Antoni Wiedlocha
Position: Group leader, Phd.
Phone: +47 22 78 19 30
Email:
 

Author network for Antoni Wiedlocha by COREMINE medical


Publications 2016

Haugsten EM, Sørensen V, Kunova Bosakova M, de Souza GA, Krejci P, Wiedlocha A, Wesche J (2016)
Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport
J Proteome Res, 15 (10), 3841-3855
PubMed 27615514

Publications 2015

Buchtova M, Chaloupkova R, Zakrzewska M, Vesela I, Cela P, Barathova J, Gudernova I, Zajickova R, Trantirek L, Martin J, Kostas M, Otlewski J, Damborsky J, Kozubik A, Wiedlocha A, Krejci P (2015)
Instability restricts signaling of multiple fibroblast growth factors
Cell Mol Life Sci, 72 (12), 2445-59
PubMed 25854632

Wendel T, Zhen Y, Suo Z, Bruheim S, Wiedlocha A (2015)
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo
Exp Cell Res, 340 (2), 220-6
PubMed 26748184

Publications 2014

Sletten T, Kostas M, Bober J, Sorensen V, Yadollahi M, Olsnes S, Tomala J, Otlewski J, Zakrzewska M, Wiedlocha A (2014)
Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1)
PLoS One, 9 (3), e90687
PubMed 24595027

Publications 2013

Nadratowska-Wesolowska B, Haugsten EM, Zakrzewska M, Jakimowicz P, Zhen Y, Pajdzik D, Wesche J, Wiedlocha A (2013)
RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789
Oncogene, 33 (40), 4823-36
PubMed 24141780

Zakrzewska M, Haugsten EM, Nadratowska-Wesolowska B, Oppelt A, Hausott B, Jin Y, Otlewski J, Wesche J, Wiedlocha A (2013)
ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling
Sci Signal, 6 (262), ra11
PubMed 23405013

Publications 2012

Szlachcic A, Pala K, Zakrzewska M, Jakimowicz P, Wiedlocha A, Otlewski J (2012)
FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation
Int J Nanomedicine, 7, 5915-27
PubMed 23226697

Zhen Y, Sørensen V, Skjerpen CS, Haugsten EM, Jin Y, Wälchli S, Olsnes S, Wiedlocha A (2012)
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1
Traffic, 13 (5), 650-64
PubMed 22321063

Publications 2011

Jin Y, Zhen Y, Haugsten EM, Wiedlocha A (2011)
The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein
Cell Signal, 23 (11), 1758-66
PubMed 21745565

Zakrzewska M, Sørensen V, Jin Y, Wiedlocha A, Olsnes S (2011)
Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity
Exp Cell Res, 317 (7), 1005-15
PubMed 21223966

Publications 2010

Haugsten EM, Wiedlocha A, Olsnes S, Wesche J (2010)
Roles of fibroblast growth factor receptors in carcinogenesis
Mol Cancer Res, 8 (11), 1439-52
PubMed 21047773

Publications 2009

Zakrzewska M, Wiedlocha A, Szlachcic A, Krowarsch D, Otlewski J, Olsnes S (2009)
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin
J Biol Chem, 284 (37), 25388-403
PubMed 19574212

Zakrzewska M, Zhen Y, Wiedlocha A, Olsnes S, Wesche J (2009)
Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane
Biochemistry, 48 (30), 7209-18
PubMed 19558187

Publications 2008

Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A (2008)
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
Mol Cell Biol, 28 (12), 4129-41
PubMed 18411303

Zakrzewska M, Marcinkowska E, Wiedlocha A (2008)
FGF-1: from biology through engineering to potential medical applications
Crit Rev Clin Lab Sci, 45 (1), 91-135
PubMed 18293181

Publications 2007

Nilsen T, Rosendal KR, Sørensen V, Wesche J, Olsnes S, Wiedłocha A (2007)
A nuclear export sequence located on a beta-strand in fibroblast growth factor-1
J Biol Chem, 282 (36), 26245-56
PubMed 17616529

Zhen Y, Sørensen V, Jin Y, Suo Z, Wiedłocha A (2007)
Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK
Oncogene, 26 (44), 6372-85
PubMed 17533378

