Kristian Holm
- Bioinformatics; Cand. scient
Education
Cand. scient., University of Oslo, 2003
Positions
2006-present: Bioinformatician, NoPSC, OUH Rikshospitalet
Responsibilities
Data handling, programming and analysis.
Publications 2024
Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV
J Infect Dis, 229 (3), 898-907
DOI 10.1093/infdis/jiad604, PubMed 38195204
Publications 2023
A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation
Hepatology, 77 (3), 715-728
DOI 10.1002/hep.32773, PubMed 36056902
Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC?
Hepatology, 77 (6), E188-E189
DOI 10.1097/HEP.0000000000000340, PubMed 36815351
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure
Front Cardiovasc Med, 10, 1160030
DOI 10.3389/fcvm.2023.1160030, PubMed 37332580
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Crit Care, 27 (1), 69
DOI 10.1186/s13054-023-04356-2, PubMed 36814280
Publications 2022
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
J Allergy Clin Immunol, 151 (3), 767-777
DOI 10.1016/j.jaci.2022.09.029, PubMed 36220400
Human Immunodeficiency Virus-Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction
J Infect Dis, 225 (4), 661-674
DOI 10.1093/infdis/jiaa714, PubMed 33216130
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
J Acquir Immune Defic Syndr, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817, PubMed 34878437
Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis
Sci Rep, 12 (1), 22378
DOI 10.1038/s41598-022-26759-x, PubMed 36572703
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations
J Intern Med, 291 (6), 801-812
DOI 10.1111/joim.13458, PubMed 35212063
Publications 2021
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511, PubMed 34329947
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0, PubMed 34611194
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Sci Transl Med, 13 (599)
DOI 10.1126/scitranslmed.abb3107, PubMed 34162753
Publications 2020
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin Infect Dis, 71 (8), e359-e367
DOI 10.1093/cid/ciz1235, PubMed 31894240
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798.e0
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943
Publications 2019
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J Allergy Clin Immunol, 143 (5), 1969-1971.e11
DOI 10.1016/j.jaci.2019.01.019, PubMed 30707969
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167 (Retracted)
DOI 10.1038/s41598-018-35367-7, PubMed 30655568
Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals
AIDS, 33 (4), 645-653
DOI 10.1097/QAD.0000000000002087, PubMed 30531315
Publications 2018
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
J Acquir Immune Defic Syndr, 78 (4), 450-457
DOI 10.1097/QAI.0000000000001693, PubMed 29874201
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
Sci Rep, 8 (1), 6725
DOI 10.1038/s41598-018-25168-3, PubMed 29712976
Publications 2017
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm Bowel Dis, 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264, PubMed 28902124
Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis
Gastroenterology, 152 (8), 1975-1984.e8
DOI 10.1053/j.gastro.2017.02.038, PubMed 28274849
Publications 2016
Genetic risk variants for autoimmune diseases that influence gene expression in thymus
Hum Mol Genet, 25 (14), 3117-3124
DOI 10.1093/hmg/ddw152, PubMed 27199374
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J Hepatol, 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002, PubMed 27647428
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am J Gastroenterol, 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329, PubMed 27527747
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500, PubMed 26887816
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J Hepatol, 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020, PubMed 27720803
Sports injuries and illnesses in the Lillehammer 2016 Youth Olympic Winter Games
Br J Sports Med, 51 (1), 29-35
DOI 10.1136/bjsports-2016-096977, PubMed 27884864
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Nat Genet, 48 (11), 1396-1406
DOI 10.1038/ng.3695, PubMed 27723756
Publications 2015
The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
PLoS One, 10 (7), e0133804
DOI 10.1371/journal.pone.0133804, PubMed 26207384
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
J Crohns Colitis, 10 (3), 330-7
DOI 10.1093/ecco-jcc/jjv204, PubMed 26526357
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
DOI 10.1002/hep.28116, PubMed 26257205
Gut microbiota diversity predicts immune status in HIV-1 infection
AIDS, 29 (18), 2409-18
DOI 10.1097/QAD.0000000000000869, PubMed 26355675
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
J Acquir Immune Defic Syndr, 70 (4), 329-37
DOI 10.1097/QAI.0000000000000784, PubMed 26258571
Publications 2013
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
DOI 10.1002/hep.25977, PubMed 22821403
Publications 2012
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342
Publications 2010
SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
BMC Bioinformatics, 11, 600
DOI 10.1186/1471-2105-11-600, PubMed 21167019
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nat Genet, 43 (1), 17-9
DOI 10.1038/ng.728, PubMed 21151127
Publications 2009
Small intestinal neuroendocrine tumors: prognostic factors and survival
Scand J Gastroenterol, 44 (9), 1084-91
DOI 10.1080/00365520903082432, PubMed 19572232