030-23629-8_7, PubMed 31520352 -
Correction to: Autophagy and Tumorigenesis in Drosophila
Adv Exp Med Biol, 1167, C1
DOI 10.1007/978-3-030-23629-8_15, PubMed 33306185 -
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Dev Cell, 49 (1), 130-144.e6
DOI 10.1016/j.devcel.2019.01.027, PubMed 30827897 -
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533 -
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
J Biol Chem, 294 (20), 8197-8217
DOI 10.1074/jbc.RA118.002829, PubMed 30926605 -
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Mol Cell, 73 (3), 429-445.e7
DOI 10.1016/j.molcel.2018.11.018, PubMed 30612879 -
The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses
J Pharmacol Exp Ther, 370 (3), 581-592
DOI 10.1124/jpet.119.258012, PubMed 30940695 -
Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast
J Biol Chem, 294 (49), 18784-18795
DOI 10.1074/jbc.RA119.009721, PubMed 31676685 -
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Elife, 8
DOI 10.7554/eLife.51063, PubMed 31868590 -
Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
Int J Nanomedicine, 14, 6269-6285
DOI 10.2147/IJN.S208938, PubMed 31496685 -
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131 -
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Oncogene, 38 (50), 7473-7490
DOI 10.1038/s41388-019-0956-6, PubMed 31444413 -
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop
J Extracell Vesicles, 8 (1), 1684862
DOI 10.1080/20013078.2019.1684862, PubMed 31762963 -
CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor
PLoS Biol, 17 (4), e2007044
DOI 10.1371/journal.pbio.2007044, PubMed 30933966 -
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
PLoS Pathog, 15 (3), e1007684
DOI 10.1371/journal.ppat.1007684, PubMed 30883606 -
The role of PS 18:0/18:1 in membrane function
Nat Commun, 10 (1), 2752
DOI 10.1038/s41467-019-10711-1, PubMed 31227693 -
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
Nat Commun, 10 (1), 2850
DOI 10.1038/s41467-019-10794-w, PubMed 31253801 -
Tumor suppression by control of matrix metalloproteinase recycling
Mol Cell Oncol, 6 (6), e1646606
DOI 10.1080/23723556.2019.1646606, PubMed 31692886 -
Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin
Toxins (Basel), 11 (6)
DOI 10.3390/toxins11060350, PubMed 31216687 -
Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death
Nanotoxicology, 13 (6), 761-782
DOI 10.1080/17435390.2019.1576238, PubMed 30760074 -
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
Cells, 8 (6)
DOI 10.3390/cells8060518, PubMed 31146385 -
Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders
Genes (Basel), 10 (7)
DOI 10.3390/genes10070510, PubMed 31284546 -
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194 -
The many functions of ESCRTs
Nat Rev Mol Cell Biol, 21 (1), 25-42
DOI 10.1038/s41580-019-0177-4, PubMed 31705132 -
Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling
Int J Mol Sci, 20 (8)
DOI 10.3390/ijms20081826, PubMed 31013829 -
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, 104 (5), e229
DOI 10.3324/haematol.2019.220533, PubMed 31040234 -
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282
Publications 2018
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Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
J Control Release, 293, 183-192
DOI 10.1016/j.jconrel.2018.11.029, PubMed 30529259 -
Differential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer
Mol Cancer, 17 (1), 114
DOI 10.1186/s12943-018-0863-4, PubMed 30075793 -
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619 -
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271 -
Gamma irradiation during gametogenesis in young adult zebrafish causes persistent genotoxicity and adverse reproductive effects
Ecotoxicol Environ Saf, 154, 19-26
DOI 10.1016/j.ecoenv.2018.02.031, PubMed 29453161 -
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors
Mol Cell Proteomics, 17 (5), 850-870
DOI 10.1074/mcp.RA117.000538, PubMed 29371290 -
Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation
J Mol Biol, 430 (21), 4087-4101
DOI 10.1016/j.jmb.2018.08.004, PubMed 30099027 -
Centromeres License the Mitotic Condensation of Yeast Chromosome Arms
Cell, 175 (3), 780-795.e15
DOI 10.1016/j.cell.2018.09.012, PubMed 30318142 -
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
J Cell Biol, 217 (3), 997-1013
DOI 10.1083/jcb.201708039, PubMed 29420192 -
Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
EMBO J, 37 (13)
DOI 10.15252/embj.201797741, PubMed 29858227 -
Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy
J Cell Biol, 217 (10), 3640-3655
DOI 10.1083/jcb.201711002, PubMed 30018090 -
The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
Biol Res, 51 (1), 3
DOI 10.1186/s40659-017-0151-6, PubMed 29316982 -
Multiple links connect central carbon metabolism to DNA replication initiation and elongation in Bacillus subtilis
DNA Res, 25 (6), 641-653
DOI 10.1093/dnares/dsy031, PubMed 30256918 -
Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation
Autophagy, 15 (1), 182-183
DOI 10.1080/15548627.2018.1532265, PubMed 30295124 -
Detection and proteomic characterization of extracellular vesicles in human pancreatic juice
Biochem Biophys Res Commun, 499 (1), 37-43
DOI 10.1016/j.bbrc.2018.03.107, PubMed 29550476 -
Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages
Cell Commun Signal, 16 (1), 17
DOI 10.1186/s12964-018-0229-y, PubMed 29690889 -
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
EMBO J, 37 (21)
DOI 10.15252/embj.201899753, PubMed 30314966 -
ESCRTs in membrane sealing
Biochem Soc Trans, 46 (4), 773-778
DOI 10.1042/BST20170435, PubMed 29903934 -
Clathrin-independent endocytosis: an increasing degree of complexity
Histochem Cell Biol, 150 (2), 107-118
DOI 10.1007/s00418-018-1678-5, PubMed 29774430 -
Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology
J Lipid Res, 60 (1), 9-18
DOI 10.1194/jlr.R084343, PubMed 30076207 -
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
J Extracell Vesicles, 7 (1), 1535750
DOI 10.1080/20013078.2018.1535750, PubMed 30637094 -
Orchestrating Nuclear Envelope Sealing during Mitosis
Dev Cell, 47 (5), 541-542
DOI 10.1016/j.devcel.2018.11.020, PubMed 30513298 -
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Nat Commun, 9 (1), 2932
DOI 10.1038/s41467-018-05345-8, PubMed 30050131 -
Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J Control Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005, PubMed 30217739 -
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445 -
Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4
Biochemistry, 57 (26), 3807-3816
DOI 10.1021/acs.biochem.8b00120, PubMed 29812912
Publications 2017
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Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Traffic, 18 (3), 176-191
DOI 10.1111/tra.12468, PubMed 28067430 -
Doping and drug testing: Anti-doping work must be transparent and adhere to good scientific practices to ensure public trust
EMBO Rep, 18 (3), 351-354
DOI 10.15252/embr.201643540, PubMed 28167676 -
Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate
Sci Total Environ, 610-611, 972-982
DOI 10.1016/j.scitotenv.2017.08.115, PubMed 28838034 -
Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits
Biochim Biophys Acta Gene Regul Mech, 1861 (4), 310-319
DOI 10.1016/j.bbagrm.2017.11.001, PubMed 29127063 -
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404 -
Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients
BMC Cancer, 17 (1), 730
DOI 10.1186/s12885-017-3737-z, PubMed 29121858 -
Anabolic transcription: Secrets of the sumo diet
Cell Cycle, 16 (7), 593-594
DOI 10.1080/15384101.2017.1294945, PubMed 28278057 -
Regulation of Cellular Processes by SUMO: Understudied Topics
Adv Exp Med Biol, 963, 89-97
DOI 10.1007/978-3-319-50044-7_5, PubMed 28197907 -
Sumo during stress: When transcription takes a pause (comment on DOI.10.1002/bies.201600263)
Bioessays, 39 (6)
DOI 10.1002/bies.201700065, PubMed 28464310 -
Phenotypes of dnaXE145A Mutant Cells Indicate that the Escherichia coli Clamp Loader Has a Role in the Restart of Stalled Replication Forks
J Bacteriol, 199 (24)
DOI 10.1128/JB.00412-17, PubMed 28947673 -
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Biochim Biophys Acta Mol Cell Res, 1864 (12), 2241-2252
DOI 10.1016/j.bbamcr.2017.08.011, PubMed 28867611 -
Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin
ChemMedChem, 12 (8), 613-620
DOI 10.1002/cmdc.201700108, PubMed 28334511 -
Current knowledge on exosome biogenesis and release
Cell Mol Life Sci, 75 (2), 193-208
DOI 10.1007/s00018-017-2595-9, PubMed 28733901 -
PtdIns3P controls mTORC1 signaling through lysosomal positioning
J Cell Biol, 216 (12), 4217-4233
DOI 10.1083/jcb.201611073, PubMed 29030394 -
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876 -
Microenvironment and tumors-a nurturing relationship
Autophagy, 13 (7), 1241-1243
DOI 10.1080/15548627.2017.1310361, PubMed 28632995 -
Protection against Shiga Toxins
Toxins (Basel), 9 (2)
DOI 10.3390/toxins9020044, PubMed 28165371 -
Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors
ACS Omega, 2 (7), 3792-3805
DOI 10.1021/acsomega.7b00116, PubMed 30023704 -
Low Concentrations of Cationic PAMAM Dendrimers Affect Lymphocyte Respiration in In vitro Studies
Curr Pharm Biotechnol, 18 (2), 150-157
DOI 10.2174/1389201017666161229153018, PubMed 28034293 -
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Nucleus, 8 (4), 404-420
DOI 10.1080/19491034.2017.1306161, PubMed 28402725 -
Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 130 (6), 1194
DOI 10.1242/jcs.202499, PubMed 28298613 -
Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis
PLoS One, 12 (1), e0170716
DOI 10.1371/journal.pone.0170716, PubMed 28114329 -
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199 -
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem Pharmacol, 144, 63-77
DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290 -
A novel community driven software for functional enrichment analysis of extracellular vesicles data
J Extracell Vesicles, 6 (1), 1321455
DOI 10.1080/20013078.2017.1321455, PubMed 28717418 -
SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms
Nucleic Acids Res, 45 (11), 6471-6485
DOI 10.1093/nar/gkx263, PubMed 28407100 -
Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
Oncotarget, 8 (14), 22606-22615
DOI 10.18632/oncotarget.15146, PubMed 28186983 -
Local Juvenile Hormone activity regulates gut homeostasis and tumor growth in adult Drosophila
Sci Rep, 7 (1), 11677
DOI 10.1038/s41598-017-11199-9, PubMed 28916802 -
Suppressing mTORC1 on the lysosome
EMBO J, 36 (13), 1809-1810
DOI 10.15252/embj.201797469, PubMed 28623241 -
A novel 3D heterotypic spheroid model for studying extracellular vesicle-mediated tumour and immune cell communication
Biochem Biophys Res Commun, 495 (2), 1930-1935
DOI 10.1016/j.bbrc.2017.12.072, PubMed 29248729 -
Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network
Exp Cell Res, 357 (1), 67-78
DOI 10.1016/j.yexcr.2017.04.025, PubMed 28450044 -
Injection of nanoparticles into cloven-hoof animals: Asking for trouble
Theranostics, 7 (19), 4877-4878
DOI 10.7150/thno.22420, PubMed 29187910 -
Lipids in exosomes: Current knowledge and the way forward
Prog Lipid Res, 66, 30-41
DOI 10.1016/j.plipres.2017.03.001, PubMed 28342835 -
Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles
Int J Mol Sci, 18 (11)
DOI 10.3390/ijms18112454, PubMed 29156588 -
HS1BP3 inhibits autophagy by regulation of PLD1
Autophagy, 13 (5), 985-986
DOI 10.1080/15548627.2017.1291483, PubMed 28318354 -
A vital sugar code for ricin toxicity
Cell Res, 27 (11), 1351-1364
DOI 10.1038/cr.2017.116, PubMed 28925387 -
Targeting Tankyrase to Fight WNT-dependent Tumours
Basic Clin Pharmacol Toxicol, 121 (2), 81-88
DOI 10.1111/bcpt.12786, PubMed 28371398 -
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
PLoS One, 12 (1), e0170508
DOI 10.1371/journal.pone.0170508, PubMed 28107521 -
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
J Cell Sci, 130 (17), 2867-2882
DOI 10.1242/jcs.202408, PubMed 28733455 -
Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
Nat Commun, 8 (1), 1264
DOI 10.1038/s41467-017-01287-9, PubMed 29097655 -
Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study
J Extracell Vesicles, 6 (1), 1344087
DOI 10.1080/20013078.2017.1344087, PubMed 28804597 -
Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28
G3 (Bethesda), 7 (6), 1753-1766
DOI 10.1534/g3.117.042317, PubMed 28428242 -
Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
Oncotarget, 8 (44), 76921-76934
DOI 10.18632/oncotarget.20217, PubMed 29100358
Publications 2016
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Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding
Sci Rep, 6, 30336
DOI 10.1038/srep30336, PubMed 27458147 -
Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins
Oncotarget, 7 (18), 25443-60
DOI 10.18632/oncotarget.8327, PubMed 27029001 -
Identification of new FGF1 binding partners-Implications for its intracellular function
IUBMB Life, 68 (3), 242-51
DOI 10.1002/iub.1480, PubMed 26840910 -
Novel ESCRT functions in cell biology: spiraling out of control?
