Publications

Publications from OUS - Photochemical Internalisation (PCI)

120 publications found

Publications 2020

  1. Berstad MEB, Cheung LH, Weyergang A (2020)
    Production of Recombinant Gelonin Using an Automated Liquid Chromatography System
    Toxins (Basel), 12 (8)
    DOI 10.3390/toxins12080519, PubMed 32823678
  2. Dal NK, Kocere A, Wohlmann J, Van Herck S, Bauer TA, Resseguier J, Bagherifam S, Hyldmo H, Barz M, De Geest BG, Fenaroli F (2020)
    Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle-Cell Interactions
    Small, 16 (5), e1906719
    DOI 10.1002/smll.201906719, PubMed 31943784
  3. Dillard P, Köksal H, Maggadottir SM, Winge-Main A, Pollmann S, Menard M, Myhre MR, Mælandsmoe GM, Flørenes VA, Gaudernack G, Kvalheim G, Wälchli S, Inderberg EM (2020)
    Targeting telomerase with an HLA class II-restricted TCR for cancer immunotherapy
    Mol Ther (in press)
    DOI 10.1016/j.ymthe.2020.11.019, PubMed 33212301
  4. Grigalavicius M, Mastrangelopoulou M, Arous D, Juzeniene A, Ménard M, Skarpen E, Berg K, Theodossiou TA (2020)
    Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
    Photochem Photobiol, 96 (3), 699-707
    DOI 10.1111/php.13257, PubMed 32125700
  5. Jerjes W, Hamdoon Z, Berg K, Høgset A, Hopper C (2020)
    Apparent Complete Response of a Treatment Refractory and Recurrent Squamous Cell Carcinoma Lesion to Photochemical Internalization: A Clinical Case Study
    Photochem Photobiol, 96 (3), 680-683
    DOI 10.1111/php.13210, PubMed 31901218
  6. Jerjes W, Theodossiou TA, Hirschberg H, Høgset A, Weyergang A, Selbo PK, Hamdoon Z, Hopper C, Berg K (2020)
    Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
    J Clin Med, 9 (2)
    DOI 10.3390/jcm9020528, PubMed 32075165
  7. Li X, Salzano G, Qiu J, Menard M, Berg K, Theodossiou T, Ladavière C, Gref R (2020)
    Drug-Loaded Lipid-Coated Hybrid Organic-Inorganic "Stealth" Nanoparticles for Cancer Therapy
    Front Bioeng Biotechnol, 8, 1027
    DOI 10.3389/fbioe.2020.01027, PubMed 33042960
  8. Mastrangelopoulou M, Grigalavicius M, Raabe TH, Skarpen E, Juzenas P, Peng Q, Berg K, Theodossiou TA (2020)
    Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
    Cancer Rep (Hoboken), e1278 (in press)
    DOI 10.1002/cnr2.1278, PubMed 32737955
  9. Nguyen L, Potma EO, Le JN, Johnson J, Romena G, Peng Q, Berg K, Hirschberg H (2020)
    Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier
    Lasers Med Sci
    DOI 10.1007/s10103-020-03140-w, PubMed 33123852
  10. Peng W, de Bruijn HS, Ten Hagen TLM, Berg K, Roodenburg JLN, van Dam GM, Witjes MJH, Robinson DJ (2020)
    In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate
    Cancers (Basel), 12 (1)
    DOI 10.3390/cancers12010190, PubMed 31940973
  11. Peng W, de Bruijn HS, Ten Hagen TLM, van Dam GM, Roodenburg JLN, Berg K, Witjes MJH, Robinson DJ (2020)
    Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model
    Photochem Photobiol, 96 (3), 708-717
    DOI 10.1111/php.13267, PubMed 32222965
  12. Romena G, Nguyen L, Berg K, Madsen SJ, Hirschberg H (2020)
    Enhanced gene transfection of macrophages by photochemical internalization; potential for gene-directed enzyme prodrug therapy of gliomas
    Photodiagnosis Photodyn Ther, 102098 (in press)
    DOI 10.1016/j.pdpdt.2020.102098, PubMed 33188941
  13. Šošić L, Selbo PK, Kotkowska ZK, Kündig TM, Høgset A, Johansen P (2020)
    Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines
    Cancers (Basel), 12 (1)
    DOI 10.3390/cancers12010165, PubMed 31936595
  14. Wong JJW, Berstad MB, Fremstedal ASV, Berg K, Patzke S, Sørensen V, Peng Q, Selbo PK, Weyergang A (2020)
    Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
    Cancers (Basel), 12 (2)
    DOI 10.3390/cancers12020417, PubMed 32053965
  15. Wong JJW, Selbo PK (2020)
    High aldehyde dehydrogenase activity does not protect colon cancer cells against TPCS2a-sensitized photokilling
    Photochem Photobiol Sci, 19 (3), 308-312
    DOI 10.1039/c9pp00453j, PubMed 32108197

