Kristian Berg

  • Professor, Head of department
  • +47 22 78 14 79
 

Original articles

Wong JJW, Berstad MB, Fremstedal ASV, Berg K, Patzke S, Sørensen V, Peng Q, Selbo PK, Weyergang A (2020)
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965

Peng W, de Bruijn HS, Ten Hagen TLM, Berg K, Roodenburg JLN, van Dam GM, Witjes MJH, Robinson DJ (2020)
In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate
Cancers (Basel), 12 (1)
DOI 10.3390/cancers12010190, PubMed 31940973

Jerjes W, Hamdoon Z, Berg K, Høgset A, Hopper C (2020)
Apparent Complete Response of a Treatment Refractory and Recurrent Squamous Cell Carcinoma Lesion to Photochemical Internalization: A Clinical Case Study
Photochem Photobiol (in press)
DOI 10.1111/php.13210, PubMed 31901218

Olsen CE, Cheung LH, Weyergang A, Berg K, Vallera DA, Rosenblum MG, Selbo PK (2019)
Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
J Clin Med, 9 (1)
DOI 10.3390/jcm9010068, PubMed 31888091

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2019)
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929

Jerjes W, Hamdoon Z, Berg K, Høgset A, Hopper C (2019)
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization
Photodiagnosis Photodyn Ther, 27, 288-290
DOI 10.1016/j.pdpdt.2019.06.018, PubMed 31252139

Shin D, Nguyen L, T Le M, Ju D, N Le J, Berg K, Hirschberg H (2019)
The effects of low irradiance long duration photochemical internalization on glioma spheroids
Photodiagnosis Photodyn Ther, 26, 442-447
DOI 10.1016/j.pdpdt.2019.05.005, PubMed 31075319

Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Schink KO, Olsen CE, Wälchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019)
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194

Sun CH, Berg K, Hirschberg H (2019)
Photochemical Internalization Enhanced Nonviral Suicide Gene Therapy
Methods Mol Biol, 1895, 165-176
DOI 10.1007/978-1-4939-8922-5_13, PubMed 30539537

Mastrangelopoulou M, Grigalavicius M, Berg K, Ménard M, Theodossiou TA (2018)
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Photochem Photobiol, 95 (1), 387-396
DOI 10.1111/php.12997, PubMed 30107033

Weyergang A, Fremstedal AS, Skarpen E, Peng Q, Mohamedali KA, Eng MS, Cheung LH, Rosenblum MG, Waltenberger J, Berg K (2018)
Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J Control Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005, PubMed 30217739

Nair RK, Christie C, Ju D, Shin D, Pomeroy A, Berg K, Peng Q, Hirschberg H (2018)
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)
Lasers Med Sci, 33 (8), 1747-1755
DOI 10.1007/s10103-018-2534-5, PubMed 29802587

Hirschberg H, Berg K, Peng Q (2018)
Photodynamic therapy mediated immune therapy of brain tumors
Neuroimmunol Neuroinflamm, 5
DOI 10.20517/2347-8659.2018.31, PubMed 30221185

Shin D, Christie C, Ju D, Nair RK, Molina S, Berg K, Krasieva TB, Madsen SJ, Hirschberg H (2017)
Photochemical internalization enhanced macrophage delivered chemotherapy
Photodiagnosis Photodyn Ther, 21, 156-162
DOI 10.1016/j.pdpdt.2017.12.002, PubMed 29221858

Gederaas OA, Johnsson A, Berg K, Manandhar R, Shrestha C, Skåre D, Ekroll IK, Høgset A, Hjelde A (2017)
Photochemical internalization in bladder cancer - development of an orthotopic in vivo model
Photochem Photobiol Sci, 16 (11), 1664-1676
DOI 10.1039/c7pp00176b, PubMed 28972608

Norum OJ, Fremstedal ASV, Weyergang A, Golab J, Berg K (2017)
Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity
J Control Release, 268, 120-127
DOI 10.1016/j.jconrel.2017.10.015, PubMed 29042319

Sellevold S, Peng Q, Fremstedal ASV, Berg K (2017)
Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice
Photodiagnosis Photodyn Ther, 20, 95-106
DOI 10.1016/j.pdpdt.2017.08.015, PubMed 28865875

Olsen CE, Sellevold S, Theodossiou T, Patzke S, Berg K (2017)
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn Ther, 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010, PubMed 28838761

Olsen CE, Weyergang A, Edwards VT, Berg K, Brech A, Weisheit S, Høgset A, Selbo PK (2017)
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem Pharmacol, 144, 63-77
DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290

Gaware VS, Håkerud M, Juzeniene A, Høgset A, Berg K, Másson M (2017)
Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization
Biomacromolecules, 18 (4), 1108-1126
DOI 10.1021/acs.biomac.6b01670, PubMed 28245649