Publications 2006

Marcinkowska E, Superat K, Wiedłocha A (2006)
FGF-1 as a possible carrier for targeted drug delivery
Oncol Res, 16 (1), 27-34
PubMed 16783965

Sørensen V, Nilsen T, Wiedłocha A (2006)
Functional diversity of FGF-2 isoforms by intracellular sorting
Bioessays, 28 (5), 504-14
PubMed 16615083

Sørensen V, Wiedlocha A, Haugsten EM, Khnykin D, Wesche J, Olsnes S (2006)
Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail
J Cell Sci, 119 (Pt 20), 4332-41
PubMed 17003104

Wesche J, Małecki J, Wiedłocha A, Skjerpen CS, Claus P, Olsnes S (2006)
FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus
J Biol Chem, 281 (16), 11405-12
PubMed 16495214

Zakrzewska M, Krowarsch D, Wiedlocha A, Olsnes S, Otlewski J (2006)
Structural requirements of FGF-1 for receptor binding and translocation into cells
Biochemistry, 45 (51), 15338-48
PubMed 17176056

Publications 2005

Wesche J, Małecki J, Wiedłocha A, Ehsani M, Marcinkowska E, Nilsen T, Olsnes S (2005)
Two nuclear localization signals required for transport from the cytosol to the nucleus of externally added FGF-1 translocated into cells
Biochemistry, 44 (16), 6071-80
PubMed 15835896

Zakrzewska M, Krowarsch D, Wiedlocha A, Olsnes S, Otlewski J (2005)
Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action
J Mol Biol, 352 (4), 860-75
PubMed 16126225

Publications 2004

Wiedłocha A, Nilsen T, Wesche J, Sørensen V, Małecki J, Marcinkowska E, Olsnes S (2004)
Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1
Mol Biol Cell, 16 (2), 794-810
PubMed 15574884

Wiedłocha A, Sørensen V (2004)
Signaling, internalization, and intracellular activity of fibroblast growth factor
Curr Top Microbiol Immunol, 286, 45-79
PubMed 15645710

Zakrzewska M, Krowarsch D, Wiedlocha A, Otlewski J (2004)
Design of fully active FGF-1 variants with increased stability
Protein Eng Des Sel, 17 (8), 603-11
PubMed 15469994

Publications 2003

Dus D, Krawczenko A, Zalecki P, Paprocka M, Wiedlocha A, Goupille C, Kieda C (2003)
IL-7 receptor is present on human microvascular endothelial cells
Immunol. Lett., 86 (2), 163-168

Duś D, Krawczenko A, Załecki P, Paprocka M, Wiedłocha A, Goupille C, Kieda C (2003)
IL-7 receptor is present on human microvascular endothelial cells
Immunol Lett, 86 (2), 163-8
PubMed 12644318

Małecki J, Wesche J, Skjerpen CS, Wiedłocha A, Olsnes S (2003)
Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism
Mol Biol Cell, 15 (2), 801-14
PubMed 14657241

Marcinkowska E, Wiedlocha A (2003)
Phosphatidylinositol-3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1
Anticancer Res, 23 (5A), 4071-7
PubMed 14666721

Olsnes S, Klingenberg O, Wiedłocha A (2003)
Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus
Physiol Rev, 83 (1), 163-82
PubMed 12506129

Publications 2002

Małecki J, Wiedłocha A, Wesche J, Olsnes S (2002)
Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1
EMBO J, 21 (17), 4480-90
PubMed 12198150

Marcinkowska E, Wiedłocha A (2002)
Steroid signal transduction activated at the cell membrane: from plants to animals
Acta Biochim Pol, 49 (3), 735-45
PubMed 12422243

Wabakken T, Hauge H, Finne EF, Wiedlocha A, Aasheim H (2002)
Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase
Scand J Immunol, 56 (2), 195-203
PubMed 12121439

Publications 2001

Citores L, Khnykin D, Sørensen V, Wesche J, Klingenberg O, Wiedłocha A, Olsnes S (2001)
Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain
J Cell Sci, 114 (Pt 9), 1677-89
PubMed 11398757

