Publications by Randi G. Syljuåsen

47 publications found

Publications 2019

  1. Hauge S, Macurek L, Syljuåsen RG (2019)
    p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775
    Cell Cycle, 18 (8), 834-847
    DOI 10.1080/15384101.2019.1593649, PubMed 30943845
  2. Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG (2019)
    Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
    Nucleic Acids Res, 47 (4), 1797-1813
    DOI 10.1093/nar/gky1233, PubMed 30541148

Publications 2018

  1. Bøe CA, Håland TW, Boye E, Syljuåsen RG, Grallert B (2018)
    A novel role for ATR/Rad3 in G1 phase
    Sci Rep, 8 (1), 6880
    DOI 10.1038/s41598-018-25238-6, PubMed 29720710

Publications 2017

  1. Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T, Syljuåsen RG (2017)
    Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
    Oncotarget, 8 (7), 10966-10979
    DOI 10.18632/oncotarget.14089, PubMed 28030798
  2. Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK (2017)
    TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
    PLoS One, 12 (10), e0185708
    DOI 10.1371/journal.pone.0185708, PubMed 28973009
  3. Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2017)
    Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
    Oncotarget, 8 (4), 7208-7213
    DOI 10.18632/oncotarget.14800, PubMed 28179591

Publications 2016

  1. Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG (2016)
    Hypoxia-induced alterations of G2 checkpoint regulators
    Mol Oncol, 10 (5), 764-73
    DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779
  2. Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2016)
    MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
    Oncotarget, 7 (26), 40297-40313
    DOI 10.18632/oncotarget.9610, PubMed 27248169

Publications 2015

  1. Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
    Simultaneous measurement of passage through the restriction point and MCM loading in single cells
    Nucleic Acids Res, 43 (22), e150
    DOI 10.1093/nar/gkv744, PubMed 26250117
  2. Syljuåsen RG, Hasvold G, Hauge S, Helland Å (2015)
    Targeting lung cancer through inhibition of checkpoint kinases
    Front Genet, 6, 70
    DOI 10.3389/fgene.2015.00070, PubMed 25774168

Publications 2014

  1. Halvorsen AR, Helland A, Fleischer T, Haug KM, Grenaker Alnaes GI, Nebdal D, Syljuåsen RG, Touleimat N, Busato F, Tost J, Saetersdal AB, Børresen-Dale AL, Kristensen V, Edvardsen H (2014)
    Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy
    Int J Cancer, 135 (9), 2085-95
    DOI 10.1002/ijc.28862, PubMed 24658971
  2. Lund-Andersen C, Patzke S, Nähse-Kumpf V, Syljuåsen RG (2014)
    PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule
    Radiother Oncol, 110 (2), 355-61
    DOI 10.1016/j.radonc.2013.12.014, PubMed 24502970

Publications 2013

  1. Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG (2013)
    The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation
    Mol Cancer Ther, 12 (5), 705-16
    DOI 10.1158/1535-7163.MCT-12-0879, PubMed 23635654

Publications 2012

  1. Beck H, Nähse-Kumpf V, Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS (2012)
    Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
    Mol Cell Biol, 32 (20), 4226-36
    DOI 10.1128/MCB.00412-12, PubMed 22907750
  2. Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H (2012)
    Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI
    Cancer Res, 72 (20), 5285-95
    DOI 10.1158/0008-5472.CAN-12-1085, PubMed 22890239

Publications 2011

  1. Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS (2011)
    SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
    J Cell Biol, 192 (1), 43-54
    DOI 10.1083/jcb.201009076, PubMed 21220508
  2. Küntziger T, Landsverk HB, Collas P, Syljuåsen RG (2011)
    Protein phosphatase 1 regulators in DNA damage signaling
    Cell Cycle, 10 (9), 1356-62
    DOI 10.4161/cc.10.9.15442, PubMed 21451260
  3. Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS (2011)
    A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
    EMBO Rep, 12 (7), 705-12
    DOI 10.1038/embor.2011.99, PubMed 21637299
  4. Sørensen CS, Syljuåsen RG (2011)
    Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
    Nucleic Acids Res, 40 (2), 477-86
    DOI 10.1093/nar/gkr697, PubMed 21937510
  5. Tkacz-Stachowska K, Lund-Andersen C, Velissarou A, Myklebust JH, Stokke T, Syljuåsen RG (2011)
    The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
    Radiother Oncol, 101 (1), 24-7
    DOI 10.1016/j.radonc.2011.05.060, PubMed 21722983

Publications 2010

  1. Beck H, Menzel T, Syljuåsen RG, Sørensen CS (2010)
    High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells
    Cell Cycle, 9 (12), 2257-8
    DOI 10.4161/cc.9.12.12017, PubMed 20699633
  2. Beck H, Nähse V, Larsen MS, Groth P, Clancy T, Lees M, Jørgensen M, Helleday T, Syljuåsen RG, Sørensen CS (2010)
    Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
    J Cell Biol, 188 (5), 629-38
    DOI 10.1083/jcb.200905059, PubMed 20194642
  3. Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T (2010)
    The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response
    EMBO Rep, 11 (11), 868-75
    DOI 10.1038/embor.2010.134, PubMed 20890310
  4. Petersen L, Hasvold G, Lukas J, Bartek J, Syljuåsen RG (2010)
    p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors
    Cell Prolif, 43 (4), 365-71
    DOI 10.1111/j.1365-2184.2010.00685.x, PubMed 20590661