Christie C, Pomeroy A, Nair R, Berg K, Hirschberg H (2017)
Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy
Photodiagnosis Photodyn Ther, 18, 140-148
DOI 10.1016/j.pdpdt.2017.02.016, PubMed 28257943

Theodossiou TA, Olsen CE, Jonsson M, Kubin A, Hothersall JS, Berg K (2017)
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol, 12, 191-197
DOI 10.1016/j.redox.2017.02.018, PubMed 28254657

Sultan AA, Jerjes W, Berg K, Høgset A, Mosse CA, Hamoudi R, Hamdoon Z, Simeon C, Carnell D, Forster M, Hopper C (2016)
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial
Lancet Oncol, 17 (9), 1217-29
DOI 10.1016/S1470-2045(16)30224-8, PubMed 27475428

Christie C, Molina S, Gonzales J, Berg K, Nair RK, Huynh K, Madsen SJ, Hirschberg H (2016)
Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization
Biomed Opt Express, 7 (4), 1240-50
DOI 10.1364/BOE.7.001240, PubMed 27446650

Reichrath J, Berg K, Emmert S, Lademann J, Seckmeyer G, Zastrow L, Vogt T, Holick MF (2016)
Biologic Effects of Light: An Enlighting Prospective
Anticancer Res, 36 (3), 1339-43
PubMed 26977035

Madsen SJ, Gonzales J, Zamora G, Berg K, Nair RK, Hirschberg H (2016)
Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization
J Environ Pathol Toxicol Oncol, 35 (1), 91-8
DOI 10.1615/JEnvironPatholToxicolOncol.2016015463, PubMed 27279586

Theodossiou TA, Wälchli S, Olsen CE, Skarpen E, Berg K (2015)
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462

Gederaas OA, Hauge A, Ellingsen PG, Berg K, Altin D, Bardal T, Høgset A, Lindgren M (2015)
Photochemical internalization of bleomycin and temozolomide--in vitro studies on the glioma cell line F98
Photochem Photobiol Sci, 14 (7), 1357-66
DOI 10.1039/c5pp00144g, PubMed 26088711

Bull-Hansen B, Berstad MB, Berg K, Cao Y, Skarpen E, Fremstedal AS, Rosenblum MG, Peng Q, Weyergang A (2015)
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-51
DOI 10.18632/oncotarget.3814, PubMed 26002552

Bostad M, Olsen CE, Peng Q, Berg K, Høgset A, Selbo PK (2015)
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J Control Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331

Baglo Y, Peng Q, Hagen L, Berg K, Høgset A, Drabløs F, Gederaas OA (2015)
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
Photodiagnosis Photodyn Ther, 12 (1), 58-66
DOI 10.1016/j.pdpdt.2014.12.005, PubMed 25575731

Christie CE, Zamora G, Kwon YJ, Berg K, Madsen SJ, Hirschberg H (2015)
Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy
PROC SPIE, 9305

Bostad M, Kausberg M, Weyergang A, Olsen CE, Berg K, Høgset A, Selbo PK (2014)
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization
Mol Pharm, 11 (8), 2764-76
DOI 10.1021/mp500129t, PubMed 24960585

Bull-Hansen B, Cao Y, Berg K, Skarpen E, Rosenblum MG, Weyergang A (2014)
Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome
J Control Release, 182, 58-66
DOI 10.1016/j.jconrel.2014.03.014, PubMed 24637464

Wang F, Zamora G, Sun CH, Trinidad A, Chun C, Kwon YJ, Berg K, Madsen SJ, Hirschberg H (2014)
Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene
J Neurooncol, 118 (1), 29-37
DOI 10.1007/s11060-014-1410-9, PubMed 24610460

Weyergang A, Cheung LH, Rosenblum MG, Mohamedali KA, Peng Q, Waltenberger J, Berg K (2014)
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin
J Control Release, 180, 1-9
DOI 10.1016/j.jconrel.2014.02.003, PubMed 24531010

Wang F, Zamora G, Sun CH, Trinidad A, Berg K, Madsen SJ, Kwon YJ, Hirschberg H (2014)
Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas.
PROC SPIE, 8928, UNSP 89280B

Zamora G, Wang F, Sun CH, Trinidad A, Kwon YJ, Cho SK, Berg K, Madsen SJ, Hirschberg H (2014)
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier
J Biomed Opt, 19 (10), 105009
DOI 10.1117/1.JBO.19.10.105009, PubMed 25341069

Sobczyński J, Kristensen S, Berg K (2013)
The influence of Pluronics nanovehicles on dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers in cancer cells
Photochem Photobiol Sci, 13 (1), 8-22
DOI 10.1039/c3pp50181g, PubMed 24158176