Loukianov EV, Wiedlocha A, Olsnes S, Kozlov YV (2001)
Two farms of the heparin-binding EGF-like growth factor precursor, a receptor for diphtheria toxin
Mol. Biol., 35 (1), 122-129

Marcinkowska E, Chrobak A, Wiedłocha A (2001)
Evading apoptosis by calcitriol-differentiated human leukemic HL-60 cells is not mediated by changes in CD95 receptor system but by increased sensitivity of these cells to insulin
Exp Cell Res, 270 (1), 119-27
PubMed 11597134

Publications 2000

Klingenberg O, Wiedlocha A, Rapak A, Khnykin D, Citores L, Olsnes S (2000)
Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus
J Cell Sci, 113 ( Pt 10), 1827-38
PubMed 10769213

Wesche J, Wiedłocha A, Falnes PO, Choe S, Olsnes S (2000)
Externally added aFGF mutants do not require extensive unfolding for transport to the cytosol and the nucleus in NIH/3T3 cells
Biochemistry, 39 (49), 15091-100
PubMed 11106487

Publications 1999

Klingenberg O, Wiedlocha A, Olsnes S (1999)
Effects of mutations of a phosphorylation site in an exposed loop in acidic fibroblast growth factor
J Biol Chem, 274 (25), 18081-6
PubMed 10364261

Wiedłocha A (1999)
Following angiogenin during angiogenesis: a journey from the cell surface to the nucleolus
Arch Immunol Ther Exp (Warsz), 47 (5), 299-305
PubMed 10604235

Wiedłocha A (1999)
[Activation of the cell proliferation program by acidic fibroblast growth factor (aFGF)]
Postepy Hig Med Dosw, 53 (2), 277-89
PubMed 10355293

Publications 1998

Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S (1998)
Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor
Biochem J, 336 ( Pt 1), 213-22
PubMed 9806903

Loukianov EV, Loukianova T, Wiedlocha A, Olsnes S (1998)
Variation in the proregion structure of heparin-binding EGF-like growth factor precursors
Gene, 212 (1), 1-4
PubMed 9661657

Marcinkowska E, Wiedlocha A, Radzikowski C (1998)
Evidence that phosphatidylinositol 3-kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol
Anticancer Res, 18 (5A), 3507-14
PubMed 9858932

Wiedłocha A (1998)
Novel protein toxin-based strategy for development of cytotoxic T lymphocyte vaccines
Arch Immunol Ther Exp (Warsz), 46 (6), 341-6
PubMed 9883312

Zalecki P, Radzikowski C, Olsnes S, Wiedłocha A (1998)
Modulation by interleukin-2 of cellular response to fibroblast growth factor-1 in F69-3 fibrosarcoma cells
Exp Cell Res, 244 (1), 61-70
PubMed 9770349

Publications 1997

Loukianov E, Loukianova T, Wiedlocha A, Olsnes S (1997)
Expression of mRNA for a short form of heparin-binding EGF-like growth factor
Gene, 195 (1), 81-6
PubMed 9300824

Marcinkowska E, Wiedłocha A, Radzikowski C (1997)
1,25-Dihydroxyvitamin D3 induced activation and subsequent nuclear translocation of MAPK is upstream regulated by PKC in HL-60 cells
Biochem Biophys Res Commun, 241 (2), 419-26
PubMed 9425286

Muñoz R, Klingenberg O, Wiedłocha A, Rapak A, Falnes PO, Olsnes S (1997)
Effect of mutation of cytoplasmic receptor domain and of genistein on transport of acidic fibroblast growth factor into cells
Oncogene, 15 (5), 525-36
PubMed 9247306

Wiedłocha A (1997)
Diphtheria toxin as a molecular tool in the study of acidic fibroblast growth factor signalling
Arch Immunol Ther Exp (Warsz), 45 (5-6), 391-409
PubMed 9437495

Publications 1996

Wiedłocha A (1996)
Retrograde transport of acidic fibroblast growth factor as a part of the growth factor signaling
Arch Immunol Ther Exp (Warsz), 44 (4), 201-7
PubMed 9017159

Wiedłocha A, Falnes PO, Rapak A, Muñoz R, Klingenberg O, Olsnes S (1996)
Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization
Mol Cell Biol, 16 (1), 270-80
PubMed 8524304

