Inflammatory and Molecular Mechanisms in Atherosclerosis and Related Metabolic Disorders

Bente Halvorsen
Group Leader 

Cardiovascular disease and related metabolic disorders such as diabetes, obesity and fatty liver disease are major causes of morbidity and mortality worldwide. They have many common features, such as dyslipidemia and inflammation. By exploring these processes through translational research, connecting basic science and the clinic, we wish to build a foundation for the development of new diagnostic and treatment targets for these conditions. Our research group works in the cross-section between molecular biology and biochemistry, and cardiovascular, cerebrovascular and endocrine medicine. Our ambitious goal is to delineate novel therapeutic targets and biomarkers. The group uses different research approaches, ranging from analyses of blood and tissue samples from patients, to studies in genetically modified mice using advanced cellular and molecular biology. The group consists of people with different educational background and includes medical doctors, nutritionists, biochemists and engineers. Such multidisciplinary competence is a great strength of our research group.

Some important subproject
  • The role of NAMPT/visfatin in atherosclerosis and metabolic disorders
  • The role of cytokines and chemokines in ischemic heart disease and stroke
  • Platelet-mediated inflammation
  • Inflammatory and metabolic effect of LIGHT
  • DNA repair enzymes in atherosclerosis and metabolic diseases
Photo Øystein H. Horgmo, University of Oslo

From left: Bente Halvorsen, Ida Gregersen, Tonje Skarpengland, Sverre Holm ,Ana Quiles Jimenes, Karolina Ryeng Skagen, Vigdis Bjerkeli, Mona Skjelland and Xiang Yi Kong.
Not present: Ellen Lund Sagen, Turid M Pedersen, Filip Segers, Tuva Børresdatter Dahl, Kjell Torp-Joakimsen, Nina Solheim and Azhar Abbas