Olsen CE, Berg K, Selbo PK, Weyergang A (2013)
Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin
Free Radic Biol Med, 65, 1300-1309
DOI 10.1016/j.freeradbiomed.2013.09.010, PubMed 24076428

Vikdal M, Weyergang A, Selbo PK, Berg K (2013)
Vascular endothelial cells as targets for photochemical internalization (PCI)
Photochem Photobiol, 89 (5), 1185-92
DOI 10.1111/php.12126, PubMed 23819771

Vikdal M, Generalov R, Berg K (2013)
The photosensitizer disulfonated aluminum phthalocyanine reduces uptake and alters trafficking of fluid phase endocytosed drugs in vascular endothelial cells--impact on efficacy of photochemical internalization
Biochem Pharmacol, 86 (6), 748-58
DOI 10.1016/j.bcp.2013.07.011, PubMed 23876343

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Høgset A, Myklebost O, Selbo PK (2013)
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta, 1830 (8), 4235-43
DOI 10.1016/j.bbagen.2013.04.033, PubMed 23643966

Bostad M, Berg K, Høgset A, Skarpen E, Stenmark H, Selbo PK (2013)
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J Control Release, 168 (3), 317-26
DOI 10.1016/j.jconrel.2013.03.023, PubMed 23567040

Singh R, Tønnesen HH, Kristensen S, Berg K (2013)
The influence of Pluronics® on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX
Photochem Photobiol Sci, 12 (3), 559-75
DOI 10.1039/c2pp25249j, PubMed 23108412

Weyergang A, Selbo PK, Berg K (2013)
Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy
Biochim Biophys Acta, 1830 (3), 2659-70
DOI 10.1016/j.bbagen.2012.11.010, PubMed 23671927

Gaware VS, Håkerud M, Leósson K, Jónsdóttir S, Høgset A, Berg K, Másson M (2013)
Tetraphenylporphyrin tethered chitosan based carriers for photochemical transfection
J Med Chem, 56 (3), 807-19
DOI 10.1021/jm301270r, PubMed 23281854

Wang JT, Berg K, Høgset A, Bown SG, MacRobert AJ (2012)
Photophysical and photobiological properties of a sulfonated chlorin photosensitiser TPCS(2a) for photochemical internalisation (PCI)
Photochem Photobiol Sci, 12 (3), 519-26
DOI 10.1039/c2pp25328c, PubMed 23232550

Berstad MB, Weyergang A, Berg K (2012)
Photochemical internalization (PCI) of HER2-targeted toxins: synergy is dependent on the treatment sequence
Biochim Biophys Acta, 1820 (12), 1849-58
DOI 10.1016/j.bbagen.2012.08.027, PubMed 22981913

Garaiova Z, Strand SP, Reitan NK, Lélu S, Størset SØ, Berg K, Malmo J, Folasire O, Bjørkøy A, Davies Cde L (2012)
Cellular uptake of DNA-chitosan nanoparticles: the role of clathrin- and caveolae-mediated pathways
Int J Biol Macromol, 51 (5), 1043-51
DOI 10.1016/j.ijbiomac.2012.08.016, PubMed 22947453

Selbo PK, Weyergang A, Eng MS, Bostad M, Mælandsmo GM, Høgset A, Berg K (2012)
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
J Control Release, 159 (2), 197-203
DOI 10.1016/j.jconrel.2012.02.003, PubMed 22349185

Weyergang A, Selbo PK, Berstad ME, Bostad M, Berg K (2011)
Photochemical internalization of tumor-targeted protein toxins
Lasers Surg Med, 43 (7), 721-33
DOI 10.1002/lsm.21084, PubMed 22057500

Jerjes WK, Upile T, Wong BJ, Betz CS, Sterenborg HJ, Witjes MJ, Berg K, van Veen R, Biel MA, El-Naggar AK, Mosse CA, Olivo M, Richards-Kortum R, Robinson DJ, Rosen J, Yodh AG, Kendall C, Ilgner JF, Amelink A, Bagnato V, Barr H, Bolotine L, Bigio I, Chen Z, Choo-Smith LP et al. (2011)
The future of medical diagnostics: review paper
Head Neck Oncol, 3, 38
DOI 10.1186/1758-3284-3-38, PubMed 21861912

Berg K, Nordstrand S, Selbo PK, Tran DT, Angell-Petersen E, Høgset A (2011)
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
Photochem Photobiol Sci, 10 (10), 1637-51
DOI 10.1039/c1pp05128h, PubMed 21773635

Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J (2011)
Photodynamic therapy of cancer: an update
CA Cancer J Clin, 61 (4), 250-81
DOI 10.3322/caac.20114, PubMed 21617154

