Publications by Johannes Espolin Roksund Hov

94 publications found

Publications 2020

  1. Derer S, Brethack AK, Pietsch C, Jendrek ST, Nitzsche T, Bokemeyer A, Hov JR, Schäffler H, Bettenworth D, Grassl GA, Sina C (2020)
    Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria
    Inflamm Bowel Dis (in press)
    DOI 10.1093/ibd/izaa069, PubMed 32304568
  2. Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F et al. (2020)
    Genomewide Association Study of Severe Covid-19 with Respiratory Failure
    N Engl J Med (in press)
    DOI 10.1056/NEJMoa2020283, PubMed 32558485
  3. Fretheim H, Chung BK, Didriksen H, Bækkevold ES, Midtvedt Ø, Brunborg C, Holm K, Valeur J, Tennøe AH, Garen T, Midtvedt T, Trøseid M, Zarè H, Lund MB, Hov JR, Lundin KEA, Molberg Ø, Hoffmann-Vold AM (2020)
    Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
    PLoS One, 15 (5), e0232739
    DOI 10.1371/journal.pone.0232739, PubMed 32437393
  4. Gelpi M, Vestad B, Hansen SH, Holm K, Drivsholm N, Goetz A, Kirkby NS, Lindegaard B, Lebech AM, Hoel H, Michelsen AE, Ueland T, Gerstoft J, Lundgren J, Hov JR, Nielsen SD, Trøseid M (2020)
    Impact of Hiv-Related Gut Microbiota Alterations on Metabolic Comorbidities
    Clin Infect Dis (in press)
    DOI 10.1093/cid/ciz1235, PubMed 31894240
  5. Kummen M, Solberg OG, Storm-Larsen C, Holm K, Ragnarsson A, Trøseid M, Vestad B, Skårdal R, Yndestad A, Ueland T, Svardal A, Berge RK, Seljeflot I, Gullestad L, Karlsen TH, Aaberge L, Aukrust P, Hov JR (2020)
    Rosuvastatin alters the genetic composition of the human gut microbiome
    Sci Rep, 10 (1), 5397
    DOI 10.1038/s41598-020-62261-y, PubMed 32214138
  6. Mayerhofer CCK, Kummen M, Holm K, Broch K, Awoyemi A, Vestad B, Storm-Larsen C, Seljeflot I, Ueland T, Bohov P, Berge RK, Svardal A, Gullestad L, Yndestad A, Aukrust P, Hov JR, Trøseid M (2020)
    Low fibre intake is associated with gut microbiota alterations in chronic heart failure
    ESC Heart Fail, 7 (2), 456-466
    DOI 10.1002/ehf2.12596, PubMed 31978943
  7. Trøseid M, Andersen GØ, Broch K, Hov JR (2020)
    The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
    EBioMedicine, 52, 102649
    DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353