Publications 1995

Falnes PO, Wiedłocha A, Rapak A, Olsnes S (1995)
Farnesylation of CaaX-tagged diphtheria toxin A-fragment as a measure of transfer to the cytosol
Biochemistry, 34 (35), 11152-9
PubMed 7669773

Wiedłocha A, Falnes PO, Rapak A, Klingenberg O, Muñoz R, Olsnes S (1995)
Translocation of cytosol of exogenous, CAAX-tagged acidic fibroblast growth factor
J Biol Chem, 270 (51), 30680-5
PubMed 8530506

Publications 1994

Madshus IH, Wiedlocha A, Sandvig K (1994)
Intermediates in translocation of diphtheria toxin across the plasma membrane
J Biol Chem, 269 (6), 4648-52
PubMed 7508447

Wiedłocha A, Falnes PO, Madshus IH, Sandvig K, Olsnes S (1994)
Dual mode of signal transduction by externally added acidic fibroblast growth factor
Cell, 76 (6), 1039-51
PubMed 7511061

Publications 1992

Jonas L, Walzel H, Bremer H, Wiedlocha A (1992)
Comparative studies on internalization of gold labelled mistletoe lectin I (MLI), its subunits, and of an immunotoxin into mouse L 1210V leukemia cells
Acta Histochem, 92 (1), 46-53
PubMed 1580141

Paprocka M, Wiedłocha A, Walzel H, Radzikowski C (1992)
The activity of two immunotoxins composed of monoclonal antibody MoAb-16 and A-chain of ricin (MoAb-16-RTA) or A-chain of mistletoe lectin I (MoAb-16-MLIA)
Arch Immunol Ther Exp (Warsz), 40 (3-4), 223-7
PubMed 1300987

Wiedlocha A, Madshus IH, Mach H, Middaugh CR, Olsnes S (1992)
Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector
EMBO J, 11 (13), 4835-42
PubMed 1281450

Publications 1991

Wiedłocha A, Paprocka M, Radzikowski C (1991)
Immunomagnetic removal of L1210V leukemic cells from mouse bone marrow ex vivo
Arch Immunol Ther Exp (Warsz), 39 (3), 235-41
PubMed 1810216

Wiedłocha A, Sandvig K, Walzel H, Radzikowsky C, Olsnes S (1991)
Internalization and action of an immunotoxin containing mistletoe lectin A-chain
Cancer Res, 51 (3), 916-20
PubMed 1988131

Publications 1990

Paprocka M, Wiedlocha A, Radzikowski C (1990)
Mouse L1210V leukemia as a model to analyse efficiency of leukemic cell elimination by immunotoxin, antibody and complement, and cytostatic agents
In Vivo, 4 (3), 209-13
PubMed 2133264

Publications 1989

Katnik I, Steuden I, Pupek M, Wiedłocha A, Dobryszycka W (1989)
Monoclonal antibodies against human haptoglobin
Hybridoma, 8 (5), 551-60
PubMed 2478448

Radzikowski CZ, Steuden I, Wiedlocha A, Kieler J, Tromholt V (1989)
The Thomsen-Friedenreich antigen on human urothelial cell lines detectable by peanut lectin and monoclonal antibody raised against human glycophorin A
Anticancer Res, 9 (1), 103-7
PubMed 2650614

Wiedłocha A, Salwa J, Paprocka M, Steuden I, Radzikowski C (1989)
Specific killing of mouse leukemic cells with ricin A-chain immunotoxin
Arch Immunol Ther Exp (Warsz), 37 (1-2), 101-13
PubMed 2619494

Publications 1988

Czerwiński M, Waśniowska K, Steuden I, Duk M, Wiedłocha A, Lisowska E (1988)
Degradation of the human erythrocyte membrane band 3 studied with monoclonal antibody directed against an epitope on the cytoplasmic fragment of band 3
Eur J Biochem, 174 (4), 647-54
PubMed 2455637

Waśniowska K, Duk M, Steuden I, Czerwiński M, Wiedłocha A, Lisowska E (1988)
Two monoclonal antibodies recognizing different epitopes of blood group N antigen
Arch Immunol Ther Exp (Warsz), 36 (5), 623-32
PubMed 2478103