Selbo PK, Weyergang A, Høgset A, Norum OJ, Berstad MB, Vikdal M, Berg K (2010)
Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules
J Control Release, 148 (1), 2-12
DOI 10.1016/j.jconrel.2010.06.008, PubMed 20600406

Berg K, Weyergang A, Prasmickaite L, Bonsted A, Høgset A, Strand MT, Wagner E, Selbo PK (2010)
Photochemical internalization (PCI): a technology for drug delivery
Methods Mol Biol, 635, 133-45
DOI 10.1007/978-1-60761-697-9_10, PubMed 20552345

Woodhams J, Lou PJ, Selbo PK, Mosse A, Oukrif D, MacRobert A, Novelli M, Peng Q, Berg K, Bown SG (2009)
Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin--quantitative studies in normal rat liver
J Control Release, 142 (3), 347-53
DOI 10.1016/j.jconrel.2009.11.017, PubMed 19932724

Selbo PK, Rosenblum MG, Cheung LH, Zhang W, Berg K (2009)
Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel
PLoS One, 4 (8), e6691
DOI 10.1371/journal.pone.0006691, PubMed 19690617

Norum OJ, Bruland ØS, Gorunova L, Berg K (2009)
Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma model
Int J Radiat Oncol Biol Phys, 75 (3), 878-85
DOI 10.1016/j.ijrobp.2009.04.039, PubMed 19665318

Upile T, Jerjes W, Sterenborg HJ, El-Naggar AK, Sandison A, Witjes MJ, Biel MA, Bigio I, Wong BJ, Gillenwater A, MacRobert AJ, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Mosse CA, Barr H, Chen Z, Berg K, D'Cruz AK, Stone N, Kendall C, Fisher S, Leunig A et al. (2009)
Head & neck optical diagnostics: vision of the future of surgery
Head Neck Oncol, 1, 25
DOI 10.1186/1758-3284-1-25, PubMed 19594907

Mojzisova H, Bonneau S, Maillard P, Berg K, Brault D (2009)
Photosensitizing properties of chlorins in solution and in membrane-mimicking systems
Photochem Photobiol Sci, 8 (6), 778-87
DOI 10.1039/b822269j, PubMed 19492105

Norum OJ, Giercksky KE, Berg K (2009)
Photochemical internalization as an adjunct to marginal surgery in a human sarcoma model
Photochem Photobiol Sci, 8 (6), 758-62
DOI 10.1039/b821129a, PubMed 19492102

Weyergang A, Berg K, Kaalhus O, Peng Q, Selbo PK (2009)
Photodynamic therapy targets the mTOR signaling network in vitro and in vivo
Mol Pharm, 6 (1), 255-64
DOI 10.1021/mp800156e, PubMed 19125612

Norum OJ, Gaustad JV, Angell-Petersen E, Rofstad EK, Peng Q, Giercksky KE, Berg K (2008)
Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery
Photochem Photobiol, 85 (3), 740-9
DOI 10.1111/j.1751-1097.2008.00477.x, PubMed 19076314

Lai PS, Pai CL, Peng CL, Shieh MJ, Berg K, Lou PJ (2008)
Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization
J Biomed Mater Res A, 87 (1), 147-55
DOI 10.1002/jbm.a.31760, PubMed 18085655

Weyergang A, Kaalhus O, Berg K (2008)
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478
Photochem Photobiol Sci, 7 (9), 1032-40
DOI 10.1039/b806209a, PubMed 18754049

Weyergang A, Kaalhus O, Berg K (2008)
Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival
Mol Cancer Ther, 7 (6), 1740-50
DOI 10.1158/1535-7163.MCT-08-0020, PubMed 18566245

Bonsted A, Wagner E, Prasmickaite L, Høgset A, Berg K (2008)
Photochemical enhancement of DNA delivery by EGF receptor targeted polyplexes
Methods Mol Biol, 434, 171-81
DOI 10.1007/978-1-60327-248-3_11, PubMed 18470645

Folini M, Bandiera R, Millo E, Gandellini P, Sozzi G, Gasparini P, Longoni N, Binda M, Daidone MG, Berg K, Zaffaroni N (2007)
Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells
Cell Prolif, 40 (6), 905-20
DOI 10.1111/j.1365-2184.2007.00470.x, PubMed 18021178

Weyergang A, Selbo PK, Berg K (2007)
Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor
Biochem Pharmacol, 74 (2), 226-35
DOI 10.1016/j.bcp.2007.04.018, PubMed 17531956

Yip WL, Weyergang A, Berg K, Tønnesen HH, Selbo PK (2007)
Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells
Mol Pharm, 4 (2), 241-51
DOI 10.1021/mp060105u, PubMed 17263556

Madsen SJ, Kharkhuu K, Berg K, Hirschberg H (2007)
Photochemical internalization for the treatment of malignant gliomas
PROC SPIE, 6424, 64242C