Publications 2019

  1. Dhillon AK, Kremer AE, Kummen M, Boberg KM, Elferink RPO, Karlsen TH, Beuers U, Vesterhus M, Hov JR (2019)
    Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
    Sci Rep, 9 (1), 8450
    DOI 10.1038/s41598-019-44762-7, PubMed 31186435
  2. Hov JR (2019)
    Editorial: proton pump inhibition - microbial complications beyond dysbiosis
    Aliment Pharmacol Ther, 50 (8), 962-963
    DOI 10.1111/apt.15495, PubMed 31591776
  3. Jørgensen SF, Holm K, Macpherson ME, Storm-Larsen C, Kummen M, Fevang B, Aukrust P, Hov JR (2019)
    Selective IgA deficiency in humans is associated with reduced gut microbial diversity
    J Allergy Clin Immunol, 143 (5), 1969-1971.e11
    DOI 10.1016/j.jaci.2019.01.019, PubMed 30707969
  4. Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2019)
    Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
    Sci Rep, 9 (1), 167
    DOI 10.1038/s41598-018-35367-7, PubMed 30655568
  5. Kummen M, Hov JR (2019)
    The gut microbial influence on cholestatic liver disease
    Liver Int, 39 (7), 1186-1196
    DOI 10.1111/liv.14153, PubMed 31125502
  6. Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2019)
    Alterations of the bile microbiome in primary sclerosing cholangitis
    Gut, 69 (4), 665-672
    DOI 10.1136/gutjnl-2019-318416, PubMed 31243055
  7. Lunder AK, Bakstad LT, Jahnsen J, Borthne A, Hov JR, Vatn M, Negård A (2019)
    Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn's Disease
    J Crohns Colitis, 13 (5), 607-614
    DOI 10.1093/ecco-jcc/jjy208, PubMed 30541145
  8. Mayerhofer CCK, Awoyemi A, Hov JR, Trøseid M, Broch K (2019)
    Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
    ESC Heart Fail, 6 (3), 557-558
    DOI 10.1002/ehf2.12437, PubMed 31034162
  9. Mazzawi T, Hausken T, Hov JR, Valeur J, Sangnes DA, El-Salhy M, Gilja OH, Hatlebakk JG, Lied GA (2019)
    Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
    Scand J Gastroenterol, 54 (6), 690-699
    DOI 10.1080/00365521.2019.1624815, PubMed 31190584
  10. Rühlemann MC, Solovjeva MEL, Zenouzi R, Liwinski T, Kummen M, Lieb W, Hov JR, Schramm C, Franke A, Bang C (2019)
    Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species
    Gut, 69 (10), 1890-1892
    DOI 10.1136/gutjnl-2019-320008, PubMed 31653787
  11. Saffioti F, Roccarina D, Vesterhus M, Hov JR, Rosenberg W, Pinzani M, Pereira SP, Boberg KM, Thorburn D (2019)
    Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis
    Eur J Clin Invest, 49 (5), e13088
    DOI 10.1111/eci.13088, PubMed 30762236
  12. Storm-Larsen C, Myhr KM, Farbu E, Midgard R, Nyquist K, Broch L, Berg-Hansen P, Buness A, Holm K, Ueland T, Fallang LE, Burum-Auensen E, Hov JR, Holmøy T (2019)
    Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial
    Mult Scler J Exp Transl Clin, 5 (4), 2055217319888767
    DOI 10.1177/2055217319888767, PubMed 31798939
  13. Storm-Larsen C, Stiksrud B, Eriksen C, Nowak P, Holm K, Thalme A, Dyrhol-Riise AM, Brix S, Hov JR, Trøseid M (2019)
    Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals
    AIDS, 33 (4), 645-653
    DOI 10.1097/QAD.0000000000002087, PubMed 30531315
  14. Trøseid M, Mayerhofer CCK, Broch K, Arora S, Svardal A, Hov JR, Andreassen AK, Gude E, Karason K, Dellgren G, Berge RK, Gullestad L, Aukrust P, Ueland T (2019)
    The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
    J Heart Lung Transplant, 38 (10), 1097-1103
    DOI 10.1016/j.healun.2019.06.003, PubMed 31301965

