Publications by Kjetil Wessel Andressen
33 publications found
-
Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture
Cells, 11 (20)
DOI 10.3390/cells11203257, PubMed 36291124 -
Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
Int J Mol Sci, 23 (4)
DOI 10.3390/ijms23042145, PubMed 35216259 -
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res, 118 (6), 1506-1519
DOI 10.1093/cvr/cvab167, PubMed 33970224 -
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394 -
An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling
Proc Natl Acad Sci U S A, 117 (48), 30755-30762
DOI 10.1073/pnas.2010801117, PubMed 33199589 -
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun Biol, 2, 394
DOI 10.1038/s42003-019-0641-x, PubMed 31701023 -
Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase
FASEB J, 33 (3), 3870-3886
DOI 10.1096/fj.201800805RR, PubMed 30508496 -
Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation
FASEB J, 32 (2), 1059-1069
DOI 10.1096/fj.201700486R, PubMed 29079700 -
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017
BMC Pharmacol Toxicol, 18 (Suppl 1), 64
DOI 10.1186/s40360-017-0170-5, PubMed 29035170 -
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014, PubMed 28697992 -
Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats
Nucl Med Biol, 43 (8), 478-89
DOI 10.1016/j.nucmedbio.2016.05.003, PubMed 27236283 -
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front Behav Neurosci, 9, 92
DOI 10.3389/fnbeh.2015.00092, PubMed 26005408 -
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors
Br J Pharmacol, 172 (15), 3846-60
DOI 10.1111/bph.13169, PubMed 25884989 -
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547, PubMed 25738589 -
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
ACS Chem Neurosci, 6 (7), 1206-18
DOI 10.1021/cn500339p, PubMed 25706089 -
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists
Bioorg Med Chem Lett, 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083, PubMed 25149506 -
Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression
Bioorg Med Chem Lett, 24 (7), 1846-50
DOI 10.1016/j.bmcl.2014.02.002, PubMed 24613701 -
Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
FASEB J, 28 (5), 2293-305
DOI 10.1096/fj.13-246363, PubMed 24500924 -
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists
Bioorg Med Chem, 21 (22), 7134-45
DOI 10.1016/j.bmc.2013.09.004, PubMed 24113240 -
The serotonin 5-HT7 receptors: two decades of research
Exp Brain Res, 230 (4), 555-68
DOI 10.1007/s00221-013-3694-y, PubMed 24042216 -
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist
Eur J Med Chem, 64, 629-37
DOI 10.1016/j.ejmech.2013.03.060, PubMed 23711770 -
Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor
FEBS J, 279 (11), 1994-2003
DOI 10.1111/j.1742-4658.2012.08581.x, PubMed 22448645 -
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg Med Chem, 18 (24), 8600-13
DOI 10.1016/j.bmc.2010.10.011, PubMed 21075638 -
The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway
Eur J Immunol, 38 (11), 3208-18
DOI 10.1002/eji.200838195, PubMed 18991294 -
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br J Pharmacol, 155 (7), 1005-14
DOI 10.1038/bjp.2008.339, PubMed 18846035 -
Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain
Gene, 426 (1-2), 23-31
DOI 10.1016/j.gene.2008.08.011, PubMed 18793707 -
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol Pharmacol, 72 (3), 582-91
DOI 10.1124/mol.107.035766, PubMed 17573483 -
Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor
Eur J Pharmacol, 532 (1-2), 1-10
DOI 10.1016/j.ejphar.2005.11.039, PubMed 16487959 -
Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression
Mol Pharmacol, 69 (1), 207-15
DOI 10.1124/mol.105.015396, PubMed 16189297 -
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure
Cardiovasc Res, 65 (4), 869-78
DOI 10.1016/j.cardiores.2004.11.017, PubMed 15721867 -
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Naunyn Schmiedebergs Arch Pharmacol, 369 (6), 616-28
DOI 10.1007/s00210-004-0919-4, PubMed 15118808 -
Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs
Recept Channels, 9 (2), 107-16
DOI 10.1080/10606820308245, PubMed 12916471 -
Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats
MedChemComm, 6 (4), 708-714
DOI 10.1039/c4md00486h