Since its discovery in 1993 (Krauss et al., Cell 75, 1431-1444) Shh has shown to be a central signal in numerous developmental systems. The laboratory for cell signalling focuses on Hh and Wnt/beta-catenin signalling in development, stem cells, and tumors. The laboratory currently works on pathways that feed into Hh and Wnt/beta-catenin signaling. Using chemical biology, the laboratory develops novel Hh and Wnt/beta-catenin.