Publications 2019

  1. Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2019)
    Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
    Nat Commun, 10 (1), 3986
    DOI 10.1038/s41467-019-12042-7, PubMed 31484929
  2. Jerjes W, Hamdoon Z, Berg K, Høgset A, Hopper C (2019)
    Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization
    Photodiagnosis Photodyn Ther, 27, 288-290
    DOI 10.1016/j.pdpdt.2019.06.018, PubMed 31252139
  3. Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre MR, Fåne A, Gaudernack G, Kvalheim G, Myklebust JH, Inderberg EM, Wälchli S (2019)
    NK cells specifically TCR-dressed to kill cancer cells
    EBioMedicine, 40, 106-117
    DOI 10.1016/j.ebiom.2019.01.031, PubMed 30665853
  4. Ney A, Mahamed I, Garcia-Sampedro A, Selbo PK, Sancho P, MacRobert AJ, Pereira SP, Acedo P (2019)
    Combination light-based therapies to treat pancreatic cancer: a proof of concept
    PROC SPIE, 11070, UNSP 1107045
  5. Olsen CE, Cheung LH, Weyergang A, Berg K, Vallera DA, Rosenblum MG, Selbo PK (2019)
    Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
    J Clin Med, 9 (1)
    DOI 10.3390/jcm9010068, PubMed 31888091
  6. Shin D, Nguyen L, T Le M, Ju D, N Le J, Berg K, Hirschberg H (2019)
    The effects of low irradiance long duration photochemical internalization on glioma spheroids
    Photodiagnosis Photodyn Ther, 26, 442-447
    DOI 10.1016/j.pdpdt.2019.05.005, PubMed 31075319
  7. Sun CH, Berg K, Hirschberg H (2019)
    Photochemical Internalization Enhanced Nonviral Suicide Gene Therapy
    Methods Mol Biol, 1895, 165-176
    DOI 10.1007/978-1-4939-8922-5_13, PubMed 30539537
  8. Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Schink KO, Olsen CE, Wälchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019)
    Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
    NPJ Breast Cancer, 5, 13
    DOI 10.1038/s41523-019-0108-8, PubMed 30993194

Publications 2018

  1. Christensen T, de Gruijl F, Hamblin M, Ishibashi Y, Kamada K, Sage E, Saltiel J, Sliwa M, Theodossiou T, Wu SP, Bassani D, Nonell S, Shore A (2018)
    Outstanding Reviewers for Photochemical and Photobiological Sciences in 2017
    Photochem. Photobiol. Sci., 17 (5), 533
  2. Eng MS, Kaur J, Prasmickaite L, Engesæter BØ, Weyergang A, Skarpen E, Berg K, Rosenblum MG, Mælandsmo GM, Høgset A, Ferrone S, Selbo PK (2018)
    Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins
    Photochem Photobiol Sci, 17 (5), 539-551
    DOI 10.1039/C7PP00358G, PubMed 29565434
  3. Fenaroli F, Repnik U, Xu Y, Johann K, Van Herck S, Dey P, Skjeldal FM, Frei DM, Bagherifam S, Kocere A, Haag R, De Geest BG, Barz M, Russell DG, Griffiths G (2018)
    Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models
    ACS Nano, 12 (8), 8646-8661
    DOI 10.1021/acsnano.8b04433, PubMed 30081622
  4. Haug M, Brede G, Håkerud M, Nedberg AG, Gederaas OA, Flo TH, Edwards VT, Selbo PK, Høgset A, Halaas Ø (2018)
    Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination
    Front Immunol, 9, 650
    DOI 10.3389/fimmu.2018.00650, PubMed 29670624
  5. Hirschberg H, Berg K, Peng Q (2018)
    Photodynamic therapy mediated immune therapy of brain tumors
    Neuroimmunol Neuroinflamm, 5
    DOI 10.20517/2347-8659.2018.31, PubMed 30221185
  6. Mastrangelopoulou M, Grigalavicius M, Berg K, Ménard M, Theodossiou TA (2018)
    Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
    Photochem Photobiol, 95 (1), 387-396
    DOI 10.1111/php.12997, PubMed 30107033
  7. Våtsveen TK, Myhre MR, Steen CB, Wälchli S, Lingjærde OC, Bai B, Dillard P, Theodossiou TA, Holien T, Sundan A, Inderberg EM, Smeland EB, Myklebust JH, Oksvold MP (2018)
    Artesunate shows potent anti-tumor activity in B-cell lymphoma
    J Hematol Oncol, 11 (1), 23
    DOI 10.1186/s13045-018-0561-0, PubMed 29458389
  8. Weyergang A, Fremstedal AS, Skarpen E, Peng Q, Mohamedali KA, Eng MS, Cheung LH, Rosenblum MG, Waltenberger J, Berg K (2018)
    Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
    J Control Release, 288, 161-172
    DOI 10.1016/j.jconrel.2018.09.005, PubMed 30217739
  9. Zhang X, de Boer L, Heiliegers L, Man-Bovenkerk S, Selbo PK, Drijfhout JW, Høgset A, Zaat SAJ (2018)
    Photochemical internalization enhances cytosolic release of antibiotic and increases its efficacy against staphylococcal infection
    J Control Release, 283, 214-222
    DOI 10.1016/j.jconrel.2018.06.004, PubMed 29883696