Publications 2018

  1. Arnbjerg CJ, Vestad B, Hov JR, Pedersen KK, Jespersen S, Johannesen HH, Holm K, Halvorsen B, Fallentin E, Hansen AE, Lange T, Kjær A, Trøseid M, Fischer BM, Nielsen SD (2018)
    Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
    J Acquir Immune Defic Syndr, 78 (4), 450-457
    DOI 10.1097/QAI.0000000000001693, PubMed 29874201
  2. Dhillon AK, Kummen M, Trøseid M, Åkra S, Liaskou E, Moum B, Vesterhus M, Karlsen TH, Seljeflot I, Hov JR (2018)
    Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
    Liver Int, 39 (2), 371-381
    DOI 10.1111/liv.13979, PubMed 30269440
  3. Hoel H, Hove-Skovsgaard M, Hov JR, Gaardbo JC, Holm K, Kummen M, Rudi K, Nwosu F, Valeur J, Gelpi M, Seljeflot I, Ueland PM, Gerstoft J, Ullum H, Aukrust P, Nielsen SD, Trøseid M (2018)
    Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
    Sci Rep, 8 (1), 6725
    DOI 10.1038/s41598-018-25168-3, PubMed 29712976
  4. Kummen M, Mayerhofer CCK, Vestad B, Broch K, Awoyemi A, Storm-Larsen C, Ueland T, Yndestad A, Hov JR, Trøseid M (2018)
    Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
    J Am Coll Cardiol, 71 (10), 1184-1186
    DOI 10.1016/j.jacc.2017.12.057, PubMed 29519360
  5. Mayerhofer CCK, Awoyemi AO, Moscavitch SD, Lappegård KT, Hov JR, Aukrust P, Hovland A, Lorenzo A, Halvorsen S, Seljeflot I, Gullestad L, Trøseid M, Broch K (2018)
    Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial
    ESC Heart Fail, 5 (5), 977-984
    DOI 10.1002/ehf2.12332, PubMed 30088346
  6. Mazzawi T, Lied GA, Sangnes DA, El-Salhy M, Hov JR, Gilja OH, Hatlebakk JG, Hausken T (2018)
    The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
    PLoS One, 13 (11), e0194904
    DOI 10.1371/journal.pone.0194904, PubMed 30427836
  7. Nielsen MJ, Thorburn D, Leeming DJ, Hov JR, Nygård S, Moum B, Saffioti F, Gilja OH, Boberg KM, Mazza G, Røsjø H, Pinzani M, Karlsen TH, Karsdal MA, Vesterhus M (2018)
    Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis
    Aliment Pharmacol Ther, 48 (2), 179-189
    DOI 10.1111/apt.14806, PubMed 29851098
  8. Pollheimer MJ, Racedo S, Mikels-Vigdal A, Marshall D, Bowlus C, Lackner C, Madl T, Karlsen TH, Hov JR, Lyman SK, Adamkewicz J, Smith V, Moreau E, Zollner G, Eide TJ, Stojakovic T, Scharnagl H, Gruber HJ, Stauber RE, Trauner M, Fickert P (2018)
    Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
    J Hepatol, 69 (2), 368-377
    DOI 10.1016/j.jhep.2018.04.009, PubMed 29709678
  9. Schmitt C, Lenglet H, Yu A, Delaby C, Benecke A, Lefebvre T, Letteron P, Paradis V, Wahlin S, Sandberg S, Harper P, Sardh E, Sandvik AK, Hov JR, Aarsand AK, Chiche L, Bazille C, Scoazec JY, To-Figueras J, Carrascal M, Abian J, Mirmiran A, Karim Z, Deybach JC, Puy H et al. (2018)
    Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver
    J Intern Med, 284 (1), 78-91
    DOI 10.1111/joim.12750, PubMed 29498764

