Project group leader Antoni WiedlochaProtein internalisation and signaling
Maintenance of tissue homeostasis depends on complex intercellular growth factor signaling networks that govern many basic cell functions. Therefore, alterations in growth factor signalling networks are prerequisites for cancer development. The fibroblast growth factor family (FGF) and their high affinity cell-surface receptors (FGFR) represent one of the fundamental signaling networks governing cell communication. Imbalances in FGF signaling are known to induce/promote all hallmarks of cancer that malignant cells must acquire.
We want to understand in details the mechanisms how FGF/FGFR generate specific signaling outputs in diverse biological context and how such signaling is regulated in normal and cancer cells. It will result in better understanding of the biology of tumor induction and progression of malignancy as well as new opportunities to develop specific targeted therapies for cancer.
Department of Molecular Cell Biology, Institute for Cancer Research
The Norwegian Radium Hospital, Montebello, 0379 Oslo, Norway
Phone +47 22 78 19 30 (Wiedlocha), Switchboard: +47 22 93 40 00