Publications 2007

  1. Syljuåsen RG (2007)
    Checkpoint adaptation in human cells
    Oncogene, 26 (40), 5833-9
    DOI 10.1038/sj.onc.1210402, PubMed 17384683

Publications 2006

  1. Syljuåsen RG, Jensen S, Bartek J, Lukas J (2006)
    Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
    Cancer Res, 66 (21), 10253-7
    DOI 10.1158/0008-5472.CAN-06-2144, PubMed 17079442

Publications 2005

  1. Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J (2005)
    Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
    Mol Cell Biol, 25 (9), 3553-62
    DOI 10.1128/MCB.25.9.3553-3562.2005, PubMed 15831461
  2. Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T (2005)
    The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    Nat Cell Biol, 7 (2), 195-201
    DOI 10.1038/ncb1212, PubMed 15665856

Publications 2004

  1. Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J (2004)
    Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
    Nat Cell Biol, 6 (9), 884-91
    DOI 10.1038/ncb1165, PubMed 15311285
  2. Syljuåsen RG, Sørensen CS, Nylandsted J, Lukas C, Lukas J, Bartek J (2004)
    Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation
    Cancer Res, 64 (24), 9035-40
    DOI 10.1158/0008-5472.CAN-04-2434, PubMed 15604269
  3. Sørensen CS, Syljuåsen RG, Lukas J, Bartek J (2004)
    ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
    Cell Cycle, 3 (7), 941-5
    PubMed 15190204

Publications 2003

  1. Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK (2003)
    Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
    J Biol Chem, 278 (17), 14806-11
    DOI 10.1074/jbc.M210862200, PubMed 12588868
  2. Löffler H, Syljuåsen RG, Bartkova J, Worm J, Lukas J, Bartek J (2003)
    Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
    Oncogene, 22 (50), 8063-71
    DOI 10.1038/sj.onc.1206976, PubMed 14603247
  3. McBride WH, Iwamoto KS, Syljuasen R, Pervan M, Pajonk F (2003)
    The role of the ubiquitin/proteasome system in cellular responses to radiation
    Oncogene, 22 (37), 5755-73
    DOI 10.1038/sj.onc.1206676, PubMed 12947384
  4. Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J (2003)
    Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    Cancer Cell, 3 (3), 247-58
    PubMed 12676583

Publications 2001

  1. Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J (2001)
    The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    Nature, 410 (6830), 842-7
    DOI 10.1038/35071124, PubMed 11298456
  2. Syljuåsen RG, Krolewski B, Little JB (2001)
    Molecular events in radiation transformation
    Radiat Res, 155 (1 Pt 2), 215-221
    PubMed 11121237

Publications 2000

  1. Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J (2000)
    Rapid destruction of human Cdc25A in response to DNA damage
    Science, 288 (5470), 1425-9
    PubMed 10827953
  2. Whang YE, Tran C, Henderson C, Syljuasen RG, Rozengurt N, McBride WH, Sawyers CL (2000)
    c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency
    Proc Natl Acad Sci U S A, 97 (10), 5486-91
    DOI 10.1073/pnas.97.10.5486, PubMed 10805805

Publications 1999

  1. Syljuâsen RG, McBride WH (1999)
    Radiation-induced apoptosis and cell cycle progression in Jurkat T cells
    Radiat Res, 152 (3), 328-31
    PubMed 10453094
  2. Syljuåsen RG, Krolewski B, Little JB (1999)
    Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status
    Cancer Res, 59 (5), 1008-14
    PubMed 10070956

Publications 1997

  1. Chiang CS, Syljuäsen RG, Hong JH, Wallis A, Dougherty GJ, McBride WH (1997)
    Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo
    Cancer Res, 57 (18), 3899-903
    PubMed 9307268
  2. Syljuåsen RG, Belldegrun A, Tso CL, Withers HR, McBride WH (1997)
    Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection
    Radiat Res, 148 (5), 443-8
    PubMed 9355869

Publications 1996

  1. McBride WH, Economou JS, Syljuåsen RG, Parrish C, Hackman D, Latham V, Chiang CS, Dougherty GJ (1996)
    The effects of cytokine gene transfer into tumors on host cell infiltration and regression
    Anticancer Res, 16 (3A), 1139-43
    PubMed 8702225
  2. Syljuåsen RG, Hong JH, McBride WH (1996)
    Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells
    Radiat Res, 146 (3), 276-82
    PubMed 8752305

Publications 1995

  1. McBride WH, Economou JS, Kuber N, Hong JH, Chiang CS, Syljuasen R, Dougherty ST, Dougherty GJ (1995)
    Modification of tumor microenvironment by cytokine gene transfer
    Acta Oncol, 34 (3), 447-51
    PubMed 7779438

Publications 1992

  1. GUSSGARD R, LINDMO T, BREVIK I (1992)
    CALCULATION OF THE TRAPPING FORCE IN A STRONGLY FOCUSED LASER-BEAM
    J. Opt. Soc. Am. B-Opt. Phys., 9 (10), 1922-1930

 
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