Publications 2017

  1. Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J et al. (2017)
    Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
    Gut, 67 (8), 1517-1524
    DOI 10.1136/gutjnl-2016-313598, PubMed 28779025
  2. de Muinck EJ, Trosvik P, Gilfillan GD, Hov JR, Sundaram AYM (2017)
    A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform
    Microbiome, 5 (1), 68
    DOI 10.1186/s40168-017-0279-1, PubMed 28683838
  3. de Vries EMG, Färkkilä M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouillères O, Pares A, Nygård S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Røsjø H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
    Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
    Liver Int, 37 (10), 1554-1561
    DOI 10.1111/liv.13402, PubMed 28267887
  4. Haissman JM, Haugaard AK, Ostrowski SR, Berge RK, Hov JR, Trøseid M, Nielsen SD (2017)
    Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
    BMC Infect Dis, 17 (1), 445
    DOI 10.1186/s12879-017-2547-x, PubMed 28645263
  5. Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouillères O, Färkkilä M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, UK-PSC Consortium, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D et al. (2017)
    HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
    HLA, 90 (4), 228-233
    DOI 10.1111/tan.13076, PubMed 28695657
  6. Hov JR, Karlsen TH (2017)
    The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
    Semin Liver Dis, 37 (4), 314-331
    DOI 10.1055/s-0037-1608801, PubMed 29272894
  7. Hov JR, Kummen M (2017)
    Intestinal microbiota in primary sclerosing cholangitis
    Curr Opin Gastroenterol, 33 (2), 85-92
    DOI 10.1097/MOG.0000000000000334, PubMed 28030369
  8. Jahnsen FL, Bækkevold ES, Hov JR, Landsverk OJ (2017)
    Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
    Trends Immunol, 39 (3), 196-208
    DOI 10.1016/j.it.2017.10.006, PubMed 29162322
  9. Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, Pick J, Markus MRP, Höpfner T, Jacobs G, Siegert S, Artati A, Kastenmüller G, Römisch-Margl W, Adamski J, Illig T, Nothnagel M, Karlsen TH, Schreiber S, Franke A, Krawczak M, Nöthlings U, Lieb W (2017)
    Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
    Eur J Clin Nutr, 71 (8), 995-1001
    DOI 10.1038/ejcn.2017.43, PubMed 28378853
  10. Lunder AK, Jahnsen J, Bakstad LT, Borthne A, Hov JR, Vatn M, Negård A, IBSEN Study Group (2017)
    Bowel Damage in Patients With Long-term Crohn's Disease, Assessed by Magnetic Resonance Enterography and the Lémann Index
    Clin Gastroenterol Hepatol, 16 (1), 75-82.e5
    DOI 10.1016/j.cgh.2017.06.053, PubMed 28694130
  11. Mayerhofer CCK, Ueland T, Broch K, Vincent RP, Cross GF, Dahl CP, Aukrust P, Gullestad L, Hov JR, Trøseid M (2017)
    Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
    J Card Fail, 23 (9), 666-671
    DOI 10.1016/j.cardfail.2017.06.007, PubMed 28688889
  12. Rühlemann MC, Degenhardt F, Thingholm LB, Wang J, Skiecevičienė J, Rausch P, Hov JR, Lieb W, Karlsen TH, Laudes M, Baines JF, Heinsen FA, Franke A (2017)
    Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
    Gut Microbes, 9 (1), 68-75
    DOI 10.1080/19490976.2017.1356979, PubMed 28816579
  13. Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Høivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR (2017)
    Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
    Inflamm Bowel Dis, 23 (10), 1752-1761
    DOI 10.1097/MIB.0000000000001264, PubMed 28902124
  14. Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F (2017)
    Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
    J Hepatol, 66 (6), 1214-1222
    DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472
  15. Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J (2017)
    Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
    BMJ Open Gastroenterol, 4 (1), e000134
    DOI 10.1136/bmjgast-2017-000134, PubMed 28761687

