Stefan Krauss' group

Cell signalling research group

 
Stefan Krauss
Stefan Krauss

Since its discovery in 1993 (Krauss et al., Cell 75, 1431-1444) Shh has shown to be a central signal in numerous developmental systems. The laboratory for cell signalling focuses on Hh and Wnt/beta-catenin signalling in development, stem cells, and tumors. The laboratory currently works on pathways that feed into Hh and Wnt/beta-catenin signaling. Using chemical biology, the laboratory develops novel Hh and Wnt/beta-catenin.

 

Challenges
Hh and Wnt signalling is central in development, in adult stem cell niches and in a broad number of malignant tumors. The group has been working on Wnt homologues since 1991 and discovered the vertebrate key signal Shh in 1993. Since then we have studied aspects of these pathways in different models and are now using developmental signaling pathways to develop selective pathway inhibitors, in particular directed towards canonical Wnt/beta-catenin signalling. In recent years we have used chemical biology to develop a series of highly specific Wnt and Hh inhibitors. One of our inhibitors (G007 LK), a highly specific tankyrase antagonist, has reached lead status and serves at current as industry benchmark. To understand the central implication of tankyrase on stemcellness, differentiation and growth, the inhibitors are currently being tested on cancer and stem cell models in vitro and in vivo. Furthermore, we analyze key elements in Wnt signalling using zinc finger nuclease (ZFN)-based knockout models. The group is currently heading an SFI innovation center.

Projects

  • Wnt signalling
  • Hh signalling
  • Stem cells and cancer
  • Chemical biology

 

Contact information:
Group leader Professor Stefan Krauss, Department of Microbiology, Oslo University Hospital,  Rikshospitalet,  PO Box 4950, Nydalen NO-0424 Oslo, Norway, Tel: +47 22958152 E-mail: stefan.krauss@rr-research.no