Curr Opin Cell Biol, 41, 1-8
DOI 10.1016/j.ceb.2016.03.008, PubMed 27031044 -
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery
Trends Biochem Sci, 42 (1), 42-56
DOI 10.1016/j.tibs.2016.08.016, PubMed 27669649 -
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
J Cell Biol, 212 (5), 499-513
DOI 10.1083/jcb.201507009, PubMed 26929449 -
An Unusual Member of the Papain Superfamily: Mapping the Catalytic Cleft of the Marasmius oreades agglutinin (MOA) with a Caspase Inhibitor
PLoS One, 11 (2), e0149407
DOI 10.1371/journal.pone.0149407, PubMed 26901797 -
Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer: a systematic review
Mol Cancer, 15 (1), 41
DOI 10.1186/s12943-016-0523-5, PubMed 27189160 -
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
ACS Nano, 10 (4), 3886-99
DOI 10.1021/acsnano.5b08015, PubMed 26978483 -
Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
Cell Cycle, 15 (21), 2943-2957
DOI 10.1080/15384101.2016.1231280, PubMed 27625181 -
Effects of perfluorinated alkyl acids on cellular responses of MCF-10A mammary epithelial cells in monolayers and on acini formation in vitro
Toxicol Lett, 259, 95-107
DOI 10.1016/j.toxlet.2016.08.004, PubMed 27511595 -
Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport
J Proteome Res, 15 (10), 3841-3855
DOI 10.1021/acs.jproteome.6b00652, PubMed 27615514 -
Lack of the H-NS Protein Results in Extended and Aberrantly Positioned DNA during Chromosome Replication and Segregation in Escherichia coli
J Bacteriol, 198 (8), 1305-16
DOI 10.1128/JB.00919-15, PubMed 26858102 -
A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking
PLoS One, 11 (6), e0156893
DOI 10.1371/journal.pone.0156893, PubMed 27300140 -
PIKfyve inhibition increases exosome release and induces secretory autophagy
Cell Mol Life Sci, 73 (24), 4717-4737
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HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
Nat Commun, 7, 13889
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Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport
Oncotarget, 7 (48), 79885-79900
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A large-scale quantitative EM study on activation of olfactory glands shows no effect of cholinergic agents
Microscopy (Oxf), 65 (5), 438-443
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Antibody Staining in Drosophila Germaria
Methods Mol Biol, 1457, 19-33
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Focusing the Spotlight on the Zebrafish Intestine to Illuminate Mechanisms of Colorectal Cancer
Adv Exp Med Biol, 916, 411-37
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ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors
Sci Signal, 9 (411), ra8
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TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation
J Cell Sci, 129 (19), 3562-3573
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The Abscission Checkpoint: Making It to the Final Cut
Trends Cell Biol, 27 (1), 1-11
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Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
PLoS One, 11 (8), e0160507
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Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
Nat Commun, 7, 10318
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Plasma membrane repairs by small GTPase Rab3a
J Cell Biol, 213 (6), 613-5
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Phosphoinositides in membrane contact sites
Biochem Soc Trans, 44 (2), 425-30
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ER-endosome contact sites in endosome positioning and protrusion outgrowth
Biochem Soc Trans, 44 (2), 441-6
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Data including GROMACS input files for atomistic molecular dynamics simulations of mixed, asymmetric bilayers including molecular topologies, equilibrated structures, and force field for lipids compatible with OPLS-AA parameters
Data Brief, 7, 1171-1174
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Phosphoinositides in Control of Membrane Dynamics
Annu Rev Cell Dev Biol, 32, 143-171
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Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility
PLoS One, 11 (7), e0159473
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How organizers of scientific meetings and journal editors could facilitate transfer of nanomedicine into the clinic
Eur. J. Nanomed., 8 (1), 61-63
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Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers
Eur J Cancer, 70, 122-132
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Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics
J Mol Biol, 428 (24 Pt A), 4856-4866
DOI 10.1016/j.jmb.2016.06.013, PubMed 27363608 -
Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow
Cell Cycle, 15 (5), 628-43
DOI 10.1080/15384101.2016.1146834, PubMed 27104745 -
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Biochim Biophys Acta, 1863 (6 Pt A), 1179-88
DOI 10.1016/j.bbamcr.2016.03.011, PubMed 26975582 -
Divergent Binding and Transactivation by Two Related Steroid Receptors at the Same Response Element
J Biol Chem, 291 (22), 11899-910
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The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport
Oncotarget, 7 (52), 86871-86888
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Closing a gap in the nuclear envelope
Curr Opin Cell Biol, 40, 90-97
DOI 10.1016/j.ceb.2016.03.001, PubMed 27016712 -
Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation
Eur J Pharm Sci, 98, 80-85
DOI 10.1016/j.ejps.2016.09.023, PubMed 27664330 -
Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport
Sci Rep, 6, 22721
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Publications 2015
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Surface Trafficking of APP and BACE in Live Cells
Traffic, 16 (6), 655-75
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Instability restricts signaling of multiple fibroblast growth factors
Cell Mol Life Sci, 72 (12), 2445-59
DOI 10.1007/s00018-015-1856-8, PubMed 25854632 -
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-51
DOI 10.18632/oncotarget.3814, PubMed 26002552 -
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Autophagy, 11 (9), 1458-70
DOI 10.1080/15548627.2015.1067359, PubMed 26207339 -
Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells
PLoS One, 10 (5), e0129214
DOI 10.1371/journal.pone.0129214, PubMed 26017782 -
Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes
Clin Exp Metastasis, 32 (8), 755-67
DOI 10.1007/s10585-015-9742-1, PubMed 26349943 -
ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo
PLoS Genet, 11 (1), e1004904
DOI 10.1371/journal.pgen.1004904, PubMed 25635693 -
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
Development, 142 (23), 4107-18
DOI 10.1242/dev.124370, PubMed 26628094 -
Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy
Autophagy, 11 (3), 460-71
DOI 10.1080/15548627.2015.1009797, PubMed 25749095 -
The DnaA Protein Is Not the Limiting Factor for Initiation of Replication in Escherichia coli
PLoS Genet, 11 (6), e1005276
DOI 10.1371/journal.pgen.1005276, PubMed 26047361 -
Novel Furin Inhibitors with Potent Anti-infectious Activity
ChemMedChem, 10 (7), 1218-31
DOI 10.1002/cmdc.201500103, PubMed 25974265 -
Dynamic Escherichia coli SeqA complexes organize the newly replicated DNA at a considerable distance from the replisome
Nucleic Acids Res, 43 (5), 2730-43
DOI 10.1093/nar/gkv146, PubMed 25722374 -
p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB
J Biol Chem, 290 (24), 14945-62
DOI 10.1074/jbc.M115.656116, PubMed 25931115 -
Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids
Biochem J, 470 (1), 23-37
DOI 10.1042/BJ20141562, PubMed 26251444 -
Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic
Cell Mol Life Sci, 73 (6), 1301-16
DOI 10.1007/s00018-015-2049-1, PubMed 26407609 -
Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells
Pathog Dis, 73 (9), ftv083
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Dissecting the cyclic di-guanylate monophosphate signalling network regulating motility in Salmonella enterica serovar Typhimurium
Environ Microbiol, 17 (4), 1310-20
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Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
Nature, 520 (7546), 234-8
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ER-endosome contact sites: molecular compositions and functions
EMBO J, 34 (14), 1848-58
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Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner
Biochim Biophys Acta, 1858 (2), 281-8
DOI 10.1016/j.bbamem.2015.12.003, PubMed 26654782 -
Cell-penetrating peptides: possibilities and challenges for drug delivery in vitro and in vivo
Molecules, 20 (7), 13313-23
DOI 10.3390/molecules200713313, PubMed 26205056 -
The Role of Lectin-Carbohydrate Interactions in the Regulation of ER-Associated Protein Degradation
Molecules, 20 (6), 9816-46
DOI 10.3390/molecules20069816, PubMed 26023941 -
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
BMC Cell Biol, 16, 1
DOI 10.1186/s12860-015-0047-7, PubMed 25655076 -
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
PLoS One, 10 (8), e0134789
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Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Exp Cell Res, 333 (1), 21-38
DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710 -
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462 -
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443 -
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
Nature, 522 (7555), 231-5
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The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo
Exp Cell Res, 340 (2), 220-6
DOI 10.1016/j.yexcr.2015.12.017, PubMed 26748184 -
Biological properties of extracellular vesicles and their physiological functions
J Extracell Vesicles, 4, 27066
DOI 10.3402/jev.v4.27066, PubMed 25979354 -
Cellular functions of Rab GTPases at a glance
J Cell Sci, 128 (17), 3171-6
DOI 10.1242/jcs.166074, PubMed 26272922 -
Identification of prostate cancer biomarkers in urinary exosomes
Oncotarget, 6 (30), 30357-76
DOI 10.18632/oncotarget.4851, PubMed 26196085 -
Functional specialization of chordate CDK1 paralogs during oogenic meiosis
Cell Cycle, 14 (6), 880-93
DOI 10.1080/15384101.2015.1006000, PubMed 25714331
Publications 2014
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Cell-cycle analyses using thymidine analogues in fission yeast
PLoS One, 9 (2), e88629
DOI 10.1371/journal.pone.0088629, PubMed 24551125 -
Flotillin depletion affects ErbB protein levels in different human breast cancer cells
Biochim Biophys Acta, 1843 (9), 1987-96
DOI 10.1016/j.bbamcr.2014.04.013, PubMed 24747692 -
The ether lipid precursor hexadecylglycerol protects against Shiga toxins
Cell Mol Life Sci, 71 (21), 4285-300
DOI 10.1007/s00018-014-1624-1, PubMed 24740796 -
Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome
J Control Release, 182, 58-66
DOI 10.1016/j.jconrel.2014.03.014, PubMed 24637464 -
The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis
Biochem Biophys Res Commun, 447 (4), 586-9
DOI 10.1016/j.bbrc.2014.04.043, PubMed 24747075 -
Trans-splicing and operons in metazoans: translational control in maternally regulated development and recovery from growth arrest
Mol Biol Evol, 32 (3), 585-99
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Investigating spermatogenesis in Drosophila melanogaster
Methods, 68 (1), 218-27
DOI 10.1016/j.ymeth.2014.04.020, PubMed 24798812 -
Escherichia coli SeqA structures relocalize abruptly upon termination of origin sequestration during multifork DNA replication
PLoS One, 9 (10), e110575
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Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling
Traffic, 15 (6), 665-83
DOI 10.1111/tra.12168, PubMed 24589086 -
The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster
Dis Model Mech, 7 (6), 659-65
DOI 10.1242/dmm.014787, PubMed 24682783 -
LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis
Traffic, 15 (12), 1390-405
DOI 10.1111/tra.12227, PubMed 25216107 -
Vps11, a subunit of the tethering complexes HOPS and CORVET, is involved in regulation of glycolipid degradation and retrograde toxin transport
Commun Integr Biol, 7 (1), e28129
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The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
MAbs, 6 (4), 1038-50
DOI 10.4161/mabs.28207, PubMed 24525727 -
The Escherichia coli datA site promotes proper regulation of cell division
Microbiology (Reading), 160 (Pt 4), 703-710
DOI 10.1099/mic.0.074898-0, PubMed 24574433 -
DNA compaction in the early part of the SOS response is dependent on RecN and RecA
Microbiology (Reading), 160 (Pt 5), 872-882
DOI 10.1099/mic.0.075051-0, PubMed 24615185 -
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
Biochem J, 461 (3), 383-90
DOI 10.1042/BJ20140132, PubMed 24840251 -
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887 -
Regulation of exosome release by glycosphingolipids and flotillins
FEBS J, 281 (9), 2214-27
DOI 10.1111/febs.12775, PubMed 24605801 -
The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
J Biol Chem, 290 (7), 4225-37
DOI 10.1074/jbc.M114.593962, PubMed 25519911 -
An ER clamp for endosome fission
EMBO J, 34 (2), 136-7
DOI 10.15252/embj.201490707, PubMed 25502456 -
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO
Cancers (Basel), 7 (1), 1-29
DOI 10.3390/cancers7010001, PubMed 25545884 -
Association of CHMP4B and autophagy with micronuclei: implications for cataract formation
Biomed Res Int, 2014, 974393
DOI 10.1155/2014/974393, PubMed 24741567 -
CK2 involvement in ESCRT-III complex phosphorylation
Arch Biochem Biophys, 545, 83-91
DOI 10.1016/j.abb.2014.01.006, PubMed 24440309 -
Lipid requirements for entry of protein toxins into cells
Prog Lipid Res, 54, 1-13
DOI 10.1016/j.plipres.2014.01.001, PubMed 24462587 -
Regulation of biofilm formation in Salmonella enterica serovar Typhimurium
Future Microbiol, 9 (11), 1261-82
DOI 10.2217/fmb.14.88, PubMed 25437188 -
Development of nanoparticles for clinical use
Nanomedicine (Lond), 9 (9), 1295-9
DOI 10.2217/nnm.14.81, PubMed 25204821 -
Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1)
PLoS One, 9 (3), e90687
DOI 10.1371/journal.pone.0090687, PubMed 24595027 -
The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol
Biochem J, 457 (3), 485-96
DOI 10.1042/BJ20130155, PubMed 24200403 -
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol
Toxicology, 326, 119-29
DOI 10.1016/j.tox.2014.10.009, PubMed 25456271 -
Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals
PLoS Genet, 10 (10), e1004685
DOI 10.1371/journal.pgen.1004685, PubMed 25340584 -
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4
Nat Cell Biol, 16 (6), 550-60
DOI 10.1038/ncb2959, PubMed 24814515 -
Monitoring phosphatidylinositol 3-phosphate in multivesicular endosome biogenesis
Methods Enzymol, 534, 3-23
DOI 10.1016/B978-0-12-397926-1.00001-9, PubMed 24359945 -
Antibody-mediated inhibition of ricin toxin retrograde transport
mBio, 5 (2), e00995
DOI 10.1128/mBio.00995-13, PubMed 24713323
Publications 2013
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Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo
J Cell Sci, 126 (Pt 8), 1806-19
DOI 10.1242/jcs.118505, PubMed 23444364 -
The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells
PLoS One, 8 (9), e75904
DOI 10.1371/journal.pone.0075904, PubMed 24098742 -
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J Control Release, 168 (3), 317-26
DOI 10.1016/j.jconrel.2013.03.023, PubMed 23567040 -
Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline
Dev Biol, 377 (1), 9-20
DOI 10.1016/j.ydbio.2013.02.021, PubMed 23499247 -
Modulation of intracellular calcium homeostasis blocks autophagosome formation
Autophagy, 9 (10), 1475-90
DOI 10.4161/auto.25900, PubMed 23970164 -
FAK regulates Cdk2 in EGF-stimulated primary cultures of hepatocytes
J Cell Physiol, 228 (6), 1304-13
DOI 10.1002/jcp.24287, PubMed 23168795 -
The Fis protein has a stimulating role in initiation of replication in Escherichia coli in vivo
PLoS One, 8 (12), e83562
DOI 10.1371/journal.pone.0083562, PubMed 24358293 -
GCN2, an old dog with new tricks
Biochem Soc Trans, 41 (6), 1687-91
DOI 10.1042/BST20130210, PubMed 24256275 -
BiP negatively affects ricin transport
Toxins (Basel), 5 (5), 969-82
DOI 10.3390/toxins5050969, PubMed 23666197 -
Phosphatidylinositol 5-phosphate is a second messenger important for cell migration
Commun Integr Biol, 6 (5), e25446
DOI 10.4161/cib.25446, PubMed 24265857 -
Molecular mechanisms of the membrane sculpting ESCRT pathway
Cold Spring Harb Perspect Biol, 5 (9)
DOI 10.1101/cshperspect.a016766, PubMed 24003212 -
Exosomal miRNAs as Biomarkers for Prostate Cancer
Front Genet, 4, 36
DOI 10.3389/fgene.2013.00036, PubMed 23519132 -
TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy
Autophagy, 9 (12), 1955-64
DOI 10.4161/auto.26085, PubMed 24128730 -
Cell density-induced changes in lipid composition and intracellular trafficking
Cell Mol Life Sci, 71 (6), 1097-116
DOI 10.1007/s00018-013-1441-y, PubMed 23921715 -
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
J Cell Biol, 202 (2), 331-49
DOI 10.1083/jcb.201205129, PubMed 23878278 -
The ERM proteins ezrin and moesin regulate retrograde Shiga toxin transport
Traffic, 14 (7), 839-52
DOI 10.1111/tra.12077, PubMed 23593995 -
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
Biochim Biophys Acta, 1831 (7), 1302-9
DOI 10.1016/j.bbalip.2013.04.011, PubMed 24046871 -
Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment
J Neural Transm (Vienna), 121 (2), 211-9
DOI 10.1007/s00702-013-1087-9, PubMed 24036894 -
RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789
Oncogene, 33 (40), 4823-36
DOI 10.1038/onc.2013.425, PubMed 24141780 -
Phosphoinositide 3-kinases as accelerators and brakes of autophagy
FEBS J, 280 (24), 6322-37
DOI 10.1111/febs.12486, PubMed 23953235 -
Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher
PLoS Biol, 11 (7), e1001612
DOI 10.1371/journal.pbio.1001612, PubMed 23935447 -
Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
FEBS J, 280 (12), 2730-42
DOI 10.1111/febs.12116, PubMed 23289851 -
Crosstalk between the Tor and Gcn2 pathways in response to different stresses
Cell Cycle, 13 (3), 453-61
DOI 10.4161/cc.27270, PubMed 24280780 -
Retrograde transport of protein toxins through the Golgi apparatus
Histochem Cell Biol, 140 (3), 317-26
DOI 10.1007/s00418-013-1111-z, PubMed 23765164 -
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
Bioessays, 35 (10), 900-12
DOI 10.1002/bies.201300064, PubMed 23881848 -
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation
PLoS One, 8 (7), e68072
DOI 10.1371/journal.pone.0068072, PubMed 23840886 -
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett, 339 (1), 25-32
DOI 10.1016/j.canlet.2013.07.026, PubMed 23916608 -
Regulating DNA replication in bacteria
Cold Spring Harb Perspect Biol, 5 (4), a012922
DOI 10.1101/cshperspect.a012922, PubMed 23471435 -
Ricin and Ricin-Containing Immunotoxins: Insights into Intracellular Transport and Mechanism of action in Vitro
Antibodies, 2 (2), 236-269
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Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages
Toxicol Lett, 219 (1), 8-17
DOI 10.1016/j.toxlet.2013.02.012, PubMed 23454835 -
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta, 1830 (8), 4235-43
DOI 10.1016/j.bbagen.2013.04.033, PubMed 23643966 -
Gene transcription from the linear plasmid pBClin15 leads to cell lysis and extracellular DNA-dependent aggregation of Bacillus cereus ATCC 14579 in response to quinolone-induced stress
Microbiology (Reading), 159 (Pt 11), 2283-2293
DOI 10.1099/mic.0.069674-0, PubMed 24002748 -
Single transmembrane peptide DinQ modulates membrane-dependent activities
PLoS Genet, 9 (2), e1003260
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The use of femto-second lasers to trigger powerful explosions of gold nanorods to destroy cancer cells
Biomaterials, 34 (26), 6157-62
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ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling
Sci Signal, 6 (262), ra11
DOI 10.1126/scisignal.2003087, PubMed 23405013
Publications 2012
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Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression
FEBS Lett, 586 (11), 1584-91
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Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases
J Biol Chem, 287 (26), 21992-2003
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Shiga toxins
Toxicon, 60 (6), 1085-107
DOI 10.1016/j.toxicon.2012.07.016, PubMed 22960449 -
Hpz1 modulates the G1-S transition in fission yeast
PLoS One, 7 (9), e44539
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Induction of a G1-S checkpoint in fission yeast
Proc Natl Acad Sci U S A, 109 (25), 9911-6
DOI 10.1073/pnas.1204901109, PubMed 22665798 -
OikoBase: a genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica
Nucleic Acids Res, 41 (Database issue), D845-53
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Depletion of acidic phospholipids influences chromosomal replication in Escherichia coli
Microbiologyopen, 1 (4), 450-66
DOI 10.1002/mbo3.46, PubMed 23233230 -
The role of ubiquitylation in receptor endocytosis and endosomal sorting
J Cell Sci, 125 (Pt 2), 265-75
DOI 10.1242/jcs.091280, PubMed 22357968 -
Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells
Biochim Biophys Acta, 1819 (11-12), 1154-63
DOI 10.1016/j.bbagrm.2012.08.016, PubMed 22982408 -
Cullin-3 regulates late endosome maturation
Proc Natl Acad Sci U S A, 109 (3), 823-8
DOI 10.1073/pnas.1118744109, PubMed 22219362 -
Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems
J Control Release, 163 (3), 385-95
DOI 10.1016/j.jconrel.2012.09.016, PubMed 23041276 -
Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism
J Nanobiotechnology, 10, 33
DOI 10.1186/1477-3155-10-33, PubMed 22849338 -
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
PLoS Biol, 10 (12), e1001450
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Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, 8 (4), 445-544
DOI 10.4161/auto.19496, PubMed 22966490 -
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin
EMBO Rep, 14 (1), 10-1
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The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain
J Cell Sci, 125 (Pt 1), 29-36
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Selective autophagy in Drosophila
Int J Cell Biol, 2012, 146767
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p62 at the interface of autophagy, oxidative stress signaling, and cancer
Antioxid Redox Signal, 17 (5), 786-93
DOI 10.1089/ars.2011.4394, PubMed 22074114 -
Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling
FEBS Lett, 586 (20), 3575-81
DOI 10.1016/j.febslet.2012.08.022, PubMed 22971756 -
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64
DOI 10.1038/embor.2012.183, PubMed 23154468 -
The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion
Traffic, 13 (11), 1547-63
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Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
Biochem J, 441 (1), 399-406
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Flotillins as regulators of ErbB2 levels in breast cancer
Oncogene, 32 (29), 3443-51
DOI 10.1038/onc.2012.357, PubMed 22869152 -
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner
Carcinogenesis, 33 (5), 1031-9
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Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3
