Publications by Jan Terje Andersen
102 publications found
Publications 2024
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Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Commun Biol, 7 (1), 922
DOI 10.1038/s42003-024-06561-3, PubMed 39085379 -
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
Nat Commun, 15 (1), 2007
DOI 10.1038/s41467-024-46321-9, PubMed 38453922 -
Insight into the avidity-affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn
MAbs, 16 (1), 2361585
DOI 10.1080/19420862.2024.2361585, PubMed 38849969 -
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Structure, 32 (9), 1404-1418.e7
DOI 10.1016/j.str.2024.07.014, PubMed 39146931
Publications 2023
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A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery
PNAS Nexus, 2 (12), pgad403
DOI 10.1093/pnasnexus/pgad403, PubMed 38077689 -
Assessing developability early in the discovery process for novel biologics
MAbs, 15 (1), 2171248
DOI 10.1080/19420862.2023.2171248, PubMed 36823021 -
Antibody blockade of Jagged1 attenuates choroidal neovascularization
Nat Commun, 14 (1), 3109
DOI 10.1038/s41467-023-38563-w, PubMed 37253747 -
Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties
Int J Retina Vitreous, 9 (1), 65
DOI 10.1186/s40942-023-00507-3, PubMed 37936232 -
Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells
Front Immunol, 14, 1178817
DOI 10.3389/fimmu.2023.1178817, PubMed 37346044 -
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Science, 379 (6639), 1336-1341
DOI 10.1126/science.abn1366, PubMed 36996217 -
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 8 (1), 4
DOI 10.1038/s41541-023-00600-6, PubMed 36697432 -
Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library
Protein Sci, 32 (12), e4821
DOI 10.1002/pro.4821, PubMed 37897425
Publications 2022
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Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
MAbs, 14 (1), 2008790
DOI 10.1080/19420862.2021.2008790, PubMed 35293269 -
In silico proof of principle of machine learning-based antibody design at unconstrained scale
MAbs, 14 (1), 2031482
DOI 10.1080/19420862.2022.2031482, PubMed 35377271 -
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge
Sci Immunol, 7 (70), eabj1640
DOI 10.1126/sciimmunol.abj1640, PubMed 35486676 -
Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life
Commun Biol, 5 (1), 832
DOI 10.1038/s42003-022-03787-x, PubMed 35982144 -
A Silicone Oil-Free Syringe Tailored for Intravitreal Injection of Biologics
Front Ophthalmol (Lausanne), 2, 882013
DOI 10.3389/fopht.2022.882013, PubMed 38983507 -
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life
iScience, 25 (2), 103746
DOI 10.1016/j.isci.2022.103746, PubMed 35118359 -
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
Immunohorizons, 6 (1), 90-103
DOI 10.4049/immunohorizons.2100097, PubMed 35074850 -
Contribution of the ex vivo placental perfusion model in understanding transplacental immunoglobulin G transfer
Placenta, 127, 77-87
DOI 10.1016/j.placenta.2022.07.019, PubMed 35981406 -
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
Front Immunol, 13, 964525
DOI 10.3389/fimmu.2022.964525, PubMed 36159859 -
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 7 (1), 174
DOI 10.1038/s41541-022-00586-7, PubMed 36585405 -
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes
Bioconjug Chem, 33 (8), 1494-1504
DOI 10.1021/acs.bioconjchem.2c00220, PubMed 35875886 -
Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders
Front Immunol, 13, 892534
DOI 10.3389/fimmu.2022.892534, PubMed 35757719 -
Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?
Cells, 11 (6)
DOI 10.3390/cells11060942, PubMed 35326398 -
Correction: Zakrzewicz et al. Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? Cells 2022, 11, 942
Cells, 11 (10)
DOI 10.3390/cells11101700, PubMed 35626757
Publications 2021
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The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs
Eur J Pharm Biopharm, 162, 99-104
DOI 10.1016/j.ejpb.2021.03.009, PubMed 33771621 -
Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery
Adv Drug Deliv Rev, 175, 113778
DOI 10.1016/j.addr.2021.04.016, PubMed 33887405 -
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial
Ann Intern Med, 174 (9), 1261-1269
DOI 10.7326/M21-0653, PubMed 34251903 -
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Front Immunol, 12, 668207
DOI 10.3389/fimmu.2021.668207, PubMed 33912195 -
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses
Vaccine, 39 (11), 1583-1592
DOI 10.1016/j.vaccine.2021.02.012, PubMed 33612340 -
Can the ampoules of covid-19 vaccine be used better?