Publications 2017

  1. Azizi M, Ghourchian H, Yazdian F, Bagherifam S, Bekhradnia S, Nyström B (2017)
    Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line
    Sci Rep, 7 (1), 5178
    DOI 10.1038/s41598-017-05461-3, PubMed 28701707
  2. Bus MP, Szafranski A, Sellevold S, Goryn T, Jutte PC, Bramer JA, Fiocco M, Streitbürger A, Kotrych D, van de Sande MA, Dijkstra PD (2017)
    LUMiC® Endoprosthetic Reconstruction After Periacetabular Tumor Resection: Short-term Results
    Clin Orthop Relat Res, 475 (3), 686-695
    DOI 10.1007/s11999-016-4805-4, PubMed 27020434
  3. Christie C, Pomeroy A, Nair R, Berg K, Hirschberg H (2017)
    Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy
    Photodiagnosis Photodyn Ther, 18, 140-148
    DOI 10.1016/j.pdpdt.2017.02.016, PubMed 28257943
  4. Gaware VS, Håkerud M, Juzeniene A, Høgset A, Berg K, Másson M (2017)
    Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization
    Biomacromolecules, 18 (4), 1108-1126
    DOI 10.1021/acs.biomac.6b01670, PubMed 28245649
  5. Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE (2017)
    Microenvironmental autophagy promotes tumour growth
    Nature, 541 (7637), 417-420
    DOI 10.1038/nature20815, PubMed 28077876
  6. Lund K, Olsen CE, Wong JJW, Olsen PA, Solberg NT, Høgset A, Krauss S, Selbo PK (2017)
    5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
    J Exp Clin Cancer Res, 36 (1), 187
    DOI 10.1186/s13046-017-0662-6, PubMed 29258566
  7. Norum OJ, Fremstedal ASV, Weyergang A, Golab J, Berg K (2017)
    Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity
    J Control Release, 268, 120-127
    DOI 10.1016/j.jconrel.2017.10.015, PubMed 29042319
  8. Olsen CE, Sellevold S, Theodossiou T, Patzke S, Berg K (2017)
    Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
    Photodiagnosis Photodyn Ther, 20, 35-47
    DOI 10.1016/j.pdpdt.2017.08.010, PubMed 28838761
  9. Olsen CE, Weyergang A, Edwards VT, Berg K, Brech A, Weisheit S, Høgset A, Selbo PK (2017)
    Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
    Biochem Pharmacol, 144, 63-77
    DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290
  10. Sellevold S, Peng Q, Fremstedal ASV, Berg K (2017)
    Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice
    Photodiagnosis Photodyn Ther, 20, 95-106
    DOI 10.1016/j.pdpdt.2017.08.015, PubMed 28865875
  11. Shin D, Christie C, Ju D, Nair RK, Molina S, Berg K, Krasieva TB, Madsen SJ, Hirschberg H (2017)
    Photochemical internalization enhanced macrophage delivered chemotherapy
    Photodiagnosis Photodyn Ther, 21, 156-162
    DOI 10.1016/j.pdpdt.2017.12.002, PubMed 29221858
  12. Theodossiou TA, Olsen CE, Jonsson M, Kubin A, Hothersall JS, Berg K (2017)
    The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
    Redox Biol, 12, 191-197
    DOI 10.1016/j.redox.2017.02.018, PubMed 28254657

