Rinholm Project Group:Oligodendrocytes in health and disease

Johanne Egge Rinholm
The white matter comprises nearly 50% of the human brain. It is composed of nerve cell axons wrapped in myelin, a specialized membrane formed by oligodendrocytes. Myelin is required for fast and reliable action potential propagation and long-term survival of neurons. Consequently, a loss of myelin can cause mental and physical handicap.

We study oligodendrocyte and myelin physiology in the healthy brain and the mechanisms that cause oligodendrocyte injury in conditions such as stroke and dementia. Our methods include in vivo 2-photon imaging, live confocal imaging, electron microscopy and immunohistochemistry.
 

Projects:

1: The role of oligodendrocyte calcium signaling in behavior

2: Oligodendrocytes in ischemic brain injury

3: Oligodendrocyte metabolism

 
 

Contact:
Johanne Egge Rinholm, PhD, Department of Microbiology, Oslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen NO-0424 Oslo, Norway
Tel: +47 907 68 382
E-mail: johrin@rr-research.no ; j.e.rinholm@medisin.uio.no