Publications 2016

  1. Hov JR, Boberg KM, Taraldsrud E, Vesterhus M, Boyadzhieva M, Solberg IC, Schrumpf E, Vatn MH, Lie BA, Molberg Ø, Karlsen TH (2016)
    Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
    Liver Int, 37 (3), 458-465
    DOI 10.1111/liv.13238, PubMed 27558072
  2. Jendrek ST, Gotthardt D, Nitzsche T, Widmann L, Korf T, Michaels MA, Weiss KH, Liaskou E, Vesterhus M, Karlsen TH, Mindorf S, Schemmer P, Bär F, Teegen B, Schröder T, Ehlers M, Hammers CM, Komorowski L, Lehnert H, Fellermann K, Derer S, Hov JR, Sina C (2016)
    Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
    Gut, 66 (1), 137-144
    DOI 10.1136/gutjnl-2016-311739, PubMed 27406039
  3. Jørgensen SF, Trøseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Høivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KE, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
    Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
    Mucosal Immunol, 9 (6), 1455-1465
    DOI 10.1038/mi.2016.18, PubMed 26982597
  4. Knudsen A, Christensen TE, Thorsteinsson K, Ghotbi AA, Hasbak P, Lebech AM, Nielsen SD, Hov JR, Berge R, Ripa RS, Kjær A, Trøseid M (2016)
    Microbiota-Dependent Marker TMAO is Not Associated With Decreased Myocardial Perfusion in Well-Treated HIV-Infected Patients as Assessed by 82Rubidium PET/CT
    J Acquir Immune Defic Syndr, 72 (4), e83-5
    DOI 10.1097/QAI.0000000000001044, PubMed 27152465
  5. Kummen M, Holm K, Anmarkrud JA, Nygård S, Vesterhus M, Høivik ML, Trøseid M, Marschall HU, Schrumpf E, Moum B, Røsjø H, Aukrust P, Karlsen TH, Hov JR (2016)
    The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
    Gut, 66 (4), 611-619
    DOI 10.1136/gutjnl-2015-310500, PubMed 26887816
  6. Kummen M, Hov JR (2016)
    Response to 'Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis' by Rühlemann et al
    Gut, 66 (4), 755-756
    DOI 10.1136/gutjnl-2016-312347, PubMed 27340191
  7. Kummen M, Vesterhus M, Trøseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR (2016)
    Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
    United European Gastroenterol J, 5 (4), 532-541
    DOI 10.1177/2050640616663453, PubMed 28588885
  8. Lunder AK, Hov JR, Borthne A, Gleditsch J, Johannesen G, Tveit K, Viktil E, Henriksen M, Hovde Ø, Huppertz-Hauss G, Høie O, Høivik ML, Monstad I, Solberg IC, Jahnsen J, Karlsen TH, Moum B, Vatn M, Negård A (2016)
    Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease
    Gastroenterology, 151 (4), 660-669.e4
    DOI 10.1053/j.gastro.2016.06.021, PubMed 27342213
  9. Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E (2016)
    The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
    J Hepatol, 66 (2), 382-389
    DOI 10.1016/j.jhep.2016.09.020, PubMed 27720803
  10. Skagen K, Trøseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JE, Halvorsen B, Skjelland M (2016)
    The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
    Atherosclerosis, 247, 64-9
    DOI 10.1016/j.atherosclerosis.2016.01.033, PubMed 26868510
  11. Trøseid M, Hov JR, Nestvold TK, Thoresen H, Berge RK, Svardal A, Lappegård KT (2016)
    Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
    Metab Syndr Relat Disord, 14 (4), 197-201
    DOI 10.1089/met.2015.0120, PubMed 27081744
  12. Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P et al. (2016)
    Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
    Nat Genet, 48 (11), 1396-1406
    DOI 10.1038/ng.3695, PubMed 27723756
  13. Zweers SJ, Shiryaev A, Komuta M, Vesterhus M, Hov JR, Perugorria MJ, de Waart DR, Chang JC, Tol S, Te Velde AA, de Jonge WJ, Banales JM, Roskams T, Beuers U, Karlsen TH, Jansen PL, Schaap FG (2016)
    Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
    Liver Int, 36 (9), 1370-7
    DOI 10.1111/liv.13092, PubMed 26866350