Publications 2016

  1. Christie C, Molina S, Gonzales J, Berg K, Nair RK, Huynh K, Madsen SJ, Hirschberg H (2016)
    Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization
    Biomed Opt Express, 7 (4), 1240-50
    DOI 10.1364/BOE.7.001240, PubMed 27446650
  2. Hjálmsdóttir Á, Bühler C, Vonwil V, Roveri M, Håkerud M, Wäckerle-Men Y, Gander B, Johansen P (2016)
    Cytosolic Delivery of Liposomal Vaccines by Means of the Concomitant Photosensitization of Phagosomes
    Mol Pharm, 13 (2), 320-9
    DOI 10.1021/acs.molpharmaceut.5b00394, PubMed 26704885
  3. Madsen SJ, Gonzales J, Zamora G, Berg K, Nair RK, Hirschberg H (2016)
    Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization
    J Environ Pathol Toxicol Oncol, 35 (1), 91-8
    DOI 10.1615/JEnvironPatholToxicolOncol.2016015463, PubMed 27279586
  4. Reichrath J, Berg K, Emmert S, Lademann J, Seckmeyer G, Zastrow L, Vogt T, Holick MF (2016)
    Biologic Effects of Light: An Enlighting Prospective
    Anticancer Res, 36 (3), 1339-43
    PubMed 26977035
  5. Sultan AA, Jerjes W, Berg K, Høgset A, Mosse CA, Hamoudi R, Hamdoon Z, Simeon C, Carnell D, Forster M, Hopper C (2016)
    Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial
    Lancet Oncol, 17 (9), 1217-29
    DOI 10.1016/S1470-2045(16)30224-8, PubMed 27475428

Publications 2015

  1. Baglo Y, Peng Q, Hagen L, Berg K, Høgset A, Drabløs F, Gederaas OA (2015)
    Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
    Photodiagnosis Photodyn Ther, 12 (1), 58-66
    DOI 10.1016/j.pdpdt.2014.12.005, PubMed 25575731
  2. Berg K (2015)
    Resistance mechanisms in photodynamic therapy
    Photochem Photobiol Sci, 14 (8), 1376-7
    DOI 10.1039/c5pp90026c, PubMed 26212047
  3. Berstad MB, Cheung LH, Berg K, Peng Q, Fremstedal AS, Patzke S, Rosenblum MG, Weyergang A (2015)
    Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy
    Oncogene, 34 (44), 5582-92
    DOI 10.1038/onc.2015.15, PubMed 25684137
  4. Bostad M, Olsen CE, Peng Q, Berg K, Høgset A, Selbo PK (2015)
    Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
    J Control Release, 206, 37-48
    DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331
  5. Bruno C, Waeckerle-Men Y, Håkerud M, Kündig TM, Gander B, Johansen P (2015)
    Photosensitizer and Light Pave the Way for Cytosolic Targeting and Generation of Cytosolic CD8 T Cells Using PLGA Vaccine Particles
    J Immunol, 195 (1), 166-73
    DOI 10.4049/jimmunol.1500431, PubMed 26019274
  6. Bull-Hansen B, Berstad MB, Berg K, Cao Y, Skarpen E, Fremstedal AS, Rosenblum MG, Peng Q, Weyergang A (2015)
    Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
    Oncotarget, 6 (14), 12436-51
    DOI 10.18632/oncotarget.3814, PubMed 26002552
  7. Christie CE, Zamora G, Kwon YJ, Berg K, Madsen SJ, Hirschberg H (2015)
    Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy
    PROC SPIE, 9305
  8. Pefkianakis EK, Theodossiou TA, Toubanaki DK, Karagouni E, Falaras P, Papadopoulos K, Vougioukalakis GC (2015)
    A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers
    Photochem Photobiol, 91 (5), 1191-202
    DOI 10.1111/php.12485, PubMed 26118404
  9. Selbo PK, Bostad M, Olsen CE, Edwards VT, Høgset A, Weyergang A, Berg K (2015)
    Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
    Photochem Photobiol Sci, 14 (8), 1433-50
    DOI 10.1039/c5pp00027k, PubMed 25805311
  10. Theodossiou TA, Wälchli S, Olsen CE, Skarpen E, Berg K (2015)
    Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
    ACS Chem Biol, 11 (1), 251-62
    DOI 10.1021/acschembio.5b00734, PubMed 26569462
  11. Weyergang A, Berstad ME, Bull-Hansen B, Olsen CE, Selbo PK, Berg K (2015)
    Photochemical activation of drugs for the treatment of therapy-resistant cancers
    Photochem Photobiol Sci, 14 (8), 1465-75
    DOI 10.1039/c5pp00029g, PubMed 25849953