Mol Cell Proteomics, 11 (7), M111.012914
DOI 10.1074/mcp.M111.012914, PubMed 22457534 -
Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use
Contrast Media Mol Imaging, 7 (1), 1-6
DOI 10.1002/cmmi.458, PubMed 22344874 -
The Rabs: a family at the root of metazoan evolution
BMC Biol, 10, 68
DOI 10.1186/1741-7007-10-68, PubMed 22873178 -
An easy-to-use simulation program demonstrates variations in bacterial cell cycle parameters depending on medium and temperature
PLoS One, 7 (2), e30981
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Characterization of liposarcoma cell lines for preclinical and biological studies
Sarcoma, 2012, 148614
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FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation
Int J Nanomedicine, 7, 5915-27
DOI 10.2147/IJN.S36575, PubMed 23226697 -
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin
PLoS One, 7 (7), e40429
DOI 10.1371/journal.pone.0040429, PubMed 22792315 -
Replication fork movement and methylation govern SeqA binding to the Escherichia coli chromosome
Nucleic Acids Res, 40 (12), 5465-76
DOI 10.1093/nar/gks187, PubMed 22373925 -
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
Cancer Res, 72 (11), 2822-32
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Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1
Traffic, 13 (5), 650-64
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Doping analyses are not on safe ground
Tidsskr Nor Laegeforen, 132 (8), 929-30
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Publications 2011
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Cell biology. Growth signaling from inside
Science, 334 (6056), 611-2
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p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
Autophagy, 7 (6), 572-83
DOI 10.4161/auto.7.6.14943, PubMed 21325881 -
Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity
Biochem Biophys Res Commun, 408 (3), 405-10
DOI 10.1016/j.bbrc.2011.04.031, PubMed 21513701 -
Derlin-dependent retrograde transport from endosomes to the Golgi apparatus
Traffic, 12 (10), 1417-31
DOI 10.1111/j.1600-0854.2011.01243.x, PubMed 21722281 -
Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner
Traffic, 13 (3), 443-54
DOI 10.1111/j.1600-0854.2011.01319.x, PubMed 22132807 -
Shiga toxin and its use in targeted cancer therapy and imaging
Microb Biotechnol, 4 (1), 32-46
DOI 10.1111/j.1751-7915.2010.00180.x, PubMed 21255370 -
Seeing is believing: the impact of electron microscopy on autophagy research
Autophagy, 7 (9), 935-56
DOI 10.4161/auto.7.9.15760, PubMed 21566462 -
Septation of infectious hyphae is critical for appressoria formation and virulence in the smut fungus Ustilago maydis
PLoS Pathog, 7 (5), e1002044
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Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation
J Biol Chem, 287 (7), 5042-58
DOI 10.1074/jbc.M111.308916, PubMed 22184107 -
The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae
Biochim Biophys Acta, 1823 (1), 150-8
DOI 10.1016/j.bbamcr.2011.09.005, PubMed 21963882 -
The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae
Biochem J, 434 (1), 161-70
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Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development
Commun Integr Biol, 4 (1), 1-9
DOI 10.4161/cib.4.1.13550, PubMed 21509167 -
Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling
PLoS One, 6 (7), e21708
DOI 10.1371/journal.pone.0021708, PubMed 21779335 -
Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling
Eur J Cell Biol, 91 (2), 129-38
DOI 10.1016/j.ejcb.2011.09.009, PubMed 22169219 -
Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification
Tissue Eng Part C Methods, 18 (4), 283-92
DOI 10.1089/ten.TEC.2011.0413, PubMed 22070632 -
Molecular mechanisms of ubiquitin-dependent membrane traffic
Annu Rev Biophys, 40, 119-42
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Nanoparticles hinder intracellular transport
Trac-Trends Anal. Chem., 30 (10), VII-VIII -
Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
Nano Today, 6 (2), 176-185
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The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein
Cell Signal, 23 (11), 1758-66
DOI 10.1016/j.cellsig.2011.06.010, PubMed 21745565 -
Hydrophilic interaction chromatography of nucleoside triphosphates with temperature as a separation parameter
J Chromatogr A, 1218 (35), 5981-6
DOI 10.1016/j.chroma.2011.01.066, PubMed 21315360 -
Role of phospholipase A(2) in retrograde transport of ricin
Toxins (Basel), 3 (9), 1203-19
DOI 10.3390/toxins3091203, PubMed 22069763 -
Cell-cycle analysis of fission yeast cells by flow cytometry
PLoS One, 6 (2), e17175
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SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
Oncogene, 30 (37), 3967-78
DOI 10.1038/onc.2011.109, PubMed 21499309 -
Cell polarity and migration: emerging role for the endosomal sorting machinery
Physiology (Bethesda), 26 (3), 171-80
DOI 10.1152/physiol.00054.2010, PubMed 21670163 -
Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
Traffic, 12 (9), 1211-26
DOI 10.1111/j.1600-0854.2011.01220.x, PubMed 21564451 -
Basic and discovery-based translational research on cancer was on the agenda at the 21st Congress of the European Association for Cancer Research (EACR) in Oslo, Norway, 26-29 June 2010
Clin. Transl. Oncol., 13 (1), 1-2
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Histone variant innovation in a rapidly evolving chordate lineage
BMC Evol Biol, 11, 208
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Endocytosis and signaling
Curr Opin Cell Biol, 23 (4), 393-403
DOI 10.1016/j.ceb.2011.03.008, PubMed 21474295 -
Cell biology. A helix for the final cut
Science, 331 (6024), 1533-4
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Shaping development with ESCRTs
Nat Cell Biol, 14 (1), 38-45
DOI 10.1038/ncb2381, PubMed 22193162 -
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor
Exp Cell Res, 317 (13), 1804-16
DOI 10.1016/j.yexcr.2011.05.016, PubMed 21635887 -
A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
PLoS One, 6 (3), e17086
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Clathrin-independent endocytosis: mechanisms and function
Curr Opin Cell Biol, 23 (4), 413-20
DOI 10.1016/j.ceb.2011.03.007, PubMed 21466956 -
Cell differentiation: midbody remnants - junk or fate factors?
Curr Biol, 21 (23), R958-60
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Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells
Photochem Photobiol Sci, 10 (11), 1773-82
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Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer, 131 (3), 570-81
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Comment on "short ligands affect modes of QD uptake and elimination in human cells"
ACS Nano, 5 (10), 7690; author reply 7691-2
DOI 10.1021/nn2021953, PubMed 22023400 -
A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation
Biochem J, 436 (2), 371-85
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Harald Stenmark: hands on FYVE-fingers. Interview by Caitlin Sedwick
J Cell Biol, 192 (4), 544-5
DOI 10.1083/jcb.1924pi, PubMed 21339328 -
Liposarcoma Cells with Aldefluor and CD133 Activity have a Cancer Stem Cell Potential
Clin Sarcoma Res, 1 (1), 8
DOI 10.1186/2045-3329-1-8, PubMed 22612877 -
Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl
FEBS Lett, 585 (12), 1741-7
DOI 10.1016/j.febslet.2011.04.056, PubMed 21570973 -
Protein C mutation (A267T) results in ER retention and unfolded protein response activation
PLoS One, 6 (8), e24009
DOI 10.1371/journal.pone.0024009, PubMed 21901152 -
cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
Autophagy, 7 (10), 1199-211
DOI 10.4161/auto.7.10.16649, PubMed 21750416 -
Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
Blood, 118 (12), 3331-9
DOI 10.1182/blood-2011-03-341651, PubMed 21725051 -
ESCRT proteins and cell signalling
Traffic, 12 (10), 1291-7
DOI 10.1111/j.1600-0854.2011.01210.x, PubMed 21518165 -
Fibroblast growth factors and their receptors in cancer
Biochem J, 437 (2), 199-213
DOI 10.1042/BJ20101603, PubMed 21711248 -
Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity
Exp Cell Res, 317 (7), 1005-15
DOI 10.1016/j.yexcr.2011.01.003, PubMed 21223966 -
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain
Autophagy, 7 (9), 1011-27
DOI 10.4161/auto.7.9.16436, PubMed 21610319
Publications 2010
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Protein secretion: unconventional exit by exophagy
Curr Biol, 20 (9), R415-8
DOI 10.1016/j.cub.2010.03.011, PubMed 20462486 -
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
Autophagy, 6 (3), 330-44
DOI 10.4161/auto.6.3.11226, PubMed 20168092 -
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
Mol Cell, 38 (2), 265-79
DOI 10.1016/j.molcel.2010.04.007, PubMed 20417604 -
An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy
PLoS One, 5 (1), e8877
DOI 10.1371/journal.pone.0008877, PubMed 20126274 -
Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster
Curr Biol, 20 (10), 944-50
DOI 10.1016/j.cub.2010.03.068, PubMed 20451383 -
Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
J Infect Dis, 201 (5), 783-92
DOI 10.1086/650493, PubMed 20121435 -
Roles of fibroblast growth factor receptors in carcinogenesis
Mol Cancer Res, 8 (11), 1439-52
DOI 10.1158/1541-7786.MCR-10-0168, PubMed 21047773 -
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
Immunity, 33 (4), 583-96
DOI 10.1016/j.immuni.2010.09.010, PubMed 20933442 -
The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication
Mol Microbiol, 79 (2), 433-46
DOI 10.1111/j.1365-2958.2010.07453.x, PubMed 21219462 -
A novel DNA gyrase inhibitor rescues Escherichia coli dnaAcos mutant cells from lethal hyperinitiation
J Antimicrob Chemother, 65 (5), 924-30
DOI 10.1093/jac/dkq071, PubMed 20228083 -
The Norse god of autophagy. Interviewed by Daniel J Klionsky
Autophagy, 6 (8), 1017-31
DOI 10.4161/auto.6.8.13092, PubMed 20814236 -
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Autophagy, 6 (7), 863-70
DOI 10.4161/auto.6.7.13033, PubMed 20724836 -
Invariant chain increases the half-life of MHC II by delaying endosomal maturation
Immunol Cell Biol, 89 (5), 619-29
DOI 10.1038/icb.2010.143, PubMed 21116285 -
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes
Dev Cell, 19 (1), 148-59
DOI 10.1016/j.devcel.2010.06.010, PubMed 20643357 -
Ubiquitination of α-integrin cytoplasmic tails
Commun Integr Biol, 3 (6), 583-5
DOI 10.4161/cib.3.6.13176, PubMed 21331246 -
Autophagy and its physiological relevance in arthropods: current knowledge and perspectives
Autophagy, 6 (5), 575-88
DOI 10.4161/auto.6.5.11962, PubMed 20458176 -
Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis
Trends Cell Biol, 20 (11), 642-9
DOI 10.1016/j.tcb.2010.08.010, PubMed 20880709 -
Autophagy as a trigger for cell death Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
Autophagy, 6 (8), 1214-+
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Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
Autophagy, 6 (8), 1214-5
DOI 10.4161/auto.6.8.13694, PubMed 20935512 -
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
J Cell Biol, 190 (4), 523-31
DOI 10.1083/jcb.201002035, PubMed 20713604 -
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
J Cell Biol, 188 (2), 253-69
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Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms
Cell Microbiol, 12 (12), 1809-20
DOI 10.1111/j.1462-5822.2010.01512.x, PubMed 20690924 -
Interplay between toxin transport and flotillin localization
PLoS One, 5 (1), e8844
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ESCRT & Co
Biol Cell, 102 (5), 293-318
DOI 10.1042/BC20090161, PubMed 20222872 -
p62, an autophagy hero or culprit?