Publications 2015

  1. Berntsen NL, Klingenberg O, Juran BD, Benito de Valle M, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR (2015)
    Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
    Gastroenterology, 148 (5), 924-927.e2
    DOI 10.1053/j.gastro.2015.01.041, PubMed 25655558
  2. Carpino G, Cardinale V, Renzi A, Hov JR, Berloco PB, Rossi M, Karlsen TH, Alvaro D, Gaudio E (2015)
    Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
    J Hepatol, 63 (5), 1220-8
    DOI 10.1016/j.jhep.2015.06.018, PubMed 26119688
  3. Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, Brant SR, Cho JH, Daly MJ, Dubinsky M, Duerr RH, Ferguson LR, Franke A, Gearry RB, Goyette P, Hakonarson H, Halfvarson J, Hov JR, Huang H, Kennedy NA, Kupcinskas L et al. (2015)
    Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
    Lancet, 387 (10014), 156-67
    DOI 10.1016/S0140-6736(15)00465-1, PubMed 26490195
  4. Hov JE, Trøseid M (2015)
    Personalised medicine targeting the gut microbiota?
    Tidsskr Nor Laegeforen, 135 (7), 624
    DOI 10.4045/tidsskr.14.1431, PubMed 25899345
  5. Hov JER, Troseid M (2015)
    Personalized intestinal flora medicine?
    Tidsskr. Nor. Laegeforen., 135 (7), 624
  6. Hov JR, Zhong H, Qin B, Anmarkrud JA, Holm K, Franke A, Lie BA, Karlsen TH (2015)
    The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
    PLoS One, 10 (7), e0133804
    DOI 10.1371/journal.pone.0133804, PubMed 26207384
  7. Kevans D, Tyler AD, Holm K, Jørgensen KK, Vatn MH, Karlsen TH, Kaplan GG, Eksteen B, Gevers D, Hov JR, Silverberg MS (2015)
    Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
    J Crohns Colitis, 10 (3), 330-7
    DOI 10.1093/ecco-jcc/jjv204, PubMed 26526357
  8. Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2015)
    High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
    Hepatology, 63 (5), 1608-19
    DOI 10.1002/hep.28116, PubMed 26257205
  9. Nowak P, Troseid M, Avershina E, Barqasho B, Neogi U, Holm K, Hov JR, Noyan K, Vesterbacka J, Svärd J, Rudi K, Sönnerborg A (2015)
    Gut microbiota diversity predicts immune status in HIV-1 infection
    AIDS, 29 (18), 2409-18
    DOI 10.1097/QAD.0000000000000869, PubMed 26355675
  10. Stiksrud B, Nowak P, Nwosu FC, Kvale D, Thalme A, Sonnerborg A, Ueland PM, Holm K, Birkeland SE, Dahm AE, Sandset PM, Rudi K, Hov JR, Dyrhol-Riise AM, Trøseid M (2015)
    Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
    J Acquir Immune Defic Syndr, 70 (4), 329-37
    DOI 10.1097/QAI.0000000000000784, PubMed 26258571
  11. Vesterhus M, Hov JR, Holm A, Schrumpf E, Nygård S, Godang K, Andersen IM, Naess S, Thorburn D, Saffioti F, Vatn M, Gilja OH, Lund-Johansen F, Syversveen T, Brabrand K, Parés A, Ponsioen CY, Pinzani M, Färkkilä M, Moum B, Ueland T, Røsjø H, Rosenberg W, Boberg KM, Karlsen TH (2015)
    Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
    Hepatology, 62 (1), 188-97
    DOI 10.1002/hep.27825, PubMed 25833813
  12. Wannhoff A, Folseraas T, Brune M, Rupp C, Friedrich K, Knierim J, Weiss KH, Sauer P, Flechtenmacher C, Schirmacher P, Stremmel W, Hov JR, Gotthardt DN (2015)
    A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
    United European Gastroenterol J, 4 (1), 84-91
    DOI 10.1177/2050640615581577, PubMed 26966527
  13. Wannhoff A, Rupp C, Friedrich K, Brune M, Knierim J, Flechtenmacher C, Sauer P, Stremmel W, Hov JR, Schirmacher P, Weiss KH, Gotthardt DN (2015)
    Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis
    Clin Gastroenterol Hepatol, 13 (13), 2372-9
    DOI 10.1016/j.cgh.2015.07.014, PubMed 26192140
  14. Wittig M, Anmarkrud JA, Kässens JC, Koch S, Forster M, Ellinghaus E, Hov JR, Sauer S, Schimmler M, Ziemann M, Görg S, Jacob F, Karlsen TH, Franke A (2015)
    Development of a high-resolution NGS-based HLA-typing and analysis pipeline
    Nucleic Acids Res, 43 (11), e70
    DOI 10.1093/nar/gkv184, PubMed 25753671

Publications 2014

  1. Fosby B, Næss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH (2014)
    HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
    World J Gastroenterol, 20 (14), 3986-4000
    DOI 10.3748/wjg.v20.i14.3986, PubMed 24744588
  2. Friedrich K, Wannhoff A, Kattner S, Brune M, Hov JR, Weiss KH, Antoni C, Dollinger M, Neumann-Haefelin C, Seufferlein T, Schemmer P, Schirmacher P, Stremmel W, Gotthardt DN (2014)
    PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival
    J Gastroenterol Hepatol, 29 (7), 1477-84
    DOI 10.1111/jgh.12540, PubMed 25273282
  3. Naess S, Björnsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SG, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
    Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
    Liver Int, 34 (10), 1488-95
    DOI 10.1111/liv.12492, PubMed 24517468
  4. Næss S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJ, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH (2014)
    Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
    PLoS One, 9 (12), e114486
    DOI 10.1371/journal.pone.0114486, PubMed 25521205
  5. Trøseid M, Ueland T, Hov JR, Svardal A, Gregersen I, Dahl CP, Aakhus S, Gude E, Bjørndal B, Halvorsen B, Karlsen TH, Aukrust P, Gullestad L, Berge RK, Yndestad A (2014)
    Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
    J Intern Med, 277 (6), 717-26
    DOI 10.1111/joim.12328, PubMed 25382824