Publications 2014

  1. Bostad M, Kausberg M, Weyergang A, Olsen CE, Berg K, Høgset A, Selbo PK (2014)
    Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization
    Mol Pharm, 11 (8), 2764-76
    DOI 10.1021/mp500129t, PubMed 24960585
  2. Bull-Hansen B, Cao Y, Berg K, Skarpen E, Rosenblum MG, Weyergang A (2014)
    Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome
    J Control Release, 182, 58-66
    DOI 10.1016/j.jconrel.2014.03.014, PubMed 24637464
  3. Håkerud M, Selbo PK, Waeckerle-Men Y, Contassot E, Dziunycz P, Kündig TM, Høgset A, Johansen P (2014)
    Photosensitisation facilitates cross-priming of adjuvant-free protein vaccines and stimulation of tumour-suppressing CD8 T cells
    J Control Release, 198, 10-7
    DOI 10.1016/j.jconrel.2014.11.032, PubMed 25482339
  4. Lund K, Bostad M, Skarpen E, Braunagel M, Kiprijanov S, Krauss S, Duncan A, Høgset A, Selbo PK (2014)
    The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
    MAbs, 6 (4), 1038-50
    DOI 10.4161/mabs.28207, PubMed 24525727
  5. Repetto-Llamazares AH, Larsen RH, Giusti AM, Riccardi E, Bruland ØS, Selbo PK, Dahle J (2014)
    177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice
    PLoS One, 9 (7), e103070
    DOI 10.1371/journal.pone.0103070, PubMed 25068508
  6. Wang F, Zamora G, Sun CH, Trinidad A, Berg K, Madsen SJ, Kwon YJ, Hirschberg H (2014)
    Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas.
    PROC SPIE, 8928, 89280B
  7. Weyergang A, Cheung LH, Rosenblum MG, Mohamedali KA, Peng Q, Waltenberger J, Berg K (2014)
    Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin
    J Control Release, 180, 1-9
    DOI 10.1016/j.jconrel.2014.02.003, PubMed 24531010
  8. Zamora G, Wang F, Sun CH, Trinidad A, Kwon YJ, Cho SK, Berg K, Madsen SJ, Hirschberg H (2014)
    Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier
    J Biomed Opt, 19 (10), 105009
    DOI 10.1117/1.JBO.19.10.105009, PubMed 25341069

Publications 2013

  1. Bostad M, Berg K, Høgset A, Skarpen E, Stenmark H, Selbo PK (2013)
    Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
    J Control Release, 168 (3), 317-26
    DOI 10.1016/j.jconrel.2013.03.023, PubMed 23567040
  2. Håkerud M, Waeckerle-Men Y, Selbo PK, Kündig TM, Høgset A, Johansen P (2013)
    Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen
    J Control Release, 174, 143-50
    DOI 10.1016/j.jconrel.2013.11.017, PubMed 24280261
  3. Olsen CE, Berg K, Selbo PK, Weyergang A (2013)
    Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin
    Free Radic Biol Med, 65, 1300-1309
    DOI 10.1016/j.freeradbiomed.2013.09.010, PubMed 24076428
  4. Weyergang A, Selbo PK, Berg K (2013)
    Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy
    Biochim Biophys Acta, 1830 (3), 2659-70
    DOI 10.1016/j.bbagen.2012.11.010, PubMed 23671927
  5. Weyergang A, Selbo PK, Berg K (2013)
    Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy (vol 1830, pg 2659, 2013)
    Biochim. Biophys. Acta-Gen. Subj., 1830 (10), 4417

Publications 2012

  1. Selbo PK, Weyergang A, Eng MS, Bostad M, Mælandsmo GM, Høgset A, Berg K (2012)
    Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
    J Control Release, 159 (2), 197-203
    DOI 10.1016/j.jconrel.2012.02.003, PubMed 22349185

