Extensive presentation in major Norwegian newspaper VG Groundbreaking study attracts worldwide attention
A Norwegian research team led by Professor Johanne Olweus has developed a new and groundbreaking method that offers the possibility of treating several aggressive forms of cancer. In an article published in Nature Immunology they propose that TCR-T cells targeting CTNNB1-S37F can serve as a basis for solid cancer immunotherapy.
The results have attracted international attention, and the research was recently featured in a major article in Norway's largest newspaper VG, entitled "Norwegian cancer study: – This is definitely a breakthrough".
– This is definitely a breakthrough in cancer research. Our finding gives hope that we can develop treatments for cancer patients who currently have no good options available, says Johanna Olweus.
She is a professor of medicine at the University of Oslo and head of the Section for Cancer Immunology at the Institute for Cancer Research at the Division of Cancer at Oslo University Hospital.
Key members of the research team are also first author and doctoral student Maria Stadheim Eggebø and senior researcher Morten Milek Nielsen.
The study was conducted in collaboration with Fridtjof Lund-Johansen's group, and both research groups are at the Precision Immunotherapy Alliance (PRIMA) at the University of Oslo.
Links:
The VG article:
Norsk kreftstudie: – Dette er absolutt et gjennombrudd (vg.no)
Comprehensive news article from the University of Oslo home page:
Ny immunterapi gir håp mot lungekreft og prostatakreft (med.uio.no)
The Nature Immunology article:
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors.
Eggebø MS, Heinzelbecker J, Palashati H, Chandler N, Tran TT, Li Y, Yang W, Laos M, Blaas I, Rustad EH, Bollineni RC, Delic-Sarac M, Lund-Johansen F, Nielsen MM, Olweus J.
Nat Immunol. 2025 Oct;26(10):1726-1736. doi: 10.1038/s41590-025-02252-1. Epub 2025 Aug 27.
PMID: 40866620
Homepage of the Experimental Immunotherapy Group, led by Johanna Olweus