Nat Cell Biol, 12 (3), 207-9
DOI 10.1038/ncb0310-207, PubMed 20190829 -
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
Nat Cell Biol, 12 (4), 362-71
DOI 10.1038/ncb2036, PubMed 20208530 -
Cytokinesis and cancer (vol 584, pg 2652, 2010)
FEBS Lett., 584 (18), 4128
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Cytokinesis and cancer
FEBS Lett, 584 (12), 2652-61
DOI 10.1016/j.febslet.2010.03.044, PubMed 20371245 -
Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine
FEBS Lett, 584 (12), 2626-34
DOI 10.1016/j.febslet.2010.04.008, PubMed 20385131 -
Purification of autophagosomes from rat hepatocytes
Autophagy, 6 (4), 542-7
DOI 10.4161/auto.6.4.11272, PubMed 20505360 -
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
EMBO J, 29 (14), 2421-32
DOI 10.1038/emboj.2010.120, PubMed 20551902 -
New metal-based nanoparticles for intravenous use: requirements for clinical success with focus on medical imaging
Nanomedicine, 6 (6), 730-7
DOI 10.1016/j.nano.2010.05.002, PubMed 20570639 -
Replication patterns and organization of replication forks in Vibrio cholerae
Microbiology (Reading), 157 (Pt 3), 695-708
DOI 10.1099/mic.0.045112-0, PubMed 21163839 -
Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate
J Histochem Cytochem, 58 (11), 1025-32
DOI 10.1369/jhc.2010.955815, PubMed 20713985 -
Activation of the ustilagic acid biosynthesis gene cluster in Ustilago maydis by the C2H2 zinc finger transcription factor Rua1
Appl Environ Microbiol, 76 (8), 2633-40
DOI 10.1128/AEM.02211-09, PubMed 20173069 -
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
Exp Cell Res, 316 (20), 3368-78
DOI 10.1016/j.yexcr.2010.07.008, PubMed 20643123 -
Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport
BMC Cell Biol, 11, 67
DOI 10.1186/1471-2121-11-67, PubMed 20815936 -
The Intracellular Journey of Shiga Toxins
The Open Toxinology Journal, 3, 3-12
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Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells
FEMS Immunol Med Microbiol, 61 (1), 63-75
DOI 10.1111/j.1574-695X.2010.00749.x, PubMed 21054580 -
Shiga toxin increases formation of clathrin-coated pits through Syk kinase
PLoS One, 5 (7), e10944
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ChIP on Chip: surprising results are often artifacts
BMC Genomics, 11, 414
DOI 10.1186/1471-2164-11-414, PubMed 20602746
Publications 2009
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Monitoring autophagic degradation of p62/SQSTM1
Methods Enzymol, 452, 181-97
DOI 10.1016/S0076-6879(08)03612-4, PubMed 19200883 -
Escherichia coli DnaA forms helical structures along the longitudinal cell axis distinct from MreB filaments
Mol Microbiol, 72 (3), 645-57
DOI 10.1111/j.1365-2958.2009.06674.x, PubMed 19400775 -
In DNA replication, the early bird catches the worm
Cell, 136 (5), 812-4
DOI 10.1016/j.cell.2009.02.023, PubMed 19269359 -
Checkpoint regulation of DNA replication
Methods Mol Biol, 521, 55-70
DOI 10.1007/978-1-60327-815-7_4, PubMed 19563101 -
Autophagy in tumour suppression and promotion
Mol Oncol, 3 (4), 366-75
DOI 10.1016/j.molonc.2009.05.007, PubMed 19559660 -
Sorting nexin 8 regulates endosome-to-Golgi transport
Biochem Biophys Res Commun, 390 (1), 109-14
DOI 10.1016/j.bbrc.2009.09.076, PubMed 19782049 -
Ligand-specific induction of endocytosis in taste receptor cells
J Exp Biol, 212 (Pt 1), 42-9
DOI 10.1242/jeb.025700, PubMed 19088209 -
Quantum dot bioconjugates: uptake into cells and induction of changes in normal cellular transport
San Jose, CA, USA, SPIE, 1, 7189[1], 71890T-9
PublikaID 29 -
Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells
Cell Microbiol, 11 (5), 780-95
DOI 10.1111/j.1462-5822.2009.01291.x, PubMed 19159389 -
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
J Cell Sci, 122 (Pt 21), 3883-93
DOI 10.1242/jcs.053801, PubMed 19808888 -
ESCRTing membrane deformation
Cell, 136 (1), 15-7
DOI 10.1016/j.cell.2008.12.029, PubMed 19135881 -
Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli
Genes Cells, 14 (5), 643-57
DOI 10.1111/j.1365-2443.2009.01298.x, PubMed 19371375 -
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
Autophagy, 5 (3), 298-302
DOI 10.4161/auto.5.3.7454, PubMed 19066465 -
A reduction in ribonucleotide reductase activity slows down the chromosome replication fork but does not change its localization
PLoS One, 4 (10), e7617
DOI 10.1371/journal.pone.0007617, PubMed 19898675 -
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
Nature, 458 (7237), 445-52
DOI 10.1038/nature07961, PubMed 19325624 -
Disruption of Vps4 and JNK function in Drosophila causes tumour growth
PLoS One, 4 (2), e4354
DOI 10.1371/journal.pone.0004354, PubMed 19194501 -
The role of ESCRT proteins in attenuation of cell signalling
Biochem Soc Trans, 37 (Pt 1), 137-42
DOI 10.1042/BST0370137, PubMed 19143618 -
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease
Exp Cell Res, 315 (17), 3014-27
DOI 10.1016/j.yexcr.2009.07.012, PubMed 19619532 -
How do ESCRT proteins control autophagy?
J Cell Sci, 122 (Pt 13), 2179-83
DOI 10.1242/jcs.050021, PubMed 19535733 -
Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin
Traffic, 10 (7), 868-82
DOI 10.1111/j.1600-0854.2009.00919.x, PubMed 19453975 -
Endocytosis and retrograde transport of Shiga toxin
Toxicon, 56 (7), 1181-5
DOI 10.1016/j.toxicon.2009.11.021, PubMed 19951719 -
Sequestration assays for mammalian autophagy
Methods Enzymol, 452, 63-83
DOI 10.1016/S0076-6879(08)03605-7, PubMed 19200876 -
Global transcriptional response after exposure of fission yeast cells to ultraviolet light
BMC Cell Biol, 10, 87
DOI 10.1186/1471-2121-10-87, PubMed 20015352 -
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
DOI 10.1371/journal.pone.0005935, PubMed 19529763 -
β-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol, 11 (5), 796-807
DOI 10.1111/j.1462-5822.2009.01292.x, PubMed 19159388 -
Rab GTPases as coordinators of vesicle traffic
Nat Rev Mol Cell Biol, 10 (8), 513-25
DOI 10.1038/nrm2728, PubMed 19603039 -
Seeing is believing
Nat Rev Mol Cell Biol, 10 (9), 582
DOI 10.1038/nrm2747, PubMed 19702012 -
The right half of the Escherichia coli replication origin is not essential for viability, but facilitates multi-forked replication
Mol Microbiol, 74 (2), 467-79
DOI 10.1111/j.1365-2958.2009.06877.x, PubMed 19737351 -
Multivesicular endosome biogenesis in the absence of ESCRTs
Traffic, 10 (7), 925-37
DOI 10.1111/j.1600-0854.2009.00920.x, PubMed 19490536 -
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
J Cell Sci, 122 (Pt 14), 2413-23
DOI 10.1242/jcs.046391, PubMed 19571114 -
The Escherichia coli SeqA protein
Plasmid, 61 (3), 141-50
DOI 10.1016/j.plasmid.2009.02.004, PubMed 19254745 -
BayesPI - a new model to study protein-DNA interactions: a case study of condition-specific protein binding parameters for Yeast transcription factors
BMC Bioinformatics, 10, 345
DOI 10.1186/1471-2105-10-345, PubMed 19857274 -
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5
Histochem Cell Biol, 133 (1), 41-55
DOI 10.1007/s00418-009-0643-8, PubMed 19830447 -
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
DOI 10.1016/j.cellsig.2009.03.005, PubMed 19289168 -
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin
J Biol Chem, 284 (37), 25388-403
DOI 10.1074/jbc.M109.001289, PubMed 19574212 -
Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane
Biochemistry, 48 (30), 7209-18
DOI 10.1021/bi9007353, PubMed 19558187 -
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway
J Immunol, 183 (9), 5909-16
DOI 10.4049/jimmunol.0900441, PubMed 19812211 -
Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues
Biochem J, 417 (2), 535-45
DOI 10.1042/BJ20081284, PubMed 18831714
Publications 2008
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The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemimethylated DNA
J Mol Biol, 384 (5), 1076-85
DOI 10.1016/j.jmb.2008.09.042, PubMed 18835566 -
Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1
EMBO Rep, 9 (2), 171-8
DOI 10.1038/sj.embor.7401152, PubMed 18188183 -
Rapid regulation of protein activity in fission yeast
BMC Cell Biol, 9, 23
DOI 10.1186/1471-2121-9-23, PubMed 18457584 -
Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates
Methods Enzymol, 451, 639-51
DOI 10.1016/S0076-6879(08)03235-7, PubMed 19185743 -
Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly
J Leukoc Biol, 85 (3), 469-80
DOI 10.1189/jlb.1107790, PubMed 19112091 -
DnaA protein interacts with RNA polymerase and partially protects it from the effect of rifampicin
Mol Microbiol, 71 (4), 1018-30
DOI 10.1111/j.1365-2958.2008.06585.x, PubMed 19170875 -
A robust screen for novel antibiotics: specific knockout of the initiator of bacterial DNA replication
FEMS Microbiol Lett, 281 (2), 210-4
DOI 10.1111/j.1574-6968.2008.01103.x, PubMed 18312360 -
A tribute to Arthur Kornberg 1918-2007
Nat Struct Mol Biol, 15 (1), 2-17
DOI 10.1038/nsmb0108-2, PubMed 18176549 -
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome
Am J Hum Genet, 82 (4), 1003-10
DOI 10.1016/j.ajhg.2008.01.013, PubMed 18342287 -
The multiple facets of the intra-S checkpoint
Cell Cycle, 7 (15), 2315-20
DOI 10.4161/cc.6389, PubMed 18677104 -
PKCbetaII modulates translation independently from mTOR and through RACK1
Biochem J, 415 (1), 77-85
DOI 10.1042/BJ20080463, PubMed 18557705 -
Eukaryotic ribosomes host PKC activity
Biochem Biophys Res Commun, 376 (1), 65-9
DOI 10.1016/j.bbrc.2008.08.118, PubMed 18768137 -
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
Mol Biol Cell, 19 (8), 3390-403
DOI 10.1091/mbc.e07-12-1219, PubMed 18480409 -
ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death
Infect Immun, 76 (10), 4600-8
DOI 10.1128/IAI.00651-08, PubMed 18710868 -
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?