Lou PJ, Lai PS, Shieh MJ, Macrobert AJ, Berg K, Bown SG (2006)
Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization
Int J Cancer, 119 (11), 2692-8
DOI 10.1002/ijc.22098, PubMed 16991130

Engesaeter BØ, Bonsted A, Lillehammer T, Engebraaten O, Berg K, Maelandsmo GM (2006)
Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
Cancer Biol Ther, 5 (11), 1511-20
DOI 10.4161/cbt.5.11.3301, PubMed 17012835

Prasmickaite L, Cekaite L, Hellum M, Hovig E, Høgset A, Berg K (2006)
Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
FEBS Lett, 580 (24), 5739-46
DOI 10.1016/j.febslet.2006.09.028, PubMed 17007842

Selbo PK, Weyergang A, Bonsted A, Bown SG, Berg K (2006)
Photochemical internalization of therapeutic macromolecular agents: a novel strategy to kill multidrug-resistant cancer cells
J Pharmacol Exp Ther, 319 (2), 604-12
DOI 10.1124/jpet.106.109165, PubMed 16902053

Kloeckner J, Boeckle S, Persson D, Roedl W, Ogris M, Berg K, Wagner E (2006)
DNA polyplexes based on degradable oligoethylenimine-derivatives: combination with EGF receptor targeting and endosomal release functions
J Control Release, 116 (2), 115-22
DOI 10.1016/j.jconrel.2006.07.002, PubMed 16959361

Engesaeter BØ, Tveito S, Bonsted A, Engebraaten O, Berg K, Maelandsmo GM (2006)
Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
J Gene Med, 8 (6), 707-18
DOI 10.1002/jgm.902, PubMed 16518880

Prasmickaite L, Hellum M, Kaalhus O, Høgset A, Wagner E, Berg K (2006)
Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter
Photochem Photobiol, 82 (3), 809-16
DOI 10.1562/2005-11-07-RA-731, PubMed 16420102

Ndoye A, Dolivet G, Høgset A, Leroux A, Fifre A, Erbacher P, Berg K, Behr JP, Guillemin F, Merlin JL (2006)
Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization
Mol Ther, 13 (6), 1156-62
DOI 10.1016/j.ymthe.2006.02.003, PubMed 16564229

Bonsted A, Engesaeter BØ, Høgset A, Berg K (2006)
Photochemically enhanced adenoviral transduction in a multicellular environment
Photochem Photobiol Sci, 5 (4), 411-21
DOI 10.1039/b515066c, PubMed 16583022

Bonsted A, Engesaeter BØ, Høgset A, Maelandsmo GM, Prasmickaite L, D'Oliveira C, Hennink WE, van Steenis JH, Berg K (2006)
Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
J Gene Med, 8 (3), 286-97
DOI 10.1002/jgm.853, PubMed 16342300

Weyergang A, Selbo PK, Berg K (2006)
Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin
J Control Release, 111 (1-2), 165-73
DOI 10.1016/j.jconrel.2005.12.002, PubMed 16466823

Dietze A, Selbo PK, Prasmickaite L, Weyergang A, Bonsted A, Engesaeter B, Hogset A, Berg K (2006)
Photochemical internalization (PCI): a new modality for light activation of endocytosed therapeuticals
J Environ Pathol Toxicol Oncol, 25 (1-2), 521-36
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.330, PubMed 16566739

Berg K, Dietze A, Kaalhus O, Høgset A (2005)
Site-specific drug delivery by photochemical internalization enhances the antitumor effect of bleomycin
Clin Cancer Res, 11 (23), 8476-85
DOI 10.1158/1078-0432.CCR-05-1245, PubMed 16322311

Dietze A, Berg K (2005)
ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies
Photodiagnosis Photodyn Ther, 2 (4), 299-307
DOI 10.1016/S1572-1000(05)00107-9, PubMed 25048871

Engesaeter BØ, Bonsted A, Berg K, Høgset A, Engebråten O, Fodstad Ø, Curiel DT, Maelandsmo GM (2005)
PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles
Cancer Gene Ther, 12 (5), 439-48
DOI 10.1038/sj.cgt.7700808, PubMed 15678152

Gederaas OA, Schønberg SA, Ramstad S, Berg K, Johnsson A, Krokan HE (2005)
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization
Photochem Photobiol Sci, 4 (4), 383-9
DOI 10.1039/b502000j, PubMed 15803209

Bonsted A, Høgset A, Hoover F, Berg K (2005)
Photochemical enhancement of gene delivery to glioblastoma cells is dependent on the vector applied
Anticancer Res, 25 (1A), 291-7
PubMed 15816550