Publications 2011

  1. Berg K, Golab J, Korbelik M, Russell D (2011)
    Drug delivery technologies and immunological aspects of photodynamic therapy
    Photochem Photobiol Sci, 10 (5), 647-8
    DOI 10.1039/c1pp90010b, PubMed 21487635
  2. Berg K, Nordstrand S, Selbo PK, Tran DT, Angell-Petersen E, Høgset A (2011)
    Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
    Photochem Photobiol Sci, 10 (10), 1637-51
    DOI 10.1039/c1pp05128h, PubMed 21773635
  3. Weyergang A, Selbo PK, Berstad ME, Bostad M, Berg K (2011)
    Photochemical internalization of tumor-targeted protein toxins
    Lasers Surg Med, 43 (7), 721-33
    DOI 10.1002/lsm.21084, PubMed 22057500

Publications 2010

  1. Berg K, Berstad M, Prasmickaite L, Weyergang A, Selbo PK, Hedfors I, Høgset A (2010)
    Photochemical internalization: a new tool for gene and oligonucleotide delivery
    Top Curr Chem, 296, 251-81
    DOI 10.1007/128_2010_63, PubMed 21504105
  2. Berg K, Weyergang A, Prasmickaite L, Bonsted A, Høgset A, Strand MT, Wagner E, Selbo PK (2010)
    Photochemical internalization (PCI): a technology for drug delivery
    Methods Mol Biol, 635, 133-45
    DOI 10.1007/978-1-60761-697-9_10, PubMed 20552345
  3. Johansen P, Berg K, Selbo PK, Hofbauer GF (2010)
    [Photochemical internalisation (PCI): a further development of photodynamic therapy for the treatment of skin cancer]
    Praxis (Bern 1994), 99 (23), 1423-8
    DOI 10.1024/1661-8157/a000310, PubMed 21082595
  4. Selbo PK, Weyergang A, Høgset A, Norum OJ, Berstad MB, Vikdal M, Berg K (2010)
    Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules
    J Control Release, 148 (1), 2-12
    DOI 10.1016/j.jconrel.2010.06.008, PubMed 20600406

Publications 2009

  1. Selbo PK, Rosenblum MG, Cheung LH, Zhang W, Berg K (2009)
    Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel
    PLoS One, 4 (8), e6691
    DOI 10.1371/journal.pone.0006691, PubMed 19690617
  2. Weyergang A, Berg K, Kaalhus O, Peng Q, Selbo PK (2009)
    Photodynamic therapy targets the mTOR signaling network in vitro and in vivo
    Mol Pharm, 6 (1), 255-64
    DOI 10.1021/mp800156e, PubMed 19125612
  3. Woodhams J, Lou PJ, Selbo PK, Mosse A, Oukrif D, MacRobert A, Novelli M, Peng Q, Berg K, Bown SG (2009)
    Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin--quantitative studies in normal rat liver
    J Control Release, 142 (3), 347-53
    DOI 10.1016/j.jconrel.2009.11.017, PubMed 19932724

Publications 2008

  1. Bonsted A, Wagner E, Prasmickaite L, Høgset A, Berg K (2008)
    Photochemical enhancement of DNA delivery by EGF receptor targeted polyplexes
    Methods Mol Biol, 434, 171-81
    DOI 10.1007/978-1-60327-248-3_11, PubMed 18470645
  2. Weyergang A, Kaalhus O, Berg K (2008)
    Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival
    Mol Cancer Ther, 7 (6), 1740-50
    DOI 10.1158/1535-7163.MCT-08-0020, PubMed 18566245
  3. Weyergang A, Kaalhus O, Berg K (2008)
    Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478
    Photochem Photobiol Sci, 7 (9), 1032-40
    DOI 10.1039/b806209a, PubMed 18754049

Publications 2007

  1. Berg K, Folini M, Prasmickaite L, Selbo PK, Bonsted A, Engesaeter BØ, Zaffaroni N, Weyergang A, Dietze A, Maelandsmo GM, Wagner E, Norum OJ, Høgset A (2007)
    Photochemical internalization: a new tool for drug delivery
    Curr Pharm Biotechnol, 8 (6), 362-72
    DOI 10.2174/138920107783018354, PubMed 18289045
  2. Folini M, Bandiera R, Millo E, Gandellini P, Sozzi G, Gasparini P, Longoni N, Binda M, Daidone MG, Berg K, Zaffaroni N (2007)
    Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells
    Cell Prolif, 40 (6), 905-20
    DOI 10.1111/j.1365-2184.2007.00470.x, PubMed 18021178
  3. Madsen SJ, Kharkhuu K, Berg K, Hirschberg H (2007)
    Photochemical internalization for the treatment of malignant gliomas
    PROC SPIE, 6424, 64242C
  4. Peng Q, Berg K (2007)
    Introduction to the special issue on photodynamic therapy and photodetection
    Photochem. Photobiol. Sci., 6 (12), 1233
  5. Weyergang A, Selbo PK, Berg K (2007)
    Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor
    Biochem Pharmacol, 74 (2), 226-35
    DOI 10.1016/j.bcp.2007.04.018, PubMed 17531956