Autophagy, 4 (7), 849-50
DOI 10.4161/auto.6845, PubMed 18758232 -
The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint
J Cell Sci, 121 (Pt 24), 4047-54
DOI 10.1242/jcs.035428, PubMed 19033384 -
The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates
Autophagy, 4 (4), 500-6
DOI 10.4161/auto.5829, PubMed 18326940 -
Mechanisms and functions of endocytosis
J Cell Biol, 180 (1), 7-11
DOI 10.1083/jcb.200711073, PubMed 18195098 -
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45
Mol Biol Cell, 19 (10), 4167-76
DOI 10.1091/mbc.e08-07-0716, PubMed 18685079 -
Monitoring autophagy in insect eggs
Methods Enzymol, 451, 669-83
DOI 10.1016/S0076-6879(08)03237-0, PubMed 19185745 -
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
J Cell Biol, 180 (6), 1065-71
DOI 10.1083/jcb.200711108, PubMed 18347073 -
Membranes and organelles
Curr Opin Cell Biol, 20 (4), 357-9
DOI 10.1016/j.ceb.2008.06.005, PubMed 18588977 -
ESCRTing autophagic clearance of aggregating proteins
Autophagy, 4 (2), 233-236
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ESCRT functions in autophagy and associated disease
Cell Cycle, 7 (9), 1166-72
DOI 10.4161/cc.7.9.5784, PubMed 18418046 -
Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity
Histochem Cell Biol, 129 (3), 267-76
DOI 10.1007/s00418-007-0376-5, PubMed 18193449 -
Cell biology: Viruses in camouflage
Nature, 453 (7194), 466-7
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Self-eating from an ER-associated cup
J Cell Biol, 182 (4), 621-2
DOI 10.1083/jcb.200807061, PubMed 18725534 -
ESCRT proteins in physiology and disease
Exp Cell Res, 315 (9), 1619-26
DOI 10.1016/j.yexcr.2008.10.013, PubMed 19013455 -
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
Mol Cell Biol, 28 (12), 4129-41
DOI 10.1128/MCB.02117-07, PubMed 18411303 -
Cellular trafficking of quantum dot-ligand bioconjugates and their induction of changes in normal routing of unconjugated ligands
Nano Lett, 8 (7), 1858-65
DOI 10.1021/nl0803848, PubMed 18570482 -
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
Mol Biol Cell, 19 (8), 3454-62
DOI 10.1091/mbc.e07-10-0988, PubMed 18508924 -
FGF-1: from biology through engineering to potential medical applications
Crit Rev Clin Lab Sci, 45 (1), 91-135
DOI 10.1080/10408360701713120, PubMed 18293181
Publications 2007
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The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
Exp Cell Res, 313 (8), 1696-709
DOI 10.1016/j.yexcr.2007.02.017, PubMed 17382318 -
Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus
J Cell Physiol, 212 (1), 148-56
DOI 10.1002/jcp.21014, PubMed 17311277 -
Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling
Biochimie, 89 (5), 637-57
DOI 10.1016/j.biochi.2006.12.012, PubMed 17335953 -
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
J Cell Biol, 179 (3), 485-500
DOI 10.1083/jcb.200702115, PubMed 17984323 -
Organization of sister origins and replisomes during multifork DNA replication in Escherichia coli
EMBO J, 26 (21), 4514-22
DOI 10.1038/sj.emboj.7601871, PubMed 17914458 -
The Gcn2 kinase as a cell cycle regulator
Cell Cycle, 6 (22), 2768-72
DOI 10.4161/cc.6.22.4933, PubMed 17986863 -
Aberrant receptor signaling and trafficking as mechanisms in oncogenesis
Crit Rev Oncog, 13 (1), 39-74
DOI 10.1615/critrevoncog.v13.i1.20, PubMed 17956217 -
Origin and evolution of self-consumption: autophagy
Adv Exp Med Biol, 607, 111-8
DOI 10.1007/978-0-387-74021-8_9, PubMed 17977463 -
How shall I eat thee?
Autophagy, 3 (5), 413-6
DOI 10.4161/auto.4377, PubMed 17568180 -
Structural requirements for furin-induced cleavage and activation of Shiga toxin
Biochem Biophys Res Commun, 357 (1), 144-9
DOI 10.1016/j.bbrc.2007.03.110, PubMed 17407762 -
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells
Eur J Cell Biol, 86 (7), 405-15
DOI 10.1016/j.ejcb.2007.05.001, PubMed 17601634 -
ESCRTs
Curr Biol, 17 (2), R42-3
DOI 10.1016/j.cub.2006.12.009, PubMed 17240322 -
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation
Traffic, 8 (11), 1617-29
DOI 10.1111/j.1600-0854.2007.00630.x, PubMed 17714434 -
Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol
Virology, 369 (1), 105-18
DOI 10.1016/j.virol.2007.07.021, PubMed 17714753 -
A nuclear export sequence located on a beta-strand in fibroblast growth factor-1
J Biol Chem, 282 (36), 26245-56
DOI 10.1074/jbc.M611234200, PubMed 17616529 -
Functional taxonomy of bacterial hyperstructures
Microbiol Mol Biol Rev, 71 (1), 230-53
DOI 10.1128/MMBR.00035-06, PubMed 17347523 -
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
J Biol Chem, 282 (33), 24131-45
DOI 10.1074/jbc.M702824200, PubMed 17580304 -
RILP is required for the proper morphology and function of late endosomes
J Cell Sci, 120 (Pt 21), 3729-37
DOI 10.1242/jcs.017301, PubMed 17959629 -
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
Exp Cell Res, 314 (4), 801-13
DOI 10.1016/j.yexcr.2007.10.014, PubMed 18031739 -
Developmental biology: moonlighting at the pole
Nature, 445 (7127), 497-9
DOI 10.1038/445497a, PubMed 17268460 -
ESCRTs and Fab1 regulate distinct steps of autophagy
Curr Biol, 17 (20), 1817-25
DOI 10.1016/j.cub.2007.09.032, PubMed 17935992 -
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Autophagy, 4 (2), 176-84
DOI 10.4161/auto.5269, PubMed 18059160 -
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles
Genetics, 176 (2), 1283-97
DOI 10.1534/genetics.106.065011, PubMed 17435236 -
Stimulating the cell's appetite for itself
Nat Chem Biol, 3 (6), 304-6
DOI 10.1038/nchembio0607-304, PubMed 17510644 -
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
Traffic, 8 (3), 297-309
DOI 10.1111/j.1600-0854.2006.00527.x, PubMed 17319803 -
Polyunsaturated fatty acids regulate Shiga toxin transport
Biochem Biophys Res Commun, 364 (2), 283-8
DOI 10.1016/j.bbrc.2007.09.126, PubMed 17942073 -
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
DOI 10.1074/jbc.M610886200, PubMed 17403690 -
A novel checkpoint mechanism regulating the G1/S transition
Genes Dev, 21 (6), 649-54
DOI 10.1101/gad.421807, PubMed 17369398 -
SNX1 and SNX2 mediate retrograde transport of Shiga toxin
Biochem Biophys Res Commun, 358 (2), 566-70
DOI 10.1016/j.bbrc.2007.04.159, PubMed 17498660 -
Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK
Oncogene, 26 (44), 6372-85
DOI 10.1038/sj.onc.1210473, PubMed 17533378 -
Proteomic analysis of membrane-associated proteins from rat liver autophagosomes
Autophagy, 3 (4), 300-22
DOI 10.4161/auto.3910, PubMed 17377489
Publications 2006
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The function of ubiquitin-binding protein complexes in endocytic downregulation of growth factor receptors
Crit Rev Oncog, 12 (3-4), 301; discussion 301-2
DOI 10.1615/critrevoncog.v12.i3-4.90, PubMed 17425510 -
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Mol Biol Cell, 17 (6), 2513-23
DOI 10.1091/mbc.e05-10-0915, PubMed 16554368 -
DisA, a busy bee that monitors chromosome integrity
Cell, 125 (4), 641-3
DOI 10.1016/j.cell.2006.05.004, PubMed 16713555 -
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Gene, 371 (1), 34-41
DOI 10.1016/j.gene.2005.11.009, PubMed 16448788 -
A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli
EMBO J, 25 (5), 1137-47
DOI 10.1038/sj.emboj.7600990, PubMed 16482221 -
Depletion of sphingolipids facilitates endosome to Golgi transport of ricin
Traffic, 7 (9), 1243-53
DOI 10.1111/j.1600-0854.2006.00456.x, PubMed 16919154 -
Working out coupled monoubiquitination
Nat Cell Biol, 8 (11), 1218-9
DOI 10.1038/ncb1106-1218, PubMed 17077855 -
Specification of SUMO1- and SUMO2-interacting motifs
J Biol Chem, 281 (23), 16117-27
DOI 10.1074/jbc.M512757200, PubMed 16524884 -
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting
Nat Struct Mol Biol, 13 (3), 272-7
DOI 10.1038/nsmb1051, PubMed 16462748 -
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain
Nat Struct Mol Biol, 13 (11), 1031-2
DOI 10.1038/nsmb1163, PubMed 17057714 -
Regulation of ubiquitin-binding proteins by monoubiquitination
Nat Cell Biol, 8 (2), 163-9
DOI 10.1038/ncb1354, PubMed 16429130 -
Annexin A2 recognises a specific region in the 3'-UTR of its cognate messenger RNA
Biochim Biophys Acta, 1763 (11), 1325-34
DOI 10.1016/j.bbamcr.2006.08.043, PubMed 17045350 -
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
EMBO J, 25 (4), 683-92
DOI 10.1038/sj.emboj.7600991, PubMed 16467847 -
Transcriptional targeting of small interfering RNAs into cancer cells
Biochem Biophys Res Commun, 350 (4), 854-9
DOI 10.1016/j.bbrc.2006.09.127, PubMed 17034763 -
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits
Mol Cell Biol, 26 (2), 389-401
DOI 10.1128/MCB.26.2.389-401.2006, PubMed 16382132 -
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae
Traffic, 7 (11), 1518-27
DOI 10.1111/j.1600-0854.2006.00487.x, PubMed 16984407 -
Reduced binding of FGF1 to mutant fibroblast growth factor receptor 3
Growth Factors, 24 (2), 111-9
DOI 10.1080/08977190600621388, PubMed 16801131 -
Ligand-specific dynamics of the androgen receptor at its response element in living cells
Mol Cell Biol, 27 (5), 1823-43
DOI 10.1128/MCB.01297-06, PubMed 17189428 -
Endocytic processing of connexin43 gap junctions: a morphological study
Biochem J, 393 (Pt 1), 59-67
DOI 10.1042/BJ20050674, PubMed 16162097 -
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
Exp Cell Res, 312 (11), 2018-27
DOI 10.1016/j.yexcr.2006.03.002, PubMed 16600212 -
Regulation of membrane traffic by phosphoinositide 3-kinases
J Cell Sci, 119 (Pt 4), 605-14
DOI 10.1242/jcs.02855, PubMed 16467569 -
How a RING finger protein and a steroid hormone control autophagy
Autophagy, 2 (4), 321-2
DOI 10.4161/auto.3091, PubMed 16874068 -
FGF-1 as a possible carrier for targeted drug delivery
Oncol Res, 16 (1), 27-34
DOI 10.3727/000000006783981242, PubMed 16783965 -
A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells
Eur J Immunol, 36 (1), 129-38
DOI 10.1002/eji.200535178, PubMed 16323243 -
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp Cell Res, 312 (16), 3036-48
DOI 10.1016/j.yexcr.2006.06.004, PubMed 16859684 -
Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films
J Struct Biol, 158 (3), 386-400
DOI 10.1016/j.jsb.2006.12.006, PubMed 17287132 -
Hrs makes receptors silent: a key to endosomal protein sorting
Crit Rev Oncog, 12 (3-4), 295, discussion 295-6
DOI 10.1615/critrevoncog.v12.i3-4.70, PubMed 17425508 -
A new side to ubiquitin
Trends Biochem Sci, 31 (10), 541-4
DOI 10.1016/j.tibs.2006.07.009, PubMed 16901703 -
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
J Cell Sci, 119 (Pt 12), 2414-24
DOI 10.1242/jcs.02978, PubMed 16720641 -
DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1
EMBO Rep, 7 (11), 1134-9
DOI 10.1038/sj.embor.7400827, PubMed 17039252 -
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
Mol Biol Cell, 17 (9), 3989-4001
DOI 10.1091/mbc.e06-03-0239, PubMed 16837550 -
Analyzing phosphoinositides and their interacting proteins
Nat Methods, 3 (4), 251-8
DOI 10.1038/nmeth867, PubMed 16554828 -
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
J Cell Sci, 119 (Pt 19), 3944-57
DOI 10.1242/jcs.03153, PubMed 16954148 -
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM
J Environ Pathol Toxicol Oncol, 25 (1-2), 159-71
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.90, PubMed 16566715 -
CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
EMBO J, 25 (16), 3738-49
DOI 10.1038/sj.emboj.7601267, PubMed 16888620 -
Endosomal and non-endosomal functions of ESCRT proteins
Trends Cell Biol, 16 (6), 317-26
DOI 10.1016/j.tcb.2006.04.004, PubMed 16716591 -
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
Mol Biol Cell, 17 (4), 1664-75
DOI 10.1091/mbc.e05-10-0961, PubMed 16452630 -
Functional diversity of FGF-2 isoforms by intracellular sorting
Bioessays, 28 (5), 504-14
DOI 10.1002/bies.20405, PubMed 16615083 -
Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail
J Cell Sci, 119 (Pt 20), 4332-41
DOI 10.1242/jcs.03209, PubMed 17003104 -
Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'
Traffic, 7 (6), 663-72
DOI 10.1111/j.1600-0854.2006.00418.x, PubMed 16683916 -
FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus
J Biol Chem, 281 (16), 11405-12
DOI 10.1074/jbc.M600477200, PubMed 16495214 -
Structural requirements of FGF-1 for receptor binding and translocation into cells
Biochemistry, 45 (51), 15338-48
DOI 10.1021/bi0618114, PubMed 17176056
Publications 2005
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An oriC-like distribution of GATC sites mediates full sequestration of non-origin sequences in Escherichia coli
J Mol Biol, 350 (1), 7-11
DOI 10.1016/j.jmb.2005.04.055, PubMed 15922360 -
The Escherichia coli baby cell column: a novel cell synchronization method provides new insight into the bacterial cell cycle
Mol Microbiol, 57 (2), 380-91
DOI 10.1111/j.1365-2958.2005.04693.x, PubMed 15978072 -
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
J Cell Biol, 171 (4), 603-14
DOI 10.1083/jcb.200507002, PubMed 16286508 -
Alix regulates cortical actin and the spatial distribution of endosomes
J Cell Sci, 118 (Pt 12), 2625-35
DOI 10.1242/jcs.02382, PubMed 15914539 -
Fluorimetric HPLC detection of endogenous riboflavin 4',5'-cyclic phosphate in rat liver at nanomolar concentrations
Anal Biochem, 341 (2), 214-9
DOI 10.1016/j.ab.2005.01.060, PubMed 15907866 -
When and from whom do female pied flycatchers (Ficedula hypoleuca) solicit copulations
Behaviour, 142, 1059-1076
DOI 10.1163/156853905774405335 -
Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism
Traffic, 6 (2), 144-56
DOI 10.1111/j.1600-0854.2005.00258.x, PubMed 15634214 -
Cellular internalization of cytolethal distending toxin: a new end to a known pathway
Cell Microbiol, 7 (7), 921-34