Ndoye A, Bouali S, Dolivet G, Leroux A, Erbacher P, Behr JP, Berg K, Guillemin F, Merlin JL (2004)
Sustained gene transfer and enhanced cell death following glucosylated-PEI-mediated p53 gene transfer with photochemical internalisation in p53-mutated head and neck carcinoma cells
Int J Oncol, 25 (6), 1575-81
PubMed 15547693

Ndoye A, Merlin JL, Leroux A, Dolivet G, Erbacher P, Behr JP, Berg K, Guillemin F (2004)
Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI-DNA complexes
J Gene Med, 6 (8), 884-94
DOI 10.1002/jgm.573, PubMed 15293347

Prasmickaite L, Høgset A, Olsen VM, Kaalhus O, Mikalsen SO, Berg K (2004)
Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir
Cancer Gene Ther, 11 (7), 514-23
DOI 10.1038/sj.cgt.7700720, PubMed 15118758

Berg K, Selbo PK, Prasmickaite L, Høgset A (2004)
Photochemical drug and gene delivery
Curr Opin Mol Ther, 6 (3), 279-87
PubMed 15264430

Kloeckner J, Prasmickaite L, Høgset A, Berg K, Wagner E (2004)
Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes
J Drug Target, 12 (4), 205-13
DOI 10.1080/10611860410001723090, PubMed 15506169

Folini M, Berg K, Millo E, Villa R, Prasmickaite L, Daidone MG, Benatti U, Zaffaroni N (2003)
Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase
Cancer Res, 63 (13), 3490-4
PubMed 12839932

Hellum M, Høgset A, Engesaeter BO, Prasmickaite L, Stokke T, Wheeler C, Berg K (2003)
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem Photobiol Sci, 2 (4), 407-11
DOI 10.1039/b211880g, PubMed 12760539

Berg K, Prasmickaite L, Selbo PK, Hellum M, Bonsted A, Høgset A (2003)
Photochemical internalization (PCI)--a novel technology for release of macromolecules from endocytic vesicles
Oftalmologia, 56 (1), 67-71
PubMed 12886687

Prasmickaite L, Høgset A, Berg K (2002)
The role of the cell cycle on the efficiency of photochemical gene transfection
Biochim Biophys Acta, 1570 (3), 210-8
DOI 10.1016/s0304-4165(02)00202-7, PubMed 12020812

Høgset A, Engesaeter BO, Prasmickaite L, Berg K, Fodstad O, Maelandsmo GM (2002)
Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy
Cancer Gene Ther, 9 (4), 365-71
DOI 10.1038/sj.cgt.7700447, PubMed 11960287

Prasmickaite L, Høgset A, Selbo PK, Engesaeter BØ, Hellum M, Berg K (2002)
Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy
Br J Cancer, 86 (4), 652-7
DOI 10.1038/sj.bjc.6600138, PubMed 11870551

Prasmickaite L, Høgset A, Berg K (2002)
Photochemical transfection. Light-induced, site-directed gene delivery
Methods Mol Med, 69, 123-35
DOI 10.1385/1-59259-141-8:123, PubMed 11987772

Selbo PK, Kaalhus O, Sivam G, Berg K (2001)
5-Aminolevulinic acid-based photochemical internalization of the immunotoxin MOC31-gelonin generates synergistic cytotoxic effects in vitro
Photochem Photobiol, 74 (2), 303-10
DOI 10.1562/0031-8655(2001)074<0303:aabpio>2.0.co;2, PubMed 11547569

Selbo PK, Sivam G, Fodstad O, Sandvig K, Berg K (2001)
In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
Int J Cancer, 92 (5), 761-6
DOI 10.1002/1097-0215(20010601)92:5<761::aid-ijc1238>3.0.co;2-4, PubMed 11340584

Prasmickaite L, Høgset A, Berg K (2001)
Evaluation of different photosensitizers for use in photochemical gene transfection
Photochem Photobiol, 73 (4), 388-95
DOI 10.1562/0031-8655(2001)073<0388:eodpfu>2.0.co;2, PubMed 11332034

Prasmickaite L, Høgset A, Tjelle TE, Olsen VM, Berg K (2000)
Role of endosomes in gene transfection mediated by photochemical internalisation (PCI)
J Gene Med, 2 (6), 477-88
DOI 10.1002/1521-2254(200011/12)2:6<477::AID-JGM137>3.0.CO;2-B, PubMed 11199268

Selbo PK, Sivam G, Fodstad O, Sandvig K, Berg K (2000)
Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
Int J Cancer, 87 (6), 853-9
DOI 10.1002/1097-0215(20000915)87:6<853::aid-ijc15>3.0.co;2-0, PubMed 10956397

Selbo PK, Sandvig K, Kirveliene V, Berg K (2000)
Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
Biochim Biophys Acta, 1475 (3), 307-13
DOI 10.1016/s0304-4165(00)00082-9, PubMed 10913830

