It is not known in detail how endocytosed receptors are trafficked to the degradative lysosomes, but work in Harald Stenmark¬ís lab has uncovered several factors involved in this process. Among these are the so-called endosomal sorting complexes required for transport (ESCRTs), and Thomas Slagsvold in Stenmark¬ís group has previously shown that the so-called GLUE domain in the ESCRT-II complex binds ubiquitin .
In a recent paper in Traffic, Lene Maler√łd, a postdoc in Stenmark¬ís lab, shows that the ESCRT-II complex is required for degradation of ubiquitinated epidermal growth factor receptor and chemokine receptors. This provides new insight into how growth factor and chemokine receptors are transported intracellularly and identifies a novel potential tumour suppressor complex.
Malerod L, Stuffers S, Brech A, Stenmark H.
Vps22/EAP30 in ESCRT-II Mediates Endosomal Sorting of Growth Factor and Chemokine Receptors Destined for Lysosomal Degradation.
Traffic. 2007 Aug 20 [Epub ahead of print]
The home page of Harald Stenmark's group (radium.no/stenmark)
Department of Biochemistry
Institute of Cancer Research