Publications 2006

  1. Berg K, Høgset A, Prasmickaite L, Weyergang A, Bonsted A, Dietze A, Lou PJ, Bown S, Norum OJ, Møllergard HM, Selbo PK (2006)
    Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents.
    Med Laser Appl, 21, 239-251
    DOI 10.1016/j.mla.2006.08.004, PublikaID 73
  2. Bonsted A, Engesaeter BØ, Høgset A, Berg K (2006)
    Photochemically enhanced adenoviral transduction in a multicellular environment
    Photochem Photobiol Sci, 5 (4), 411-21
    DOI 10.1039/b515066c, PubMed 16583022
  3. Bonsted A, Engesaeter BØ, Høgset A, Maelandsmo GM, Prasmickaite L, D'Oliveira C, Hennink WE, van Steenis JH, Berg K (2006)
    Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
    J Gene Med, 8 (3), 286-97
    DOI 10.1002/jgm.853, PubMed 16342300
  4. Dietze A, Selbo PK, Prasmickaite L, Weyergang A, Bonsted A, Engesaeter B, Hogset A, Berg K (2006)
    Photochemical internalization (PCI): a new modality for light activation of endocytosed therapeuticals
    J Environ Pathol Toxicol Oncol, 25 (1-2), 521-36
    DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.330, PubMed 16566739
  5. Prasmickaite L, Cekaite L, Hellum M, Hovig E, Høgset A, Berg K (2006)
    Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
    FEBS Lett, 580 (24), 5739-46
    DOI 10.1016/j.febslet.2006.09.028, PubMed 17007842
  6. Prasmickaite L, Hellum M, Kaalhus O, Høgset A, Wagner E, Berg K (2006)
    Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter
    Photochem Photobiol, 82 (3), 809-16
    DOI 10.1562/2005-11-07-RA-731, PubMed 16420102
  7. Selbo PK, Weyergang A, Bonsted A, Bown SG, Berg K (2006)
    Photochemical internalization of therapeutic macromolecular agents: a novel strategy to kill multidrug-resistant cancer cells
    J Pharmacol Exp Ther, 319 (2), 604-12
    DOI 10.1124/jpet.106.109165, PubMed 16902053
  8. Weyergang A, Selbo PK, Berg K (2006)
    Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin
    J Control Release, 111 (1-2), 165-73
    DOI 10.1016/j.jconrel.2005.12.002, PubMed 16466823

Publications 2005

  1. Berg K, Dietze A, Kaalhus O, Høgset A (2005)
    Site-specific drug delivery by photochemical internalization enhances the antitumor effect of bleomycin
    Clin Cancer Res, 11 (23), 8476-85
    DOI 10.1158/1078-0432.CCR-05-1245, PubMed 16322311
  2. Bonsted A, Høgset A, Hoover F, Berg K (2005)
    Photochemical enhancement of gene delivery to glioblastoma cells is dependent on the vector applied
    Anticancer Res, 25 (1A), 291-7
    PubMed 15816550
  3. Dietze A, Berg K (2005)
    ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies
    Photodiagnosis Photodyn Ther, 2 (4), 299-307
    DOI 10.1016/S1572-1000(05)00107-9, PubMed 25048871
  4. Dietze A, Peng Q, Selbo PK, Kaalhus O, Müller C, Bown S, Berg K (2005)
    Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
    Br J Cancer, 92 (11), 2004-9
    DOI 10.1038/sj.bjc.6602600, PubMed 15886704

Publications 2004

  1. Berg K, Selbo PK, Prasmickaite L, Høgset A (2004)
    Photochemical drug and gene delivery
    Curr Opin Mol Ther, 6 (3), 279-87
    PubMed 15264430
  2. Bonsted A, Engesaeter BØ, Høgset A, Maelandsmo GM, Prasmickaite L, Kaalhus O, Berg K (2004)
    Transgene expression is increased by photochemically mediated transduction of polycation-complexed adenoviruses
    Gene Ther, 11 (2), 152-60
    DOI 10.1038/sj.gt.3302166, PubMed 14712299