Berg K, Selbo PK, Prasmickaite L, Tjelle TE, Sandvig K, Moan J, Gaudernack G, Fodstad O, Kjølsrud S, Anholt H, Rodal GH, Rodal SK, Høgset A (1999)
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
Cancer Res, 59 (6), 1180-3
PubMed 10096543

Berg K, Maziere JC, Geze M, Santus R (1998)
Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine
Biochim Biophys Acta, 1370 (2), 317-24
DOI 10.1016/s0005-2736(97)00282-4, PubMed 9545591

Berg K (1992)
The unpolymerized form of tubulin is the target for microtubule inhibition by photoactivated tetra(4-sulfonatophenyl)porphine
Biochim Biophys Acta, 1135 (2), 147-53
DOI 10.1016/0167-4889(92)90130-4, PubMed 1616935

Review articles

Jerjes W, Theodossiou TA, Hirschberg H, Høgset A, Weyergang A, Selbo PK, Hamdoon Z, Hopper C, Berg K (2020)
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J Clin Med, 9 (2)
DOI 10.3390/jcm9020528, PubMed 32075165

Weyergang A, Berstad ME, Bull-Hansen B, Olsen CE, Selbo PK, Berg K (2015)
Photochemical activation of drugs for the treatment of therapy-resistant cancers
Photochem Photobiol Sci, 14 (8), 1465-75
DOI 10.1039/c5pp00029g, PubMed 25849953

Selbo PK, Bostad M, Olsen CE, Edwards VT, Høgset A, Weyergang A, Berg K (2015)
Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
Photochem Photobiol Sci, 14 (8), 1433-50
DOI 10.1039/c5pp00027k, PubMed 25805311

Upile T, Jerjes WK, Sterenborg HJ, Wong BJ, El-Naggar AK, Ilgner JF, Sandison A, Witjes MJ, Biel MA, van Veen R, Hamdoon Z, Gillenwater A, Mosse CA, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Barr H, Chen Z, Berg K, D'Cruz AK, Sudhoff H, Stone N, Kendall C et al. (2011)
At the frontiers of surgery: review
Head Neck Oncol, 3 (1), 7
DOI 10.1186/1758-3284-3-7, PubMed 21306627

Johansen P, Berg K, Selbo PK, Hofbauer GF (2010)
[Photochemical internalisation (PCI): a further development of photodynamic therapy for the treatment of skin cancer]
Praxis (Bern 1994), 99 (23), 1423-8
DOI 10.1024/1661-8157/a000310, PubMed 21082595

Berg K, Berstad M, Prasmickaite L, Weyergang A, Selbo PK, Hedfors I, Høgset A (2010)
Photochemical internalization: a new tool for gene and oligonucleotide delivery
Top Curr Chem, 296, 251-81
DOI 10.1007/128_2010_63, PubMed 21504105

Reiners JJ, Agostinis P, Berg K, Oleinick NL, Kessel D (2010)
Assessing autophagy in the context of photodynamic therapy
Autophagy, 6 (1), 7-18
DOI 10.4161/auto.6.1.10220, PubMed 19855190

Norum OJ, Selbo PK, Weyergang A, Giercksky KE, Berg K (2009)
Photochemical internalization (PCI) in cancer therapy: from bench towards bedside medicine
J Photochem Photobiol B, 96 (2), 83-92
DOI 10.1016/j.jphotobiol.2009.04.012, PubMed 19467605

Berg K, Folini M, Prasmickaite L, Selbo PK, Bonsted A, Engesaeter BØ, Zaffaroni N, Weyergang A, Dietze A, Maelandsmo GM, Wagner E, Norum OJ, Høgset A (2007)
Photochemical internalization: a new tool for drug delivery
Curr Pharm Biotechnol, 8 (6), 362-72
DOI 10.2174/138920107783018354, PubMed 18289045

Berg K, Høgset A, Prasmickaite L, Weyergang A, Bonsted A, Dietze A, Lou PJ, Bown S, Norum OJ, Møllergard HM, Selbo PK (2006)
Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents.
Med Laser Appl, 21, 239-251
DOI 10.1016/j.mla.2006.08.004, PublikaID 73

Prasmickaite L, Høgset A, Engesaeter B BØ, Bonsted A, Berg K (2004)
Light-directed gene delivery by photochemical internalisation
Expert Opin Biol Ther, 4 (9), 1403-12
DOI 10.1517/14712598.4.9.1403, PubMed 15335308

Høgset A, Prasmickaite L, Selbo PK, Hellum M, Engesaeter BØ, Bonsted A, Berg K (2004)
Photochemical internalisation in drug and gene delivery
Adv Drug Deliv Rev, 56 (1), 95-115
DOI 10.1016/j.addr.2003.08.016, PubMed 14706447

