Endosomes of fab1 mutants have an expanded size and accumulate the signalling molecules Notch, Wingless and Dpp. The signalling of these molecules is nevertheless normal. The results suggest that Fab1 controls late stages of endocytic trafficking at a point when signal termination has occurred. The mechanism by which Fab1 regulates growth remains a subject for further research.
From major journals, first or last author from the Institute for Cancer Research
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus
Cell Mol Life Sci (in press)
The role of lipid species in membranes and cancer-related changes
Cancer Metastasis Rev
Patient-derived organoids from multiple colorectal cancer liver metastases reveal moderate intra-patient pharmacotranscriptomic heterogeneity
Clin Cancer Res (in press)