The overall goal of this project is to identify individual gene targets and sets of genes that contribute to the potential of breast cancer to be aggressive and metastatic, and genes that reflect and predict treatment responses. We will apply state-of-the-art microarray tools, novel functional technologies and associated statistical and bioinformatics methods to profile breast tumors at the DNA, RNA and protein level.

Current projects:

• Progression of DCIS to invasive breast cancer
• Characterization of tumor initiating cells in breast cancer model systems
• Molecular factors of therapy response
• Molecular classification of breast cancer

Funding sources:

Norwegian Cancer Society
Helse Sør Øst
Norwegian Research Council

Contact information:

Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet
email:tsorlie@rr-research.no