Editorial in Cell highligths paper from Rusten and co-workers.
Cell 131, December 28, 2007 Leading Edge - Cell Biology Select (PDF format)
(from the ingress:) "The cellular process of autophagy (literally self-eating) is important during development and in the normal physiology of an organism. During autophagy, cellular components destined for degradation are enclosed in a double-membraned vesicle (the autophagosome), which then fuses with a lysosome where the contents are degraded and mostly recycled. Dysregulation of autophagy occurs in many diseases including cancer and neurodegeneration. Several recent papers contribute to our understanding of autophagy by identifying new molecular players in this process and new ways to manipulate autophagic pathways."
Rusten TE, Vaccari T, Lindmo K, Rodahl LM, Nezis IP, Sem-Jacobsen C, Wendler F, Vincent JP, Brech A, Bilder D, Stenmark H.
ESCRTs and Fab1 regulate distinct steps of autophagy. (link to PubMed)
Curr Biol. 2007 Oct 23;17(20):1817-25. Epub 2007 Oct 11.
Tor Erik Rusten
Harald Stenmark's group: Intracellular communication (radium.no/stenmark)
Department of Biochemistry
Institute for Cancer Research