Publications 2013

  1. Andersen IM, Tengesdal G, Lie BA, Boberg KM, Karlsen TH, Hov JR (2013)
    Effects of coffee consumption, smoking, and hormones on risk for primary sclerosing cholangitis
    Clin Gastroenterol Hepatol, 12 (6), 1019-28
    DOI 10.1016/j.cgh.2013.09.024, PubMed 24076415
  2. Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al. (2013)
    Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
    Hepatology, 58 (3), 1074-83
    DOI 10.1002/hep.25977, PubMed 22821403
  3. Friedrich K, Rupp C, Hov JR, Steinebrunner N, Weiss KH, Stiehl A, Brune M, Schaefer PK, Schemmer P, Sauer P, Schirmacher P, Runz H, Karlsen TH, Stremmel W, Gotthardt DN (2013)
    A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis
    PLoS One, 8 (3), e58734
    DOI 10.1371/journal.pone.0058734, PubMed 23505555
  4. Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S et al. (2013)
    Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
    Nat Genet, 45 (6), 670-5
    DOI 10.1038/ng.2616, PubMed 23603763
  5. Wannhoff A, Hov JR, Folseraas T, Rupp C, Friedrich K, Anmarkrud JA, Weiss KH, Sauer P, Schirmacher P, Boberg KM, Stremmel W, Karlsen TH, Gotthardt DN (2013)
    FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
    J Hepatol, 59 (6), 1278-84
    DOI 10.1016/j.jhep.2013.08.005, PubMed 23958938

Publications 2012

  1. Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
    Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
    J Hepatol, 57 (2), 366-75
    DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342
  2. Næss S, Shiryaev A, Hov JR, Franke A, Karlsen TH (2012)
    Genetics in primary sclerosing cholangitis
    Clin Res Hepatol Gastroenterol, 36 (4), 325-33
    DOI 10.1016/j.clinre.2012.02.003, PubMed 22554879

Publications 2011

  1. Hov JR, Keitel V, Schrumpf E, Häussinger D, Karlsen TH (2011)
    TGR5 sequence variation in primary sclerosing cholangitis
    Dig Dis, 29 (1), 78-84
    DOI 10.1159/000324138, PubMed 21691110
  2. Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH (2011)
    Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
    Hepatology, 53 (6), 1967-76
    DOI 10.1002/hep.24299, PubMed 21413052

Publications 2010

  1. Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
    Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
    PLoS One, 5 (8), e12403
    DOI 10.1371/journal.pone.0012403, PubMed 20811628
  2. Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P (2010)
    Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C
    J Hepatol, 52 (5), 712-7
    DOI 10.1016/j.jhep.2009.11.029, PubMed 20347497
  3. Karlsen TH, Hov JR (2010)
    Genetics of cholestatic liver disease in 2010
    Curr Opin Gastroenterol, 26 (3), 251-8
    DOI 10.1097/MOG.0b013e328336807d, PubMed 20042859
  4. Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2010)
    Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    Nat Genet, 43 (1), 17-9
    DOI 10.1038/ng.728, PubMed 21151127

Publications 2009

  1. Hov JR, Clench-Aas J, Bartonova A, Stavem K (2009)
    Agreement of a child's respiratory symptom diary with parental reports and peak expiratory flow
    Int J Tuberc Lung Dis, 13 (3), 400-6
    PubMed 19275804
  2. Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2009)
    Genome-wide association analysis in primary sclerosing cholangitis
    Gastroenterology, 138 (3), 1102-11
    DOI 10.1053/j.gastro.2009.11.046, PubMed 19944697

Publications 2008

  1. Hov JR, Boberg KM, Karlsen TH (2008)
    Autoantibodies in primary sclerosing cholangitis
    World J Gastroenterol, 14 (24), 3781-91
    DOI 10.3748/wjg.14.3781, PubMed 18609700

Publications 2003

  1. Røsjø HR, Hov JE, Borchsenius F, Skjønsberg OH (2003)
    [Wasp allergy vaccination]
    Tidsskr Nor Laegeforen, 123 (8), 1075-7
    PubMed 12760227

 
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