Publications 2003

  1. Berg K, Prasmickaite L, Selbo PK, Hellum M, Bonsted A, Høgset A (2003)
    Photochemical internalization (PCI)--a novel technology for release of macromolecules from endocytic vesicles
    Oftalmologia, 56 (1), 67-71
    PubMed 12886687
  2. Hellum M, Høgset A, Engesaeter BO, Prasmickaite L, Stokke T, Wheeler C, Berg K (2003)
    Photochemically enhanced gene delivery with cationic lipid formulations
    Photochem Photobiol Sci, 2 (4), 407-11
    DOI 10.1039/b211880g, PubMed 12760539
  3. Høgset A, Prasmickaite L, Engesaeter BO, Hellum M, Selbo PK, Olsen VM, Maelandsmo GM, Berg K (2003)
    Light directed gene transfer by photochemical internalisation
    Curr Gene Ther, 3 (2), 89-112
    DOI 10.2174/1566523034578438, PubMed 12653404

Publications 2002

  1. Prasmickaite L, Høgset A, Selbo PK, Engesaeter BØ, Hellum M, Berg K (2002)
    Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy
    Br J Cancer, 86 (4), 652-7
    DOI 10.1038/sj.bjc.6600138, PubMed 11870551
  2. Selbo PK, Høgset A, Prasmickaite L, Berg K (2002)
    Photochemical internalisation: a novel drug delivery system
    Tumour Biol, 23 (2), 103-12
    DOI 10.1159/000059713, PubMed 12065848

Publications 2001

  1. Prasmickaite L, Høgset A, Berg K (2001)
    Evaluation of different photosensitizers for use in photochemical gene transfection
    Photochem Photobiol, 73 (4), 388-95
    DOI 10.1562/0031-8655(2001)073<0388:eodpfu>2.0.co;2, PubMed 11332034
  2. Selbo PK, Kaalhus O, Sivam G, Berg K (2001)
    5-Aminolevulinic acid-based photochemical internalization of the immunotoxin MOC31-gelonin generates synergistic cytotoxic effects in vitro
    Photochem Photobiol, 74 (2), 303-10
    DOI 10.1562/0031-8655(2001)074<0303:aabpio>2.0.co;2, PubMed 11547569
  3. Selbo PK, Sivam G, Fodstad O, Sandvig K, Berg K (2001)
    In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
    Int J Cancer, 92 (5), 761-6
    DOI 10.1002/1097-0215(20010601)92:5<761::aid-ijc1238>3.0.co;2-4, PubMed 11340584

Publications 2000

  1. Prasmickaite L, Høgset A, Tjelle TE, Olsen VM, Berg K (2000)
    Role of endosomes in gene transfection mediated by photochemical internalisation (PCI)
    J Gene Med, 2 (6), 477-88
    DOI 10.1002/1521-2254(200011/12)2:6<477::AID-JGM137>3.0.CO;2-B, PubMed 11199268
  2. Selbo PK, Sandvig K, Kirveliene V, Berg K (2000)
    Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
    Biochim Biophys Acta, 1475 (3), 307-13
    DOI 10.1016/s0304-4165(00)00082-9, PubMed 10913830
  3. Selbo PK, Sivam G, Fodstad O, Sandvig K, Berg K (2000)
    Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
    Int J Cancer, 87 (6), 853-9
    DOI 10.1002/1097-0215(20000915)87:6<853::aid-ijc15>3.0.co;2-0, PubMed 10956397

Publications 1999

  1. Berg K, Selbo PK, Prasmickaite L, Tjelle TE, Sandvig K, Moan J, Gaudernack G, Fodstad O, Kjølsrud S, Anholt H, Rodal GH, Rodal SK, Høgset A (1999)
    Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
    Cancer Res, 59 (6), 1180-3
    PubMed 10096543

Publications 1998

  1. Berg K, Maziere JC, Geze M, Santus R (1998)
    Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine
    Biochim Biophys Acta, 1370 (2), 317-24
    DOI 10.1016/s0005-2736(97)00282-4, PubMed 9545591

Publications 1992

  1. Berg K (1992)
    The unpolymerized form of tubulin is the target for microtubule inhibition by photoactivated tetra(4-sulfonatophenyl)porphine
    Biochim Biophys Acta, 1135 (2), 147-53
    DOI 10.1016/0167-4889(92)90130-4, PubMed 1616935

 
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