Tidsskr. Nor. Laegeforen., 141 (2), 110 -
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
J Neurol Neurosurg Psychiatry, 94 (1), 19-22
DOI 10.1136/jnnp-2021-327612, PubMed 34670844 -
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
Commun Biol, 4 (1), 310
DOI 10.1038/s42003-021-01790-2, PubMed 33686177 -
Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling
Eur J Pharm Biopharm, 167, 104-113
DOI 10.1016/j.ejpb.2021.07.011, PubMed 34303832 -
Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
MAbs, 13 (1), 1893888
DOI 10.1080/19420862.2021.1893888, PubMed 33691596 -
Cluster of symptomatic silicone oil droplets following intravitreal injections: a 1-year observational study
BMJ Open Ophthalmol, 6 (1), e000764
DOI 10.1136/bmjophth-2021-000764, PubMed 34485702 -
Trends in seroprevalence of SARS-CoV-2 and infection fatality rate in the Norwegian population through the first year of the COVID-19 pandemic
Influenza Other Respir Viruses, 16 (2), 204-212
DOI 10.1111/irv.12932, PubMed 34751488 -
The neonatal Fc receptor in mucosal immune regulation
Scand J Immunol, 93 (2), e13017
DOI 10.1111/sji.13017, PubMed 33351196
Publications 2020
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Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin
J Control Release, 327, 161-173
DOI 10.1016/j.jconrel.2020.08.005, PubMed 32771477 -
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243 -
Intracellular neutralisation of rotavirus by VP6-specific IgG
PLoS Pathog, 16 (8), e1008732
DOI 10.1371/journal.ppat.1008732, PubMed 32750093 -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538 -
FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity
J Exp Med, 217 (10)
DOI 10.1084/jem.20200359, PubMed 32658257 -
[Can vials of COVID-19 vaccine be used more effectively?]
Tidsskr Nor Laegeforen, 140 (2)
DOI 10.4045/tidsskr.20.1039, PubMed 33528143 -
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
MAbs, 12 (1), 1686319
DOI 10.1080/19420862.2019.1686319, PubMed 31671278 -
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072
Publications 2019
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Complement C4 Prevents Viral Infection through Capsid Inactivation
Cell Host Microbe, 25 (4), 617-629.e7
DOI 10.1016/j.chom.2019.02.016, PubMed 30926239 -
TRIM21-From Intracellular Immunity to Therapy
Front Immunol, 10, 2049
DOI 10.3389/fimmu.2019.02049, PubMed 31555278 -
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
EMBO J, 38 (21), e101365
DOI 10.15252/embj.2018101365, PubMed 31468569 -
A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes
Sci Rep, 9 (1), 18021
DOI 10.1038/s41598-019-54226-7, PubMed 31792234 -
Targeting B-cell malignancies with the beta-emitting anti-CD37 radioimmunoconjugate 177Lu-NNV003
Eur J Nucl Med Mol Imaging, 46 (11), 2311-2321
DOI 10.1007/s00259-019-04417-1, PubMed 31309259 -
The Neonatal Fc Receptor (FcRn): A Misnomer?
Front Immunol, 10, 1540
DOI 10.3389/fimmu.2019.01540, PubMed 31354709 -
Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies
Nat Nanotechnol, 14 (2), 184-190
DOI 10.1038/s41565-018-0336-3, PubMed 30643273 -
Publisher Correction: Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies
Nat Nanotechnol, 14 (4), 398
DOI 10.1038/s41565-019-0404-3, PubMed 30783200
Publications 2018
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TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination
Proc Natl Acad Sci U S A, 115 (41), 10440-10445
DOI 10.1073/pnas.1806314115, PubMed 30209217 -
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
Nat Commun, 9 (1), 621
DOI 10.1038/s41467-018-03061-x, PubMed 29434196 -
Human and mouse albumin bind their respective neonatal Fc receptors differently
Sci Rep, 8 (1), 14648
DOI 10.1038/s41598-018-32817-0, PubMed 30279529 -
Animal models for evaluation of albumin-based therapeutics
Curr. Opin. Chem. Eng., 19, 68-76
DOI 10.1016/j.coche.2017.11.007 -
Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties
Sci Rep, 8 (1), 2101
DOI 10.1038/s41598-018-20525-8, PubMed 29391560 -
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport
Mol Immunol, 95, 1-9
DOI 10.1016/j.molimm.2018.01.006, PubMed 29367080
Publications 2017
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Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 7, 45418
DOI 10.1038/srep45418, PubMed 28382939 -
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Proc Natl Acad Sci U S A, 114 (14), E2862-E2871
DOI 10.1073/pnas.1618291114, PubMed 28330995
Publications 2016
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Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 6, 37457
DOI 10.1038/srep37457, PubMed 27881870 -
Dissecting the interaction between transglutaminase 2 and fibronectin
Amino Acids, 49 (3), 489-500
DOI 10.1007/s00726-016-2296-y, PubMed 27394141 -
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230
Publications 2015
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The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery
J Control Release, 211, 144-62
DOI 10.1016/j.jconrel.2015.06.006, PubMed 26055641 -
Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies
FEBS J, 282 (11), 2063-75
DOI 10.1111/febs.13276, PubMed 25808416 -
Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease
J Biol Chem, 290 (35), 21365-75
DOI 10.1074/jbc.M115.669895, PubMed 26160175 -
Developing the IVIG biomimetic, hexa-Fc, for drug and vaccine applications
Sci Rep, 5, 9526
DOI 10.1038/srep09526, PubMed 25912958 -
Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization
J Control Release, 223, 42-52
DOI 10.1016/j.jconrel.2015.12.033, PubMed 26718855 -
TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity
Immunol Rev, 268 (1), 328-39
DOI 10.1111/imr.12363, PubMed 26497531 -
Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions
J Immunol, 194 (11), 5497-508
DOI 10.4049/jimmunol.1401218, PubMed 25904551 -
Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics
Front Immunol, 5, 682
DOI 10.3389/fimmu.2014.00682, PubMed 25674083
Publications 2014
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Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290 -
On the perplexingly low rate of transport of IgG2 across the human placenta
PLoS One, 9 (9), e108319
DOI 10.1371/journal.pone.0108319, PubMed 25251461 -
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
Immunobiology, 220 (4), 452-9
DOI 10.1016/j.imbio.2014.11.003, PubMed 25468724 -
The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure
Biochemistry, 53 (13), 2091-100
DOI 10.1021/bi401436h, PubMed 24625295 -
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603 -
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301
Publications 2013
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Single-chain variable fragment albumin fusions bind the neonatal Fc receptor (FcRn) in a species-dependent manner: implications for in vivo half-life evaluation of albumin fusion therapeutics
J Biol Chem, 288 (33), 24277-85
DOI 10.1074/jbc.M113.463000, PubMed 23818524 -
Selection of nanobodies that target human neonatal Fc receptor
Sci Rep, 3, 1118
DOI 10.1038/srep01118, PubMed 23346375 -
B-cell tolerance to the B-cell receptor variable regions
Eur J Immunol, 43 (10), 2577-87
DOI 10.1002/eji.201243203, PubMed 23839948 -
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
J Immunol, 191 (9), 4769-77
DOI 10.4049/jimmunol.1301653, PubMed 24062486 -
Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions
Blood, 122 (7), 1174-81
DOI 10.1182/blood-2012-12-473843, PubMed 23843496
Publications 2012
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Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Nat Commun, 3, 610
DOI 10.1038/ncomms1607, PubMed 22215085 -
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life
J Biol Chem, 287 (27), 22927-37
DOI 10.1074/jbc.M112.355131, PubMed 22570488 -
Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity
ACS Chem Biol, 8 (2), 368-75
DOI 10.1021/cb300455f, PubMed 23030766 -
A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance
Protein Eng Des Sel, 26 (3), 187-93
DOI 10.1093/protein/gzs096, PubMed 23175797
Publications 2011
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Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells
Proc Natl Acad Sci U S A, 108 (24), 9927-32
DOI 10.1073/pnas.1019037108, PubMed 21628593 -
Polymeric human Fc-fusion proteins with modified effector functions
Sci Rep, 1, 124
DOI 10.1038/srep00124, PubMed 22355641 -
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential
Nat Commun, 2, 599
DOI 10.1038/ncomms1608, PubMed 22186895
Publications 2010
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Extending half-life by indirect targeting of the neonatal Fc receptor (FcRn) using a minimal albumin binding domain
J Biol Chem, 286 (7), 5234-41
DOI 10.1074/jbc.M110.164848, PubMed 21138843
Publications 2009
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Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
J Biol Chem, 285 (7), 4826-36
DOI 10.1074/jbc.M109.081828, PubMed 20018855 -
FcRn binding properties of an abnormal truncated analbuminemic albumin variant
Clin Biochem, 43 (4-5), 367-72
DOI 10.1016/j.clinbiochem.2009.12.001, PubMed 20006594 -
The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics
Drug Metab Pharmacokinet, 24 (4), 318-32
DOI 10.2133/dmpk.24.318, PubMed 19745559
Publications 2008
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Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation
J Biol Chem, 284 (2), 1126-35
DOI 10.1074/jbc.M803584200, PubMed 18957413 -
Dependence of antibody-mediated presentation of antigen on FcRn
Proc Natl Acad Sci U S A, 105 (27), 9337-42
DOI 10.1073/pnas.0801717105, PubMed 18599440
Publications 2007
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A strategy for bacterial production of a soluble functional human neonatal Fc receptor
J Immunol Methods, 331 (1-2), 39-49
DOI 10.1016/j.jim.2007.11.003, PubMed 18155020 -
A receptor-mediated mechanism to support clinical observation of altered albumin variants
Clin Chem, 53 (12), 2216
DOI 10.1373/clinchem.2007.097071, PubMed 18267931
Publications 2006
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The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin
Eur J Immunol, 36 (11), 3044-51
DOI 10.1002/eji.200636556, PubMed 17048273
Publications 2005
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Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
J Immunol Methods, 298 (1-2), 93-104
DOI 10.1016/j.jim.2005.01.002, PubMed 15847800