The ASAC study, Scandinavian multicentre, placebo-controlled, randomized trial, initiated by our group, investigating the role of aspirin as adjuvant after surgery for colorectal liver metastases, is still recruiting patients and has now 300 of 800 patients included (www.asac.no). The trial is funded by Research Council of Norway, Norwegian Cancer Society, and KLINBEFORSK.
EXCALIBUR study; single centre, un-blinded, three-armed randomized trial for patients with high load of colorectal liver metastases, treated with 1)liver transplantation 2)liver resection 3)hepatic artery infusion of chemotherapy. The trial is approved by the Ethical committee and Norwegian Medicinal Agency and will to be initiated in 2021 (www.excaliburstudy.com).
Precision Medicine in Early Diagnostics and Therapy of Biliary Tract Cancer; is a collaborative project between several groups, led by Sheraz Yaqub, started December 2020.
TESLA trial: Liver Transplantation for Non-Resectable Intrahepatic Cholangiocarcinoma: a prospective exploratory trial; this is a collaborative study between several groups at OUH-KIT treating patients with cholangiocarcinoma
CAMINO study: Investigate the value of MRI in assessing CRC liver mets compared to CT scan, and if MRI affects the surgical decision.
Labib PL, McKay SC, Perrodin SF, Bolm L, Mownah OA, Bellotti R, McClements J, Sultana A, Skipworth JR, Balakrishnan A, Durán M, Moris D, Milburn JA, Kurtoğlu GK, Carino ND, Domínguez-Rosado I, Pandanaboyana S, Ghotbi J, Marchegiani G, Athwal TS, Stättner S, Karavias DD, Al-Sarireh B, Morris PD, Connor Set al.(2025) Anticoagulation Practice and Risk of Portal Vein Thrombosis Following Pancreaticoduodenectomy or Total Pancreatectomy with Venous Resection: An International Multicentre Cohort Study Ann Surg(in press) DOI 10.1097/SLA.0000000000006954, PubMed 40996212
Reese T, Björk D, Longva AMH, Kiim KS, Evers M, Larsen PN, Schultz NA, Røsok BI, Carling U, Holmquist F, Lindell G, Sandström P, Böcker J, Gilg S, Engstrand J, Sturesson C, Oldhafer KJ, Björnsson B, Sparrelid E(2025) Oncological safety of portal vein embolization without prior tumour clearance in the future liver remnant followed by one-stage hepatectomy for bilateral colorectal liver metastases Br J Surg, 112(9) DOI 10.1093/bjs/znaf198, PubMed 40982475
Yaqub S, Brudvik KW, Smedman TM, Syversveen T, Line PD, Dueland S(2025) Liver transplantation for colorectal metastases following hepatic resection Br J Surg, 112(9) DOI 10.1093/bjs/znaf193, PubMed 40971970