Stefan Krauss
Position: Professor, Research Team Leader
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Email:
Visit the homepage of the Krauss group at the CMBN for more information.
 

Publications 2017

Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M (2017)
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
J Med Chem (in press)
PubMed 29155568

Habs M, Binder K, Krauss S, Müller K, Ernst B, Valentini L, Koller M (2017)
A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Tea and Herbal Infusions
Nutrients, 9 (7)
PubMed 28686224

Solberg NT, Waaler J, Lund K, Mygland L, Olsen PA, Krauss S (2017)
Tankyrase inhibition enhances the anti-proliferative effect of PI3K and EGFR inhibition, mutually affecting β-catenin and AKT signaling in colorectal cancer
Mol Cancer Res (in press)
PubMed 29222171

Vehus T, Waaler J, Krauss S, Lundanes E, Wilson SR (2017)
Combining HIC, SEC, and IEX with Fluorescence Polarization for Drug Target Discovery
LC GC Eur., 30 (5), 232-239

Publications 2016

Roberg-Larsen H, Lund K, Seterdal KE, Solheim S, Vehus T, Solberg N, Krauss S, Lundanes E, Wilson SR (2016)
Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes
J Steroid Biochem Mol Biol, 169, 22-28
PubMed 26877254

Vehus T, Seterdal KE, Krauss S, Lundanes E, Wilson SR (2016)
Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics
Future Sci OA, 2 (2), FSO119
PubMed 28031966

Publications 2015

Haikarainen T, Waaler J, Ignatev A, Nkizinkiko Y, Venkannagari H, Obaji E, Krauss S, Lehtiö L (2015)
Development and structural analysis of adenosine site binding tankyrase inhibitors
Bioorg Med Chem Lett, 26 (2), 328-333
PubMed 26706174

Lund K, Dembinski JL, Solberg N, Urbanucci A, Mills IG, Krauss S (2015)
Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment
PLoS One, 10 (4), e0123684
PubMed 25860483

Machon O, Masek J, Machonova O, Krauss S, Kozmik Z (2015)
Meis2 is essential for cranial and cardiac neural crest development
BMC Dev Biol, 15, 40
PubMed 26545946

Olsen PA, Lund K, Krauss S (2015)
Expression profiling of wild type and β-catenin gene disrupted human BxPC-3 pancreatic adenocarcinoma cells
Genom Data, 4, 150-2
PubMed 26484203

Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H (2015)
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
PubMed 26124443

Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW (2015)
The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice
Diabetologia, 59 (3), 582-91
PubMed 26631215

Publications 2014

Haikarainen T, Krauss S, Lehtio L (2014)
Tankyrases: structure, function and therapeutic implications in cancer
Curr Pharm Des, 20 (41), 6472-88
PubMed 24975604

Hustoft HK, Vehus T, Brandtzaeg OK, Krauss S, Greibrokk T, Wilson SR, Lundanes E (2014)
Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts
PLoS One, 9 (9), e106881
PubMed 25222838

Lund K, Bostad M, Skarpen E, Braunagel M, Kiprijanov S, Krauss S, Duncan A, Høgset A, Selbo PK (2014)
The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
MAbs, 6 (4), 1038-50
PubMed 24525727

Olsen PA, Solberg NT, Lund K, Vehus T, Gelazauskaite M, Wilson SR, Krauss S (2014)
Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells
PLoS One, 9 (12), e115496
PubMed 25536063

Roberg-Larsen H, Lund K, Vehus T, Solberg N, Vesterdal C, Misaghian D, Olsen PA, Krauss S, Wilson SR, Lundanes E (2014)
Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols
J Lipid Res, 55 (7), 1531-6
PubMed 24792927

Roberg-Larsen H, Strand MF, Krauss S, Wilson SR (2014)
Metabolites in vertebrate Hedgehog signaling
Biochem Biophys Res Commun, 446 (3), 669-74
PubMed 24486313

Publications 2013

Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M (2013)
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
Cancer Res, 73 (10), 3132-44
PubMed 23539443

Lehtiö L, Chi NW, Krauss S (2013)
Tankyrases as drug targets
FEBS J, 280 (15), 3576-93
PubMed 23648170

Solberg N, Krauss S (2013)
Luciferase assay to study the activity of a cloned promoter DNA fragment
Methods Mol Biol, 977, 65-78
PubMed 23436354

Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O (2013)
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
Cancer Med, 3 (1), 36-46
PubMed 24403055