DOI 10.1111/j.1462-5822.2005.00520.x, PubMed 15953025 -
Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
J Cell Sci, 118 (Pt 17), 3869-81
DOI 10.1242/jcs.02509, PubMed 16091423 -
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity
J Neurosci, 25 (11), 2793-802
DOI 10.1523/JNEUROSCI.4090-04.2005, PubMed 15772339 -
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B
Cell, 121 (3), 437-50
DOI 10.1016/j.cell.2005.02.017, PubMed 15882625 -
Caveolae: stable membrane domains with a potential for internalization
Traffic, 6 (9), 720-4
DOI 10.1111/j.1600-0854.2005.00314.x, PubMed 16101676 -
[Ricin--a therapeutic agent and a biological weapon]
Tidsskr Nor Laegeforen, 125 (18), 2477-9
PubMed 16186864 -
Tumour-associated Proteins in Oral Squamous Cell Carcinomas by Proteomics
Cancer Genomics Proteomics, 2 (6), 353-363
PubMed 31394652 -
Manipulation of male quality in wild tits: effects on paternity loss
Behav. Ecol., 16 (4), 747-754
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The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5delta differ in their ability to interact with the small GTPase Rab4
FEBS J, 272 (1), 37-46
DOI 10.1111/j.1742-4658.2004.04387.x, PubMed 15634330 -
Shiga toxin regulates its entry in a Syk-dependent manner
Mol Biol Cell, 17 (3), 1096-109
DOI 10.1091/mbc.e05-08-0766, PubMed 16371508 -
Pancreatic trypsin activates human promatrix metalloproteinase-2
J Mol Biol, 350 (4), 682-98
DOI 10.1016/j.jmb.2005.05.018, PubMed 15950241 -
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
Int J Cancer, 116 (3), 359-67
DOI 10.1002/ijc.21015, PubMed 15800944 -
Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication
J Bacteriol, 187 (12), 3913-20
DOI 10.1128/JB.187.12.3913-3920.2005, PubMed 15939703 -
Specific N-terminal interactions of the Escherichia coli SeqA protein are required to form multimers that restrain negative supercoils and form foci
Genes Cells, 10 (11), 1039-49
DOI 10.1111/j.1365-2443.2005.00898.x, PubMed 16236133 -
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins
Biochem J, 386 (Pt 2), 237-44
DOI 10.1042/BJ20040609, PubMed 15461583 -
Delivery into cells: lessons learned from plant and bacterial toxins
Gene Ther, 12 (11), 865-72
DOI 10.1038/sj.gt.3302525, PubMed 15815697 -
Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs
Methods Mol Biol, 309, 83-91
DOI 10.1385/1-59259-935-4:083, PubMed 15990399 -
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain
J Biol Chem, 280 (20), 19600-6
DOI 10.1074/jbc.M501510200, PubMed 15755741 -
Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels
Autophagy, 1 (3), 157-62
DOI 10.4161/auto.1.3.2037, PubMed 16874067 -
Diphtheria toxin translocation across cellular membranes is regulated by sphingolipids
Biochem Biophys Res Commun, 329 (2), 465-73
DOI 10.1016/j.bbrc.2005.02.005, PubMed 15737610 -
Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria
Toxicon, 46 (8), 900-6
DOI 10.1016/j.toxicon.2005.08.015, PubMed 16260019 -
Individual fluctuating asymmetry in pied flycatchers (Ficedula hypoleuca) persists across moults, but is not heritable and not related to fitness
Evol. Ecol. Res., 7 (3), 381-406 -
The A-subunit of surface-bound Shiga toxin stimulates clathrin-dependent uptake of the toxin
FEBS J, 272 (16), 4103-13
DOI 10.1111/j.1742-4658.2005.04835.x, PubMed 16098193 -
Actin-based motility of endosomes is linked to the polar tip growth of root hairs
Eur J Cell Biol, 84 (6), 609-21
DOI 10.1016/j.ejcb.2004.12.029, PubMed 16032929 -
Two nuclear localization signals required for transport from the cytosol to the nucleus of externally added FGF-1 translocated into cells
Biochemistry, 44 (16), 6071-80
DOI 10.1021/bi047403m, PubMed 15835896 -
Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action
J Mol Biol, 352 (4), 860-75
DOI 10.1016/j.jmb.2005.07.066, PubMed 16126225
Publications 2004
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Re-replication from non-sequesterable origins generates three-nucleoid cells which divide asymmetrically
Mol Microbiol, 51 (6), 1589-600
DOI 10.1111/j.1365-2958.2003.03943.x, PubMed 15009887 -
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation
Mol Biol Cell, 15 (9), 4337-46
DOI 10.1091/mbc.e04-03-0250, PubMed 15240819 -
Defective downregulation of receptor tyrosine kinases in cancer
EMBO J, 23 (14), 2707-12
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Protein targeting to endosomes and phagosomes via FYVE and PX domains
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[Impaired cerebral autoregulation in asymptomatic patients with carotid artery stenosis: comparison of acetazolamide-SPECT and transcranial CO(2)-dopplersonography]
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The biogenesis of multivesicular endosomes
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Early learning affects social dominance: interspecifically cross-fostered tits become subdominant
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ERK2 prohibits apoptosis-induced subcellular translocation of orphan nuclear receptor NGFI-B/TR3
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Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors
Bioessays, 26 (9), 993-1004
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Positive supercoiling is generated in the presence of Escherichia coli SeqA protein
Mol Microbiol, 54 (1), 123-31
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Cloning and characterization of the genes encoding toxic lectins in mistletoe (Viscum album L)
Eur J Biochem, 271 (12), 2350-60
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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases
J Biol Chem, 279 (31), 32786-95
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Efficient endosome-to-Golgi transport of Shiga toxin is dependent on dynamin and clathrin
J Cell Sci, 117 (Pt 11), 2321-31
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Comparison of cAMP-dependent protein kinase substrate specificity in reaction with proteins and synthetic peptides
Biochim Biophys Acta, 1747 (2), 261-6
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Replication fork and SeqA focus distributions in Escherichia coli suggest a replication hyperstructure dependent on nucleotide metabolism
Mol Microbiol, 52 (6), 1597-612
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Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation
Toxicol Sci, 82 (2), 628-37
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Germinating fission yeast spores delay in G1 in response to UV irradiation
BMC Cell Biol, 5 (1), 40
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The history of ricin, abrin and related toxins
Toxicon, 44 (4), 361-70
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Genetic instability of heterozygous, hybrid, natural wine yeasts
Appl Environ Microbiol, 70 (8), 4686-91
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Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
Dev Cell, 7 (2), 179-92
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Pathways followed by protein toxins into cells
Int J Med Microbiol, 293 (7-8), 483-90
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Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
J Cell Biol, 164 (6), 923-33
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Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
J Cell Sci, 117 (Pt 18), 4239-51
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The structure of an endosomal protein sorter
Dev Cell, 7 (4), 457-8
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Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol Biol Cell, 15 (8), 3591-604
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Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus
J Cell Sci, 117 (Pt 9), 1807-19
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Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria
Mol Cell Biol, 24 (10), 4593-604
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Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1
Mol Biol Cell, 16 (2), 794-810
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Signaling, internalization, and intracellular activity of fibroblast growth factor
Curr Top Microbiol Immunol, 286, 45-79
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Design of fully active FGF-1 variants with increased stability
Protein Eng Des Sel, 17 (8), 603-11
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Publications 2003
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Excess SeqA prolongs sequestration of oriC and delays nucleoid segregation and cell division
EMBO J, 22 (2), 315-23
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Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
J Cell Biol, 162 (3), 435-42
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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
J Biol Chem, 278 (14), 12513-21
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Coupling the cell cycle to cell growth
EMBO Rep, 4 (8), 757-60
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Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines
Bioorg Med Chem Lett, 13 (5), 877-80
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Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein
J Bacteriol, 185 (10), 3244-8
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IL-7 receptor is present on human microvascular endothelial cells
Immunol Lett, 86 (2), 163-8
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Lack of SeqA focus formation, specific DNA binding and proper protein multimerization in the Escherichia coli sequestration mutant seqA2
Mol Microbiol, 47 (3), 619-32
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Lack of inverse dose-rate effect and binding of the retinoblastoma gene product in the nucleus of human cancer T-47D cells arrested in G2 by ionizing radiation
Int J Radiat Biol, 79 (6), 413-22
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Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes
Histochem Cell Biol, 120 (6), 445-53
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Endocytosis and signaling: a relationship under development
Cell, 115 (5), 513-21
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The cytoplasmic tail of invariant chain modulates antigen processing and presentation
Eur J Immunol, 33 (2), 277-86
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Thermal depolymerization of alginate in the solid state
Carbohydr. Polym., 54 (4), 431-438
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Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA
Proc Natl Acad Sci U S A, 100 (9), 5175-80
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SeqA protein stimulates the relaxing and decatenating activities of topoisomerase IV
J Biol Chem, 278 (49), 48779-85
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Characterization and tissue expression of acidic fibroblast growth factor binding protein homologue in Drosophila melanogaster
Gene, 310, 185-91
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Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors
J Biol Chem, 278 (41), 39735-46
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Induction of direct endosome to endoplasmic reticulum transport in Chinese hamster ovary (CHO) cells (LdlF) with a temperature-sensitive defect in epsilon-coatomer protein (epsilon-COP)
J Biol Chem, 278 (37), 35850-5
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Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism
Mol Biol Cell, 15 (2), 801-14
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The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
Dev Cell, 5 (5), 709-22
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Phosphatidylinositol-3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1
Anticancer Res, 23 (5A), 4071-7
PubMed 14666721 -
DpiA binding to the replication origin of Escherichia coli plasmids and chromosomes destabilizes plasmid inheritance and induces the bacterial SOS response
J Bacteriol, 185 (20), 6025-31
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Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks, delayed replication initiation and delayed cell division
Mol Microbiol, 50 (1), 349-62
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Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes
Biochem J, 372 (Pt 3), 861-9
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Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes
Biochem J, 373 (Pt 2), 505-13
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Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner
J Biol Chem, 279 (6), 4794-801
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Intra-G1 arrest in response to UV irradiation in fission yeast
Proc Natl Acad Sci U S A, 100 (19), 10758-63
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Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus
Physiol Rev, 83 (1), 163-82
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PI3P signaling regulates receptor sorting but not transport in the endosomal pathway
J Cell Biol, 162 (6), 971-9
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Protein sorting into multivesicular endosomes
Curr Opin Cell Biol, 15 (4), 446-55
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Isolation and characterization of a new d-galactose-binding lectin from Sambucus racemosa L
Protein Pept Lett, 10 (3), 287-93
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Cholera toxin internalization and intoxication - Reply
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Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation
