Photochemical internalisation (PCI) is a novel technology for improving the transfer of macromolecules into the cytosol of cells. This is executed through photochemical targeting of endocytic vesicles, leading to release of the contents of these vesicles into the cytosol. The groups main focus is to develop PCI for therapeutic purposes.
Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers
Front Immunol, 11, 576756
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
Mol Ther (in press)
Enhanced gene transfection of macrophages by photochemical internalization; potential for gene-directed enzyme prodrug therapy of gliomas
Photodiagnosis Photodyn Ther, 102098 (in press)