Voronkov A, Holsworth DD, Waaler J, Wilson SR, Ekblad B, Perdreau-Dahl H, Dinh H, Drewes G, Hopf C, Morth JP, Krauss S (2013)
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor
J Med Chem, 56 (7), 3012-23
PubMed 23473363

Voronkov A, Krauss S (2013)
Wnt/beta-catenin signaling and small molecule inhibitors
Curr Pharm Des, 19 (4), 634-64
PubMed 23016862

Publications 2012

Holsworth DD, Krauss S (2012)
Recent Advances in Wnt/beta-Catenin Pathway Small-Molecule Inhibitors
Annu. Rep. Med. Chem., 47, 393-409

Roberg-Larsen H, Strand MF, Grimsmo A, Olsen PA, Dembinski JL, Rise F, Lundanes E, Greibrokk T, Krauss S, Wilson SR (2012)
High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry
J Chromatogr A, 1255, 291-7
PubMed 22410154

Solberg N, Machon O, Machonova O, Krauss S (2012)
Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites
Mol Cell Biochem, 365 (1-2), 53-63
PubMed 22270545

Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S (2012)
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
Cancer Res, 72 (11), 2822-32
PubMed 22440753

Publications 2011

Irvine EE, Drinkwater L, Radwanska K, Al-Qassab H, Smith MA, O'Brien M, Kielar C, Choudhury AI, Krauss S, Cooper JD, Withers DJ, Giese KP (2011)
Insulin receptor substrate 2 is a negative regulator of memory formation
Learn Mem, 18 (6), 375-83
PubMed 21597043

Jing Y, Machon O, Hampl A, Dvorak P, Xing Y, Krauss S (2011)
In vitro differentiation of mouse embryonic stem cells into neurons of the dorsal forebrain
Cell Mol Neurobiol, 31 (5), 715-27
PubMed 21424551

Solberg N, Machon O, Krauss S (2011)
Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene
Mol Cell Biochem, 360 (1-2), 289-99
PubMed 21935611

Strand MF, Wilson SR, Dembinski JL, Holsworth DD, Khvat A, Okun I, Petersen D, Krauss S (2011)
A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model
PLoS One, 6 (6), e19904
PubMed 21698280

Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, Gradl D, Paulsen JE, Machonova O, Dembinski JL, Dinh H, Krauss S (2011)
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth
Cancer Res, 71 (1), 197-205
PubMed 21199802

Publications 2010

Dembinski JL, Krauss S (2010)
A Distinct Slow-Cycling Cancer Stem-like Subpopulation of Pancreatic Adenocarcinoma Cells is maintained in Vivo
Cancers (Basel), 2 (4), 2011-25
PubMed 24281215

Dembinski JL, Krauss S (2010)
A Distinct Slow-Cycling Cancer Stem-like Subpopulation of Pancreatic Adenocarcinoma Cells is maintained in Vivo
Cancers, 2 (4), 2011-2025
PublikaID 116

Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS (2010)
Dachshund homologues play a conserved role in islet cell development
Dev Biol, 348 (2), 143-52
PubMed 20869363

Olsen PA, Gelazauskaite M, Randøl M, Krauss S (2010)
Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction
BMC Mol Biol, 11, 35
PubMed 20459736

Wilson SR, Strand MF, Krapp A, Rise F, Herstad G, Malterud KE, Krauss S (2010)
Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album
J Pharm Biomed Anal, 53 (3), 497-502
PubMed 20646889

Wilson SR, Strand MF, Krapp A, Rise F, Petersen D, Krauss S (2010)
Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified
J Pharm Biomed Anal, 52 (5), 707-13
PubMed 20236786

Publications 2009

Dembinski JL, Krauss S (2009)
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma
Clin Exp Metastasis, 26 (7), 611-23
PubMed 19421880

Hildrestrand GA, Neurauter CG, Diep DB, Castellanos CG, Krauss S, Bjørås M, Luna L (2009)
Expression patterns of Neil3 during embryonic brain development and neoplasia
BMC Neurosci, 10, 45
PubMed 19426544

Kunke D, Bryja V, Mygland L, Arenas E, Krauss S (2009)
Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs
Biochem Biophys Res Commun, 386 (4), 628-33
PubMed 19545542

Publications 2008

Olsen PA, Solhaug A, Booth JA, Gelazauskaite M, Krauss S (2008)
Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases
DNA Repair (Amst), 8 (3), 298-308
PubMed 19071233

Solberg N, Machon O, Krauss S (2008)
Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
Dev Dyn, 237 (7), 1799-811
PubMed 18521945

Publications 2007

Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL (2007)
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling
Cereb Cortex, 18 (9), 2117-31
PubMed 18165280