Endocrinology, 144 (5), 1984-93
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Circles in the sand
EMBO Rep, 4 (7), 661-5
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Stable co-existence of separate replicons in Escherichia coli is dependent on once-per-cell-cycle initiation
EMBO J, 22 (1), 140-50
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Degradation of mutant initiator protein DnaA204 by proteases ClpP, ClpQ and Lon is prevented when DNA is SeqA-free
Biochem J, 370 (Pt 3), 867-71
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Role of lipids in the retrograde pathway of ricin intoxication
Traffic, 4 (8), 544-52
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Time resolved spectroscopic optical coherence tomography for diffusion measurements
P SOC PHOTO-OPT INS, 4956, 197-204
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Caveolae: anchored, multifunctional platforms in the lipid ocean
Trends Cell Biol, 13 (2), 92-100
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Cholesterol loading induces a block in the exit of VSVG from the TGN
Traffic, 4 (11), 772-84
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Publications 2002
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Cytotoxic and antibacterial activity of 2-oxopurine derivatives
Bioorg Med Chem Lett, 12 (4), 567-9
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Phosphorylation of Hrs downstream of the epidermal growth factor receptor
Eur J Biochem, 269 (16), 3881-7
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Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
J Biol Chem, 278 (3), 1991-7
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The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor
J Biol Chem, 277 (45), 42755-62
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Membrane ruffling and macropinocytosis in A431 cells require cholesterol
J Cell Sci, 115 (Pt 14), 2953-62
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Synthesis and antimycobacterial activity of 6-arylpurines: the requirements for the N-9 substituent in active antimycobacterial purines
J Med Chem, 45 (6), 1383-6
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The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking
J Cell Sci, 115 (Pt 5), 899-911
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Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments
Proc Natl Acad Sci U S A, 99 (3), 1515-20
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Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes
J Biol Chem, 277 (38), 34826-35
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Selective regulation of the Rab9-independent transport of ricin to the Golgi apparatus by calcium
J Cell Sci, 115 (Pt 17), 3449-56
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[A short form of the heparin-binding EGF-like growth factor with a changed EGF domain]
Mol Biol (Mosk), 36 (1), 76-83
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A short form of the heparin-binding EGF-like growth factor with a changed EGF domain
Mol. Biol., 36 (1), 58-64
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Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1
EMBO J, 21 (17), 4480-90
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Steroid signal transduction activated at the cell membrane: from plants to animals
Acta Biochim Pol, 49 (3), 735-45
PubMed 12422243 -
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
Traffic, 3 (6), 416-27
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The cytoplasmic tail of invariant chain regulates endosome fusion and morphology
Mol Biol Cell, 13 (6), 1846-56
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Early endosomal regulation of Smad-dependent signaling in endothelial cells
J Biol Chem, 277 (20), 18046-52
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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat Cell Biol, 4 (5), 394-8
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Hrs and endocytic sorting of ubiquitinated membrane proteins
Cell Struct Funct, 27 (6), 403-8
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Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding
J Biol Chem, 277 (21), 18954-60
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Membrane traffic exploited by protein toxins
Annu Rev Cell Dev Biol, 18, 1-24
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Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin
FEBS Lett, 529 (1), 49-53
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Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain
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Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity
EMBO J, 21 (15), 4058-69
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Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor
J Biol Chem, 277 (26), 23864-71
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The phosphatidylinositol 3-phosphate-binding FYVE finger
FEBS Lett, 513 (1), 77-84
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A novel chk1-dependent G1/M checkpoint in fission yeast
J Cell Sci, 115 (Pt 18), 3609-18
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Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis
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Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase
Scand J Immunol, 56 (2), 195-203
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Retrograde transport of ricin
Int J Med Microbiol, 291 (6-7), 517-21
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Publications 2001
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Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells
Toxicon, 39 (2-3), 349-62
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Defective initiation in an Escherichia coli dnaA(Cs,Sx) mutant
Biochimie, 83 (1), 25-32
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Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain
J Cell Sci, 114 (Pt 9), 1677-89
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Ability of the Tat basic domain and VP22 to mediate cell binding, but not membrane translocation of the diphtheria toxin A-fragment
Biochemistry, 40 (14), 4349-58
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Reconstitution of clathrin-independent endocytosis at the apical domain of permeabilized MDCK II cells: requirement for a Rho-family GTPase
Traffic, 2 (1), 26-36
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Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins
Biochem J, 355 (Pt 2), 249-58
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Phosphoinositides and phagocytosis
J Cell Biol, 155 (1), 15-7
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Cell biology. A lipid oils the endocytosis machine
Science, 291 (5506), 993-4
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Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases
Mol Biol Cell, 12 (7), 2099-107
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Trafficking of phosphatidylinositol 3-phosphate from the trans-Golgi network to the lumen of the central vacuole in plant cells
Plant Cell, 13 (2), 287-301
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Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole
J Cell Biol, 153 (2), 381-96
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Fluid phase endocytosis of [125I]iodixanol in rat liver parenchymal, endothelial and Kupffer cells
Cell Tissue Res, 304 (2), 221-30
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Wortmannin-sensitive trafficking steps in the endocytic pathway in rat liver endothelial cells
Biochem J, 357 (Pt 2), 497-503
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Cell cycle progression and radiation survival following prolonged hypoxia and re-oxygenation
Int J Radiat Biol, 77 (3), 319-28
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Proteoglycan synthesis is increased in cells with impaired clathrin-dependent endocytosis
J Cell Sci, 114 (Pt 2), 335-43
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Two farms of the heparin-binding EGF-like growth factor precursor, a receptor for diphtheria toxin
Mol. Biol., 35 (1), 122-129
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[Two forms of precursors of a heparin-binding EGF-like growth factor-diphtheria toxin receptor]
Mol Biol (Mosk), 35 (1), 136-45
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'Troy-bodies': antibodies as vector proteins for T cell epitopes
Biomol Eng, 18 (3), 109-16
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Evading apoptosis by calcitriol-differentiated human leukemic HL-60 cells is not mediated by changes in CD95 receptor system but by increased sensitivity of these cells to insulin
Exp Cell Res, 270 (1), 119-27
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Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region
Biochim Biophys Acta, 1521 (1-3), 73-80
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Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy
Biochim Biophys Acta, 1510 (1-2), 243-57
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Ricin
Toxicon, 39 (11), 1723-8
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Microbiology. Fighting anthrax with a mutant toxin
Science, 292 (5517), 647-8
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A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells
Curr Biol, 11 (20), 1636-42
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Hrs recruits clathrin to early endosomes
EMBO J, 20 (17), 5008-21
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Function of Hrs in endocytic trafficking and signalling
Biochem Soc Trans, 29 (Pt 4), 472-5
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FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes
J Cell Sci, 114 (Pt 12), 2255-63
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Shiga toxins
Toxicon, 39 (11), 1629-35
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Pathways followed by ricin and Shiga toxin into cells
Histochem Cell Biol, 117 (2), 131-41
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In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
Int J Cancer, 92 (5), 761-6
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PX domains: attracted by phosphoinositides
Nat Cell Biol, 3 (8), E179-82
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The role of phosphoinositides in membrane transport
Curr Opin Cell Biol, 13 (4), 485-92
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The Escherichia coli SeqA protein binds specifically to two sites in fully and hemimethylated oriC and has the capacity to inhibit DNA replication and affect chromosome topology
Biochimie, 83 (1), 49-51
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DNA binding-independent transcriptional activation by the androgen receptor through triggering of coactivators
J Biol Chem, 276 (33), 31030-6
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SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor
Mol Microbiol, 40 (6), 1371-9
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Introduction. Trafficking of lipids
Semin Cell Dev Biol, 12 (2), 135-7
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Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate
Semin Cell Dev Biol, 12 (2), 193-9
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The Rab GTPase family
Genome Biol, 2 (5), REVIEWS3007
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The Rab GTPase family
Genome Biol., 2 (5), 3007.1 -
GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris
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Internalization of cholera toxin by different endocytic mechanisms
J Cell Sci, 114 (Pt 20), 3737-47
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The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome
Mol Microbiol, 40 (2), 498-507
DOI 10.1046/j.1365-2958.2001.02409.x, PubMed 11309131 -
Mutations in DnaA protein suppress the growth arrest of acidic phospholipid-deficient Escherichia coli cells
EMBO J, 20 (5), 1164-72
DOI 10.1093/emboj/20.5.1164, PubMed 11230139
Publications 2000
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Mapping of a chromosome replication origin in an archaeon
Trends Microbiol, 8 (12), 535-7
DOI 10.1016/s0966-842x(00)01878-3, PubMed 11115744 -
Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin
Cell Death Differ, 7 (8), 739-46
DOI 10.1038/sj.cdd.4400705, PubMed 10918448 -
Limiting DNA replication to once and only once
EMBO Rep, 1 (6), 479-83
DOI 10.1093/embo-reports/kvd116, PubMed 11263490 -
Regulation and intracellular trafficking pathways of the endothelin receptors
J Biol Chem, 275 (23), 17596-604
DOI 10.1074/jbc.M000142200, PubMed 10747877 -
Reduced [3H]IP3 binding but unchanged IP3 receptor levels in the rat hippocampus CA1 region following transient global ischemia and tolerance induction
Neurochem Int, 36 (4-5), 379-88
DOI 10.1016/s0197-0186(99)00129-1, PubMed 10733005 -
An interaction between ricin and calreticulin that may have implications for toxin trafficking
J Biol Chem, 276 (10), 7202-8
DOI 10.1074/jbc.M009499200, PubMed 11113144 -
Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages
J Cell Sci, 113 Pt 19, 3531-41
DOI 10.1242/jcs.113.19.3531, PubMed 10984443 -
Hypoxia, normoxia and hyperoxia--terminology for medical in vitro cell biology
Acta Oncol, 39 (2), 247-8
DOI 10.1080/028418600430888, PubMed 10859022 -
Recombinant antibodies as carrier proteins for sub-unit vaccines: influence of mode of fusion on protein production and T-cell activation
J Immunol Methods, 245 (1-2), 119-31
DOI 10.1016/s0022-1759(00)00274-x,