A main research paper from Eivind Hovig's group has recently been placed online in the well reputed open access journal "Public Library of Science (PLoS) Computational Biology". It represents four years of cross-diciplinary research to open a new field of computational science, by calculating the complete melting profile of the human genome.
Brief Introduction of the Human Genomic Melting Map Project (from meltmap.uio.no)
The human genomic melting map is a calculated representation of cooperativity in the human genome. This implies that it provides information with respect to the probability that a DNA bubble is formed, thus providing single stranded DNA to be accessible for cellular functions. The map was established in order to provide a resource for the community to explore its biological content further.
Eivind Hovig's group has had a long standing interest in methods for mutation detection, and has published a significant body of papers on variations of denaturing gradient gel electrophoresis to this end. Presently, the methodology is developed for capillary electrophoresis using a cycling temperature system, for robust, cheap and fast assays using standard sequencing machines. This work has proven to us (and others) that prediction algorithms for DNA denaturation is well founded.
Please contact Eivind Hovig for further inquiries regarding these matters.
The Human Genomic Melting Map - research article published in PLoS Computational Biology, early online release (accepted April 11 2007)
Home page of Eivind Hovig's group (radium.no/hovig)
Department of Tumor Biology
Institute for Cancer Research