Endosomes of fab1 mutants have an expanded size and accumulate the signalling molecules Notch, Wingless and Dpp. The signalling of these molecules is nevertheless normal. The results suggest that Fab1 controls late stages of endocytic trafficking at a point when signal termination has occurred. The mechanism by which Fab1 regulates growth remains a subject for further research.
From major journals, first or last author from the Institute for Cancer Research
Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler
Cancers (Basel), 13 (17)
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Nat Commun, 12 (1), 5307
Towards evidence-based personalised precision medicine for Lynch syndrome
Lancet Oncol, 22 (9), e383