Høgset A, Prasmickaite L, Engesaeter BO, Hellum M, Selbo PK, Olsen VM, Maelandsmo GM, Berg K (2003)
Light directed gene transfer by photochemical internalisation
Curr Gene Ther, 3 (2), 89-112
DOI 10.2174/1566523034578438, PubMed 12653404

Høgset A, Prasmickaite L, Hellum M, Engesaeter BO, Olsen VM, Tjelle TE, Wheeler CJ, Berg K (2002)
Photochemical transfection: a technology for efficient light-directed gene delivery
Somat Cell Mol Genet, 27 (1-6), 97-113
DOI 10.1023/a:1022979806314, PubMed 12774944

Selbo PK, Høgset A, Prasmickaite L, Berg K (2002)
Photochemical internalisation: a novel drug delivery system
Tumour Biol, 23 (2), 103-12
DOI 10.1159/000059713, PubMed 12065848

Other articles

Berg K (2015)
Resistance mechanisms in photodynamic therapy
Photochem Photobiol Sci, 14 (8), 1376-7
DOI 10.1039/c5pp90026c, PubMed 26212047

Weyergang A, Selbo PK, Berg K (2013)
Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy (vol 1830, pg 2659, 2013)
Biochim. Biophys. Acta-Gen. Subj., 1830 (10), 4417

Berg K, Golab J, Korbelik M, Russell D (2011)
Drug delivery technologies and immunological aspects of photodynamic therapy
Photochem Photobiol Sci, 10 (5), 647-8
DOI 10.1039/c1pp90010b, PubMed 21487635

Peng Q, Berg K (2007)
Introduction to the special issue on photodynamic therapy and photodetection
Photochem. Photobiol. Sci., 6 (12), 1233

Book chapters

Berg K, Selbo PK (2016)
Photochemical Internalization (PCI) — A Technology for Intracellular Drug Delivery
In Handbook of Porphyrin Science (Kadish KM, Smith KM, Guilard R, eds.), World Scientific Publishing Co, Singapore, 43, 245-300
DOI 10.1142/9789813149632_0004, PublikaID 252, ISBN 978-981-3149-63-2

Weyergang A, Selbo PK, Berg K (2016)
Photochemical Internalization-Enhanced Targeting of Vasculature and Cancer Stem Cells—Present and Future Perspectives
In Photodynamic Medicine: From Bench to Clinic (Kostron H, Hasan T, eds.), The Royal Society of Chemistry, London, 15, 161-180
DOI 10.1039/9781782626824-00161, PublikaID 251, ISBN 978-1-78262-451-6

Berg K, Weyergang A, Høgset A, Selbo PK (2010)
The Potential of Photochemical Internalixation (PCI) for the Cytosolic Delivery of Nanomedicines
In Organelle-Specific Pharmaceutical Nanotechnology (Weissing V, D'Souza, eds.), John Wiley and Sons Inc, New Jersey, USA, 311-322
PublikaID 72

Bonsted A, Wagner E, Prasmickaite L, Høgset A, Berg K (2008)
Photochemical enhancement of DNA delivery by EGF reeceptor targeted polyplexes
In Series: Methods in Molecular Biology. Gene therapy protocols Vol 2. Design and characterization of gene transfer vectors. (LeDoux JM, ed.), Humana Press, 434
PublikaID 60

Bonsted A, Høgset A, Berg K (2008)
Photochemical internalization: A technology for effiecient site-directed gene delivery.
In Gene and Cell Therapy. Therapeutic mechanisms and strategies. 3rd edition. (Templeton NS, ed.), CRC Press, 435-442
PublikaID 61

Berg K, Bonsted A, Weyergang A, Høgset A, Selbo PK (2008)
Photochemical Internalization
In Advances in Photodynamic therapy; basic, translational , and clinical (Hamblin MR, Mroz P, eds.), Norwood: Artech House, Norwood MA, USA, 299-312
PublikaID 71

Bonsted A, Høgset A, Wagner E, Berg K (2006)
Photochemical internalization for light directed gene delivery
In Delivery and expression of DNA and RNA, A laboratory manual (Friedmann T, Rossi J, eds.), Cold Spring Harbour Laboratory Press, New York
PublikaID 59

Theses

Berg K (1990)
Cellular uptake and photosensitizing effects of porphyrins and phthalocyanines
Department of Biophysics, The Norwegian Radium Hospital, Oslo, Flere pag.
BIBSYS 901007765, ISBN 82-992250-0-0

Berg K (1985)
Mitokondriell fettsyreoksydasjon i brunt fettvev. Fluksregulerende trinn
K. Berg, Oslo, 174 s.
BIBSYS 961256575

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