Hildrestrand GA, Diep DB, Kunke D, Bolstad N, Bjørås M, Krauss S, Luna L (2007)
The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair (Amst), 6 (6), 723-32
PubMed 17236821

Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z (2007)
Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function
Genesis, 45 (4), 157-68
PubMed 17410548

Machon O, Backman M, Machonova O, Kozmik Z, Vacik T, Andersen L, Krauss S (2007)
A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus
Dev Biol, 311 (1), 223-37
PubMed 17916349

Publications 2006

Fujimura N, Vacik T, Machon O, Vlcek C, Scalabrin S, Speth M, Diep D, Krauss S, Kozmik Z (2006)
Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5
J Biol Chem, 282 (2), 1225-37
PubMed 17090534

Kadowaki M, Nakamura S, Machon O, Krauss S, Radice GL, Takeichi M (2006)
N-cadherin mediates cortical organization in the mouse brain
Dev Biol, 304 (1), 22-33
PubMed 17222817

Publications 2005

Backman M, Machon O, Mygland L, van den Bout CJ, Zhong W, Taketo MM, Krauss S (2005)
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Dev Biol, 279 (1), 155-68
PubMed 15708565

Lorico A, Bratbak D, Meyer J, Kunke D, Krauss S, Plott WE, Solodushko V, Baum C, Fodstad O, Rappa G (2005)
Gamma-glutamylcysteine synthetase and L-buthionine-(S,R)-sulfoximine: a new selection strategy for gene-transduced neural and hematopoietic stem/progenitor cells
Hum Gene Ther, 16 (6), 711-24
PubMed 15960602

Machon O, Backman M, Krauss S, Kozmik Z (2005)
The cellular fate of cortical progenitors is not maintained in neurosphere cultures
Mol Cell Neurosci, 30 (3), 388-97
PubMed 16150605

Olsen PA, Randol M, Krauss S (2005)
Implications of cell cycle progression on functional sequence correction by short single-stranded DNA oligonucleotides
Gene Ther, 12 (6), 546-51
PubMed 15674399

Olsen PA, Randøl M, Luna L, Brown T, Krauss S (2005)
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
J Gene Med, 7 (12), 1534-44
PubMed 16025558

Publications 2004

Diep DB, Hoen N, Backman M, Machon O, Krauss S (2004)
Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain
Brain Res Dev Brain Res, 153 (2), 261-70
PubMed 15527894

Petersen PH, Zou K, Krauss S, Zhong W (2004)
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
Nat Neurosci, 7 (8), 803-11
PubMed 15273690

Rappa G, Kunke D, Holter J, Diep DB, Meyer J, Baum C, Fodstad O, Krauss S, Lorico A (2004)
Efficient expansion and gene transduction of mouse neural stem/progenitor cells on recombinant fibronectin
Neuroscience, 124 (4), 823-30
PubMed 15026123

Publications 2003

Backman M, Machon O, Van Den Bout CJ, Krauss S (2003)
Targeted disruption of mouse Dach1 results in postnatal lethality
Dev Dyn, 226 (1), 139-44
PubMed 12508235

Machon O, van den Bout CJ, Backman M, Kemler R, Krauss S (2003)
Role of beta-catenin in the developing cortical and hippocampal neuroepithelium
Neuroscience, 122 (1), 129-43
PubMed 14596855

Olsen PA, McKeen C, Krauss S (2003)
Branched oligonucleotides induce in vivo gene conversion of a mutated EGFP reporter
Gene Ther, 10 (21), 1830-40
PubMed 12960973

Publications 2002

Machon O, van den Bout CJ, Backman M, Røsok Ø, Caubit X, Fromm SH, Geronimo B, Krauss S (2002)
Forebrain-specific promoter/enhancer D6 derived from the mouse Dach1 gene controls expression in neural stem cells
Neuroscience, 112 (4), 951-66
PubMed 12088753

van den Bout CJ, Machon O, Røsok Ø, Backman M, Krauss S (2002)
The mouse enhancer element D6 directs Cre recombinase activity in the neocortex and the hippocampus
Mech Dev, 110 (1-2), 179-82
PubMed 11744379

Publications 2000

Machon O, Backman M, Julin K, Krauss S (2000)
Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac
Mech Dev, 97 (1-2), 3-12
PubMed 11025202

Publications 1999

Shadidy M, Caubit X, Olsen R, Seternes OM, Moens U, Krauss S (1999)
Biochemical analysis of mouse FKBP60, a novel member of the FKPB family
Biochim Biophys Acta, 1446 (3), 295-307
PubMed 10524204