Øyvind Haugen Lie
- MD, PhD
Øyvind Haugen Lie, MD, PhD, Department of Cardiology, Rikshospitalet, Oslo University Hospital
Øyvind Haugen Lie successfully defended his PhD thesis "Risk stratification and management of patients with right ventricular arrhythmias" in December 2018. His supervisors were Associate Professor Kristina Hermann Haugaa, MD, PhD and Professor Thor Edvardsen, MD, PhD.
During his fellowship Lie was awarded with Prof. J. Roelandt’s Young Investigator Award for best original work in clinical science at the 2017 EuroEcho-Imaging Congress. The award was given in recognition of the work “Harmful effects of exercise intensity and exercise duration in patients with arrhythmogenic cardiomyopathy”.
Lie also won the best poster prize in the session for “Diagnostic and therapeutical strategies for cardiac disease” at the annual Center for Heart Failure Research Symposium two years in a row. He was give the prize in recognition of the work “How many are too many – Frequent premature ventricular contractions and left ventricular function” and "V-3 QRS-duration of premature ventricular contractions relates to ventricular tachycardia in patients with outflow tract arrhythmia", respectively.
Lie, together with his colleagues, discovered that the threshold ectopy burden associated with impaired left ventricular function was lower than previously assumed when accurate and sensitive echocardiographic tools were used. Patients with frequent premature ventricular contractions of right ventricular outflow tract origin may contract an ectopy-induced cardiomyopathy, those with more than 8000 premature ventricular contractions per 24 hours may benefit from antiarrhythmic therapy.
Higher exercise intensity is a strong and independent marker of adverse outcome in patients with arrhythmogenic cardiomyopathy, irrespective of longer exercise duration. Together with ECG-abnormalities and subtle left ventricular contraction abnormalities, information on exercise intensity at study entry yielded precise risk stratification that may be useful in the challenging selection of patients with arrhythmogenic cardiomyopathy who may benefit from a primary preventive implantable cardioverter-defibrillator.
Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A/C Genotype
J Am Heart Assoc, 9 (2), e012937
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Eur Heart J, 40 (23), 1850-1858
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
High penetrance and similar disease progression in probands and in family members with arrhythmogenic cardiomyopathy
Eur Heart J (in press)
Reply: Arrhythmic Mitral Annulus Disjunction and Mitral Valve Prolapse: Components of the Same Clinical Spectrum?
J Am Coll Cardiol, 73 (6), 739-740
Cardiac amyloidosis: can imaging shed light on mechanisms and prognosis?
Eur Heart J Cardiovasc Imaging, 20 (5), 500-501
Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block
Eur Heart J Cardiovasc Imaging, 20 (3), 271-278
Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Am J Cardiol, 123 (7), 1156-1162
Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmias
Open Heart, 6 (1), e001016
Contraction alterations in Brugada syndrome; association with life-threatening ventricular arrhythmias
Int J Cardiol, 299, 147-152
Speckle tracking echocardiography data in Brugada syndrome patients
Data Brief, 25, 104330
Vigorous exercise in patients with hypertrophic cardiomyopathy
Int J Cardiol, 250, 157-163
The Mitral Annulus Disjunction Arrhythmic Syndrome
J Am Coll Cardiol, 72 (14), 1600-1609
Reveal the Concealed: The Quest for Early Disease Detection in Family Members at Risk of Developing Arrhythmogenic Cardiomyopathy
JACC Cardiovasc Imaging, 12 (3), 456-457
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC Clin Electrophysiol, 4 (6), 744-753
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study
JACC Cardiovasc Imaging, 11 (10), 1377-1386
Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center
Int J Cardiol, 279, 79-83
Right ventricular remodeling in athletes and in arrhythmogenic cardiomyopathy
Scand Cardiovasc J, 52 (1), 13-19
Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy
Data Brief, 15, 30-39
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail, 4 (4), 585-594